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      • KCI등재

        Fluoxetine 병용 투여 후 만성 정신분열증 환자에서 혈장 5-Hydroxyindoleacetic Acid 농도에 따른 Hamilton Rating Scale for Depression의 변화

        심세훈,정한용,한선호,Shim, Se Hoon,Jung, Han Yong,Han, Sun Ho 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2

        Object : The aim of this study was to examine an association between plasma 5-Hydroxyindoleacetic Acid(HIAA) level and the change of depressive symptom after fluoxetine trial in haloperidol-stabilized schizoprenic in-patients. Method : According to plasma 5-HIM level, 32 patients were classified to either group with high 5-HIAA level(N=11) or that with low 5-HIM(N=11). For each patient, fluoxetine(20mg/day) added to stable haloperidol dose for 6 weeks. The authors measured Hamilton Rating Scale for Depression (HRSD) at baseline, the 2nd week, the 4th week, the 6th week of treatment. Result : 1) Age, duration of illness, number of admission, duration of present admission, dosage of haloperidol between high 5-HIAA group and low 5-HIM group were significantly different. 2) As time went on, the association between the change of depressive symptom and plasma 5-HIAA concentration was not significant. 3) Of depressed group, as lime went an, depressive symptoms were improved significantly in high 5-HIAA group, but not in law 5-HIM group. Conclusion : We suggest that the association between plasma 5-HIAA level and the change of depressive symptoms after fluoxetine trial in haloperidol stabilized schizophrenic in-patients was not significant.

      • KCI등재후보

        한국형 양극성장애 약물치료 알고리듬 2014 : 소아 청소년

        심세훈,박원명,손인기,김문두,이정구,윤보현,정종현,왕희령,우영섭,전덕인,서정석,신영철,민경준 대한우울조울병학회 2014 우울조울병 Vol.12 No.2

        Objectives : Clinicians who treat children and adolescents with bipolar disorder desperately need current treatment guidelines. Therefore, we decided to develop first the algorithms for children and adolescents with bipolar disorder when we revise the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2010. Method : We performed the survey using questionnaire comprising 16 questions according to each situation in children and adolescents with bipolar disorder. Twenty-three members of the review committee completed the survey. The executive committee analyzed the results and discussed the final production of algorithm considering scientific evidences. Results : The first-line strategy for manic episode in children and adolescents with bipolar disorder is combina-tion of mood stabilizer and an atypical antipsychotic. There was no first-line strategy including expert consensus for depressive episode in children and adolescents with bipolar disorder and at high risk for bipolar disorder. Conclusion : We developed the algorithm for children and adolescents with bipolar disorder first in KMAP-BP 2014. We expect this algorithm may provide clinicians good information and help about the treatment of children and adolescents with bipolar disorder.

      • KCI등재

        한국형 양극성 장애 약물치료 알고리듬 2018 : 소아/청소년

        심세훈,박원명,윤보현,전덕인,서정석,김원,이정구,우영섭,정종현,김문두,손인기,송후림,민경준 대한우울조울병학회 2018 우울조울병 Vol.16 No.3

        Objectives : The objective of this study was to revise the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2014: Children and Adolescents. Methods : We performed the survey, using a questionnaire comprising 22 questions according to each situation, in children and adolescents with bipolar disorder. Results : First-line pharmacotherapeutic strategies for manic episode in children with bipolar disorder were a combination of mood stabilizer (MS) and an atypical antipsychotics (AAP), monotherapy with an AAP, risperidone, and aripiprazole. Aripiprazole was selected as first-line medication for depressive episode in children with bipolar disorder, and aripiprazole, and risperidone were selected as first-line at high-risk children. First-line pharmacotherapeutic strategies for manic episode in adolescents were a combination of MS and an AAP, monotherapy with an AAP valproate, lithium, risperidone (Treatment of Choice, TOC), aripiprazole, and quetiapine. First-line pharmacotherapeutic strategies for depressive episode in adolescents, were a combination of an atypical antipsychotics and lamotrigine, valproate, aripiprazole (TOC), risperidone, and quetiapine. For depressive episodes in adolescents at high risk for bipolar disorder, valproate, aripiprazole (TOC), and risperidone were selected as first-line medication. Conclusion : We expect that the present KMAP-BP 2018-children and adolescents, is useful for clinicians to treat children and adolescents with bipolar disorder.

      • KCI등재

        The Relationship between Plasma Erythropoietin Levels and Symptoms of Attention Deficit Hyperactivity Disorder

        심세훈,Yong-Ku Kim,Young Hwangbo,Heejung Yoon,Ji Sun Kim,Youn Jung Lee,Young Sup Woo,박원명 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2

        Objective: There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this study was to examine the EPO plasma levels and determine whether there was any correlation between plasma EPO levels and clinical characteristics of ADHD. Methods: Plasma EPO levels were measured in 78 drug-naïve children with ADHD and in 81 healthy children. The severity of ADHD symptoms was determined by scores on the Korean ADHD Rating Scale (K-ARS) in ADHD children and healthy controls. Results: The difference between median plasma EPO levels in ADHD children and in healthy controls was not statistically significant. Adjusting for age and sex, a linear regression analysis showed that inattention score was significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Hyperactivity-impulsivity score was significantly higher in the highest tertile of plasma EPO compared to those in the lowest tertile. Moreover, total K-ARS scores were significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Conclusion: These findings suggest that plasma EPO levels were related to some ADHD symptoms, which could be used in the monitoring of the disorder.

      • KCI등재

        자살을 시도한 우울증 환자에서 혈장 ${\beta}$-Nerve Growth Factor 농도의 변화

        심세훈,원성두,이분희,한창수,양종철,권영준,김용구,Shim, Se-Hoon,Won, Seong-Doo,Lee, Bun-Hee,Han, Chang Su,Yang, Jong-Chul,Kwon, Young-Joon,Kim, Yong-Ku 대한생물정신의학회 2006 생물정신의학 Vol.13 No.2

        Object : Nerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt. Methods : The subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale(HDRS). The severity of the suicidal behavior was evaluated by Weisman and Worden's risk-rescue rating(RRR) system and the Lethality Suicide Attempt Rating Scale(LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay(ELISA) method. Results : There were no statistically significant differences of the plasma NGF levels among groups. LSARS and RRR did not reveal any significant correlation with ${\beta}$-NGF level in suicidal depressive patients. Conclusion : This study do not support an association between ${\beta}$-NGF and suicidal depression. However it is necessary to investigate this association through other route such as postmortem brain.

      • KCI등재후보

        자살을 시도한 우울증 환자에서 혈장 ß -Nerve Growth Factor 농도의 변화

        심세훈,김용구,권영준,이분희,원성두,양종철 대한생물정신의학회 2006 생물정신의학 Vol.13 No.2

        ObjectNerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt.MethodsThe subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). The severity of the suicidal behavior was evaluated by Weisman and Wordens risk-rescue rating (RRR) system and the Lethality Suicide Attempt Rating Scale (LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay (ELISA) method.

      • KCI등재후보

        A Case of Galactorrhea Associated with Excitalopram

        심세훈,Yeon-Jeong Lee,Eun-Chan Lee 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Escitalopram is one of the most popular selective serotonin reuptake inhibitors (SSRIs) in current use as a first-line treatment for depression. Escitalopram is well-tolerated and rarely associated with serious side effects. Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is very rarely mentioned among SSRIrelated side effects. Serotonin-enhancing antidepressants may result in a rise in prolactin levels through suppression of dopamine neurotransmission. In the present study, we report a case of hyperprolactinemic galactorrhea associated with escitalopram. A 36-year-old woman developed galactorrhea after initiation of escitalopram for depression and was found to have an elevated prolactin level. Escitalopram was discontinued with resolution of the patient’s galactorrhea and normalization of her prolactin level.

      • KCI등재

        우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성

        심세훈,황보영,권영준,정희연,이분희,김용구 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Objectives : Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, Plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. Methods : The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). Results : There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. Conclusion : This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.

      • KCI등재

        한국형 우울장애 약물치료 알고리듬 2017(V) : 소아·청소년/노인/여성

        심세훈,박영민,김원,왕희령,우영섭,서정석,정종현,이정구,전덕인,민경준,박원명 대한우울조울병학회 2017 우울조울병 Vol.15 No.2

        vision of the previous version. The main purpose of the current study was an amendment of the guidelines for the treatment of major depressive disorder (MDD) for a special population. Methods : The survey consisted of 11 questionnaires for children and adolescents, 7 questionnaires for the elderly, and 8 questionnaires for females. A total of 24 of the 42 experts in pediatric psychiatry, and 79 of the 144 experienced adult psychiatrists answered the survey. Results : As the 1st line of treatment for MDD without psychotic features in children and adolescents, antidepressant (AD) monotherapy was the preferred choice, and AD augmented with atypical antipsychotics (AAP) was preferred for MDD with psychotic features. In geriatric depression, AD monotherapy was recommended as the treatment of choice for mild to moderate episodes and for severe episodes without psychotic features. For the latter, combination of AD and AAP was recommended as the treatment of choice. For MDD in pregnancy, AD monotherapy was as the preferred 1st line in both mild to moderate and severe episodes without psychotic features. In severe episode with psychotic features, a combination of AD and AAP was selected as the 1st line option. Conclusion : We developed the algorithm for special populations with depressive disorders, more specifically than the KMAP-DD 2012. We expect this algorithm will provide clinicians useful information and help the treatment of children and adolescents with depressive disorders

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