생쥐에서 유발된 멜라노마의 잠재표지 인자로서 생체내 스핑고지질 함량

최헌교, 김정미, 오세관, 이용문, 윤여표, 유환수 충북대학교 약품자원개발연구소 2004 약학논문집 Vol.19 No.-

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우리나라 농촌지역사회 주민의 위장관 증상의 유병률

추교영(Kyo Young Choo),최명규(Myung Gyu Choi),최황(Hwang Choi),이동수(Dong Soo Lee),김진일(Jin Il Kim),김성수(Sung Soo Kim),방춘상(Choon Sang Bhang),박수헌(Soo Heon Park),김재광(Jae Kwang Kim),한석원(Sok Won Han),최규용(Kyu Yong Cho 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.1

N/A Background/Aims: Chronic gastrointestinal (GI) symptoms are believed to be common in the general population, but there is a lack of data from Korea. The aim of this study was to es1imate the prevalence of chronic gastrointestinal symptoms in a rural community in Korea by using the Bowel Symptom Questionnaire (BSQ), which was based on the multinational diagnotic Rome criteria for functional bowel disorders, as a measure of GI symptoms. Methods: A cross-sectional survey, using a reliable and valid questionnaire based on the fulfillment of the Rome criteria, was performed in a densely populated district in a Korean rural community on the residents aged l8-69 yr (mean 48±14 yr). 95,5% responded (n=420). All respondents were interviewed at their home or offices by a team of interviewers. Results: Two thirds of Korean rural residents experience gastrointestinal symptoms and one fifth of them visit a clinic or hospital at least once a year. Prevalences of weekly heartburn, gastroesophageal reflux disease, dyspepsia, irritable bowel syndrome (IBS), and chronic constipation were 5.2% (95% confidence interval [CI], 3.l-7.4, 2.6% (95% Cl, 1.1-4.2), 15.5% (95% CI, 11.9-19.0), 8.6% (95% CI, 3.8-11,3), and 24.3% (95% CI, 20.1-28.5) respectively. The prevalence of dyspepsia was 25%, taking medication usage into consideration. Ulcer-like dyspepsia (11.2%) was the most common subtype and 40% of the subjects with dyspepsia were classified into more than one subtype of dyspesia. There was an overlap between subjects with IBS and dypepsia with 6.1% of dypeptics having IBS and ll,l% of IBS patients having dypepsia. Conclusions: The prevalence of GERD was low in Korea compared with that of the Western countries. The prevalences of dyspepsia and IBS were similar to those of the Western countries. The most common gastrointestinal symptom in a rural community in Korea is dyspepsia, (Korean Journal of Castrointestinal Motility 2000;6:31-43)

혈청 anti - HCV 양성자의 역학 및 가족내 감염과 HBV 표지자에 관한 조사

이헌주(Heon Ju Lee),강호정(Ho Jung Kang),김기덕(Kee Duck Kim),박찬원(Chan Won Park),윤현대(Hyun Dae Yoon),전진종(Jin Chong Chun),최교원(Kyo Won Choi),최희진(Hee Jin Choi) 대한내과학회 1992 대한내과학회지 Vol.43 No.6

N/A Background: Transfusion is a well-known source of hepatitis C virus (HCV) infection but over half of the hepatitis C patients do not have any suspicious source of infection. Epidemiological survey and serological test for HBV marks were done among anti-HCV positive chronic liver disease patient and their family members. Method: 74 cases of anti-HCV postitive chronic liver disease patients were evaluated for the evident source of HCV infection and 188 of their family members were consulted for the infection of HCV. To compare the mode of HBV infection with HCV, serum HBsAg, anti-HBc and anti-HBs were checked in 43 of HBsAg positive chronic liver disease patients, 190 of their family members, 64 anti-HCV postive chronic liver disease patients and 239 of normal control persons. Results: 35cases (47.3%) of 74 anti-HCV positive chronic liver disease patients had no suspicious source of infection and only 16 cases (21.6%) had the history of past transfusion. No family members except 3 (one infant, one IV drug abuser and one wife) in 3 families among 74 families were anti-HCV positive. 29 of 43 (67. 4%) families of HBsAg positive chronic liver disease patients had at least one of HBsAg positive member. Characteristically, HBsAg was positive in almost all cases of offsprings born to mothers of HBsAg and HBeAg positive chronic liver disease. 2 of 64 (3.1%) serum anti-HCV positive patients had HBsAg in their sera. Anti-HBs positive cases were 11 of 64 (17.2%.) anti-HCV positive chronic liver disease patients and isolated anti-HBc positive cases were 40 of 64 (62.5%). On the other hand, in normal control, the positive rate of anti-HBs and isolated anti-HBc were 57,4% and 24.3%(> in each (p<0,005, in both). Conclusion: In Korea, vertical transmission was the main source of HBV infection but HCV disease might be horizontal and sporadic. No remarkable difference in HBV infection rate between anti-HCV positive chronic liver disease patients and control persons. Superinfection of HCV on person who already was exposed to HBV may occur but this assumption could be depend on accurate testings for HBV and HCV. Some derangement in immune system and reaction or interaction between HBV and HCV should be considered in anti- HCV positive patients but before, isolated serum anti- HBc positive sera of chronic liver disease patients should be examined by confirmatory tests. To reduce the number of HCV patients, defining the evident source of the sporadically infected HCV cases could be helpful.

간세포암에서 방사선 치료의 역할

이헌주,최교원,김명세,은종렬 영남대학교 의과대학 2000 Yeungnam University Journal of Medicine Vol.17 No.2

간세포암에 대한 방사선 치료의 효과를 평가하고자 1984년 1월부터 2000년 1월까지 영남대학교 의과대학 부속병원에서 간세포암으로 진단된 환자들 중에서 방사선 치료 단독 혹은 간동맥 색전술과 병합요법을 한 18명의 환자들의 의무기록과 방사선 사진을 검토하여 다음과 같은 결과를 얻었다. 남자가 15명, 여자가 3명이었으며 평균 나이는 51세였다. 복수가 4명(22.2%)에서 있었으며 간경변이 11명(61.1%)에서 있었다. 간기능은 Child-Pugh class A, B, C가 각각 6명, 3명, 2명이었다. 14명(77.8%)에서 HBs 항원 양성이었으며 anti-HCV 양성은 없었다. 사망원인은 간성혼수를 포함한 간부전이 2명(11.1%), 위장관출혈이 1명(5.6%), 암사망이 1명(5.6%), 현재 생존이 4명(22.2%)였으며 10명(55.6%)은 불명이었다. 종양의 위치는 간우엽이 10례 좌엽이 3례 양쪽 모두가 5례였으며, 종양의 형태는 결절형이 4례, 괴상형이 7례, 미만형이 7례였다. 8례(44.4%)에서 동정맥우회(shunt)가 있었으며 간문맥혈전증이 4례(22.2%)에서 있었다. 병기는 Ⅰ기, Ⅱ기, Ⅲ기, Ⅳ기 각각 0례, 5례, 4례, 9례였다. 종양의 크기(volume percentage)는 4025%(5-96)였다. 치료에 대한 반응은 partial response가 2례(11.1%), minimal response가 4례(22.2%), no change가 11례(61.1%), progressive disease가 1례(5.6%)였다. 평균 생존률은 97개월(2-25)로 반응률(response rate)은 33.3%였다. 3개월, 6개월, 12개월, 24개월 생존률은 각각 81.3%, 43.8%, 18.8%, 6.3%였다. 결론적으로, 간세포암에 있어서 방사선 치료는 생존률을 향상시키지는 못하더라도 종양의 크기를 줄이는데 효과가 있었다. 간동맥 색전술과의 병합치료가 치료효과를 강화하는 것으로 생각되나 방사선 단독 치료의 효과를 알기 위해서는 더 많은 연구가 필요할 것으로 생각된다. Background : Hepatocellular carcinoma(HCC) has been considered to be relatively radioresistant. The role of radiotherapy(RT) in the treatment of HCC is controversial. But RT has a role in the treatment of hepatocellular carcinoma as a single or combination modalities. The effect of radiotherapy on HCC was evaluated. Material and Methods : From January 1984 through January 2000, a total of 18 patients with unresectable HCC underwent radiotherapy alone or in conjunction with transarterial imbolization(TAE). We reviewed the medical records of patients with RT and measured the tumor size using planimetry method. The Kaplan-Meier method was used to calculate the survival rate. Results : The RT patients were 15 men and 2 women. The mean age was 51 years. Four(22.2%) of them were accompanied with ascites. Eleven(61.1%) of them were accompanied with liver cirrhosis and their functions were 6, 3, 2 in each Child-Pugh A, B, C, respectively. A partial response(PR) was observed in 1 patients(11.1%), minimal response(MR) in 4 patients(22.2%) and no change(NC), in 11 patients(61.1%), whereas progressive disease(PD) was seen in 1 patients(6%). The survival rate determined at 3, 6, 12, and 24 months were 81.3%, 43.8%, 18.8%, and 6.3%, respectively. Conclusions : Although the radiotherapy in HCC did not improve the survival rate, it decreased the tumor size. Radiotherapy strengthens the therapeutic efficacy when compbined with TAE, but more studies are needed.

블록 단위 모션정보를 이용한 감시시스템의 움직임 객체추적

신헌수(Heon Soo Shin),현교환(Kyo Hwan Hyun),김성민(Sung Min Kim),최원갑(Weon Gab Choi),원치선(Chee Sun Won),엄기환(Ki Hwan Eam) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7

Object tracking is one of the attractive issues in many applications such as security and surveillance. Although many algorithms have been studies for improving the object tracking technique. We proposed method that the image is divided into several sub-blocks. And the motion information of current image is calculated by block-based motion estimation.

동결 온도와 재하속도에 따른 동결토의 일축강도 특성에 관한 실험적 연구

최헌우(Heon-Woo Choi),서영교(Young-Kyo Seo),안승만(Sung-Man An),조현주(Hyun-Ju Cho) 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6

The mechanical properties governing the behavior of frozen soil structure have been interested design factors for some field applications. In this research, a series of laboratory tests were performed to investigate the compression strength properties of mixed soil(standard sand and kaolinite) in three different temperature such to the 5, 10 and 15 degrees below zero environment. The effects of strain rate(1.11*10-4 to 2.22*10-2) on the compressive properties of artificial soil have been determined experimentally using uniaxial compression test. Data included on the initial tangent modulus, compressive strength and failure strain.

식도확장이 뚜렷하지 않은 아칼라지아

추교영,최명규,박성규,이성희,최황,박수현,한준열,김재광,한석원,정인식,정규원,선희식 대한소화관운동학회 1999 Journal of Neurogastroenterology and Motility (JNM Vol.5 No.2

간내 포충낭 1예

김정미,최교원,이헌주 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

In humans, echinococcal species produce cystic lesions primarily involving the liver and lung. Echinococcal infection is caused far more commonly by Echinococcus granulosa than by E. multilocularis, which accounts for less than 5 per cent of all cases of hydatid liver disease. Hydatid disease occurs principally in sheep grazing areas, particularly in the Australia, New Zealand, Greece, Yugoslavia, Middle East, and South American countries, but with increasing migration and traveling, this disease now has a worldwide distribution. This disease is rare in Korea and only few cases have been reported. This is a clinical case report of hydatid cyst of liver caused by Echinococcus granulosus in a 52-year-old man who had been dispatched in the Vietnam from 1966 to 1968.

위암에서 APC 유전자의 이형접합성 상실과 - Catenin 발현과의 관계

박수헌,김재광,정규원,최명규,한준열,선희식,문성배,추교영 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6

Background/Aims: Wide-type Adenomatous polyposis coli (APC) gene binds to β-catenin and APC mutants lead to cytosolic accumulation of β-catenin which serves as a component of carcinogenesis. We investigated the relationship between loss of heperozygosity (LOH) of APC gene and β-catenin expression in gastric cancer. Methods: We examined the LOH of exon 11 of APC gene in frozen specimens of 28 gastric adenocarcinomas and 28 normal gastric tissues obtained from the same patient using polymerase chain reaction and restriction fragment length polymorphism. The cytoplasmic and nuclear β-catenin were investigated by Western blotting. Results: The heterozygosity of APC gene was observed in 21% (6/28), and LOH of APC gene was observed in 33% (2/6). In 14% (4/28) of gastric cancers, β-catenin was strongly expressed both in the cytoplasm and the nucleus. The LOH of APC gene was not correlated with accumulation of β-catenin. Conclusions: The LOH of exon 11 of APC gene is not correlated with an increase of β-catenistric cancer. The cytoplasmic accumulation of β-catenin may be associated with mutations in APC-β-catenin-Tcf-4 pathway.

Protection of LLC-PK1 Cells Against Hydrogen Peroxide-Induced Cell Death by Modulation of Ceramide Level

유재명,이윤선,Heon-Kyo Choi,이용문,홍진태,윤여표,오세관,유환수 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.3

Oxidative stress has been reported to elevate ceramide level during cell death. The purpose of the present study was to modulate cell death in relation to cellular glutathione (GSH) level and GST (glutathione S-transferase) expression by regulating the sphingolipid metabolism. LLCPK1 cells were treated with H2O2 in the absence of serum to induce cell death. Subsequent to exposure to H2O2, LLC-PK1 cells were treated with desipramine, sphingomyelinase inhibitor, and N-acetylcysteine (NAC), GSH substrate. Based on comparative visual observation with H2O2-treated contro l cells, it was observed that 0.5 µM of desipramine and 25 mM of NAC exhibited about 90 and 95% of cytoprotection, respectively, against H2O2-induced cell death. Desipramine and NAC lowered the release of LDH activity by 36 and 3%, respectively, when compared to 71% in H2O2-exposed cells. Cellular glutathione level in 500 µM H2O2-treated cells was reduced to 890 pmol as compared to control level of 1198 pmol per mg protein. GST P1-1 expression was decreased in H2O2-treated cells compared to healthy normal cells. In conclusion, it has been inferred that H2O2-induced cell death is closely related to cellular GSH level and GST P1-1 expression in LLC-PK1 cells and occurs via ceramide elevation by sphingomyelinase activation.