심한 소장침범을 보인 Henoch-Schonlein Purpura의 치료 2례

김형태,문진수,장현오,조희승,이종국,김기홍,서정욱,김민경,Kim, Hyung Tae,Moon, Jin Soo,Jang, Hyun Oh,Jo, Heui Seung,Lee, Jong Guk,Kim, Ki Hong,Seo, Jung Wook,Kim, Min Kyung 대한소아소화기영양학회 2004 Pediatric gastroenterology, hepatology & nutrition Vol.7 No.1

보존적인 스테로이드 치료로 호전이 없는 심한 복부증상을 동반한 HSP 환자의 치료에는 아직까지 정설이 없으나, 저자들은 면역글로불린 정맥투여로 증상이 호전된 증례와 소장의 경장괴사를 동반하고 수술적 치료로 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a vasculitis of the small vessels in skin, joints, gastrointestinal (GI) tract and kidney. GI symptoms occur in up to 85% of patients and may lead to severe problems such as intussusception, obstruction, and perforation. GI symptoms may not be easily controlled, showing refractoriness to the conventional corticosteroid therapy. Although GI involvements of HSP are acute, and self-limited in most instances, they may cause fatal results in some unusual cases. In such conditions all the possible therapeutic modalities should be considered. We report two cases of severe small bowel involvement of HSP. One case presented with severe abdominal pain showing refractoriness to corticosteroid, but improved with IV immunoglobulin therapy. In the second case, HSP with transmural infarction in the small bowel could be cured with surgical intervention.

중금속 제거용 셀룰로오즈 잔테이트의 제조 및 응용

김형태,이태호,김상대,이경렬,윤진수,이기세 ( Hyung Tae Kim,Tae Ho Lee,Sang Dae Kim,Kyung Youl Lee,Jin Soo Yun,Ki Say Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

경항문 내시경 수술 도구에서의 최적 활동 반경 개선을 위한 컴퓨터 시뮬레이션 연구

김형태,김광기,남경원,김현호,손대경,Kim, Hyung-Tae,Kim, Kwang-Gi,Sohn, Dae-Kyung,Kim, Hyun-Ho,Nam, Kyoung-Won 대한의용생체공학회 2009 의공학회지 Vol.30 No.6

Conventional devices for transanal endoscopic microsurgery that are currently used clinically for intestine or rectal cancer patients have 40 mm external diameter of rectoscope tube - induces anal damage and long-term postoperative pain for small-sized patients. In this paper, we designed rectum and rectoscope models and calculated the changing trends of operation area of the surgical tools in accordance with the step-by-step variation of design parameters of the rectoscope tube - external diameter, axial length, and distal angle. Using the results of computer simulation, we suggested an optimal set of design parameters that minimizes external diameter of the rectoscope tube and at the same time, maintains similar operation area of the surgical tools compared with commercialized devices (${\geq}\;4274.7mm^2$). The results of the simulation showed that the optimal design parameters were 35 mm external diameter, 100 mm axial length, and $45^{\circ}$ distal angle of the rectoscope tube. This result can be applied to the development of endoscopic microsurgery device that can minimize side effects to the intestine or rectal cancer patients.

만성 육아종 질환에 동반된 급성 연쇄상 구균 감염 후 사구체 신염 1례

김형태,서정욱,김한성,이종국,Kim Hyung-Tae,Seo Jung-Wook,Kim Han-Seong,Lee Chong-Guk 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.2

Chronic granulomatous disease(CGD) is a rare inherited disorder of phagocytic cells which results in a susceptibility to infections by catalase-positive bacteria and fungi, as well as granuloma formation. And acute poststreptococcal glomerulonephritis(APSGN) is one of the most common glomerular lesions of gross hematuria in children. We experienced a case of APSGN accompanied with CGD presenting with a liver granuloma. 저자들은 만성 육아종 질환에 동반된 APSGN을 경험하였기에 문헌 고찰과 함께 보고한다.

가임신 흰쥐에 있어서 자궁척출 및 Prostaglandin F2α 투여가 혈청 Progesterone 의 농도 및 황체에 미치는 영향

김형태,정영채,김창근 ( Hyung Tae Kim,Yung Chai Chung,Chang Keun Kim ) 한국축산학회 1981 한국축산학회지 Vol.23 No.4

The purpose of this experiment was to investigate the effects of hysterectomy and administration of PGF₂α on serum progesterone level and corpus luteum in pesudopregnant rats. PGF₂α administration or hysterectomy was performed at day S of pseudopregnancy. Five rats from each group were randomly sacrificed at day 5,6,7,8,9 and 12 of pseudopregnancy for assay of serum progesterone level and microscopic observation of ovary. The results obtained were as follows; 1. In both normal and hysterectomized groups, PGF₂α administration caused significant reduction in serum progesterone level to 24.2% and 30.8% at day 6 and to 11.3% and 34.3% at day 9 of pseudopregnancy as compared with pretreatment level. The serum progesterone level of hysterectomized group untreated with PGF₂α remained elevated until day 12 of pseudopregnancy as compared to those of other three groups. 2. The ovarian weights of control group treated with PGF₂α were significantly reduced as compared to those of other three groups at day 9 of pseudopregnancy (p$lt;0.05). 3. The number of corpus luteum in groups treated with PGF₂α was slightly reduced, but there were no significant difference between PGF₂α and non-PGF₂α treated groups at day 6,7,8,9 of pseudopregnancy. 4. The number of lutein cell in corpus luteum of PGF₂α treated groups on day 9 of pseudopregnancy was significantly lower than those of PGF₂α untreated groups (p$lt;0.05).

하악골의 발육중인 생쥐에서 기능력의 변화가 특이-유전자 발현에 미치는 영향

김형태,박주철,이창섭,박헌동,Kim, Hyung-Tae,Park, Joo-Cheol,Lee, Chang-Seop,Park, Heon-Dong 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.2

기능력은 뼈의 형성, 유지 및 개조 이외에도 치아이동, 교정치료, 기능성 악교정장치의 사용 등과 관련한 치주인대세포의 특성 변화 등에 중요한 영향을 미친다. 또한, 하악과두에서도 기능력의 변화에 따라서 다양한 특성의 변화가 나타난다. 본 연구에서는 ICR 생쥐를 8주 동안 soft-diet와 hard-diet의 식이 조절을 통해 기능력의 변화를 유도하여, 기능력의 변화와 관련한 특이 유전자를 검출하기 위하여 subtractive hybridization, northern 분석 및 mRNA in-situ hybidization 등의 실험을 시행하여 다음과 같은 결과를 얻었다. 1. Soft-diet군과 hard-diet군의 subtractive hybridization을 통하여 총 39개의 clone을 얻었고 이중에서 11개의 서로 다른 hard-diet군 특이 후보 유전자들을 분리하였다. 2. 11개의 후보 유전자들 중에서 homology 검색과 northern 분석을 통하여 기능력과 관련이 있을 것으로 생각되거나 hard-diet군에서 mRNA가 선택적으로 발현되는 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자를 선택하였다. 3. Soft-diet군과 hard-diet군의 형태학적 분석에서 soft-diet군은 hard-diet군에 비하여 골모세포의 활성과 골개조의 특성은 저하된 것으로 관찰되었으나, 하악과두의 연골성골화 과정은 오랜 시간동안 지속되는 것으로 나타났다. 4. FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자의 cRNA 탐침자를 이용한 in-situ hybridization에서 4개의 유전자의 mRNA들은 hard-diet군의 세포들에서는 강하게 발현되었으나 soft-diet군의 세포들에서는 그 발현이 미약하거나 나타나지 않았다. 이상의 결과를 종합하여 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자들은 대부분이 기능이 거의 알려져 있지 않는 것들로 기능력의 변화 과정에서 중요한 역할을 할 것으로 생각되나 앞으로 보완 연구를 통하여 각 각의 유전자들의 보다 정확한 기능을 이해하는 것이 필요 할 것으로 사료된다. Mechanical forces are known to have an effect on bone formation, maintenance and remodeling, and there is evidence that the development of the mandibular condyle in the rat or mouse is influenced by altered functional force. However, studies are lacking in molecular-biologic mechanism such as the identification of differentiation factor induced from functional force. Here a mouse model was used to investigate the functional stress-responsive gene or factors which is related to the altered force by comparing the expression genes of functional state and hypo-functional state of the mouse mandible. ICR mice were provisioned with either a soft, mushy diet (soft-diet group) or hard rat pellets (hard-diet group) beginning at weaning for the alteration of functional force and subsequently sacrificed at 89 days of age. Incisor of mice in group 1 were trimmed twice a week to reduce occlusal forces. After killing the animals, mandibular bone including condyle were collected for RNA extraction, subtractive hybridization, northern blot analysis and mRNA in-situ hybridization. The results as follows; 1. A total of 39 clones were sequenced, and 11 individual sequence types were subsequently identified by subtractive hybridization, as 28 clones were represented twice in the analyzed sets. 2. Consequently four candidate clones, FS-s (functional stress-specific)2, -5, -18, and -22 were identified and characterized by homolgy search and northern analysis. Four of these clones, FS-s2, -5, -18, and -22, were shown to be expressed differentially in the hard-diet group. 3. Histologic sections showed that osteoblastic activity along the bone trabeculae and active bone remodeling were significantly lower in soft than in hard diet animals. A soft diet seems to enable a longer period of endochondral ossification in the mandibular condyle. 4. Although the mRNAs of FS-s2, -5, -18, and -22 were expressed rarely by cells of the soft-diet group, highest expression was detected in the cells of the hard-diet group. Together with the above results, it is suggested that FS-s2, -5, -18, and -22 could act as an important factors controlling the tissue changes in response to functional stress. The exact functional significance of these findings remains to be established.

트리메토프림과 ${\beta}$-시클로덱스트린 고분자 간의 포접복합체 형성에 의한 용출 및 안정성 향상

김형태,박경옥,서성훈,Kim, Hyung-Tae,Park, Kyung-Ock,Seo, Seong-Hoon 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2

To improve the solubility and dissolution rate of trimethoprim (TMP), which is slightly soluble drug, its inclusion complexes were prepared and studied in this experiment. Inclusion complexes of TMP with ${\beta}-cyclodextrin$ and ${\beta}-cyclodextrin$ polymer (CDPS) were prepared according to Fenyvesi method. These were compared with TMP and its physical mixture with CDPS. Water, diluted hydrochloric acid and phosphate buffer solution were used as dissolution media. And accelerated stability test was studied at $50,\;70\;and \;80^{\circ}C$. It was found that solubility and dissolution rate of inclusion complexes were increased in water. Especially, the solubility and dissolution rate of TMP was found to be markedly increased by inclusion complexation with CDPS. In stability test, ${\beta}-cyclodextrin$ inclusion complexes were more or less stable than TMP alone. This tendency was not led in CDPS. Consequently, CDPS was useful in increasing dissolution rate and stability of TMP.

외래에서 시행되는 585 nm 펄스다이레이져 후두수술

김형태,Kim, Hyung-Tae 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.1

Introduction: 585 nm Pulsed dye laser (PDL) laryngeal surgery is based on the photodynamic characteristics of selective photothermolysis and photoangiolysis and recently considered to be the treatment for a variety of benign laryngeal disease. Objective: To review the indications and outcome of office-based 585nm PDL surgery and summarize new developments. Method: Retrospective study involving 402 patients was performed, The PDL surgery could be applied to various laryngeal diseases such as laryngeal papilloma, vocal fold dysplasia, laryngeal granuloma, vocal polyp, capillarectasia, scarred vocal fold and sulcus vocalis. Results : The physiologic properties of the vascular specificity of PDL provide many advantages and appear to be effective for laryngeal treatment. The PDL resulted in precise, selective coagulation of the microvasculature without damage to the surrounding tissue. Therefore PDL surgery is safe and effective for office-based treatment of benign laryngeal disease and for all patients regardless of their overall medical condition. Conclusion: PDL surgery provides potential benefits and advantage for treating common benign laryngeal disease.

통신사 의원필담(醫員筆談)에 구현된 조선후기와 에도(江戶)시대 의료문화 고찰

김형태(Hyung-Tae Kim) 한국문학회 2022 韓國文學論叢 Vol.92 No.-

The purpose of this thesis is to examine the medical-related culture of Japan in the Edo period by taking a written answer of the medical members[醫員筆談] to the Tong-sin mission[通信使] as the research object. Through this process, we will objectively examine the major diseases and medicines prevalent in the Edo period in Japan, the medical system at that time, and the people who were related to it. This is the beginning to compose the study of Japanese medical culture and the 18th and 19th century through a written answer of the medical members[醫員筆談] to the Tong-sin mission[通信使] that this researcher will proceed in the future. The research subject is a written answer of the medical members[醫員筆談]. This is a text in Pi1-dam-chang-hwa-jib[筆談唱和集] in which the medical members[醫員] participates as the main character of the writing. As for the research method, the contents of a written answer of the medical members[醫員筆談] were divided into ‘disease and methods of healing’, ‘medicine-related culture’, and ‘medical members[醫員] and medical institutions’. ‘Diseases and methods of healing’ were again divided into chronic diseases and infectious diseases. ‘Medicine-related culture’ was divided into internal medicine and external medicine. In the case of ‘Medical members[醫員] and medical institutions, divided the life of the medical members[醫員] and the situation of medical institutions in the Edo period. In conclusion, it is possible to know relatively detailed diseases, treatment methods, and medical systems that were prevalent in Japan and Chosun[朝鮮] during the Edo period. In addition, it was possible to identify the identities of various objects, focusing on the drugs used for treatment at the time. In this way, it can be said that it even functions as a kind of encyclopedia[類書]. Because it is possible to acquire knowledge of the natural history of Japan and Chosun[朝鮮]. This suggests a lot for humanities majors in relation to the use of that knowledge. This is because the importance of nurturing talents related to convergence and complex education is being highlighted these days. 본 논문의 목적은 통신사 의원필담을 연구 대상으로 삼아 조선후기와 에도시대 일본의 의료 관련 문화를 살펴보는 것이다. 이러한 과정을 통해서 조선과 일본에 유행했던 주요 질병과 의약, 당시 의료 체계와 이와 관련 있던 사람들의 모습을 객관적으로 살펴보고자 한다. 이는 앞으로 본 연구자가 진행할 통신사 의원필담을 통한 18·19세기 조선과 일본의 의료문화 연구를 구성하기 위한 출발점에 해당한다. 연구 방법으로는 그간 본 연구자가 고찰한 임진왜란 이후 통신사 필담창화집 중에서 의원이 등장하여 필담의 주체로 참여하는 의원필담을 중심으로 크게 ‘질병과 그 치유의 방법’, ‘의약 관련 문화’, ‘의원과 의료기관’으로 나누어 고찰했다. 질병과 그 치유의 방법은 다시 만성 질환과 전염성 질환으로 나누어 살펴보았고, 의약 관련문화는 내복약과 외용약으로 나누어 고찰하였다. 의원과 의료기관의 경우에는 의원의 삶과 에도시대 의료 기관의 상황으로 나누어 살펴보았다. 이와 같은 고찰을 통해 에도시대 당시에 조선과 일본에 유행했던 질병과 치료 방법 및 의료 체계를 비교적 상세하게 알 수 있다. 나아가 당시 치료에 사용했던 약물을 중심으로 각종 물명에 대한 정체성을 규명함으로써 두 나라의 박물학적 지식을 얻을 수 있기 때문에 의원필담은 중요한 기록문학이자 일종의 유서(類書)적 기능까지 수행한다고 할 수 있다. 이는 융·복합적 교육과 관련한 인재 양성의 중요성이 크게 부각되고 있는 요즈음에 그 지식의 활용과 관련하여 인문학 전공자들에게 많은 시사점을 던져준다.

임상연구 : Propofol을 이용한 마취유도 시 기관내삽관에 의한 혈역학적 변화에 대한 Fentanyl과 Remifentanil의 효과

김형태 ( Hyung Tae Kim ),김철근 ( Cheal Kun Kim ),이준학 ( Jun Hak Lee ),권영은 ( Young Eun Kwon ),이정우 ( Jeong Woo Lee ),김동찬 ( Dong Chan Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.5

Background: Laryngoscopy and endotracheal intubation cause hemodynamic changes such as hypertension and tachycardia. Adjuvant fentanyl administration have been used to reduce the hemodynamic changes. Remifentanil, a newly developed ultra short acting opioid, has recently been used to reduce the hemodynamic changes. This study investigated the effects of fentanyl and remifentanil on hemodynamic responses to laryngoscopy and endotracheal intubation. Methods: Sixth ASA class I or II patients who scheduled for elective surgery were divided randomly into 3 groups. Each patient received normal saline, fentanyl 1.5μg/kg or remifentanil 1.5μg/kg, respectively. Predetermined drugs for each group were administered over 30 seconds after induction of anesthesia with TCI of propofol effect site target concentration 4.0μg/ml and rocuronium 1.0 mg/kg. Laryngoscopy and endotracheal intubation was carried out and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were measured baseline (initial), before intubation (BI) and during 5 minutes after intubation (I1 to I5). Results: In the fentanyl group, I1 HR value was significantly higher than baseline. In the remifentanil group, SBP and MAP were significantly lower than baseline during post-intubation period. Fentanyl and remifentanil groups show lesser hemodynamic changes than those in the control group. There were no significant differences of hemodynamic changes between fentanyl and remifentanil group. Conclusions: Fentanyl and remifentanil can attenuate hemodynamic responses after laryngoscopy and endotracheal intubation. (Korean J Anesthesiol 2006; 51: 552~7)