출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

배양 대장암 세포주에서 변이 p21 단백질이 DNA 및 단백질 합성에 미치는 영향

최훈,장석균 대한대장항문학회 1999 Annals of Coloproctolgy Vol.15 No.4

Dipyridamole 부하 심근 SPECT에서 Dipyridamole의 작용과 부작용

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),최창운(Chang Woon Choi),배상균(Sang Kyun Bae),양형인(Hyung In Yang),여정석(Jeong Suk Yeo) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Dipyridamole is an agent that may be used to noninvasively evaluate coronary artery disease. The effect of dipyridamole infusion its generally related to its induced peripheral vasodilatory effect. In normal person, heart rate is generally increased slightly while blood pressure decrease, but the achieved double product and related myocardial oxygen consumption have no significant change. The purpose of this study is to examine the effect and side effect of dipyridamole, and to compare different response to dipyridamole among the patients. We evaluated 847 patients who underwent dipyridamole stress myocardial SPECT. 93.6% of them had induced hypotension 0.9% showed no change of blood pressure, 5.5% had increased blood pressure 8.3% had no change of pulse rate more than 10% of basal pulse rate. Among diabetes, 16.9% was not change of pulse rate, 6.7% in non-diabetes. There was no significant correlation between age and rate pressure product rest(RPPr), in patients without perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01). As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9 r=0.17 p〈0.01), similar results were obtained in patients with perfusion defect. The size of perfusion defect on myocardial SPECT have no correlation between RPPr and RPPs/RPPr. The side effects of dipyridamole included chest pain and chest tightness, headache, abdominal pain, dizzness, nausea, and dyspnea. As increasing age, dipyridamole-induced cardiac work at rest was increased, cardiac response to dipyridamole was decreased.

방사선조사가 Porphyromonas gingivalis에 미치는 영향

이창환,김규태,최용석,황의환 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

Purpose : The aim of this study was to observe a direct effect of irradiation on the periodontopathic Porphyromonas gingivalis (P. gingivalis). Materials and Methods : P. gingivalis 2561 was exposed to irradiation with a single absorbed dose of 10, 20, 30, and 40 Gy. Changes in viability and antibiotic sensitivity, morphology, transcription, and protein profile of the bacterium after irradiation were examined by pour plating method, disc diffusion method, transmission electron microscopy, RT-PCR, and immunoblot, respectively. Results : Viability of irradiated P. gingivalis drastically reduced as irradiation dose was increased. Irradiated P. gingivalis was found to have become more sensitive to antibiotics as radiation dose was increased. With observation under the transmission electron microscope, the number of morphologically abnormal cells was increased with increasing of irradiation dose. In RT-PCR, decrease in the expression of fimA and sod was observed in irradiated P. gingivalis. In immunoblot, change of profile in irradiated P. gingivalis was found in a number of proteins including 43-kDa fimbrillin. Conclusion : These results suggest that irradiation may affect the cell integrity of P. gingivalis, which is manifested by the change in cell morphology and antibiotic sensitivity, affecting viability of the bacterium.

간 허혈성괴상의 CT소견에 대한 실험적 연구 : 간실질 및 피막의 경시적 변화와 병리조직의 비교 Changes of CT Findings of Liver Parenchyama and Capsule with Time Lapse Correlated with Histopathology

김창근,김강득,최시성,정선관,노병석,원종진 圓光大學校 醫科學硏究所 1994 圓光醫科學 Vol.10 No.1-2

In order to evaluate CT findings with time and to confirm the capsular structure correlating with its histopathologic findings, we experimentally induced ischemic necrosis of liver in 20 rabbits. Incision of the abdomen was performed under anesthesia. Ligation of hepatic artery, portal vein and hepatic duct of right inferior posterior lobe of the liver after injection of macroaggregated albumin into right inferior posterior portal vein in order to prevent from developing collateral circulation as possible. Precontrast and postcontrast enhanced CT images were obtained at 1. 2. 4 days and 1, 2. 4. 6 weeks after induction of ischemic necrosis. Necrotic area in the liver showed homogeneous low density compared to normal liver, and no contrast enhancement after contrast material administration, and marked volume loss with time. CT attenuation value of necrotic area at 1 day(36.7±6.4 M±SD, Hounsfield unit) approached to two third of that of normal liver(56.3±7.3) and showed no significant change until two weeks but increased significantly after four weeks. On contrast enhanced CT images, capsular structure was obsereved as a high density rim along the liver surface of the necortic area in 8 of 15 cases. From the first day on, homogenous ischemic or coagulation necrosis was observed but rarely findings of edema, hemorrhage and cystic change were observed on histopathologic specimen. In all of the histologic samples taken from 10 cases during th 2nd to 6th week, fibrous thickening with rich vascularity was observed along the surface of the necrotic area. In conclusion, ischemic necrosis of the liver showed homogeneous low density and no contrast enhancement. CT attenuation value of necrotic area increased significantly with time associated with markedly decrease in volume. Capsular structure attributed to the hypertrophy of the liver capsule and rich vascularity within it.

Analysis of Research Trends in Nitrous Oxide Emissions from Upland in Korea

Sun-Il Lee,Chang-Kyu Lee,Gun-Yeob Kim,Hyo-Suk Gwon,Jong-Sik Lee,Eun-Jung Choi,Joung-Du Shin 한국토양비료학회 2019 한국토양비료학회지 Vol.52 No.4

Global climate change, especially global warming is considered as threat to our future and posterity. Increasing concentrations of greenhouse gas such as carbon dioxide (CO₂), methane (CH₄) and nitrous oxide (N₂O) are the main causes of global warming. The Korean government has set a goal to cut the carbon emissions by 37% based on business-as-usual levels by 2030. According to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC), agricultural sector is an important source of greenhouse gas emissions. In this regard, it is common belief that reducing of such emission is of great significance to global climate change. In Korea, upland is one of the main sources of agricultural N₂O emission. In order to analyze domestic research trends related to N₂O emissions in the upland, 53 academic publications from 2009 to September 2019 were critically reviewed. The results were classified according to the research purposes. Reduction technologies of N₂O emission account for approximately 28.3%. N₂O characteristics and assessment for 24.5%, development of N₂O emission factors for 22.6%, and N₂O inventory assessment for 20.8% etc. Biochar, green manure, no tillage, and inhibitor were studied as a means of reducing N₂O release. The optimum technologies to reduce N₂O emission in Korea were discussed and proposed through the previous researches.

가강수량의 변화패턴과 기후인자와의 상관성 분석

이다래 ( Darae Lee ),한경수 ( Kyung Soo Han ),권채영 ( Chaeyoung Kwon ),이경상 ( Kyeong Sang Lee ),서민지 ( Minji Seo ),최성원 ( Sungwon Choi ),성노훈 ( Noh Hun Seong ),이창석 ( Chang Suk Lee ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.3

수증기는 지구 장파 복사에너지의 주요 흡수인자이다. 따라서 수증기량의 변화를 모니터링하고 변화의 원인을 세밀하게 조사하는 것은 필수적이다. 본 연구에서는 위성관측에 의해 얻어지는 Total Precipitable Water (TPW)자료를 사용하여 가강수량의 변화패턴을 모니터링 하고자 한다. 또한 기후인자들 중 수증기를 통해 생성되어 수증기의 변화패턴을 분석하는데 있어 중요한 역할을 하는 강수량과 다른 기후인 자들에 비해 비교적 주기적으로 나타나는 엘니뇨를 통해 가강수량의 변화패턴과 기후인자와의 상관성분석을 실시하고자 한다. 본 연구에서는 TERRA/AQUA 위성의 Moderate-Resolution Imaging Spectroadiometer (MODIS) 센서를 통해 관측된 TPW의 장기적인 변화와 한반도 중남부지방의 강수량변화를 정량적으로 분석 하고, 이들의 관계를 엘니뇨와 함께 비교하였다. 이를 통해 엘니뇨의 발생이 한반도 중남부지방의 강수량과 TPW의 변화에 영향을 주고 있는 지에 대해 조사하고자 한다. 먼저, 시계열 분석을 통해 TPW와 중남부지방 강수량의 변화를 정량적으로 산출하고 anomaly분석을 통해 이들의 변화를 세밀하게 분석한 결과 서로 반대 의 양상을 띠는 부분이 발견되어 엘니뇨의 anomaly분석결과와 비교하였다. 그 결과 대부분 같은 양상을 띠고 있던 TPW와 강수량이 엘니뇨가 발생한 후 서로 반대의 양상을 띠는 것을 확인하였다. Water vapor is main absorption factor of outgoing longwave radiation. So, it is essential to monitoring the changes in the amount of water vapor and to understanding the causes of such changes. In this study, we monitor temporal variability of Total Precipitable Water (TPW) which observed by satellite. Among climate variables, precipitation play an important part to analyze temporal variability of water vapor because it is produced by water vapor. And El Nino is one of climate variables which appear regularly in comparison with the others. Through them, we analyze relationship between temporal variability of TPW and climate variable. In this study, we analyzed long-term change of TPW from Moderate-Resolution Imaging Spectroadiometer (MODIS) data and change of precipitation in middle area of Korea peninsula quantitatively. After these analysis, we compared relation of TPW and precipitation with El Nino. The aim of study is to research El Nino has an impact on TPW and precipitation change in middle area of Korea peninsula. First of all, we calculated TPW and precipitation from time series analysis quantitatively, and anomaly analysis is performed to analyze their correlation. As a result, TPW and precipitation has correlation mostly but the part had inverse correlation was found. This was compared with El Nino of anomaly results. As a result, TPW and precipitation had inverse correlation after El Nino occurred. It was found that El Nino have a decisive effect on change of TPW and precipitation.

선천성 후비공 폐쇄증 : 7예의 분석

김창훈,이정권,최윤석,유신영,윤주헌 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.3

Mori 체계의 이해

崔尙惇,金泰縣,安琮準,李相錫,崔昌鎬 경북대학교 과학교육연구소 1989 科學敎育硏究誌 Vol.13 No.-

Heuristic understanding of Mori's problem is introduced

만성 재발성 소아 흉통의 원인 질환과 임상양상

최은정,이은아,이창우,최두영,오연균,김종덕,윤향석 대한소아과학회 2004 小兒科 Vol.47 No.6