러시아 민주화에 대한 비교 민주화이행론적 고찰

박수헌 경희대학교 사회과학대학 1997 社會 科學 論叢 Vol.15 No.-

의약품의 시판 후 조사와 리베이트

박수헌 숙명여자대학교 법학연구소 특성화센터 2016 청파법학 Vol.- No.13

위장관 이식편대 숙주질환 4 예

박수헌,정인식,박종원,정규원,김부성,최황,최명규,조세현,선희식,김춘추,한준열,김석은,김동집 대한내과학회 1995 대한내과학회지 Vol.49 No.2

Graft-versus-host disease(GVHD) is a major cause of morbidity and mortality following bone marrow transplantation(BMT). Moderate to severs GVHD occurs in nearly one half of recipients of HLA identical sibling BMT, and 10-30% of these patients die due to acute GVHD or its complications. Target organs injured by GVHD include the skin, liver, and gastrointestinal tract. The clinical staging and grading of acute GVHD are based on the degree of target organ damage. In Korea, the occurrence of GVHD is about 20%. We report four typical eases of histologically con- firmed GUHD after allogeneic BMT, and review the literature to compare the difference$quot; in primary ill-ness, clinical manifestations, and disease progression.

대장관 내압 상승으로 유발된 허혈성 대장염 15예의 분석

박수헌,김명훈,김기범,조세현,차상복,문성배,배상수,한원희,최규용,조환석 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.6

It was suggested that temporary vascular insufficiency within the wall of the colon causes iachemic colitis. So, motivated by this fact, we studied and analyzed 15 cases of iachemic colitis, which were confirmed by the diagnostic criteria of Nagasako(1982), through 32 months from January, 1993 to August, 1995 at Our Lady of Mercy Hospital, Incheon. The results were as follows: 1) Average age was 51.3 years(17 to 79 years), 10 of 15 cases were above 50 years and the rest were below 50 years. The ratio of men to women was 7:8. 2) The causes were 8 cases of enema, 3 cases' of taking laxative drugs, 3 cases of strain, and 1 case of having colonofiberscopy. 3) The symptoms were 15 cases of abdominal pain(100%), 15 cases of bloody stool (100%), and 7 cases of diarrhea(47%). The signs were 13 cases of abdominal tenderness(87%), 3 cases of fever(20%), and 11 cases of leukocytosis(above 10.0000/㎣)(73 %). 4) The involved sites were 13 cases in the sigpnoid colon(87%), 10 cases in the descending colon(67%), and 9 cases in the rectum(60%). 5) The colonafiberscopc findings were 15 cases of diffuse hyperemia(100%), 13 cases of erosions and hemorrhage(87%), 13 cased of edema(87%). 9 cases of exudate (60%), and 6 cases of ulcer(40%). The longitudinlal hyperemia or shallow ulceration, which are characteristic of colonofiberscopic findings of ischemic colitis, were found in 11 eases(73%). After a week, the follow-up endoscqpy showed that most of lesions were improved. And after another wek, sill cases had recovered. 6) All cases were improved by NPO and fluid therapy; the period of fluid therapy was 5.89 days. 7) The pathological findings were 11 cases of chronic ulceration(79%) and 1 cases each of erosion, superficial hemorrhage, melansis coli(7%). And only a patient was not biopsy.

위장관 2 : 바렛식도는 어떻게 관리해야 하는가?

박수헌 대한소화기학회 2004 대한소화기학회 춘계학술대회 Vol.2005 No.-

과민성 대장염환자에서 이중 맹검 투여한 Tiropramide의 치료 효과

박수헌,정창훈,한준열,최명규,최규용,정인식,정규원,선희식,김부성 大韓消化器病學會 1993 大韓消化器病學會誌 Vol.25 No.5

위암에서 APC 유전자의 이형접합성 상실과 - Catenin 발현과의 관계

박수헌,김재광,정규원,최명규,한준열,선희식,문성배,추교영 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6

Background/Aims: Wide-type Adenomatous polyposis coli (APC) gene binds to β-catenin and APC mutants lead to cytosolic accumulation of β-catenin which serves as a component of carcinogenesis. We investigated the relationship between loss of heperozygosity (LOH) of APC gene and β-catenin expression in gastric cancer. Methods: We examined the LOH of exon 11 of APC gene in frozen specimens of 28 gastric adenocarcinomas and 28 normal gastric tissues obtained from the same patient using polymerase chain reaction and restriction fragment length polymorphism. The cytoplasmic and nuclear β-catenin were investigated by Western blotting. Results: The heterozygosity of APC gene was observed in 21% (6/28), and LOH of APC gene was observed in 33% (2/6). In 14% (4/28) of gastric cancers, β-catenin was strongly expressed both in the cytoplasm and the nucleus. The LOH of APC gene was not correlated with accumulation of β-catenin. Conclusions: The LOH of exon 11 of APC gene is not correlated with an increase of β-catenistric cancer. The cytoplasmic accumulation of β-catenin may be associated with mutations in APC-β-catenin-Tcf-4 pathway.

이종이식에 따른 평생추적관찰을 강제하기 위한 미국의 규제법적 방안

박수헌 한국공법학회 2008 공법연구 Vol.37 No.1

Xenotransplantation is a promising therapy to rescue human lives by using animal organ, tissue, and cell. However, xenotransplantation comes with numerous risks unknown and potential to our society. Due to these risks, xenotransplant recipients are required to consent to long-term surveillance. Regardless of the necessity of life-long surveillance to prevent these risks, it might be invasive to xenotransplant recipients. In addition, there're some legal problems related to xenotransplant recipients' privacy and third-party consent as well. It's also required that life-long surveillance program must be constitutional and effective in order to be successful. Thus far, however, the law relating to xenotransplantation is underdeveloped and current public health law are inadequate to enforce consent to life-long surveillance. This paper will analyze and discuss the legal issues regarding how to enforce xenotransplant recipients to comply with life-long surveillance, informed consent issues in compelling life-long surveillance, and the need to enact xeno-specific legislation. Part II will examine the causes of difficulties in compelling xenotransplant recipients to comply with life-long surveillance. Part III will analyze the issues of obtaining xenotransplant recipients and third-party consents. Part IV will address the current legal and regulatory framework at both state and federal levels, demonstrating that such framework insufficiently addresses the legal issues on life-long surveillance. Part V will evaluate proposed solutions, including strategies implemented in dealing with other commuicable diseases, and will suggest measures for effective compliance with life-long surveillance. Part VI will emphasize again the need to enact xeno-specific legislation in order to protect public health through making xenotransplant recipients comply with life-long surveillance. On top of that, in Part VI, I will suggest some contents regarding effective compliance with long-term surveillance that xeno-specific legislation has to include. 이종이식은 동물로부터 인간에게로 이식이라는 유망한 치료법이지만 동시에 많은 위험을 동반하기도 한다. 이러한 위험이 이종이식 수령자들로 하여금 평생추적관찰을 받는데 동의할 것을 요구한다. 그러나, 평생추적관찰은 이종이식 수령자에 대하여 침해적일 수 있고, 프라이버시를 위태롭게 할 수도 있으며, 제3자 동의를 확보해야 할 경우도 있다. 또한, 추적관찰 프로그램은 합헌·합법적이어야 하고 효과적이어야 한다. 주지하다시피, 동물장기로부터 이종이식 수령자에게 감염체 이전에 의한 질병인 인수공통감염병의 발생 가능성이 항존한다. 이러한 인수공통감염병이 발생할 때 이를 인식, 연구, 치료할 수 있는 능력은 추적관찰을 통하여 제공되기 때문에, 추적관찰은 이종이식 임상시험에 있어서 불변의 조건으로 설정되어야 한다. 이종이식과 관련한 충분한 설명에 의한 동의에 있어서는 피험자들에게 추적관찰을 받아야 하고 이를 준수하지 못하면 법률(특히, 공중보건법)상 제재를 받을 수 있다고 완전하게 정보를 제공받는 것이 필수적이다. 또한, 발현되는 어떠한 인수공통감염병이라도 신종이어서 과학자들 또는 보건의료인이 이미 알고 있는 방법으로 발현하지 않을 수 있기 때문에 수령자로 하여금 추적관찰을 준수하는 것이 매우 중요하다는 것을 인식시켜야 한다. 따라서, 이 논문은 i) 이종이식에 있어서 수령자로 하여금 추적관찰을 준수하도록 어떻게 강제할 것인가?, ii) 이와 밀접히 관련되는 충분한 설명에 의한 동의에 관련된 법적 이슈들을 분석·논의하고, iii) 독립된 이종이식법 제정의 필요성 등에 관한 고찰을 그 목적으로 한다. 이러한 목적을 달성하기 위하여 II. 에서는 수령자의 추적관찰을 강제하는데 있어서 어려움의 이유를 고찰한다. III. 에서는 이종이식 임상시험에 있어서 수령자뿐만 아니라 수령자의 가족, 친지, 관련 보건의료 종사자등과 같은 제3자의 충분한 설명에 의한 동의와 관련된 문제를 고찰한다. IV. 에서는 수령자의 추적관찰 강제를 위한 현행 법제가 불충분하다는 사실을 밝힌다. V. 에서는 이종이식과 유사한 다른 위험과 관련한 해결책에 대한 평가를 통하여 이종이식에 따른 추적관찰의 강제를 어떻게 할 것인가에 대한 방안을 고찰한다. VI. 에서는 수령자로부터의 감염을 예방하기 위한 추적관찰을 강제적으로 준수시키기 위하여서는 독립된 이종이식법의 제정이 필요함을 다시 한번 강조하고, 입법시 고려해야 할 사항들을 검토한다.

미국 행정법에 있어서 규칙제정기피 및 그 방지수단에 관한 고찰

박수헌 안암법학회 2000 안암 법학 Vol.- No.11

24시간 보행성식도 pH검사 및 담즙역류검사의 문제점

박수헌 대한소화관운동학회 1997 Journal of Neurogastroenterology and Motility (JNM Vol.3 No.1