원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

아세톤-물 혼합용매내에서 1_1 전해질의 전기전도도에 대한 연구

오형식,김종현,전동철 木浦大學校基礎科學硏究所 1988 基礎科學硏究誌 Vol.6 No.-

여러가지 조성의 아세톤-물 혼합용매중에서 LiC1, LiBr 및 Lil의 희박용액 전도도를 25℃에서 측정하였다. 그 결과 각 전해질들의 여러 농도에 따르는 당량전도도의 변화가 Fuoss-Onsager's semiem-pirical 식에 대해서 좋은 일치를 보여 주었다. 또한 아세톤-물 혼합용매의 몰 분율이 증가함에 따라 극한당량전도도??값이 LiC1, LiI는 0.3 몰 분율에서, LiBr는 0.2 몰 분율에서 가장 작은 값을 나타내었다. Walden Product??는 LiC1와 LiBr가 0.1 몰 분율에서, LiI는 0.0 몰 분율에서 최대치를 보여 주었고, 그 후로는 아세톤 몰 분율의 증가에 따라 계속 감소하였다. The equivalent conductance of LiC1, LiBr and LiI have been measured in Acetone-Water mixtures of various composition (0.0∼0.6 mole fraction) at 25℃. The value of equivalent conductance agreed well with the Fuoss-Onsager's semiempirical equation. The minimum limiting equivalent conductance was found in 0.3 mole fraction Acetone for LiC1, LiI and LiBr was found in 0.2 mole fraction Acetone. The maximum Limiting Walden Products?? of LiC1 and LiBr was found in 0.0 mole fraction Acetone, and LiI was found in 0.0 mole fraction Acetone. And also, after 0.1 mole fraction and 0.0 mole fraction, decreased with increasing of mole fraction Acetone.

치과용 심미 수복 재료들의 색상 연구를 통한 새로운 치과용 색체계의 제안

오윤정,박수정,김동준,조현구,황윤찬,오원만,황인남 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.1

본 연구는 새로운 치과용 색체계 개발을 목적으로 현재 치과에서 사용되고 있는 Vita shade를 사용하는 9 제조사의 12종의 광중합형 복합레진과 1종의 치과용 도재의 색상을 diffuse/8° 수광 방식을 사용하는 분광색체계 (MiniScan XE plus, Model 4000S, Hunter Lab, USA)를 이용해 D65 표준광과 10도 관찰자 시야 하에서 CIE L^(*)a^(*)b^(*) 값을 측정하고 색상 범위를 분석하였다. 분석한 정보를 color sorting system을 응용한 CNU Cons Dental Color Chart의 색상 표현 방식인 T###에 치과용 수복 재료들의 범위를 적용하여 다음의 결과를 얻었다. 측정된 L^(*)a^(*)b^(*)값의 분포를 분석해 보면 L^(*)값은 80.40과 52.70 사이에, a^(*)값은 10.60과-3.60 사이에, 그리고 b^(*)값은 28.40과 2.21 사이에 분포한다. L^(*)값의 평균값은 67.40, 중앙값은 67.30이며, a^(*)값은 2.89와 2.91, b^(*)값은 14.30 과 13.90 이다. 이러한 분석을 토대로 CNU Cons Dental Color Chart의 T###의 첫 번째 숫자에 해당하는 L^(*)값의 각 숫자간의 차이는 2.0으로, 그리고 2번째 숫자인 a^(*)값의 각 숫자간의 차이는 1, 그리고 세 번째 숫자인 b^(*)값의 각 숫자간의 차이는 2로 정하였다. T555에 해당하는 L^(*)값의 범위는 66.0이상, 68.0미만으로, a^(*)값의 범위는 3이상 4미만으로, b^(*)값의 범위는 14이상 16미만으로 결정하였다. The purpose of this study is to develope new dental color-space system. Twelve kinds of dental composites and one kind of dental porcelain were used in this study. Disk samples (15 ㎜ in diameter, 4 ㎜ in thickness) of used materials were made and sample’s CIE L^(*)a^(*)b^(*) value was measured by Spectrocolorimeter (MiniScan XE plus, Model 4000S, diffuse/8° viewing mode, 14.3 ㎜ Port diameters, Hunter Lab. USA). The range of measured color distribution was analyzed. All the data were applied in the form of T### which is expression unit in CNU Cons Dental Color Chart. The value of L^(*) lies between 80.40 and 52.70. The value of a^(*) are between 10.60 and 3.60 and b^(*) are between 28.40 and 2.21. The average value of L^(*) is 67.40, and median value is 67.30. The value of a^(*) are 2.89 and 2.91 respectively. And for the b^(*), 14.30 and 13.90 were obtained. The data were converted to T### that is the unit count system in CNU-Cons Dental Color Chart. The value of L^(*) is converted in the first digit of the numbering system. Each unit is 2.0 measured values. The second digit is the value of a^(*) and is converted new number by 1.0 measured value. For the third digit b^(*) is replaced and it is 2.0 measured unit apart. T555 was set to the value of L^(*) ranging from 66.0 to 68.0, value of a^(*) ranging from 3 to 4 and b^(*) value ranging from 14 to 16.

모바일 로봇의 지능제어

오세봉,심병균,Nguyen Van Quyet,한성현,박동준 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper achieves a research about remote control of robot based on voice recognition. Through real-time remote control and wireless network capabilities of an unmanned remote-control experiments and Home Security / exercise with an unmanned robot, remote control and voice recognition and voice transmission are possible to transmit on a PC using a microphone to control a robot to pinpoint of the source. Speech recognition can be controlled robot by using a remote control. In this research, speech recognition speed and direction of self-driving robot were controlled by a wireless remote control in order to verify the performance of mobile robot controller.

企業危險에 관한 硏究

吳東弦 제주대학교 1984 논문집 Vol.18 No.2

The investment under uncertainty often gives rise to several types of risk. It is very important to provide investors or financial managers with tile accurate analysis of risk and the appropriate return on risk in order to help them make reasonable investment decisions. If the return on investment risk is revenue, it will be able to classify into two parts; one is that the expected rate of return on the riskless assets investment is a return on the investment period, the other is that the return on risky assets has the nature of return on investment period and risk. Therefore, in the investment decisions it is very important to compare and analize the mutual relation between expected return on investment and risk. To analize risk in this study, I explained the unfolding process of systematic risk, and examined closly theorical feasibility of Beta-coefficient as a criterion of risk laying stress on CAMP induced by capital market line. Also, through analizing the mutual relations between systematic risk and financial factors, I has grouped several schemes to provide the basic data that can be applied to the efficient use and management of financial factors for the purpose of the expected utility maximization and the risk minimization.

다이아몬드용 자동연마기의 성능평가

오재국,김우순,김동현 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The present study deals design and manufacture of automatic polishing machine that can cut diamond to have 58 facets in a brilliant cutting which has been hardly achieved by a conventional manually operating polishing machine. Upon the 3-dimensional Sarin M/C test and analysis on the diamond processed by the automatic polishing machine developed in this study its proportion and finishing turned out to be better than the diamond processed by the conventional method, by being rated as "very good".

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.