췌장의 점액성 낭선암 1예

송현주,김도영,정혜경,남승현,문일환,구혜수 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.2

Nowadays increasing use of abdominal ultrasound in routine check-up may increase the detection rate asymtomatic cystic lesions of pancreas. Even through the majority of the cystic lesions of pancreas is pseudocyst, about 10-15% of those lesions are caused by pancreatic cystic tumor. In the pancreatic cystic tumor, especially, mucinous cystic tumor should be exicised due to its malignant potential, while the pancreatic pseudocyst or serous cystic tumon can be observed for a period or treated medically. Several clinical, radiological, biochemical and pathologic guidelines have been developed in order to distinguish among them. Among pancreatic cystic tumors, mucinous cystic adenocarcinoma is very rare and accounts for only 1% of all pancreatic neoplasms. Unlike extremely poor prognosis of pancreatic adenocarcinoma, mucinous cystic adenocarcinoma has an indolent course and shows a good prognosis after its curative resection. Recently we experienced a 69-year-old woman who had a mucinous cystic adenocarcinoma of the pancreas. We report this case with a review of literature.

초등학교 고학년 학생의 과학 탐구능력 측정을 위한 평가 도구 개발

송경혜,이항로,임청환 한국과학교육학회 2004 한국과학교육학회지 Vol.24 No.6

본 연구에서는 평가도구의 구비조건을 갖춘 초등학교 고학년 학생의 과학탐구능력을 측정할 수 있는 과학탐구 능력 평가도구를 개발하고자 하였다. 평가도구를 구성하는 문항은 R&D 방법에 의해 개발되었으며, 2차례에 걸친 과학교육 전문가의 점검과 2번의 현장 검증을 통해 문항을 수정ㆍ보완하였다. 각 평가 문항은 교과 내용에 대한 지식이 없어도 해결할 수 있는 범교과적인 문항으로 제작하여 과학탐구능력의 하위 요소들을 측정하고자 하였다. SAPA 교육과정과 제7차 과학과 교육과정에서 제시한 과학탐구과정 요소를 근간으로 관찰, 분류, 측정, 예상, 추리, 문제인식, 변인통제, 자료해석, 결론도출, 실험설계의 10가지 하위 요소들을 선정하고 각 요소에 대한 조작적 정의와 평가 목표를 설정하였다. 물질과 에너지, 생명과 환경, 지구와 순환의 3가지 내용 영역의 소재를 중심으로 총 30문항을 개발하였다. 개발된 문항을 과학교육 전문가에게 2회 의뢰하여 타당도, 객관도, 문항의 명료성을 점검 받았으며 2번의 현장 검증을 통해 신뢰도, 변별도, 난이도를 검증하였다. 그 결과 타당도 91.6%, 신뢰도 지수 Cronbach α값 0.79, 객관도 93.3%, 변별도 지수 0.30, 난이도 지수 66.1%로 나타났다. 위와 같은 값들은 평가도구가 갖추어야 할 구비조건의 허용 범위내에 있는 것으로 보아 본 연구에서 개발한 과학탐구능력 평가도구는 양호한 것으로 볼 수 있다. 따라서 본 연구에서 개발한 과학탐구능력 평가도구는 초등학생들의 과학탐구능력 성취 수준의 진단, 과학과 교육과정과 교수?학습 자료 및 과학과 교수ㆍ학습 방법의 과학탐구능력 반영 수준을 평가하는 도구로도 이용될 수도 있을 것이다. The purpose of this study is to develop a valid and reliable evaluating instrument for elementary school fifth and sixth graders. The instrument is developed through R&D procedure, which includes two checks of science specialist and two field trials of the instrument. Evaluating items are content-free for each science inquiry skill. Each science inquiry element is based on SAPA and the 7th curriculum. This study has selected 10 science inquiry skills(observing, classifying, measuring, predicting, inferring, recognizing of a problem, controlling variables, interpreting data, drawing a conclusion, designing an experiment), formulated a clear definition of the elements of science inquiry skills, and established the objectives of evaluation. The content areas are divided into three categories, material and energy, life and environment, and the earth and circulation. Each category contains 10 items. So the instrument consists of 30 items. The content validity of items, objectivity of the scoring keys, and clarity of the items has been checked twice by specialists in science education. At the same time, two field trials were performed to produce the reliability of the instruments, discrimination index, and item difficulty index. The instrument has the content validity is 91.6%, reliability 0.79, objectivity 93.3%, discrimination index 0.30, and item difficulty index 66.1%.

발기부전 검사에서 천연색 복합초음파촬영술과 야간음경발기검사의 일치도

송윤섭,구자현,김민의,이혜경,김두상,박영호,이남규 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

We intended to know that the result of color duplex ultrasonography corresponded to that nocturnal penile tumescence rigidity in the diagnosis of erctile dysfunction. We performed both color duplex ultrasonography and nocturnal penile tumescence rigidity in 15 erectile dysfunction men. Colr duplex ultrasonography was done with a 7 MHz. color Doppler unit after intracorporeal pharmacological injection and measured maximal arterail diameter, peak systolic velocity, end-diastolic velocity and the results were compared with rigidity and tumescence in nocturnal penile tumescence rigidity using RigiScan. The positive predictive value, negative predictive value, sensitivity, specificity, overall accuracy of color duplex ultrasonography was reasonable when the result of color duplex ultrasonography was compared with the that of nocturnal penile tumescence rigidity. According to this results, color duplex ultrasonography could not only predict but also correspond to nocturnal penile tumescence. Therefore, we suggest that color duplex ultrasonography can relpace nocturnal penile tumescence rigidity if psychogenic and neurogenic erectile dysfunction are distinguished by history and neurologic examination.

고등급 이형성을 보인 편평톱니샘종

권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.

여학생 동복 하의 착용시의 생리반응과 주관적 착용감

권수애,오미경,강미영,송혜원,박진채,권리현 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.5 No.-

In this study, physiological responses and subjective sensations were investigated depending on various high school girls' lower cloth uniform in winter. Four healthy young women were selected, and they wore same underwear and jacket. The types of lower cloth were tight skirt+stocking, flared skirt+stocking, tight skirt+legings+socks, flared skirt+legings+socks, and slacks+socks. The results were as follows: 1) The effect of the type of lower cloth in winter on the skin temperature, humidity inside clothing and subjective sensations were significant. 2) It is desirable for high school girls to wear slacks in winter, Since physiological responses and subjective sensations of slacks are superior to those of skirts. 3) It is desirable for high school girls to wear flared skirt, legings, socks in winter, Since insulation and subjective sensations of flared skirts are superior to those of tight skirts.

정의적 특성이 수학적 문제 해결력에 미치는 영향

강호욱,노은환,박은진,송현준,이혜경,주채연 진주교육대학교 초등교육연구소 2005 科學敎育硏究 Vol.28 No.-

The purpose of this study is to provide some basic data which can be helpful for improving the methods of mathematics teaching-learning emphasizing the affective factors by investigating the effect on affective characteristics and mathematical problem solving ability of the students on the elementary school sixth grade. In order to achieve these purpose, the following research problems were set up for the present study: The results of this study are as follows: First, it was appeared that there was not any difference on attitude on mathematics, belief, self-confidence and the degree of mathematical problem solving ability by sex. Second, it was appeared that there was some statistical meaningful difference on attitude on mathematics, belief, self-confidence and the degree of mathematical problem solving ability according to high middle low ability on mathematics which the students think that they have. Based on the results of this study, I'd like to give some suggestions as followings to provide some help to teaching and learning mathematics. First, the succeeding studies are needed by selecting different population from the population of this study, classifying low-ranking factors consisting of affective characteristics differently from this study, compounding each low-ranking factors in various manners like using new items, etc. Second, the succeeding studies are needed in this part, because what mathematical belief teachers have mathematics can have an effect on students' mathematical belief and action as well as on teachers' thinking process and action in the class. Third, the succeeding studies are needed to develop concrete field study and program which can be helpful for improving actually students' affective behavior characteristics in school field.

급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과 : 다기관 개방연구

김광수,배치운,윤진상,김영훈,이양현,지익성,이철,송혜경,최성구,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Ohjective : The primary purpose of this study was a replication of the effectiveness and tolerability of rispehdone in the treatment of patients with acute mania in very larger cohon in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-TV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extra-pyramidal symptom (EPS). Results : This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5±11.8, p<0.0001 ; mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respec-tively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion : The present larger open study demonstrates that hsperidone add-on therapy is effective and tolerable in treat-ment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.

The survival impact of surgical waiting time in patients with resectable pancreatic head cancer

Hye Kyoung Seo,Dae Wook Hwang,Seo Young Park,Yejong Park,Seung Jae Lee,Jae Hoon Lee,Ki Byung Song,Young-Joo Lee,Song Cheol Kim 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4

Backgrounds/Aims: After centralization policy, clinical outcomes have been improved in patients underwent pancreaticoduodenectomy for pancreatic cancer. However, centralization could exacerbate the prolongation of surgical waiting time. This study aims to investigate whether the shorter waiting time correlates with the better survival and to identify the major confounders that influence the association between those. Methods: In this retrospective cohort study, a total 554 patients with pathologically confirmed pancreatic ductal adenocarcinoma were assessed the eligibility from 2014 through 2015. Patients with neoadjuvant chemotherapy, body-tail resection, total pancreatectomy and combined adjacent organ resection were excluded. All patients were divided into two groups by median waiting time, 21 days, defined as the date difference between initial imaging diagnosis and operation. Results: Median overall survival did not differ between long and short waiting group (30.4 vs 24.8 months, p=0.35; HR=0.84, 95% CI=0.58-1.21). The proportion of cancer stage shifting, the difference between clinical and pathologic staging, did not differ depending on waiting time group (p=0.811 and 0.255, each of reviewers). Short waiting time was highly correlated with high initial clinical stage (Spearman correlation coefficients –0.201 (p=0.006) and –0.100 (p=0.175), each of reviewers). Conclusions: Initial clinical stage had confounding effect on the association between waiting time and overall survival. Therefore, in evaluating centralization policy at the national level, evidence for maximum acceptable waiting time should be investigated in the near future with considering that surgical waiting time could be affected by initial clinical stage.

Choledochal Cyst Associated the with Anomalous Union of Pancreaticobiliary Duct ( AUPBD ) Has a More Grave Clinical Course Than Choledochal Cyst Alone

(Hye Kyoung Song),(Myung Hwan Kim),(Seung Jae Myung),(Sung Koo Lee),(Hong Ja Kim),(Kyo Sang Yoo),(Dong Wan Seo),(Hyun Joo Lee),(Byeong Cheol Lim),(Young Il Min) 대한내과학회 1999 The Korean Journal of Internal Medicine Vol.14 No.2

N/A Objective:Previous pathObjective: Since choledochal cyst is frequently associated with the anomalous union of pancreaticobiliary duct(AUPBD), AUPBD has been regarded to be the etiologic factor of choledochal cyst. However, the clinical significance of AUPBD an patients with choledochal cyst has not been clearly defined. Therefore, to clarify the significance of AUPBD in choledochal cyst patients, we compared the clinical features of patients with choledochal cyst according to the presence or absence of AUPBD. Methods: Among 52 cases which were diagnosed as choledochal cyst out of 5,037 ERCP referrals between August 1990 and December 1996, we selected 44 cases, in which the pancreaticobillary junction was clearly visualized on cholangio-pancreaticography. These cases were divided into AUPBD-present group (n=28) and AUPBD-absent group (n=16). Clinical features were compared between the two groups. Furthermore, in AUPBD-present group, clinical data were also analyzed according to Kimura's classification of AUPBD. Results: In our study, AUPBD was associated with choledochal cyst in 28 (64%) cases. AUPBD was found only in type I and IV according to Todani's classification of choledochal cyst. There were no significant differences between the AUPBD-present group and the AUPBD-absent group in the incidence of gallstone disease, while the incidence of acute inflammation was 93% (26/28) in the AUPBD-absent group (p<0.01). Carcinoma developed only in the AUOBD-present group (9/28, 32%) (p<0.05). Pancreatic disorders (I.e. pancreatic stone, pancreatitis or pancreatic cancer) occurred in 12 of 28 cases in the AUPBD-present group(43%), while only in 1 of 16 cases in the AUPBD-absent group(6%)(p<0.05). Conclusion: AUPBD associated with choledochal cyst may have implications not only as a possible etiologic factor but also as an important factor that may affect the clinical course, surgical planning and prognosis. In cases with choledochal cyst, we should make an effort to evaluate the presence of AUPBD.

Tissue-specific Regulation of Calbindin-D<SUB>9κ</SUB> Gene in Transgenic Mouse

Hye Kyoung Song,Joo-Hyoung Kang,Kun Yeong Lee,Jae-Hoon Choi,Sun Ja Cho,Young-Han Ryu,Eun-Young Kim,Seung Phil Park,Hye Jin Kim,Eun-Kyoung Kim,Yun Jeoung Seo,Sung Kyu Park,Goo Taeg Oh(오구택) 한국실험동물학회 2004 한국실험동물학회 학술발표대회 논문집 Vol.2004 No.-