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Jun Guan,Yu Xue,Rong-yu Zang,Ji-hong Liu,Jian-qing Zhu,Ying Zheng,Bo Wang,Hua-ying Wang,Xiao-jun Chen 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4
Background: Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN mapping alone instead of systematic lymphadenectomy on EC patients remains unclear. Methods: A multi-center, open label, non-inferiority randomized controlled trial has been designed to identify if SLN mapping alone is not inferior to pelvic lymphadenectomy on prognosis of patients with intermediate-high-risk EC clinically confined to uterus. Eligible patients will be 1:1 randomly assigned to accept SLN mapping or pelvic lymphadenectomy. The primary endpoint is the 2-year progression-free survival (PFS). The second points are the 5-year PFS, 5-year overall survival, surgery-related adverse events and life quality. A total of 780 patients will be enrolled from 6 hospitals in China within 3-year period and followed up for 5 years. Trial Registration: ClinicalTrials.gov Identifier: NCT04276532
Immunoprofiling of the Tryptophan-Rich Antigen Family in <i>Plasmodium vivax</i>
Wang, Bo,Lu, Feng,Cheng, Yang,Chen, Jun-Hu,Jeon, Hye-Yoon,Ha, Kwon-Soo,Cao, Jun,Nyunt, Myat Htut,Han, Jin-Hee,Lee, Seong-Kyun,Kyaw, Myat Phone,Sattabongkot, Jetsumon,Takashima, Eizo,Tsuboi, Takafumi,H American Society for Microbiology 2015 Infection and immunity Vol.83 No.8
<P>Tryptophan-rich antigens (TRAgs) are an antigen family that has been identified in human and rodent malaria parasites. TRAgs have been proposed as candidate antigens for potential vaccines. The <I>Plasmodium vivax</I> TRAg (PvTRAg) family includes 36 members. Each PvTRAg contains a tryptophan-rich (TR) domain in the C-terminal region. In this study, we recombinantly expressed all 36 PvTRAgs using a cell-free expression system, and, for the first time, profiled the IgG antibody responses against all PvTRAgs in the sera from 96 vivax malaria patients and 40 healthy individuals using protein microarray technology. The mean seropositive rate for all PvTRAgs was 60.3%. Among them, nine PvTRAgs were newly identified in this study and showed a seropositive rate of >50%. Five of them, PvTRAg_13, PvTRAg_15, PvTRAg_16, PvTRAg_26, and PvTRAg_29, produced higher levels of IgG antibody, even in low-endemicity countries. In addition, the results of an immunofluorescence analysis suggest that PvTRAgs are, at least in part, associated with caveola-vesicle complexes, a unique structure of <I>P. vivax</I>-infected erythrocytes. The mechanism of formation and the function of these abundant membrane structures are not known. Further investigation aimed at determining the functions of these proteins would lead to a better understanding of the blood-stage biology of <I>P. vivax</I>.</P>
Jian-bo Wang,Jun-gong Zhao,Ming-hua Li,Yue-qi Zhu,Jue Wang,Pei-lei Zhang 대한영상의학회 2010 Korean Journal of Radiology Vol.11 No.4
Objective: To determine the efficacy, safety and primary follow-up results of a guidewire looping technique for the treatment of infrapopliteal arteries. Materials and Methods: From October 2006 to May 2008, an intraluminal angioplasty of the infrapopliteal arteries was attempted in 200 consecutive patients. Altogether, 417 infrapopliteal lesions, with lengths varying from 2 cm to 32 cm, were treated as part of this study, including 305 lesions in the anterior tibial arteries, 89 in the posterior tibial arteries, and 23 in the peroneal arteries. The ‘U’-shaped guidewire technique was attempted in 393 lesions from 361 limbs. The tip of a hydrophilic 0.035-inch guidewire was formed into a ‘U’ shape with the aid of a 4-Fr catheter and collateral branch vessel to recanalize the completely occluded long segment lesions. Results: A successful angioplasty with at least one artery recanalized directly to the malleolar or dorsal foot was achieved in 322 limbs (89%). The looping technique had a success rate of 90% (352 of 393 lesions). After the procedure, the rest pain was relieved in 58 of 69 patients, while 207 of 245 limbs (85%) showed improvement for intermittent claudication. Complete wound healing was noted in 21 of 54 patients, while 20 of 54 patients showed an improvement in the wound size or depth. A total of 38 major immediate procedure-related complications were noted, including retroperitoneal hematoma, distal emboli, and vessel rupture. Conclusion: The results of this study suggests that the guidewire looping technique is a safe and effective method for the recanalization of the occluded lesions in infrapopliteal vessels. Objective: To determine the efficacy, safety and primary follow-up results of a guidewire looping technique for the treatment of infrapopliteal arteries. Materials and Methods: From October 2006 to May 2008, an intraluminal angioplasty of the infrapopliteal arteries was attempted in 200 consecutive patients. Altogether, 417 infrapopliteal lesions, with lengths varying from 2 cm to 32 cm, were treated as part of this study, including 305 lesions in the anterior tibial arteries, 89 in the posterior tibial arteries, and 23 in the peroneal arteries. The ‘U’-shaped guidewire technique was attempted in 393 lesions from 361 limbs. The tip of a hydrophilic 0.035-inch guidewire was formed into a ‘U’ shape with the aid of a 4-Fr catheter and collateral branch vessel to recanalize the completely occluded long segment lesions. Results: A successful angioplasty with at least one artery recanalized directly to the malleolar or dorsal foot was achieved in 322 limbs (89%). The looping technique had a success rate of 90% (352 of 393 lesions). After the procedure, the rest pain was relieved in 58 of 69 patients, while 207 of 245 limbs (85%) showed improvement for intermittent claudication. Complete wound healing was noted in 21 of 54 patients, while 20 of 54 patients showed an improvement in the wound size or depth. A total of 38 major immediate procedure-related complications were noted, including retroperitoneal hematoma, distal emboli, and vessel rupture. Conclusion: The results of this study suggests that the guidewire looping technique is a safe and effective method for the recanalization of the occluded lesions in infrapopliteal vessels.
Bo Liu,Chao Li,Yicheng Wang,Jun Nie,Xiaoqun Zhu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
The vortex-ring derived particles are new type of non-spherical hydrogel particles, which are prepared byimitating the process of vortex-ring in nature. However, the traditional existing vorticity ring derivedhydrogel particles were prepared by dropping polyelectrolyte solution into contra-ion coagulation bath,which limited the choice of materials. In this paper, a strategy of preparation non-spherical hydrogel particlesby using non-polyelectrolyte polyvinyl alcohol through the method of vortex ring was proposed. Based on the principle that the boraciated polyvinyl alcohol solution could be quickly gelled underalkaline condition, the spherical and various derivative shapes (red cell, bowl, dish, ring) of polyvinylalcohol vortex-ring derived hydrogel particles (PVHP) were prepared. The hydrogel particles have theability to assemble into different modules by dynamic borate bond in the hydrogel particles. Also, thisdynamic borate bond endowed the PVHP decomposable and recyclable performances. In addition,two-compartments, three-compartments and magnetic PVHP were also prepared, endowing PVHP withseveral functions. which opens up a new environmentally friendly way for the preparation of multifunctionalparticles.
Wang, Hee Seung,Jeong, Chang Kyu,Seo, Min-Ho,Joe, Daniel J.,Han, Jae Hyun,Yoon, Jun-Bo,Lee, Keon Jae unknown 2017 Nano energy Vol.35 No.-
<P><B>Abstract</B></P> <P>Herein, we report a triboelectric nanogenerator (TENG) with improved performance using extremely-long sub-50nm grating patterns with high aspect ratio (4,000,000:1) fabricated by the multistep pattern downscaling (MS-PaD) method, which is advantageous in terms of fast throughput, high resolution, cost-effectiveness, industrial compatibility, and large-area scalability in nanofabrication. The intensely-arrayed nanograting pattern is replicated to the flexible substrate on the 8-in. wafer-scale without any defects for the nanograting-assisted TENG (NGTENG). As the well-aligned nanoscale morphology in sub-50nm grating leads to efficient triboelectric charges, the NGTENG shows an outstanding performance enhancement by a factor of 200 compared to non-patterned surface during repetitive contact electrification. To demonstrate capability of self-powered electronics, the output power from the NGTENG is directly used for charging a commercial capacitor and turning on the LEDs. In addition, theoretical study of triboelectric signals according to nanoscale-tuned metal electrodes were investigated to improve the effective output and robustness of triboelectric device.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Performance-enhanced TENG was demonstrated via 8-in. wafer-scale sub-50nm grating by the multistep pattern downscaling. </LI> <LI> Well-aligned and size-tunable nanograting for TENG enhanced power by a factor of 200 compared to the non-patterned. </LI> <LI> Investigation of output signal according to nanoscale-tuned surface were studied to improve performance and stability. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Mechanical and Rheological Properties of Isotactic Polypropylene/Bacterial Cellulose Composites
Bo Wang,Hai-Rong Zhang,Chao Huang,Lian Xiong,Jun Luo,Xin-De Chen 한국고분자학회 2017 폴리머 Vol.41 No.3
To improve the mechanical performance of isotactic polypropylene (iPP), the iPP/bacterial cellulose (BC) composites were prepared. The tensile and impact strength of the composites were maximized (38.21MPa and 2.812 KJ/m²) when maleic anhydride grafted polypropylene (MAPP) content was 7 wt%, the tensile modulus was increased with the higher MAPP content and the maximum value was 1858.39 MPa. Compared with pure iPP, the tensile strength, impact strength and tensile modulus increased by 6.32 MPa, 0.75 KJ/m², and 279.68 MPa, respectively. Compared with the control group (the sample which added BC but no MAPP added), the tensile strength, impact strength and tensile modulus increased by 5.61 MPa, 0.692 KJ/m², and 11.24 MPa, respectively. Moreover, the elongation at break of the composites was decreased. Besides, the rheological results and SEM photographs indicated that with the addition of MAPP, the compatibility of the composites was improved greatly, which demonstrated the increase of the mechanical properties of the composites.
Jun Wei Wu,Yu Rong Xing,Yi Bo Wen,Tian Fang Li,Quan De Feng,Xiao Ping Shang,Yun Long Li,Jin Jin Feng,Xin Xin Wang,Rong Qun Zhai,Xiang Fei He,Tao Chen,Xin Jian Liu,Jian Guo Wen 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.2
Purpose: To investigate the prevalence of spina bifida occulta (SBO) and its relationship with the presence of overactive bladder (OAB) in middle-aged and elderly people in China. Methods: A cross-sectional community-based survey was carried out at 7 communities in Zhengzhou City, China from December 15, 2013 to June 10, 2014, where residents aged over 40 years were randomly selected to participate. All of the participants underwent lumbosacral radiographic analysis and relevant laboratory tests. A questionnaire including basic information, past medical history and present illness, and the OAB symptom score was filled out by all participants. Chi-square tests and logistic regression were used for data analysis with a P-value of <0.05 denoting statistical significance. Results: A total of 1,061 subjects were qualified for the final statistical analysis (58.8±11.7 years; male, 471 [44.4%]; female, 590 [55.6%]). The overall prevalence of SBO was 15.1% (160 of 1,061): 18.3% (86 of 471) in men and 12.5% (74 of 590) in women. Among these subjects, 13.7% (145 of 1,061) had OAB: 13.2% (62 of 471) in men and 14.1% (83 of 590) in women. The results of logistic regression showed that age, SBO, history of cerebral infarction (HCI), and constipation were risk factors for OAB (P<0.05), while sex, history of childhood enuresis (HCE), body mass index (BMI), and diabetes mellitus (DM) were not (P>0.05). In men, age, SBO, and constipation were risk factors for OAB (P<0.05), while HCE, BMI, DM, HCI, and benign prostate hyperplasia were not (P>0.05). In women, age, SBO, and HCI were risk factors for OAB (P<0.05), while HCE, BMI, DM, vaginal delivery, and constipation were not (P>0.05). Conclusions: The prevalence of SBO is high and it is related to OAB in middle-aged and elderly people in China.