사무직 근로자들의 직무 스트레스와 피로

차경태,김일희,고상백,현숙정,박준호,박종구,차봉석,장세진 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 이 연구는 전국 규모의 조사 연구에서 수집된 자료 중 사무직 근로자들을 대상으로,사회인구학적 특성,직업 특성,건강행태,직무 스트레스와 피로수준 간의 관련성을 분석하는 데 있다. 방법:‘한국인 직무스트레스 측정도구의 표준화 전국 조사연구National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002∼2004)’를 위해 2002년 5월 1일부터 2003년 5윌 30일 까지 수행되었으며,전국의 사업장에 근무하는 근로자 30,146명(남자: 84%,여자: 16%) 중 사무직 근로자 4,457명(남자: 68.9%,여자 31.1%)을 연구 대상으로 하였다. 자료수집방법은 사업장을 방문하여 보건 및 안전관리자 등에게 연구의 취지를 알린 후 설문조사에 대한 협조를 구하고 응답자 직접 기입법을 이용 하였으며,사회인구학적 특성,직업적 특성,건강관련 요인,KOSS-SF를 이용한 7개의 직무 스트레스 요인,그리고 MFS를 이용하여 피로 수준에 영향을 주는 요인에 대해 분석하였다. 결과: 일반적 특성,작업관련 특성,건강행태관련 특성 및 직무 스트레스 요인이 근로자들의 피로와 강한 관련성이 있음이 입증되었으며,특히 직무 스트레스의 하부 요인 중에서도 피로와 관련성을 보이는 요인이 남녀별로 다소 상이 하게 관련된다는 것을 발견할 수 있었다. 남자의 경우는 직무 스트레스의 하부 영역 중 직무 요구도,직무 불안정성,보상부적절 등이 영향력이 높은 주요 직무 스트레스 요인이었던 반면,여자는 직무 요구도,보상부적절,직장문화가 주요한 직무 스트레스 요인이었다. 결론: 직장인 피로가 갖는 보건학적 의학적 경제학적 중요성을 감안할 때,조직의 생산성 향상과 근로자 개개인의 삶의 질 향상 및 건강증진을 위해선 직무 스트레스 관리 프로그램이 절실히 요청된다고 볼 수 있다. Background & Objectives: A growing body of research has documented that occupational stress is closely associated with increased risk of fatigue. This study was conducted in an effort to assess the relationship of occupational stress to self-perceived fatigue among Korean white collar employees. Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002-2004). Among them, a total of 4,502 white collar employees were recruited. A structured questionnaire was employed to evaluate the participants' sociodemographics, job-related factors, health-related behaviors, occupational stress, and self-perceived fatigue. Occupational stress and self-perceived fatigue were assessed using the Korean Occupational Stress ScaleShort form (KOSS-SF) and the Multidimensional Fatigue Scale (MFS), respectively. Results: In logistic regression analyses, occupational stress was associated with an increased risk of fatigue, and some domains of occupational stress had different effects on fatigue by gender (job demand, job insecurity, and lack of reward for men, job demand, lack of reward, and discomfort in occupational climate for women), which indicates that occupational stress may perform a slightly different role in increasing the risk of fatigue by gender. Conclusion: The results of this study suggest that occupational stress is a determinant predictor of self-perceived fatigue. Thus, a stress management program for the reduction of occupational stress, and the promotion of white collar worker's health and quality of life is strongly recommended. Some limitations of this study and considerations for future studies were also discussed.

자궁경부암 선별검진을 위한 세포진 검사와 인유두종바이러스 검사의 임상적 유용성

안태규,이경,김동원,한세준 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4

목적 : 자궁경부 세포진 검사와 HPV DNA (Hybrid capture 1) 검사의 임상적 유용성을 알아보고자 본 연구를 시행하였다. 연구 방법 : 1995년 12월 1일부터 1998년 3월 31일까지 조선대학교병원 산부인과 외래를 방문한 1028명의 환자중 질확대경을 통한 조직검사 및 수술을 시행한 후 조직 검사를 시행하여 결과 비교가 가능한 환자 305명을 대상으로 본 연구를 시행하였다. 결과 : 1. 세포진 검사의 민감도는 63.0%, 특이도는 88.1%, 양성 예측율은 89.7%, 음성 예 측율은 59.3%이었다. 2. HPV DNA 검사의 민감도는 51.9%, 특이도는 85.3%, 양성 예측율은 85.2%, 음성 예측율은 52.1%이었다. 3. HPV DNA검사와 세포진 검사를 병행하였을 경우 민감도는 76.9%, 특이도는 76.9%, 위양성률은 23.1%, 위음성률은 23.1%이다. 결론 : 본 연구에서 자궁경부암 선별 검사로서 형태학적 검사인 세포진 검사와 생물학적 검사인 HPV DNA 검사를 동시에 사용하면 서로의 단점을 보완하여 향후 적절한 선별검진의 간격을 결정하는 등 자궁경부암 조기 진단에 매우 유용하게 사용할 수 있을 것으로 생각된다. Objective : The purpose of this study was to find out the efficacy of cytology and HPV DNA test (Hybrid capture I) in early diagnosis of cervical cancer. Methods :This study included 1028 patients who visited the Department of Obstetrics and Gynecology, Cho-sun University Hospital From December 1, 1995 to March 31, 1998. And we chose 305 samples who underwent biopsies among taking the cytology and HPV DNA test. All women simultaneously underwent an exo- and endo-cervical smear. Results : 1. The sensitivity and specificity of cytology were 63.0% and 88.1%, respectively. 2. The positive predictive value and negative predictive value of cytology were 89.7% and 59.3%, respectively. 3. The sensitivity and specificity of HPV DNA test were 51.9% and 85.3%, respectively. 4. The positive predictive value and negative predictive value of HPV DNA test were 85.2% and 52.1%, respectively. 5. When HPV DNA test and Papanicloaou smear were combined, the sensitivity and specificity were 76.9% and 76.9%, respectively. However, the specificity of the combined test with HPV DNA test and Papanicloaou smear was lower than Papanicloaou smear alone. Conclusion : The sensitivity of cervical cytology was markedly improved by combination with HPV DNA test. So, the combined test could improve the high false negativity of cervical cytology, if the effectiveness is confirmed by mass screening study.

Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study

Kim Kyoung Jin,Choi Jimi,Kim Ji Yoon,Bae Jae Hyun,Kim Kyeong Jin,Kim Hee Young,Yoo Hye Jin,Seo Ji A,Kim Nan Hee,Choi Kyung Mook,Baik Sei Hyun,김신곤,김남훈 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.3

Objective: We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in patients with metabolic syndrome (MetS). Methods: A nested case-control study was performed in patients with MetS (≥50 years) who had no history of osteoporotic fracture using the Korean National Health Insurance Service- Health Screening Cohort. This study included 17,041 patients diagnosed with new-onset osteoporotic fractures and controls matched in a 1:1 ratio by age, sex, body mass index, cohort entry date, and follow-up duration. Conditional logistic regression analysis was used to evaluate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: During a 4-year follow-up period, the risk of major osteoporotic fractures was significantly reduced by 9% (OR, 0.91; 95% CI, 0.85–0.97) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for vertebral fracture (OR, 0.86; 95% CI, 0.79–0.94) but not for non-vertebral fracture (OR, 0.97; 95% CI, 0.88–1.06). Longer duration (OR, 0.97; 95% CI, 0.96–0.99, per 1-year increase) and higher cumulative dose (OR, 0.97; 95% CI, 0.95–0.99, per 365 defined daily doses) of statins were negatively associated with the risk of major osteoporotic fracture. Conclusion: This study supports the hypothesis that statin therapy has a beneficial effect on major osteoporotic fractures, especially vertebral fractures, in patients with MetS.

김대중 행정부 규제완화의 분석 : 기관유형별 비교분석을 중심으로

김근세(Kim Keun-Sei),이경호(Lee Kyoung-Ho) 한국지방정부학회 2006 지방정부연구 Vol.9 No.4

이 논문은 김대중 행정부의 규제완화 성과를 기관유형별로 비교 분석하였다. 정부규제 등록건수는 1998~2002년 기간 연평균 8.2%의 감소율을 기록하면서 전반적으로 감소되었다. 특히 기관별로는 보건복지부 관련기관, 유형별로는 인허가 및 면허, 부문별로는 사회복지 및 보건 위생분야, 근거법령별로는 행정명령과 행정규칙에 근거한 정부규제가 대폭 감소하였다. 그리고 정부규제완화의 성과를 기관유형별로 비교 분석한 결과, 의회기관, 생산 및 통합기능, 주변기관에서 규제개혁이 상대적으로 크게 일어났다. 기관유형의 종합적 교차분석 결과를 요약하면 중심-의회-생산기능에서 규제개혁이 가장 활발하게 이루어 졌다. 요약하면, 김대중 행정부의 정부규제완화 개혁은 규제총량을 감축하는 데는 성공했으나, 전략적인 규제감축에는 실패했다. 정부규제 감축의 내용에서 대통령의 정치집행부 강화의도, 경제규제와 사회규제의 획일적 감축, 중앙관리기관의 내부규제완화 미비, 주변기관에 상대적으로 큰 감축부담의 정치성을 지적할 수 있다. This paper examined the characteristics of Kim DJ Administration's deregulatory reforms, using registered regulation DB of Regulatory Reform Committee. Overall, Kim DJ Administration had strongly implemented deregulatory reform. In fact, the number of registered regulation had been decreased in 1988-2002. However, we found that there was difference of deregulation pattern among state apparatus. Severe regulatory reduction was heavily on parliament agency, production and integration state apparatus, and periphery state apparatus. In sum, Kim DJ Administration's reform of deregulation was successful in terms of total size, but ineffective in terms of strategic regulatory reduction.

The Korean Cough Guideline: Recommendation and Summary Statement

Rhee, Chin Kook,Jung, Ji Ye,Lee, Sei Won,Kim, Joo-Hee,Park, So Young,Yoo, Kwang Ha,Park, Dong Ah,Koo, Hyeon-Kyoung,Kim, Yee Hyung,Jeong, Ina,Kim, Je Hyeong,Kim, Deog Kyeom,Kim, Sung-Kyoung,Kim, Yong H The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.1

Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered. If UACS is suspicious, first generation anti-histamine and nasal decongestant can be used empirically. In CVA, inhaled corticosteroid is recommended in order to improve cough. In GERD, proton pump inhibitor is recommended in order to improve cough. Chronic bronchitis, bronchiectasis, bronchiolitis, lung cancer, aspiration, angiotensin converting enzyme inhibitor, habit, psychogenic cough, interstitial lung disease, environmental and occupational factor, tuberculosis, obstructive sleep apnea, peritoneal dialysis, and idiopathic cough can be also considered as cause of chronic cough. Level of evidence for treatment is mostly low. Thus, in this guideline, many recommendations are based on expert opinion. Further study regarding treatment for cough is mandatory.

Health Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats.

Kim, Dajeong,Kyung, Jangbeen,Park, Dongsun,Choi, Ehn-Kyoung,Kim, Kwang Sei,Shin, Kyungha,Lee, Hangyoung,Shin, Il Seob,Kang, Sung Keun,Ra, Jeong Chan,Kim, Yun-Bae unknown 2015 Stem cells translational medicine Vol.4 No.10

<P>: Aging brings about the progressive decline in cognitive function and physical activity, along with losses of stem cell population and function. Although transplantation of muscle-derived stem/progenitor cells extended the health span and life span of progeria mice, such effects in normal animals were not confirmed. Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) (1 ?? 10(6) cells per rat) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives. Transplantation of AMMSCs and ADMSCs improved cognitive and physical functions of naturally aging rats, extending life span by 23.4% and 31.3%, respectively. The stem cell therapy increased the concentration of acetylcholine and recovered neurotrophic factors in the brain and muscles, leading to restoration of microtubule-associated protein 2, cholinergic and dopaminergic nervous systems, microvessels, muscle mass, and antioxidative capacity. The results indicate that repeated transplantation of AMMSCs and ADMSCs elongate both health span and life span, which could be a starting point for antiaging or rejuvenation effects of allogeneic or autologous stem cells with minimum immune rejection.</P>

Chronic intermittent hypoxia augments lipopolysaccharide induced acute lung injury

( Sei Won Kim ),( In Kyoung Kim ),( Hee Young Kwon ),( Sung Bae Cho ),( Jong Min Lee ),( Jick Hwan Ha ),( Hyeon Hui Kang ),( Seok Chan Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse during sleep, causing chronic intermittent hypoxia (CIH). OSA affects 2-5% of the middle-aged population and is associated with significant morbidity and mortality. In intensive care unit, considerable numbers of patients with acute lung injury (ALI) have underlying OSA. However, little is known regarding the effects of OSA on the clinical course of ALI. This study is aimed to evaluate the impact of CIH on inflammation, fibrosis and related pathway in a murine model of ALI. Seven-to-eight week-old male, C57BL/6J mice were used. The mice were divided into two groups and exposed to room air (RA) or CIH. During 4 weeks, the CIH group was exposed to a 30 s RA/hypoxia (approximately fractional inspired O2 7±0.5%) cycle for 8 hours a day. After 4 weeks, each group was divided into two additional groups with intratracheal lipopolysaccharide (LPS, 0.5 mg/kg) or saline exposure. In CIH group with LPS exposure, lung wet/dry ratio and lung injury score were higher than other three groups. Level of hyproxyproline, TGF-beta, VEGF and collagen deposition were also higher in CIH group with LPS exposure compared to other groups. From the cell differentiation of bronchoalveolar lavage, CIH group with LPS exposure showed significantly higher number of total cell and neutrophil compared with other groups, especially compared with RA group with LPS exposure (p<0.001, respectively). These results suggest that CIH may aggravate inflammation and fibrosis in LPS induced ALI, resulting more damage.

Clinical investigation of bisphosphonate-related osteonecrosis of the jaws in patients with malignant tumors

Sei-Kyoung Kim,Tae-Geon Kwon 대한구강악안면외과학회 2012 대한구강악안면외과학회지 Vol.38 No.3

Objectives: This study evaluated bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients diagnosed with malignant bone tumors. Demographic findings, laboratory, and radiographic analyses were performed to characterize disease severity and progression. Materials and Methods: Patients who had been diagnosed with BRONJ (2005-2010) at the authors’ hospital according to the American Association of Oral and Maxillofacial Surgeons were investigated. Twenty-one patients (12 with multiple myelomas, 7 with breast cancer, and 2 with prostate cancer) who had been treated with bisphosphonates (BPs) for malignant bone tumors were included. Radiographic evaluations with a panorama, computed tomography, whole body bone scan, and laboratory findings were evaluated for erythrocyte sedimentation rate (ESR), c-reactive proteins (CRPs), and c-terminal cross-linked telopeptides (CTXs). Results: The average age of the patients was 64.3 (range 51-80), and they were treated with BPs for an average of 35±19 months before BRONJ was diagnosed. Types of BPs were zolendronic acid (81%, intravenous [IV]), pamidronate (4.8%, IV), zoledronic acid+pamidronate (4.8%, IV), alendronate (4.8%, per os [PO]), and ibadronate (4.75%, PO). Extraction (67%) and persistent irritation of dentures (20%) were the most common triggering factors. BRONJ in the mandible was reported in 62% of the cases, in the maxilla 24%, and both 14%. BRONJ occurred more frequently in patients with multiple myelomas (n=12, 57.1%). Most of the patients revealed an advanced BRONJ stage; Stage I (n=2, 9%), Stage II (n=13, 62%), and Stage III (n=6, 29%). Conclusion: The differences of the ESR, CRP, and CTX values between the BRONJ-recurring and non-recurring patients after the treatment were not evident. Later stage BRONJ patients showed lower CTX levels. A drug holiday after the diagnosis of BRONJ did not remarkably influence the surgical outcomes. However, the limited number of patients in the study should be considered.

Rapha diet<SUP>Ⓡ</SUP>, a Combinational Preparation for the Improvement of Dietary Obesity

Jihyun Kim,Jangbeen Kyung,Dajeong Kim,Jingmei Cai,Ehn-Kyoung Choi,Ja Young Jang,Youngeun Kim,Kwang Sei Kim,Kyungha Shin,Dongsun Park,Yun-Bae Kim 한국실험동물학회 2013 한국실험동물학회 학술발표대회 논문집 Vol.2013 No.2

Human Nattokinase Iimproves Blood Flow by Inhibiting Platelet Aggregation and Thrombus Formation

Jihyun Kim(김지현),Ja-Young Jang,Jingmei Cai,Kyungha Shin,Kwang Sei Kim,Dongsun Park,Ehn-Kyoung Choi,Tae-Su Kim,Sung-Pyo Lee,Man Hee Rhee,Yun-Bae Kim 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.2