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셀레나움을 투여한 백서에 간에 있어 glutathione S - transferase 의 유도
박영일,정안식 ( Young Yil Bark,An Sik Chung ) 생화학분자생물학회 1989 BMB Reports Vol.22 No.1
The effect of sodium selenites (Na₂SeO₃, Se) on the activities of glutathione (GSH) S-transferase was examined. The treatment of rats with Se(5,10 and 20μmoles) caused dose-dependent increase in the activities of GSH S-transferases in male rats. Furthermore, repeated sodium selenite administration increased the activities of GSH S-transferases in male and female rats. GSH S-transferases are a dimer and composed of Ya, Yb (or Yb`) and Yc subunits. Se treatment elevated the relative amount of Yb (Yb`) subunits in both sexes. The increaments of Yb (Yb`) subunits were from 29.5% to 46.4% in male rats and from 4.8% to 9.3% in female rats. The separation of GSH S-transferases into basic and neutral/acidic ones was performed using the method of chromatofocusing. Six peaks of enzymes correspond to fractions of isozymes L₂, BL, B₂, A₂, AC and C₂ by the order of chromatofocusing elution. The administration of Se in male and female rats induced, basic transferases, A₂ and C₂ isozymes but not AC isozymes. C₂ isozyme increased 7.72 fold in males and 2.72 fold in females, and A₂ isozyme increased 1.56 fold and 2.04 fold, respectively. Selenium treatment also increased activity of neutral/acidic isozymes 1.37 fold in male but did not increased the activity of neutral/acidic isozymes in female. The significant differences between male and female rats by Se administration were C₂ isozymes and neutral/acidic GSH S-transferases.
박영일,Kim Min-Ho,Kim Tong-Soo,Park Sang Jung,Kim Jeong-Myeong,Rhee Ok-Jae,Lee Sang-Seob 한국미생물학회 2020 The journal of microbiology Vol.58 No.11
Waterborne diseases have critical public health issues and socioeconomic relevancy worldwide. Various viral pathogens are ordinarily associated with waterborne diseases. Six-yearsurveillance (a total of 20 times) of norovirus, hepatitis A virus, group C rotavirus, and enterovirus was conducted at five raw water sampling sites including two lakes (Lakes Soyang and Juam), Hyundo region of Geum River in Daejeon City, and Guui region of Han River in Seoul Metropolitan City and Moolgeum region of Nakdong River in Gimhae City which are located near two water intake plants. In this study, we routinely investigated virus contamination in water samples through reverse transcription polymerase chain reaction (RTPCR) and integrated cell culture RT-PCR with high sensitivity and specificity. A total 100 samples were tested. Most of the targeted viruses were found in 32% of the samples and at least one of the indicator bacteria was detected in 65% of these occurrences. Among all the detected viruses, enterovirus was the most prevalent with a detection frequency of 12% and 2.71 MPN/10 L on average, while hepatitis A virus was the least prevalent with a detection frequency of 4%. Nearly all of the analyzed viruses (except for group C rotavirus) were present in samples from Han River (the Guui region), Geum River (the Hyundo region), Lake Juam, and Nakdong River (the Moolgeum region), while group C rotavirus was detected in those from the Guui region. During the six-year sampling period, the targeted waterborne viruses in water samples exhibited seasonal patterns in their occurrence that were different from the indicator bacteria levels in the water samples. The fact that they were detected in the five representative Korean water environments makes it necessary to establish the chemical and biological analysis systems for waterborne viruses and sophisticated management systems.