Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention

Byoung-won Park,Seong Soon Kwon,Min Ho Lee,Do Hoi Kim,Min Su Hyon,Duk Won Bang 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1

Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). Methods: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. Results: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. Conclusion: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.

필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.

부착증식 공정에서 여재의 개선에 따른생물막 특성

권재혁,김병욱,조원태,임재명 江原大學校 附設 環境硏究所 1999 環境硏究 Vol.16 No.-

This study was conducted to investigate the performance and biofilm characteristics of modified media(RUN 2) in comparison with conventional media(RUN 1) on wastewater treatment system. The results were as follows ; At four different HRT of 6, 12, 18 and 24hr, BOD removal efficiency was 65.5, 85.6, 92.2 and 91.9% in RUN 1 and 70.7, 88.7, 94.7 and 95.9% in RUN 2. Biofilm characteristics in each treatment system could be classed as following : i) In RUN 1, the biomass was 2.54 to 3.01㎎/㎥ and its thickness was 342 to 907μm and in RUN 2, this was 560 to 1,180μm and that was 2.54~3.01㎎/㎥. ii) The biofilm dry density was 32.60㎎/㎥ in RUN 1 and 39.06㎎/㎥ in RUN2, respectively. iii) The VSS contents pe unit area were 2,675~2,822㎎VSS/㎠ in RUN 1 AND 2,954~3,123㎎VSS/㎠ in RUN 2. In consider of organic removal rates and biofilm attachment characteristics, it was proved that modified media in RUN 2 was higher than conventional media in RUN 1.

치과 방문 시 어린이와 부모의 치과 불안도의 상관 관계

김성희,백병주,김재곤,양연미,권병우 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

어린이에게 있어서 치과 불안의 문제는 오랫동안 환자 행동조절의 문제로서 여겨져 왔으며 이러한 문제로 인해 치료 시의 비협조도, 치료 악속 취소 및 회피 둥이 발생할 수 있다. 따라서 치과의사 및 치과 팀에게 가능한 한 빨리 어린이의 치과 불안을 인지하여 적절히 대처할 것이 요구 되어진다. 한편, 부모의 치과 불안이 그들의 아이의 치과 불안과 치료 협조도에 영향을 줄 수 있음이 이전의 여러 연구들로부터 언급 되어지고 있다. 또한 치과 방문 결정의 주체가 어린이라기보다는 부모임을 고려할 때, 부모와 어린이 사이의 치과 불안도의 관계 규명이 중요하다 하겠다. 본 연구는 전북대학교 병원 소아치과에 내원한 3~10세(평균 연령 5.27세, 표준 편차 2.172세)의 어린이 78명(남아 45명, 여아 33명)과 그들의 부모 78명을 대상으로 하였으며, 치과 치료 전의 어린이의 치과 불안도 평가를 위해 Venham Picture Scale을, 부모의 치과 불안도 평가를 위해 Corah's dental anxiety scale을 사용하여 두 값을 비교하였다. 또한 어린이의 치료 시 협조도, 기질, 성별, 나이, 부모의 교육 정도를 평가하여 치과 불안도와 비교하였다. 이에 다음과 같은 결론을 얻었다. 1. 어린이의 치과 불안도와 부모의 치과 불안도 사이의 상관 분석 및 회귀분석에서 상호 관계성이 존재하였다(P<0.02). 2. 어린이의 치과 불안도와 치료 협조도사이의 상관 분석 및 교차 분석에서 음의 상호 관계를 나타내었다(P<0.001). 3. 어린이의 치과 불안도와 기질에 관한 Student's t-test에서 낮은 불안도와 높은 불안도 그룹의 네 가지 기질 평균 점수비교 시, 낮은 불안도 그룹에서 모두 약간 낮은 평균 점수를 보였으나 통계학적 유의차는 없었다(P>0.1) 4. 어린이의 치과 불안도와 어린이의 성별, 나이에 관한 Student's t-test에서, 여아에서 높은 불안도, 3~6세의 어린 그룹에서 높은 불안을 보였다(P<0.001). 5. 부모의 치과 불안도와 부모의 학력에 관한, Student's t-test에서, 대학교육을 받지 않은 저학력 부모 그룹에서 더 높은 불안도를 보였으나 통계학적 유의차는 없었다(P>0.1). In children, dental anxiety of dental treatment has been recognized as a source of problems in patient management for many years. Dental anxiety can be causes of negative cooperation, cancel and avoid of dental treatment. Therefore, dentist and dental team should recognize of child's dental anxiety as early as possible and manage appropriately. In previous studies, it is reported that parental dental anxiety affect dental anxiety and cooperation of their child. And it is parental decision which results in a child's visit to the dentist, rather than a child's decision in most cases. Therefore, it is important to identify the relationship of dental anxiety between child and parent. We estimated child's dental anxiety before dental treatment using Venham Picture Scale that is useful even a very young child and parental dental anxiety using Corah's dental anxiety scale. Then, two values above were compared. Child's cooperation, temperament, sex, age, parental education were estimated and compared with dental anxiety, too. The results were as follows: 1. There are positive relationship of dental anxiety between child and parent with the correlation analysis (P<0.02). 2. There are negative relationship of child's dental anxiety and child's cooperation with the correlation and regression analysis (P<0.001). 3. Low anxiety group has lower mean value of four temperament item with the Student's t-test. But, there is no statistical differences (P>0.1). 4. Girl and younger group have higher mean value of dental anxiety than boy and older group with the Student s t-test (P<0.001). 5. Low educated parents have higher mean value of dental anxiety than high educated parents with the Student s t-test (P>0.1).

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

전신마취하에 치료한 환자에 대한 실태조사

김하나,백병주,김재곤,권병우,양연미 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

소아환자를 진료하다 보면 불안과 공포가 극도로 심하여 일반적인 행동조절법으로는 양질의 치과치료가 불가능한 상황에 자주 접하게 된다. 음성조절과 신체 속박 또는 입 가리기 등의 강압적이고 물리적인 방법을 사용하여도 역시 치료결과가 만족스럽지 않고 이러한 경우 환자와 보호자에게 가해지는 정신적인 상해는 결코 무시할 수 없다. 따라서 행동 조절의 어려움과 치과 질환의 심각성 등으로 인해 전신마취하의 치과치료가 필요한 경우가 많으며 이 경우 전신마취는 행동조절법의 하나로 간주될 수 있다. 치과전신마취는 비용이 많이 드는 것과 적지만 있을 수 있는 부작용의 위험성을 가지고 있다. 그러나 환자의 내원 횟수를 줄일 수 있고 치과치료에 대한 부정적인 행동반응을 유발하지 않아 의사와 환자의 스트레스를 줄일 수 있으며 양질의 진료가 가능하다는 점에서 장점을 갖는다. 이번 실태조사는 2000년 12월부터 2005년 4월까지 전북대학교 치과병원 소아치과에서 전신마취하에 광범위한 치과치료를 받은 200여명의 환자를 대상으로 하여 나이, 성별 등의 인적 사항, 전신마취가 필요했던 이유, 전신마취시간, 치료의 종류, 전신마취횟수 등에 관하여 조사하였다. Dental caries in children has declined over the past few decades. However, Certain populations of children experience high levels of dental disease. To perform the highest quality dental care for the pediatric patient, the practitioner may need to use pharmacological means to obtain a quiescent, cooperative patient. Furthermore, complex treatment can impose high demands on the very young, making use of general anesthesia the preferred approach for some patients. General anesthesia is widely used to provide comprehensive dental treatment for children in USA and Europe and Scandinavia etc. Parental and patient satisfaction following completion of dental care under general anesthesia is reportedly high. Dental general anesthesia has disadvantage that it is expansive and carries a small but significant risk of mortality. However, It has the advantage of permitting treatment at a single visit, allowing immediate relief of pain and requiring little or no cooperation from the child. Rampant caries was the major indication for use of general anesthesia in the youngest age group or medically compromised patients. This study describe the characteristics of patient receiving comprehensive dental treatment under general anesthesia at the pediatric dentistry of Chonbuk National University Hospital in Jeonju. Korea in the 4year period between December 2001 and April 2005.

안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성

안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.

정신분열병 환자에서 존속살인의 임상적 특성

안병훈,최상섭,안성호,하태현,김선범,권경희,김정현 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : This study aimed to describe the demographic, clinical and offense characteristics of the patients with Schizophrenia who committed parricide. This study also investigated the risk factors of parricide by comparing with characteristics of stranger killers to prevent the tragic offense. Methods : The sample consisted of 88 schizophrenic patients who committed homicide, 59 of them committed parricide and 29 of them killed strangers. Medical chart review regarding demographic and clinical characteristics as well as offense Characteristics was conducted. The information that was difficult to be obtained through chart review was acquired by direct interview. Results : Parricide group had earlier age of onset, more conflicts with the victims, more violence history toward victims and more offense provoking events than stranger killing group. Parricide group showed higher rate of past treatment than that of stranger killing group. However drug compliance at the time of offense was low in both groups. Offense provoking events in the parricide group included blaming, threatening a forced hospitalization or medication toward patients. The most common Psychiatric symptoms associated with homicide were threat/control override (TCO) symptoms, delusional perception, commanding auditory hallucination and especially with parricide, Capgras syndrome (CS). Conclusion : Interaction between psychotic symptoms such as TCO, CS and underlying emotion toward victims are likely to be associated with parricide. Mental health professionals are expected to play an important role in preventing this tragic offense by active history taking of the violence and effective management with active caregiver education/intervention of intrafamilial conflicts.

토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험

황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.

UGR(Unified Glare Rating)의 보정 및 불쾌글레어 주관평가를 위한 실험적 연구

이진숙,김병수,권혁일 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

Glare in one of the major factors influencing comfort appraisal for lighting. Although a predictive formula for such glare has been proposed by CIE, it has not been investigated for domestic adjustment. The correlation between glare and the closely related dazzling-sensation has not been investigated enough. In the study, subjective discomfort glare appraisal and dazzling-sensation appraisal for discomfort glare was performed to produce a corrected UGR formula. Analyses between appraisal for dazzling-sensation and results of subjective appraisal for discomfort glare were performed to produce a formula that could represent the correlation between discomfort glare and dazzling-sensation. The results of the comparison and analysis is that results computed by UGR differed from those of subjective perception, so a corrected UGR formula and corrected glare index and dazzling-sensation was produced. Also, a formula that could represent the state of dazzling-sensation verying with change of luminance was produce.