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RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)
김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3
Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.
강성홍,남문희,임지혜 인제대학교 2009 仁濟論叢 Vol.24 No.1
This study was aimed to investigate medical utilization statistics of type and it’s reliability. Second objective is to suggest methods to improγe reliability of patient survey statistics. We collected patient survey data, health insurance data, discharge summary data in 2005 and reliability of medical utilization statistics analyzed using rate of diagnosis. We found correspondence rate of diagnosis among health insurance statistics, patient survey statistics, discharge injury survey statistics was not high. The rate of Mental and behavioral disorders was 5.0% in health insurance statistics, was 2.4% in patient survey statistics, was 1.3% in discharge injury survey statistics. The rate of diseases of the respiratory system was 10.3% in health insurance statistics, was 8.5% in patient survey statistics, was 12.1% in discharge injury survey statistics. Based on these results, to improvement reliability of medical utilization statistics, this study suggest public health statistics system building, performance of patient survey four times yearly, securing expert.
Y-TZP의 물성에 미치는 Al₂O₃의 첨가방법의 영향
이홍림,문지웅 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1
To fabricate (Y-TZP)-Al₂O₃composite, two different mixing methods, conventional mechanical mixing and coprecipitation were studied. Mechanically mixed powder was properly densified by pressureless sintering, but its microstructural homogeneity and resistance against low temperature degradation were poor. Due to its umique powder structure, which was consisted of ZrO₂embeded by transition Al₂O₃, coprecipitated powder could not be fully densified by pressureless sintering, so exhibits poorer flexural strength than mechanically mixed powder, but its resistance against low temperature degradation was improved. By hot-pressing at 1550℃ for 1 h, coprecipitated powder could be fully densified, so the flexural strength decrease was not occurred. Al₂O₃size and its distribution of coprecipitated powder composite were smaller and more homogeneous, respectively, than mechanically mixed powder.
골격근 근형질세망의 ATPase활성도에 대한 Vanillylnonanamide의 영향
박경섭,홍장희,류영수,성지연,허강민,임종호,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2
To investigate the effect of vanillylnonanamide(VN) on the ATPase activity of the sarcoplasmic reticulum(SR) of the skeletal muscle, we prepared the SR vesicles from the back muscle of the rabbit, and measured ATPase activity. The results as follows: Ca-ATPase activity was about 50% in the total ATPase activity of skeletal muscular SR. In the reaction mixture with calcium, 100μM VN increased ATPase activity to 20%, and 100 nM and 10 μM thapsigargin(THP) inhibited the ATPase activity to 50% and 60%, respectively. And 100 μM VN plus 100 nM or 10 μM THP more inhibited ATPase activity than THP alone did it. However, without calcium, 100μM VN did not affect ATPase activity, and 10 μM THP inhibited it to 41%, but VN plus THP inhibited it to 31%. The above results show that VN in the reaction mixture with or without calcium has the different action to ATPase activity when it is used alone or together with Ca-ATPase inhibitor THP. This suggests that VN might increase or decrease the skeletal SR Ca-ATPase activity through affecting the lipid membrane around the Ca-ATPase.
박영만,임영,강성규,김지홍,이종욱,최용휴,김경아 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2
Aplastic anemia is characterized by pancytopenia with hypocellular bone marrow. Fifty percent of the cases are idiopathic and the rest are caused by various agents including drugs, chemicals, radiation and viruses. It is difficult to link specific etiologic agents, especially chemicals to the development of aplastic anemia because multiple or unknown exposures may be involved in. Benzene, a common industrial chemical and a component of gasoline, may lead progressively to pancytopenia, aplastic anemia and leukemia when exposed. A petrochemical worker with aplastic anemia was referred to our hospital to evaluate a relationship between the job history and the disease. He worked in the petrochemical plant for 21 years and was exposed to low-level benzene. There was not anyother etiologic agent except benzene and this is the case report of aplastic anemia which possibly due to benzene exposure.
침엽수로부터 발생되는 방향성 테르펜의 배출속도 비교 연구
김조천,홍지형,강창희,선우영,김기준,임준호 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.2
In order to investigate the composition ratio and the emission rate of monoterpenes emitted from coniferous trees during summer, the enclosure chamber experiments were carried out for two tree species (Pinus densiflora and Pinus rigida). The major monoterpenes from the pine trees were α-pinene, β-pinene, myrcene and β-phellan-drene. There was no difference of the composition ratio between two sites for P. densiflora, but the difference was observed for P.rigida, Clearly, the ratio of β-pinene (26.1%) for P.rigida was higher than that of β-phellandrene (12%) at the Gumsung mountain site, but the ratio of β-phellandrene (22.2%) was higher than that of β-pinene (9.9%) at the Chiri mountain site. Particularly, the composition ratio of β-phellandrene was higher than that of β-pinene for P.densiflora, and the opposite trend was found for P.rigida at the Gumsung mountain site. The characteristics of the composition ratio between two species were similar at the Chiri mountain site. As a result of the emission rate measurements, it was observed that both sites did not show any significant β value (slope between emission rate and temperature) and ERs (Standard Emission rate at 30℃) difference. However, the β value and ERs at the Chiri mountain site were slightly greater than those of Gumsung mountain site for both pine species. P.densiflora(1.703 and 1.971㎍C/gdw/hr) showed the higher monoterpene ERs than those of P.rigida (0.572 and 0.698 ㎍C/gdw/hr) at both sites.
김태연,유진홍,박성환,김연식,임상현,신완식,강문원,정창훈,최문구,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2
저자들은 최근 화농성 슬관절염과 병발한 수막구균성 수막염 1예를 체험하였고, 이는 국내에서 아직 보고되지 않은 드문 예로 사료되어 문헌고찰과 함께 보고하는 바이다. We recently experienced a case of meningococcal meningitis associated with pyogenic arthritis in a 37-year old male patient. Pyogenic arthritis developed in right knee joint during treatment for meningococcal meningitis. He was treated successfully by appropriate antibiotics and arthroscopic irrigation. To our knowledge, such a rare case has not ever been reported in Korea, Hence we report this case with a review of related literatures.