http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shin, Kyungha,Cha, Yeseul,Kim, Kwang Sei,Choi, Ehn-Kyoung,Choi, Youngjin,Guo, Haiyu,Ban, Young-Hwan,Kim, Jong-Choon,Park, Dongsun,Kim, Yun-Bae Hindawi Publishing Corporation 2016 Behavioural neurology Vol.2016 No.-
<P>Amygdala is involved in the fear memory that recognizes certain environmental cues predicting threatening events. Manipulation of neurotransmission within the amygdala affects the expression of conditioned and unconditioned emotional memories such as fear freezing behaviour. We previously demonstrated that F3.ChAT human neural stem cells (NSCs) overexpressing choline acetyltransferase (ChAT) improve cognitive function of Alzheimer's disease model rats with hippocampal or cholinergic nerve injuries by increasing acetylcholine (ACh) level. In the present study, we examined the effect of F3.ChAT cells on the deficit of unconditioned fear freezing. Rats given N-methyl-<SMALL>D</SMALL>-aspartate (NMDA) in their amygdala 2 weeks prior to cat odor exposure displayed very short resting (freezing) time compared to normal animals. NMDA induced neuronal degeneration in the amygdala, leading to a decreased ACh concentration in cerebrospinal fluid. However, intracerebroventricular transplantation of F3.ChAT cells attenuated amygdala lesions 4 weeks after transplantation. The transplanted cells were found in the NMDA-injury sites and produced ChAT protein. In addition, F3.ChAT-receiving rats recuperated freezing time staying remote from the cat odor source, according to the recovery of brain ACh concentration. The results indicate that human NSCs overexpressing ChAT may facilitate retrieval of unconditioned fear memory by increasing ACh level.</P>
빛의 효과를 활용한 섬유 소재 예술성 연구-신소재 섬유의 활용 예시를 중심으로-
신경하 ( Shin Kyungha ),차영순 ( Cha Youngsoon ) 한국공간디자인학회 2021 한국공간디자인학회논문집 Vol.16 No.1
(연구배경 및 목적) 산업혁명 이후, 섬유소재 분야는 끊임없이 발전하였고, 신소재의 개발로 인해 그 사용범위가 넓어지고 있다. 본 연구는 섬유소재가 다양한 디자인 분야에서 새롭게 사용되는 것을 중심으로 빛과 관련된 조형성에 주안점을 두어 섬유미술의 예술성을 고찰하고자 하는데 목적이 있다. 이에 섬유예술에서 빛에 의한 조형성을 부각시키기 위한 소재로써 섬유소재의 투명성과 투과성을 지닌 소재를 중심으로 알아보고 이를 이용한 빛의 반사 효과와 조명을 활용한 빛에 관한 섬유소재의 예술성에 대해서 연구하고자 한다. (연구방법) 본 연구에서는 신소재를 근간으로 하여 신소재의 특성을 살려 디자인에 어떻게 예술적으로 적용하였는지의 사례를 설명하였으며 이를 토대로 미래 섬유소재의 발전방향을 예측해보고자 한다. (결과) 신소재는 단지 과학과 기술의 발전에만 영향을 미치고 있는 것이 아니라, 모든 인간 삶의 질을 향상시키고자 하는 디자인 영역의 본질과 연관되어 있기 때문에 신소재는 미래 디자인 발전에 반드시 필요한 핵심 소재로서의 매우 중요하다. 본 연구에서는 새로운 섬유 소재들의 종류와 영역별 고찰을 통해 이들이 발산할는 조형적 효과를 살펴보았다. 이를 통해 소재의 미적 가치를 발견하고 미래소재의 현실화를 통해 섬유미술의 조형적, 미적 가치를 논의할 수 있었다. 또한 신소재 섬유를 활용하여 빛의 효과인 소재의 투명성과 투과성, 반사에 의한 공간에서의 빛의 효과, 인공조명을 활용한 신소재를 발견하였다. 빛의 다양한 개발은 환경, 건축, 디자인 등에 접목되면서 우리 사회와 문화에 큰 영향을 주고, 기술 발달에 따라 빛의 소재는 다양한 각도, 시각적으로 새로움과 즐거움을 주는 소재로 접목됨으로써 더욱 매력적이고 새로운 감성을 느끼게 한다. 이를 통하여 섬유에 적용되는 빛은 공학, 심리학 등과 같은 다양한 분야에서 시도되고 있으며 이러한 시도들은 테크놀로지와 융합되면서 빛의 섬유가 예술적인 섬유, 더 나아가 생활섬유예술로서의 가능성이 큼을 보여주었다. (결론) 이를 통해 섬유 조형은 과학기술의 발전에 따른 새로운 소재 개발을 통하여 표현영역을 다양하게 확대시켜 나가며 예술성을 발휘하고 있음을 알 수 있었다. (Background and Purpose) Advances in the field of textile materials have continued since the Industrial Revolution. With the development of advanced materials, these are now being utilized more widely than ever before. This study examines the artistic value of fiber art, by focusing on the recent attempts to use textile materials in design areas, especially with an emphasis on the artistic values that are related to light. For this purpose, the researcher has focused on materials that are transparent or offer permeability to highlight the form shaping effect of light in fiber art while studying the artistic value of textile materials that are related to the use and reflection of light. (Method) The focus is on advanced materials and the usage has been explained, while highlighting how these materials are utilized in an artistic manner, especially considering their characteristics. An attempt has been made to identify the future direction of development of textile materials. (Results) The impact of advanced materials is not limited to science and technology. It is directly connected with the essence of art, which aims to enhance the quality of life of all human beings. Therefore, advanced materials are important as they are essential for the progress of design in future. In this study, the researcher reviews the artistic impact of advanced textile materials by examining their types and areas of use. The researcher has identified the aesthetic value of these materials and focused on materials that would be available in future to initiate a discussion regarding the value of fiber art in its form and aesthetics. The development of light has been associated with the environment, architecture, and design, to have an impact on society and culture. The material of light is considered as a medium that gives us something new and something pleasant to look at from various angles, making items even more attractive and allowing us to feel new emotions. With this, the light applied to textile materials has an impact on various fields such as engineering science and psychology. These attempts are converged with technology to show the possibilities. These textiles of light indicate their possibilities as the artistic textiles or the art of textile in our daily lives. (Conclusions) This study indicates that the creation of forms by textile materials are expanding its scope of expression through the development of novel advanced materials, as their artistic value increases.
Shin, Seulmee,Park, Yoonhee,Kim, Seulah,Oh, Hee-Eun,Ko, Young-Wook,Han, Shinha,Lee, Seungjeong,Lee, Chong-Kil,Cho, Kyunghae,Kim, Kyungjae The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.4
Background: Cordyceps militarys water extract (CME) has been reported to exert antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not yet been elucidated. In this study, we examined the effects of CME on the antigen presenting function of antigen presenting cells (APCs). Methods: Dendritic cells (DCs) were cultured in the presence of CME, and then allowed to phagocytose microspheres containing ovalbumin (OVA). After washing and fixing the efficacy of OVA, peptide presentation by DCs were evaluated using CD8 and CD4 T cells. Also, we confirmed the protein levels of proinflammatory cytokines through western blot analysis. Results: CME enhanced both MHC class I and class II-restricted presentation of OVA in DCs. In addition, the expression of both MHC class I and II molecules was enhanced, but there was no changes in the phagocytic activity of exogenous OVA. Furthermore, CME induced the protein levels of iNOS, COX-2, proinflammatory cytokines, and nuclear p65 in a concentration-dependent manner, as determined by western blot. Conclusion: These results provide an understanding of the mechanism of the immuno-enhancing activity of CME on the induction of MHC-restricted antigen presentation in relation to their actions on APCs.