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- 저자 : ( Hyeon Hui Kang ) (검색결과 229 건)
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월악산 잣나무 및 화백나무 형성층의 계절적 활동과 적산온도와의 관계
박준희, 강현정, 이해진, 서정욱 충북대학교 농업과학기술연구소 2022 農業科學硏究 Vol.38 No.2
The current study was conducted to investigate (1) the duration of cambial activity and (2) the effect of degree days on the initiation of cambial activity of the Pinus koraiensis (PK) and Chamaecy- paris picifera (CP) planted in Mt. Worak. In addition, the differences of the seasonal cambial activities according to the diameter were also investigated using C. picifera with a diameter of 30 cm (CPL) and 15 cm (CPS), which were planted in the same year. The cambium samples were weekly collected using a mini-borer (Ø 2 mm), so called Traphor, between April and October in 2017. The results obtained are as follow. The initiation of the cambial activity of CP (April 21-28) were slightly earlier than PK (April 21). The species with the longest cambial activity was CPS (147.2±12.1 days), followed by PK (141.6±9.8 days) and CPL (139±12.1 days). The degree days inducing the initiation of the cambial activ- ity for PK and CP were 180.5 and 180.5-242.8, respectively.
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( Hyeon Hui Kang ),( In Kyoung Kim ),( Chang Dong Yeo ),( Sei Won Kim ),( Hea Yon Lee ),( Jeong Hyeon Im ),( Hee Young Kwon ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.-
Background: Obstructive sleep apnea (OSA) is associated with pulmonary fibrosis. Chronic intermittent hypoxia (CIH) is considered to be a surrogate of OSA. However, its exact role in pulmonary fibrosis remains uncertain. Therefore, we investigated the mechanism underlying CIH-induced pulmonary fibrosis and the role of the anti-fibrotic agent in bleomycin (BLE) induced lung injury. Methods: Mice were divided into eight groups: the normoxia (NOR), CIH, NOR plus BLE, CIH plus BLE, NOR plus pirfenidone (PF), CIH plus PF, NOR plus BLE and PF, and CIH plus BLE and PF groups. BLE was administered intratracheally on day 14 following CIH or NOR exposure. Subsequently, the mice were exposed to CIH or NOR for an additional 4 weeks. PF was administered orally on day 5 after BLE instillation once daily for 3 weeks. Results: In the BLE-treated groups, CIH-induced more collagen deposition in lung tissues than NOR, and significantly increased hydroxyproline and transforming growth factor-β expression. The CIH and BLE-treated groups showed increased lung inflammation compared to NOR or CIH groups. Following CIH with BLE treatment, nuclear factor-κB (NF-κB) protein expression was significantly increased, whereas nuclear factor-erythroid-related factor 2 (Nrf2) and heme oxygenase-1 protein levels were decreased. After PF treatment, NF-κB and Kelch-like ECH-associated protein 1 expression were suppressed, and Nrf2 expression was increased. Conclusion: CIH accelerated lung fibrosis in BLE-induced lung injury in mice, potentially by regulating the NF-κB/Nrf2 signaling pathway. Our results implicate PF as a potential therapeutic agent for treating pulmonary fibrosis in individuals with OSA and idiopathic pulmonary fibrosis.
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( Hyeon Hui Kang ),( Jin Young Mo ),( Song Hee Park ),( Jeong Uk Lim ),( Sang Haak Lee ),( Hwa Sik Moon ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Introduction: Obstructive sleep apnea (OSA) causes chronic intermittent hypoxia (CIH). Several studies have shown that OSA is associated with liver injury. The purpose of this study was to investigate the proteins related to inflammation in liver subjected to CIH in conjunction with diet-induced obesity (DIO). Methods: Male C57BL/6J mice were fed a high fat or regular diet for 12 weeks and then exposed to CIH or room air for 4 weeks. And we assessed the level of inflammation in the liver tissue. The expression of NF-κB and MAP kinase (MAPK) were measured by Western blotting. Results: In DIO mice, CIH induced significant increase in the expression of NF-κB in liver, which occurred in the nuclear fraction. Compared with control mice, animals exposed to CIH showed increases in protein expression of Interleukin 1 ß (IL-lß), toll like receptor 4 (TLR4), myeloid differentiation primary response protein 88 (MyD88), phospho I kappa B (I-κB), and p-ERK activation in liver, which was augmented in DIO mice. There was no significant change in p38 MAPK and JNK activation in all groups. Conclusions: Exposure to CIH in DIO mice by simulating OSA patients leads to hepatic inflammation via TLR4/ MyD88/MAPK/NF-kB signaling pathways.
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( Hyeon Hui Kang ),( In Kyoung Kim ),( Hye In Lee ),( Jongmin Lee ),( Sang Haak Lee ),( Hwa Sik Moon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Obstructive sleep apnea (OSA) causes chronic intermittent hypoxia (CIH) during sleep. Infiammatory processes and oxidative stress are known to play a key role in the development of metabolic complications induced by CIH. Several evidences suggest that innate immune defense mechanisms might interact with proinfiammatory pathways in OSA. This study examined the activity of toll like receptor 4 (TLR4) in mice with diet-induced obesity (DIO) under CIH condition. Methods: Eight-week old C57BL/6J mice were randomly divided into 4 groups. Two groups of mice were fed a high fat diet for 12 weeks and then exposed to CIH or control conditions (room air) for 4 weeks. Two groups of age-matched mice were fed a regular chow diet for 12 weeks and then exposed to CIH or room air also for 4 weeks. At the end of the exposure, we examined myeloid differentiation primary response protein 88 (MyD88), Toll/interleukin-1-receptor-domain-containing adaptor-inducing interferon-ß (TRIF), I kappa B (I-κB), nuclear factor kappa B (NF-κB), and TLR4 in liver. Results: There was a significant reduction in body weight in DIO mice exposed to CIH steadily through 4 weeks compared with DIO group exposed to room air (P<0.05). In DIO mice, CIH exposure elevated the expression of NF-κB in the nuclear fraction of hepatocytes and mRNA levels of TLR4, which was not observed in lean mice. The protein expressions of TLR4, phospho I-κB and MyD88 were significantly elevated in CIH + DIO group compared to the room air + DIO group, while there was no significant change in the level of TRIF in all groups. Conclusions: Our data indicates that CIH may accelerate TLR4-MyD88 mediated hepatic infiammatory processes in DIO mice. These results suggest that TLR4 may play a critical role in CIH-induced hepatic infiammation.
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( Hyeon Hui Kang ),( Shin Bum Kim ),( Hwa Sik Moon ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Introduction: Patients with OSA commonly complain of fatigue, daytime sleepiness, and poor sleep quality. Depression and obstructive sleep apnea (OSA) are two common entities, with common symptoms that make identification of either condition difficult. We evaluated factors that were associated with depressive symptoms and excessive daytime sleepiness in patients with OSA. Methods: We analyzed the data for 134 subjects, who were admitted to our sleep clinic for evaluation of OSA between 2015 and 2017. Physical examination, Center for Epidemiologic Studies-Depression (CES-D) Scale, and Epworth Sleepiness Scale (ESS) were applied, and a polysomnography was performed. Results: Of the 134 subjects, 49 (36.6%) had depression. A total of 123 patients (mean±SD age: 51.0±13.8 years; apnea/hypopnea index: 45.2±26.7 event/hour; female/male 24/99) had OSA. The association between depression and the severity of OSA was not significant. CES-D scores in the OSA group correlated with positively with ESS (p<0.001), body mass index (p<0.001), neck circumference (p=0.040), waist circumference (p<0.001), and hip circumference (p=0.003). Conclusions: Depression is common in patients with snoring or OSA. There is no association between depressive symptoms and the severity of OSA. However, depressive symptoms in patients with OSA are related with daytime sleepiness and obesity.
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Decolorization of Triphenylmethane Dyes by Wild Mushrooms
Kang, Hyeon Woo,Yang, Yun Hui,Kim, Sang Woo,Kim, Soonok,Ro, Hyeon-Su 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.3
Triphenylmethane dyes such as Crystal Violet (CV) and Malachite Green (MG) are common textile dyes. MG, which is toxic to humans, is widely used in aquaculture as an antifungal agent. In this study, 56 mushroom strains from 12 species of wild mushrooms were examined on dye-containing PDA plates to evaluate their potential for the bioremediation of synthetic dyes. Pycnoporus coccineus, Coriolus versicolor, and Lentinula edodes showed fair growth on CV, but only a few survived on MG. However, a decolorization experiment in an aqueous system revealed that the growth on MG-containing solid medium did not directly match the decolorization of MG in the aqueous system. C. versicolor IUM0061 grew well on both MG and CV plates, but could not decolorize MG in the reaction mixture. Conversely, HPLC analysis revealed that P. coccineus IUM0032, which could not grow on the MG plate, completely mineralized MG within 3 days. A subsequent enzyme activity assay revealed a high lignin peroxidase activity in the reaction mixture, indicating that lignin peroxidase is the key enzyme involved in degradation of MG in P. coccineus IUM0032.
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( Hyeon Hui Kang ),( Jong Min Lee ),( Sang Haak Lee ),( Hwa Sik Moon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Obstructive sleep apnea (OSA) has been assumed to be condition associated primarily in men. The prevalence of OSA has not been well studied in women. We aimed to evaluate the frequency of sleep apnea among females in a Korean population and associated factors. Methods: We analyzed the data for 402 consecutive female = 18 years of age, who were admitted to our sleep clinic for evaluation of OSA between 1994 and 2014. All subjects performed overnight polysomnography. OSA was defi ned as apnea-hypopnea index (AHI) = 5. Excessive daytime sleepiness was considered at an Epworth Sleepiness Scale score of = 10. Results: Among 402 subjects (mean age 50.1±13.3, 18 to 83 yr), the mean obstructive AHI among females was 11.4±17.6 events/h, and OSA was found in 183 (45.5%) of females (mean age 54.7±10.8), 24.1% of females have moderate and 10.4% severe OSA. Age, hypertension, body mass index, witnessed apnea and snoring were related to OSA (P < 0.001, respectively), while daytime sleepiness and smoking status were not. The prevalence of hypertension (21.1%) in patients with OSA was higher than non-OSA groups (14.2%, P < 0.001). OSA was independently related to hypertension among females with an odds ratio of 1.9 (95% CI 1.2 3.1) after adjustments for age, BMI. Conclusions: OSA occurs in 45.5% of females across a wide age range (18 to 80 yr). OSA is related to age, BMI and hypertension. Our fi ndings suggest that OSA is common and an independent risk factor for hypertension among females.
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( Hyeon Hui Kang ),( Jongmin Lee ),( Sang Haak Lee ),( Hwa Sik Moon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Obstructive sleep apnea (OSA) has been assumed to be condition associated primarily in men. The prevalence of OSA has not been well studied in women. We aimed to evaluate the frequency of sleep apnea among females in a Korean population and associated factors. Methods: We analyzed the data for 402 consecutive female = 18 years of age, who were admitted to our sleep clinic for evaluation of OSA between 1994 and 2014. All subjects performed overnight polysomnography. OSA was defined as apnea-hypopnea index (AHI) = 5. Excessive daytime sleepiness was considered at an Epworth Sleepiness Scale score of = 10. Results: Among 402 subjects (mean age 50.1±13.3, 18 to 83 yr), the mean obstructive AHI among females was 11.4±17.6 events/h, and OSA was found in 183 (45.5%) of females (mean age 54.7±10.8), 24.1% of females have moderate and 10.4% severe OSA. Age, hypertension, body mass index, witnessed apnea and snoring were related to OSA (P < 0.001, respectively), while daytime sleepiness and smoking status were not. The prevalence of hypertension (21.1%) in patients with OSA was higher than non-OSA groups (14.2%, P < 0.001). OSA was independently related to hypertension among females with an odds ratio of 1.9 (95% CI 1.2-3.1) after adjustments for age, BMI. Conclusions: OSA occurs in 45.5% of females across a wide age range (18 to 80 yr). OSA is related to age, BMI and hypertension. Our findings suggest that OSA is common and an independent risk factor for hypertension among females.
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Sleep quality and quality of life in chronic obstructive pulmonary disease patients
( Hyeon Hui Kang ),( Noh Hyun Jin ),( Lim Jeong Uk ),( Sang Haak Lee ),( Hwa Sik Moon ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Introduction: Sleep problems are common and cause significant disruption in quality of life in chronic pulmonary disease (COPD) patients, but there is little data about the impact of quality of sleep on health-related quality of life in patients with COPD in Korea. The purpose of this study was to determine association between obstructive sleep apnea (OSA) with sleep quality and quality of life in COPD patients. Methods: Two hundred patients with mild to severe COPD were enrolled prospectively. All patients were evaluated by pulmonary function test for determination of severity of COPD (mild 55; moderate 111; severe 34). The Modified Medical Research Council Scale, Berlin questionnaire, Pittsburgh Sleep Quality Index (PSQI), and St. George Respiratory Questionnaire (SGRQ) were employed for assessment of patients. Results: Sixty-two (31%) patients were at high risk for OSA. Eighty-two (41%) patients showed poor quality of sleep. The patients with OSA and COPD had worse quality of sleep compared to COPD without OSA. The SGRQ was significantly correlated with quality of sleep (r=0.376; P<0.001), post-bronchodilator FEV1% predicted (r=-0.424; p<0.001), and severity of dyspnea (r=0.360; P<0.001). Conclusions: OSA is common in patients with COPD. Sleep quality is also poor among this group. Quality of life in COPD patients is associated with sleep quality, underlying lung function, and the degree of dyspnea. It is recommended that more adequate attention is needed to manage the sleep problem of COPD patients.
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