FAN용 외전형 BLDC전동기 설계 및 특성해석

윤선기,박영일,이광호,조윤현 東亞大學校 1999 東亞論叢 Vol.36 No.-

Permanent magnet brushless motors are increasingly being used in high performance applications. The advantage of using a BLDC motor is that is can be controlled to have the speed-torque characteristics similar to that of a permanent magnet DC motor. In addition, the BLDC motor has low ineria, large power to volume ratio, and low noise as compared with the permanent magnet DC servo motor having the same output rating. This paper is proposed the design method of Outer Roter BLDC for a blower fan by the magnetic equivalent method. In order to compute and estimate the performance parameter of Outer type BLDC, the dynamic model and charateristics analysis of BLDC is simulated by Matlab.

원발성 두개강내종양 2,616례의 통계학적 연구(1976-1995)

황승균,정희원,오창완,양희진,남도현,이상형,정영섭,김동규,왕규창,한대희,최길수,조병규 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.7

Association of gut microbiota with obesity in children and adolescents

Cho Ky Young 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.4

Pediatric obesity is among the most serious global health problems whose prevalence has increased over the past decade. Pediatric obesity increases concomitant health problems, including type 2 diabetes mellitus, hypertension, dyslipidemia, fatty liver disease, and psychological problems, which often progress into adulthood. The gut microbiota is a new factor in the development of obesity, which is affected by renowned risk factors such as diet, lifestyle, and socioeconomic status. This review aimed to describe the association between the gut microbiota and childhood obesity. According to advances in gene sequencing technologies, many findings of experimental animal and human studies of adults and children demonstrated that compositional and functional changes in the gut microbiota (dysbiosis) are associated with the development of obesity. Many studies have reported that an increased Firmicutes/Bacteroidetes (F/B) ratio is a biomarker of obesity susceptibility; however, with the rapid accumulation of data, meta-analyses of human gut microbiota and obesity showed no clear association between F/B ratio and obesity status. The contribution of the microbiota to obesity has been considered using multifactorial approaches, such as supplying additional calories to the host, modulating blood lipopolysaccharide levels, favoring fat storage, and affecting satiety. Probiotics are proposed to manipulate the gut microbiota population to improve obesity; however, their clinical application remains limited because trials have shown different results. Further studies are required to better understand the mechanisms underlying the observed association between the gut microbiota and pediatric obesity.

Disorders of Gastrointestinal Motility & Sensation : Intestinal Pseudo-Obstruction As The Initial Presentation Of Systemic Lupus Erythematosus In A 13-Year-Old Girl

( Ky Young Cho ),( Tae Young Khil ),( Hye Mi Ahn ),( Sun Wha Lee ),( Jeong Wan Seo ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The intestinal pseudo-obstruction (IPO) is a rare and poorly understood manifestation of systemic lupus erythematosus (SLE), especially in children. It is characterized by clinical features of intestinal obstruction without identifiable obstructive lesion. Methods: We report a 13-year-old girl whose first symptom of SLE was IPO. The patient presented with a 3-day history of nausea, billous vomiting, abdominal distention and no stool passing. Results: Simple abdomen revealed mind dilatation with partial air-fluid level in the small intestine. Abdominal CT and methylcellulose small bowel studies showed massive ascites, engorgement of small mesenteric vessels, pleural effusion and diffuse bowel wall thickening of the gastric antrum, duodenum and jejunum. Delayed passage of contrast for 15 days after abdominal CT was suggestive of the decreased bowel motility. Laboratory finding were positive in ANA, anti-double stranded DNA, anti-Sm and lymphopenia. After a 10-day treatment with a high dose corticosteroid, the symptom was improved. Conclusions: IPO associated with SLE should be considered as a differential diagnosis for patients presenting the symptoms of intestinal obstruction. Early recognition of IPO in SLE and appropriate therapy are important for preventing complications and unnecessary surgery. Our case can raise awareness among pediatricians that although rare, IPO can be the presenting symptom of SLE in children.

Successful Combined Treatment with Total Parenteral Nutrition Fluid Extravasation Injuries in Preterm Infants

Ky Young Cho,Soo Jung Lee,Jin Sik Burm,박은애 대한의학회 2007 Journal of Korean medical science Vol.22 No.3

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Assessment Of Lifestyle In Obese Children And Adolescents By Questionnaires

( Ky Young Cho ),( Byung Ho Choe ),( Hye Sook Park ),( Jeong Wan Seo ),( Jae Sung Ko ),( Jae Young Kim ),( Yong Joo Kim ),( Eell Ryoo ),( Sun Hwan Bae ),( Jea Geon Sim ),( Hye Ran Yang ),( Ji Ah Jung 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The identification of specific behaviors conducive to overeating or inactivity is the comerstone of obesity management. The aim of this study is to assess the detailed lifestyle associated with obesity in children and adolescents by questionnaires. Methods: A total of 352 children and adolescents aged 6 to 16 years were included from 7 hospitals between May 2006 and January 2007. They completed parent and self reported questionnaires developed by the Committee on Nutrition of the Korean Pediatric Society. We divided them into normal, overweight and obese group. Data were analyzed by SAS (P<0.05). Results: The type of feeding and weight at birth, past medical history, the kind of food and exercise did not differ significantly between the normal, overweight and obese group (P<0.05). In both children and adolescents, the proportion of sedentary activity (>9 hr/day: 10.17% vs 26.23% vs 27.54%) and inappropriate dietary behaviors (strong appetite, high eating speed, eating without hunger, late meal time, etc) were significantly higher in overweight and obese group than in normal group (P<0.05). In adolescents, overweight and obese group had a positive correlation with television viewing (>2 hr/day: 5.88% vs 20% vs 25.49%) and with computer time (>1 hr/day: 25.72% vs 56.67% vs 46.61%) (P<0.05). Conclusions: Obesity management should include modification of dietary behaviors and sedentary activity. Consultation using questionnaires will be efficient in pediatric office.

Computational Drug Discovery Approach Based on Nuclear Factor-κB Pathway Dynamics

Nam, Ky-Youb,Oh, Won-Seok,Kim, Chul,Song, Mi-Young,Joung, Jong-Young,Kim, Sun-Young,Park, Jae-Seong,Gang, Sin-Moon,Cho, Young-Uk,No, Kyoung-Tai Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.12

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

노반보강재 실내 침하시험 분석

엄기영(Ky-Young Eum),홍기채(Ki-Chae Hong),김주환(Joo-Hwan Kim),박상현(Sang-Hyun Park),조영규(Young-Gyu Cho),최유복(Yoo-Bok Choi) 한국철도학회 2019 한국철도학회 학술발표대회논문집 Vol.2019 No.5

Efficacy of the Arbekacin and Teicoplanin Combination on Glycopeptide Intermediate Staphylococcus aureus in a Rabbit Model of Endocarditis

Cho, Cheong Ho,Choi, Jun Yong,Han, Sang Hoon,Lee, Han Sung,Choi, Suk Hoon,Chin, Bum Sik,Choi, Hee Kyoung,Jeoung, Su Jin,Kim, Myung Soo,Kim, Chang Oh,Kim, Chang Ki,Yong, Dongeun,Song, Young Goo,Lee, Ky 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

목적 : 동물 모델을 이용하여 GISA에 의한 심내막염에서 teicoplain과 arbekacin 병용 요법의 치료 효과를 알아보고자 하였다. 재료 및 방법 : 토끼 심내막염 모델을 이용하여 GISA 에 의한 심내막염에서 teicoplanin과 arbekacin 병용 요법의 효과를 단독 요법의 효과와 비교하였다. GISA 균주는 Mu50 균주를 사용하였고, 기존 문헌과 동일한 방법으로 토끼를 이용하여 동맥판 심내막염 모델을 사용하였다. 항생제 치료는 균을 주사한지 20시간 이후에 시작하였다. Teicoplanin은 40 mg/kg를 1회 근육 주사한 후에 20 mg/kg의 용량을 12시간 마다 4일간 투여하였다. Arbekadn은 5 mg/kg를 12시간 마다 4일간 근육 주사하였다. 마지막 항균제 투여 20시간 이후에 토끼 대동맥판의 증식(vegetation)을 채취하였다. 항균제를 투여하지 않은 대조군, teicoplanin 단독 치료군, arbekacin 단독 치료군, teicoplanin과 arbekacin 병용치료 군간의 증식의 무게(gram) 당 log_10)CFU의 차이를 비교하였다. 결과 : Teicoulanin과 arbekacin 병용 치료군에서 teicoplanin단독 치료군, 혹은 arbekacin 단독 치료군에 비해 증식의 무게(gram)당 log_10)CFU 값이 유의하게 낮았다(P<0.05). 결론 : 동물 모델에서 GISA에 의한 심내막염에 대한 teicoplanin과 arbekacin 병용 치료의 효과가 teicoplanin이나 arbekacin 단독 치료에 비해 우월하였다. Background : There have been no reports to evaluate the usefulness of combination therapy with glycopeptide and arbekacin in endocarditis by in vivo model. Materials and Methods : We investigated the efficacy of the arbekacin and teicoplanin combination on glycopeptide intermediate Staphylococcus aureus (GISA) in rabbit model of endocardits. GISA Mu50 strain was used for the experiment. The rabbit model of aortic valve endocarditis as described previously was used. Treatment was started 20h later inoculation with teicoplanin alone (at 20 mg/kg of body weight intramuscularly every 12 hours for 4 days after loading dose of 40 mg/kg of body weight intramuscularly), arbekacin alone (5 mg/kg of body weight intramuscularly every 12h for 4 days), or teicoplanin plus arbekacin. Results : The results of therapy for experimental endocarditis due to Mu50 showed that teicoplanin and arbekacin combination was more effective than the administration of both drugs alone in reducing the log_10)CFU/g of aortic vegetation (P<0.05). Conclusion : The combination of teicoplanin and arbekacin was more effective against GISA (Mu50) than both drugs alone in vivo endocarditis model.

Metabolic Survey of Defense Responses to a Compatible Hemibiotroph, Phytophthora parasitica var. <i>nicotianae</i>, in Ethylene Signaling-Impaired Tobacco

Cho, Kyoungwon,Kim, Yuran,Wi, Soo jin,Seo, Jong Bok,Kwon, Joseph,Chung, Joo Hee,Park, Ky Young,Nam, Myung Hee American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.35

<P>Reactive oxygen species (ROS) and ethylene play an important role in determining the resistance or susceptibility of plants to pathogen attack. A previous study of the response of tobacco cultivar (Nicotiana tabacum L. cv. Wisconsin 38) to a compatible hemibiotroph, Phytophthora parasitica var. <I>nicotianae</I> (<I>Ppn</I>) showed that biphasic bursts of ROS and ethylene are positively associated with disease severity. The levels of ethylene and ROS might influence the susceptibility of plants to pathogens, with changing levels of metabolite related to disease resistance or susceptibility. In this study, to obtain more detailed information on the interaction of ROS and ethylene signaling related to resistance and/or susceptibility of plants to pathogen, <I>Ppn</I>-induced metabolic profiles from wild type (WT) and ethylene signaling-impaired transgenic plants that expressed <I>Ein3</I> antisense (<I>Ein3-AS</I>) were compared using ultraperformance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Nonredundant mass ions (576 in ESI+ mode and 336 in ESI– mode) were selected, and 56 mass ions were identified on the basis of their accurate mass ions and MS/MS spectra. Two-way hierarchical clustering analysis of the selected mass ions revealed that nicotine and phenylpropanoid–polyamine conjugates, such as caffeoyl-dihydrocaffeoyl–spermidine, dicaffeoyl–spermidine, caffeoyl-feruloyl–spermidine, and two bis(dihydrocaffeoyl)–spermine isomers, and their intermediates, such as arginine and putrecine, were present at lower levels in <I>Ein3-AS</I> transgenic plants during <I>Ppn</I> interaction than in WT, whereas galactolipid and oxidized free fatty acid levels were higher in <I>Ein3-AS</I> transgenic plants. Taken together, these results reveal a function for ethylene signaling in tobacco defense responses during <I>Ppn</I> interaction.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-35/jf401785w/production/images/medium/jf-2013-01785w_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf401785w'>ACS Electronic Supporting Info</A></P>