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Kim, Dajeong,Kyung, Jangbeen,Park, Dongsun,Choi, Ehn-Kyoung,Kim, Kwang Sei,Shin, Kyungha,Lee, Hangyoung,Shin, Il Seob,Kang, Sung Keun,Ra, Jeong Chan,Kim, Yun-Bae unknown 2015 Stem cells translational medicine Vol.4 No.10
<P>: Aging brings about the progressive decline in cognitive function and physical activity, along with losses of stem cell population and function. Although transplantation of muscle-derived stem/progenitor cells extended the health span and life span of progeria mice, such effects in normal animals were not confirmed. Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) (1 ?? 10(6) cells per rat) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives. Transplantation of AMMSCs and ADMSCs improved cognitive and physical functions of naturally aging rats, extending life span by 23.4% and 31.3%, respectively. The stem cell therapy increased the concentration of acetylcholine and recovered neurotrophic factors in the brain and muscles, leading to restoration of microtubule-associated protein 2, cholinergic and dopaminergic nervous systems, microvessels, muscle mass, and antioxidative capacity. The results indicate that repeated transplantation of AMMSCs and ADMSCs elongate both health span and life span, which could be a starting point for antiaging or rejuvenation effects of allogeneic or autologous stem cells with minimum immune rejection.</P>
Dajeong Kim,Dongsun Park,Jangbeen Kyung,Yun-Hui Yang,Ehn-Kyoung Choi,Yoon-Bok Lee,Hyun-Kyu Kim,Bang Yeon Hwang,Yun-Bae Kim 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.2
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 ㎎/㎏) suppressed carrageenaninduced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 ㎎/㎏). Intraperitoneal injection of dexamethasone (2 ㎎/㎏) only decreased exudation and cell infiltration, while indomethacin (2 ㎎/㎏, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE2 pathways.
Dajeong Kim,Hojung An,Nyeonjun Kim,Ayeon Kim,Geurin Hong,Soonhee Kim 국제물리치료연구학회 2020 Journal of International Academy of Physical Ther Vol.11 No.3
Background: Adults with forward head posture (FHP) often suffer from thoracic hyperkyphosis and thoracic dysfunction, and including reduction of the craniovertebral angle (CV angle) and tightening of the superficial neck muscles. In order to treat thoracic dysfunction, interventions aimed at improving thoracic mobility are necessary. Objectives: To examine the effects of maitland manual mobilization therapy on the thoracic spine in adults with FHP. Design: Single-blind randomized controlled trial. Methods: Thirty adults with FHP who met the selection criteria were randomized to the thoracic multiple joint mobilization (TMJM; n=15) group and the thoracic general joint mobilization (TGJM; n=15) group. Joint mobilizations were performed for 23 minutes a day for 4 weeks continuously, two times per week. Outcome measures were ImageJ, BTS FREE EMG 1000, neck disability Index (NDI). Results: Although changes in the left sternocleidomastoid muscle activity and NDI scores over time between the two groups differed, other variables were noted only changes observed over time. Muscle activity in the right sternocleidomastoid increased again in the TGJM group post-intervention and 2 weeks after the end of the experiment, but changes in other variables were retained or improved, confirming the lasting effects of thoracic joint mobilization. Conclusion: Thoracic multiple joint mobilization may be recommended as a more effective intervention for adults with FHP.
Lee, Dajeong,Kim, Hyuk Soon,Shin, Eunju,Do, Seon-Gil,Lee, Chong-Kil,Kim, Young Mi,Lee, Min Bum,Min, Keun Young,Koo, Jimo,Kim, Su Jeong,Nam, Seung Taek,Kim, Hyun Woo,Park, Young Hwan,Choi, Wahn Soo Elsevier 2018 Biomedicine & pharmacotherapy Vol.101 No.-
<P><B>Abstract</B></P> <P>An allergic reaction occurs when the immune system overreacts to harmless substance called allergen that gains access to the body. Food allergy is a hypersensitive immune reaction to food proteins and the number of patients with food allergy has recently increased. <I>Aloe Vera</I> is used for wellness and medicinal purposes. In particular, <I>Aloe vera</I> has been reported to enhance immunity. However, the effect of <I>Aloe vera</I> on food allergy is not yet known. In this study, we investigated the effects of processed <I>Aloe vera</I> gel (PAG) containing low molecular weight Aloe polysaccharide (AP) on ovalbumin (OVA)-induced food allergy in mice. Allergic symptoms, rectal temperature, and diarrhea were measured in OVA-induced food allergy mice. Other allergic parameters were also analyzed by RT-PCR, ELISA, flow cytometry, and other biochemical methods. As the results, PAG suppressed the decrease of body temperature, diarrhea, and allergic symptoms in OVA-induced food allergy mice. PAG also reduced serum concentrations of type 2 helper T cell (Th2) cytokines (Interleukin-(IL)-4, IL-5, and IL-13) as well as histamine, mast cell protease-1 (MCP-1), and immunoglobulin (Ig)E. PAG blocked the degranulation of mast cells and infiltration of eosinophils in intestine. Furthermore, PAG suppressed the population of Th2 cells in spleen and mesenteric lymph nodes. PAG also increased the production of IL-10 and population of type 1 regulatory T (Tr1) cells in mice with food allergy. Taken together, our findings suggest that PAG suppressed Th2 immune responses through, at least partially, stimulating the secretion of IL-10 in food allergy mice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Processed <I>Aloe vera</I> gel (PAG) suppresses food allergy in mice. </LI> <LI> PAG inhibits Th2 immune responses in mice. </LI> <LI> PAG increases the production of IL-10 in vitro and in vivo. </LI> <LI> PAG stimulates the activation of Tr1 cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hong, Geurin,Kim, Yongyoun,Kim, Bokyung,Kim, Dajeong,Kim, Ayeon,Kim, Soonhee International Academy of Physical Therapy Research 2020 Journal of International Academy of Physical Ther Vol.11 No.4
Background: Incorrect postures of adolescents caused by the use of smart devices have been noted as a factor causing spinal diseases. Objectives: To examine the effect of joint mobilization and stretching on Cobb's angle and respiratory function in adolescent idiopathic scoliosis (AIS). Design: Cluster-randomized controlled trial. Methods: A total of 22 subjects with AIS were enrolled. They were allocated to two groups: the joint mobilization (n=11) and the stretching (n=11). All interventions were conducted for 30 minutes, three times a week for six weeks. Outcome measures were the Cobb's angle and respiratory function. The Cobb's angle and respiratory function measured using the X-ray and Micro-Quark. Results: Joint mobilization group showed significant differences in Cobb's angle and respiratory function, but stretching group showed significant differences Cobb's angle. The differences in peak expiratory flow (PEF) between the two groups were significant. Conclusion: This study proved that joint mobilization is a more effective intervention for AIS to improve Cobb's angle and respiratory function, when compared to stretching.
( Hyuk Soon Kim ),( Jun Ho Lee ),( Hee Dong Han ),( A Ram Kim ),( Seung Taek Nam ),( Hyun Woo Kim ),( Young Hwan Park ),( Dajeong Lee ),( Min Bum Lee ),( Yeong Min Park ),( Hyung Sik Kim ),( Young Mi 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.1
IL-10-producing B (Breg) cells regulate various immune responses. However, their phenotype remains unclear. CD40 expression was significantly increased in B cells by LPS, and the Breg cells were also enriched in CD40hiCD5+ B cells. Furthermore, CD40 expression on Breg cells was increased by IL-10, CD40 ligand, and B cell-activating factor, suggesting that CD40hi is a common phenotype of Breg cells. LPS-induced CD40 expression was largely suppressed by an anti-IL-10 receptor antibody and in IL-10./.CD5+CD19+ B cells. The autocrine effect of IL-10 on the CD40 expression was largely suppressed by an inhibitor of JAK/STAT3. In vivo, the LPS treatment increased the population of CD40hiCD5+ Breg cells in mice. However, the population of CD40hiCD5+ B cells was minimal in IL-10./. mice by LPS. Altogether, our findings show that Breg cells are largely enriched in CD40hiCD5+ B cells and the autocrine effect of IL-10 is critical to the formation of CD40hiCD5+ Breg cells. [BMB Reports 2015; 48(1): 54-59]
Anti-atherosclerotic Effect of Carnitine in Rabbits
Yun-Bae Kim, Dongsun Park, Dajeong Kim, Jangbeen Kyung, Yun-Hui Yang, Ehn-Kyoung Choi 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
Effects of carnitine on atherosclerosis and steatosis of hypercholesterolemic rabbits induced by a high-cholesterol diet (HCD) containing 0.5% cholesterol and 2.0% corn oil were investigated. Male New Zealand white rabbits with hypercholesterolemia (blood cholesterol 1,000-1,500 mg/dl) induced by two-week feeding a HCD, were fed a HCD containing 0.008 or 0.075% L-carnitine for an additional eight weeks. Feeding a HCD for 10 weeks resulted in severe atheromatous change, covering 55.7% of the aortic walls, in addition to profound hepatic steatosis. However, carnitine supplementation resulted in recovery of the increased low-density lipoproteins and triglycerides and a decrease in the levels of high-density lipoproteins following HCD feeding, although the increased cholesterol concentration was not potentially attenuated. Notably, carnitine induced a marked reduction of the atheroma area and hepatic lipid accumulation as well as lipid peroxidation. The results of this study indicated that carnitine exerted anti-atherosclerotic and fatty liver-preventing activities through blockade of lipid peroxidation and regulation of lipid metabolism.