한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

Polyphosphate가 Porphyromonas endodontalis의 성장에 미치는 영향에 관한 연구

최성백,최호영,민병순,박상진,이진용,최기운 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

Polyphosphate has been used to prevent decomposition of foods and has been shown to have inhibitory effect on the growth of gram positive bacteria. The purpose of this study was to evaluate the effect of polyphosphate on the growth of Porphyromonas endodontalis, a gram negative endodontopathic bacterium. Porphyromonas endodontalis ATCC 35406 was grown in the presence of polyphosphates with different chain lengths. Inhibitory effect of each polyphosphate which was added at the beginnig or during the culture, was determined by measuring the optical density of the bacterial cell at 540nm and by viable cell count. The results from this study were as follows : 1. Polyphosphates were shown the growth inhibition of the Porphyromonas endodontalis. 2. The minimal inhibitory concentration(MIC) of polyphosphate was observed to be 0.04%. 3. Polyphosphates with chain lengths of 25 and 75 demonstrated the greatest inhibitory effect on the growth of Porphyromonas endodontalis. 4. Polyphosphates are bactericidal to Porphyromonas endodontalis, demonstrating the growth inhibition of the bacterium. The overall results suggest that use of polyphosphate may affect the growth of Porphyromonas endodontalis. Further studies will be needed to confirm the effect of Polyphosphate.

Nanogenerators: Fully Rollable Transparent Nanogenerators Based on Graphene Electrodes (Adv. Mater. 19/2010)

Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19

<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

해양공간 정책시뮬레이션 기술 개발 - 현황 및 도전과제

조성진(Sung-Jin Cho),강전영(Jeon-Young Kang),박재영(Jaeyoung Park),최희정(Hee-Jung Choi),남정호(Jungho Nam) 한국해양환경·에너지학회 2021 한국해양환경·에너지학회 학술대회논문집 Vol.2021 No.5

“실제로 존재하지 않는 대상을 존재하는 것처럼 만들어 놓은 인공물"을 뜻하는 라틴어 '시뮬라크르(simulacre)'에서 파생된 시뮬레이션(simulation)은, 복잡한 문제를 해석하기 위해서 실제와 비슷한 상태(시스템)를 모델로서 구현하고, 반복 연산을 통해 최적해를 찾는 과정을 뜻한다(Baudrillard, 1994). 전통적인 분석적 방법론(analytical method)은 계수 추정을 통해서 특정 시점의 두 변수, 즉 독립변수와 종속변수의 상관성을 규명하는데 반해, 시뮬레이션 방법론(simulation method)은 현상의 재현을 통해서 과정을 파악하는데 목적을 둔다. 이러한 특징으로 말미암아 시뮬레이션 기법은 문제의 최적해보다 현상의 규명에 더 적합한 방법론이다. 자연계 (nature system)의 문제(가령, 산사태의 발생원인)는 요인들 간 단순하고 명확한 관계에 의해서 정의되지만, 인간계(human system)의 문제(가령, 부동산 가격상승의 원인)는 비교적 복잡하고 불명확한 관계에 의해서 규정된다. 따라서 주로 인간관계에서 비롯되는 사회 문제를 해결하기 위한 수단으로써 정책은 시뮬레이션 기술을 적용하기에 적합한 대상이다. 일반적으로 정책은 결과 못지않게 과정도 중요하며(당위성), 현재·미래 문제를 포괄하고, 긍정적·부정적 효과(양면성)를 함께 고려하므로, 시뮬레이션은 이러한 요건에 잘 부합하는 기술이다. 최근 노인복지(백의현, 2019), 미세먼지(심창섭, 2019), 주택시장(최명섭&변세일, 2016), 인구센서스(배장현 외, 2016) 등 다양한 정책분야에서 시뮬레이션 기술이 활용되고 있다. 2019년에 재정된 “해양공간계획 및 관리에 관한 법률”에 근거한 해양공간기본·관리계획, 해양용도구역, 해양공간적합성협의 등은 해양자원의 효율적 이용과 해양공간의 갈등 및 상충을 해소하기 위한 해양수산 분야의 新정책수단이다. 최근 해양관광, 골재채취, 해상풍력, 해상경계분쟁 등 사회적 이용 및 갈등이 심화되면서 실효성 있는 해양공간정책의 요구가 높아지고 있는 실정으로, 해양정책을 정확하게 평가하고 지원할 수 있는 과학적 도구가 절실하다. 해양공간은 환경·생태계, 지역사회, 수산업, 관광업, 에너지개발 등 복잡한 이해관계가 얽혀 있으며, 정책평가 시 이러한 관계를 명확하게 정의하고 고려해야 한다. 본 연구는 해양공간정책 지원도구로써 해양정책시뮬레이터(Ocean Policy Simulator, OPSim)를 제안하며, 대표적인 복잡계 연구방법론으로서 거시적 현상을 미시적 행위자의 상호작용으로 설명하기 위해 제안된 행위자기반모형(Agent-Based Model, ABM)을 적용하고자 한다. ABM은 정책 대상 및 환경의 동적 변화와 더불어, 자연·인문 환경과의 상호작용(상충 또는 시너지)이 활발한 해양 분야에 적합한 방법이지만, 동시에 시뮬레이션 결과에 대한 검증의 어려움과 모델 인자의 초기값에 대한 의존성 등 한계점을 내포하고 있다. 따라서 ABM을 적용한 OPSim 개발 과정에서 빅 데이터를 활용한 AI기술, 자가진화 시뮬레이션 기법(self-evolving simulation), 시스템다이나믹스(system dynamics) 등을 활용하여 한계점을 보완할 수 있다(Scheutz et al., 2016; Kang et al., 2016; Bae et al., 2018; Kavak et al., 2018). Simulation derived from the Latin word "simulacre" for "artificial objects that actually do not exist" means the process of modeling a realistic state (system) to interpret complex problems and finding an optimal solution through repeated operations (Baudrillard, 1994). While a traditional analytical method defines the correlation of two variables (i.e., independent variables and dependent variables) through coefficient estimation, a simulation method aims to identify the process through the reproduction of phenomena. Therefore, a simulation technique is a more suitable methodology for identifying phenomena rather than finding an optimal solution. The problem of the natural system (e.g. landslides) is defined by simple and clear relationships between factors, but that of the human system (e.g. real estate prices) is defined by relatively complex and unclear relationships. Therefore, a policy as a means of solving social problems, primarily derived from human relationships, is suitable for applying a simulation technique. Simulation is a technology that meets these requirements well, as a policy addresses the procedure as important as the result, solving current and future problems, and considering both positive and negative effects. Recently, simulation technology has been used in various policy areas such as welfare for senior citizens (Baek, 2019), fine dust (Shim, 2019), housing market (Choi&Byun, 2016), and population census (Bae et al, 2016). Marine space policies based on the Marine Space Planning and Management Act, which was enacted in 2019, such as marine spatial basic and management plans, marine use zones, and marine space suitability consultations are new political tools for efficient use of marine resources and management of conflicts. As social use and conflicts such as maritime tourism, aggregate collection, off-shore wind power, and maritime border disputes have intensified recently, calls for effective marine spatial policies are increasing, and scientific tools are urgently needed to accurately evaluate marine policies. Since marine space is intertwined with complex interests such as the environment, ecosystem, community, fisheries, tourism, and energy development, a marine spatial policy support tool should define and consider these relationships for policy evaluation. This paper proposes Ocean Policy Simulator (OPSim) as a support tool for marine spatial policy. Specifically, we aim to highlight the usefulness of an agent-based model (ABM) to explore human-nature interactions (i.e., conflict or synergy) and to provide policy implications. Using an ABM for such purposes often meet the issues in regard to verification and validation of the model’s structures and outcomes. However, AI technology using spatiotemporal bigdata, self-evolution simulation techniques, and system dynamics can help to tackle validation and verification procedures in the development process of OPSim using ABM (Scheutz et al., 2016; Kang et al., 2016; Bae et al., 2018; Kavak et al., 2018).

식민시대 지식인, 유상규(劉相奎)의 삶의 궤적

최규진(CHOI Q-Jin),황상익(HWANG Sang-Ik),김수연(KIM Soo-Youn) 大韓醫史學會 2009 醫史學 Vol.18 No.2

Many of the Korean intellectuals resisted against suppression of Japanese Imperialism with the people during the Japanese occupation period. Ryu Sang-Kyu was also one of those intellectuals. Ryu Sang-Kyu was born in Gang-gye of North Pyongan-do on 10th November, 1897. He entered Keijo Medical College as one of the first entering students in 1916. However, at the end of his third year, he participated in the 3·1 Independence Movement of Korea and was suspended from the college which was run by the Japanese on account of his participation. Then moving to Shanghai, he joined Heung Sa Dan(興士團), an active patriotic group fighting for independence of Korea. He initiated the provisional government of Korea as a network investigator and he played second string to Ahn Chang-Ho(安昌浩), one of major Korean independence activists for four years. In 1923, following Ahn Chang-Ho’s advice, he returned to Keijo Medical College to complete the course. Even in colonial Korea, he continued independence movement and was involved in Dong Woo Hoe(同友會), the branch of Heung Sa Dan in Korea. After the graduation of Keijo Medical College in 1927, he had served at the department of surgery in Keijo Medical College. In 1930, he participated in founding of the Korean Medical Association(朝鮮醫師協會). He also raised public awareness by writing to many articles on hygiene and public health issues in public journals and newspapers. In short, he did his best as an intellectual, a medical doctor, an activist of independence movement until he died from streptococcal infection on 7th July, 1936.

주민참여 지도화 기법을 활용한 마을 공간 자원 발굴에 관한 연구

최성진(Choi, Sung Jin) 한국지역사회학회 2018 지역사회연구 Vol.26 No.3

그동안 많은 사례연구가 밝혀왔듯이 마을 자원조사는 도시계획에서 지역 문제에 대한 주민의 참여와 이해를 높이기 위한 중요한 과정이었다. 마을 지도 그리기는 이 과정에서 가장 잘 알려진 기법 중 하나였지만, 지도화 기법 자체와 분석 방법을 개발하는 데는 한계가 있었다. 따라서 거주자의 다양한 관점을 실제계획에 적용하는 것이 중요함을 인식하면서도 대부분 결과적으로는 자원의 발굴, 개발과 사업화가 여전히 전문가에게 맡겨지고, 주민에 의한, 혹은 주민 관점에서의 자원 발굴과 사업화 분야는 주민참여를 촉진하기 위한 프로그램의 한 부분으로 한정되어 있었다. 이에, 본 연구는 지역에 대한 좀 더 나은 이해와 지역공간 자원조사 기법의 개발을 위해 주민참여에 의한 인지 지도의 적용 가능성과 효과를 밝히고자 하였다. 구체적인 연구 방법으로서 대구시 수성구 두산동과 상동을 대상으로 사례연구를 하였으며, 대상지역 주민에게 설문 및 인터뷰를 진행하였다. 그 결과, 첫 번째, 문헌 및 단순 설문조사에 의한 결과와 대조적으로, 거주자의 인지 지도는 다른 지역의 사람들이 발견하기 어려운 다양한 공간 자원과 문제들을 드러냈다. 둘째, 사전 정보를 주지 않은 인지 지도는 주민의 생활에 더욱 밀접한 공간 자원을 나타내었다. 마지막으로 본 연구가 진행되는 과정에서 조사 응답의 양에 따라 공간의 위상을 결정했던 기존의 연구들이 가질 수 있는 잠재적 오류를 밝힐 수 있었다. As many case studies have been addressed, a village resource investigation has been a critical process in urban planning to increase the residents’ participation and their understanding on the regional issues. A village map drawing was the one of the popular techniques for the process, but a limit was exist in developing the mapping and analysis techniques. So, even though the importance of planning application of the residents’ various perspectives, in most cases, the discovery, development and commercialization of resources are still left to experts, and the area of resource discovery and commercialization by residents or from a resident"s perspective is limited to a part of the program to promote community participation. This study aims to reveal an applicability and effectiveness of the cognitive map by residents’ participation for a better understanding of the region and for a development of regional spatial resource investigation techniques. Specifically, this study used a case study of Dusan-Dong and Sang-Dong, Suseong-Gu in Daegu conducting a survey and interview. The first result is that, contrast with the findings by simple documents’ investigation and questionnaire, residents’ cognitive map reveals much more spacial resources and issues that are difficult to be found by people from other regions. Second, a cognitive map without preliminary information indicates more diverse spatial resources which are more connected to residents’ life. Finally, during the course of this study, a previous study on community resource exploration was able to identify possible errors in the results of the study, which determined the status of the space according to the amount of survey responses.

What makes hybrid insourcing successful: A new public–private partnership model for social welfare services

Yang Jae‐jin,Kim Hey Sung,Choi Seong Eun,Ryu Lanhee,Choi Young Jun 한국사회복지학회 2020 Asian Social Work and Policy Review Vol.14 No.1

Outsourcing has been a key policy tool for delivering a range of social services, and regarded as more effective than insourcing or direct government provision. At the same time, it has also caused many delivery issues such as principal‐agent problems, a lack of policy coordination, and poor‐quality welfare services. While the pendulum continues to swing between insourcing and outsourcing, we aim to propose a new public–private partnership model called the “hybrid insourcing model” and examine which factors influence the performance of the model. In South Korea, around 2010, the local government in Namyangju City was the first to implement the “Hope Care Center model,” a kind of hybrid insourcing model, which has been praised for its innovation and widely emulated by central and local governments. Our analysis utilizes data collected between December 2017 and January 2018 from public sector employees and civilian staff in Namyangju and a comparable city, A. From this, we draw a number of implications, both for theory and for policy. We argue that, for public–private partnerships, active cooperation and equality are the biggest factors in contributing to positive performance. These work alongside leaders with a clear vision and with employees' positive attitude

한국인의 우울증 진단기준의 특성

장성만,손지훈,이준영,최지환,조성진,전홍진,함봉진,이동현,조맹제 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

목적 국내의 여러 역학 조사에 따르면 한국인은 서구에 비하여 우울증의 유병률이 낮은 것으로 보고되고 있다. 낮은 유병률에 대하여 서구에서 정의하는 우울증의 진단 기준이 한국인의 문화에 맞지 않다는 진단 기준의 오류를 제시하거나, 실제로 유병률이 낮다는 설명을 시도하기도 하였다. 본 연구는 DSM-IV에서 제시하는 우울증의 진단 기준에 대하여 한국인의 반응 특성을 알아보고자 한다. 방법 2001년 KECA 연구에 응답한 만 18세 이상 65세 미만의 6,275명을 대상으로 하였다. 한국어판 CIDI (K-CIDI)를 통해 정신장애의 이환을 진단하였으며, K-CIDI 내의 우울장애 진단 기준만을 추출하여 분석하였다. 분석은 문항반응이론(Item Response Theory)을 적용하였다. 결과 한국인에서 DSM-IV의 주요우울장애 진단 기준의 오류는 없었으나, 진단 기준의 역치는 높았다. 한국인이 호소하는 우울증상으로서 "피로감"과 "집중력 저하", "수면 변화"는 진단되는 우울증의 초기부터 잘 나타나는 증상 들이며, "정선운동변화", "죽음/자살사고", "무가치함/죄책감"은 보다 심한 우울증에서 잘 나타나는 증상들이었다. 결론 DSM-IV가 제시하는 주요우울장애 진단 기준은 한국인의 우울증을 평가하는 데 있어 타당하기는 하나, 진단 기준의 역치가 높다. 우울증의 중증도에 따라 호소하는 증상들이 달랐다. Baekgrounds : Many Korean epidemiologic studies reported lower prevalence rates of depression than those of Western countries. For the low prevalence, it is explained that there's something wrong in the direct application of diagnostic criteria of depression to Korean culture, i.e. categorical fallacy, or it may be truly low-prevalent. We will analyze diagnostic criteria for depression detined by Western. Methods : Six thousand and two hundred seventy-five cummunity dwelling subjects, aged 18-64 years were interviewed by using Korean version of Composite International Diagnostic Interview (K-CIDI). Diagnostic criteria for depression defined by DSM-IV were analyzed using the item response theory. Rcsults : We could not find any fallacies of diagnostic critcria tbr depression defined by DSM-IV when assessing depre-ssion among Koreans. Fatigue, concentration difficultics, and sleep disturbance appeared more fequently in mild depression, while psychomotor change, death/suicide, and worthlessness/guilt did not appear until severe depression. Cunclusion : The diagnostic criteria for depression defined by DSM-IV arc appropriate for the Koreans. There are different responding levels, i.e. threshold, of depressive criteria according to severities of depression. Koreans with depression are more likely to complain of appetite change, but less of worthless or guilty feelings than Western people.