작물 보호제 대사체에 대한 유럽의 지하수 오염평가

황경택,채명윤,강성은,정봉진 한국농약과학회 2015 한국농약과학회 학술발표대회 논문집 Vol.2015 No.4

소양막이식편이 개의 전층 피부 창상치유에 미치는 효과

황경택,권오경,우흥명,김대용,남치주,Hwang, Kyeong-teak,Kweon, Oh-kyeong,Woo, Heung-myung,Kim, Dae-young,Nam, Tchi-chou 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.3

The purpose of the present study was to investigate the effect of bovine amniotic membrane grafts on healing of full-thickness skin wound in dogs. Two $3cm{\times}3cm$ area-matched full-thickness skin wounds were induced bilaterally on the dorsolateral aspect of the trunk of 15 dogs. Chlorhexidine-treated amnion, dried amnion, silver sulfadiazine and 0.9% sterile saline solution were applied on the wound area and examined grossly and histopathologically. Begining 14 days after wounding, amnion applied group had appreciably less amount of inflammatory exudate and hemorrhage than sulfadiazine and saline treated groups. From 14 days after wounding, the degree of wound contraction in amnion groups, especially in the dried amnion group was greater than that of the sulfadiazine and saline treated groups. The percentages of wounds completely healed on 28 days after wounding in saline treated group, chlorhexidine-treated amnion group, dried amnion group and sulfadiazine treated group were 33%, 50%, 83% and 50%, respectively. Microscopically neovascularization and fibrosis were first noticed on 5 days after wounding in the dried amnion group and sulfadiazine treated group, on 7 days in the chlorhexidine-treated amnion group and on 14 days in the saline treated group. Epithelialization in the dried amnion and sulfadiazine treated groups was first noticed on 9 days after wounding, which was faster than that in the other groups. The present study suggests that bovine amniotic membrane, especially dried bovine amnion is effective on healing of full-thickness skin wound in dogs through both wound contraction and epithelialization.

梓木이 腦血流 및 血壓에 미치는 影響

황경택,경은호,나한일,소응향,최병화,한종현 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

The purpose of this study is to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) in rats, following the intravenous injection of Catalpa Ovata Water Extract (COWE). The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure tranducer(Grass, USA) in anesthetized adult Sprague-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as following : COWE increased the changes of rCBF and BP significantly. After pretreatment with propranolol and indomethacin, the changes of rCBF were inhibited significantly, but not by L-NNA and methylene blue. Also, after pretreatment with propranolol, the changes of BP were inhibited significantly, but not by L-NNA, methylene blue and indomethacin. According to above result, it is considered that Catalpa Ovata increased the rCBF and BP, related to adrenergic β-receptor.

백강잠(白?蠶)의 뇌혈류역학(腦血流力學)에 관한 연구(硏究)

황경택,한종현,강성용,Whang Kyung-Taig,Han Jong-Hyun,Kang Sung-Yong 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1

Oriental medicine prescription has been used for the treatment of various clinical symptoms associated with cerebral apoplexy. However, single herb drug does not used cerebral apoplexy and there mechanisms of action have not been defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation. The study was aimed to investigate the effect batryticatus bombycis(BB) on the vascular systems including changes in blood pressure (BP), and regional cerebral blood flow (rCBF) and of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry. 1. Blood pressure was not affected by BB in rats. 2. rCBF was increased by BB in a dose-dependent manner. 3. Pretreatment with methylene blue(1mg/kg), and propranolol(1mg/kg) did not inhibited BB induced increased in rCBF. 4. Pretreatment with propranolol(1mg/kg) was increased by BB in a dose-dependent manner in blood perssure. 5. Pretreatment with ODQ($10{\mu}g/kg$) and L-NNA(1mg/kg) were inhibited BB induced increased in rCBF. 6. Pretreatment with L-NNA(1mg/kg) was increased rCBF in a dose-dependent manner. These results suggest that BB causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased in rCBF is also mediated by nitric oxide synthease and guanylate cyclase.

蔓荊子의 腦血流力學에 대한 硏究

黃勁澤,申榮日,趙卿化,鄭鉉雨,康城溶 대한동의병리학회 2000 동의생리병리학회지 Vol.14 No.1

腦血管 疾患인 中風은 中樞神經系에 影響을 미치는 成人病중 다른 疾患에 비해 致命的이며, 그 後遺症 또한 深刻 社會的 問題를 惹起하는 重要한 問題이다. 現在 이러한 腦血管病患은 歐美 先進 各國에서는 물론 우리나라에서도 發病 頻度나 이로 因한 後遺症 및 死亡率이 繼續 增加하고 있어 各種 癌으로 因한 死亡을 除外하고는 單一 臟器의 病患으로서는 단연 首位를 차지하고 있으나 이에 대한 뚜렷한 되어 豫防 및 治療法은 물론 根源的인 病因論마저 제대로 確立되어 있지 못한 實情이다. 中風의 治療法으로는 鍼과 藥을 使用하였으며, 주로 理氣 順氣에 역점을 두었다. 中風의 治療 方法이 이러하기에 理氣之劑에 屬하는 藥物중 香附子, 厚子, 檳랑 및 白荳寇 選擇하여 效能을 살펴보았다. 그 結果 香附子, 厚朴, 檳랑 및 白荳寇는 局所腦血流量을 增加시켰으며, 血壓은 濃度에 依存하여 低下하는 것을 알 수 있었으며, 앞으로 理氣之劑가 中風 病患의 豫防 및 治療에 있어 血壓의 低下 및 腦 保護를 할수 있는 것이라 思料되며, 또한 多樣한 活性을 나타내는 약물들에 대해서 實驗을 繼續 進行하여 機轉을 밝혀야 할 것으로 思料된다. Fructus Viticis(FV) has been used in Korea for many centuries as a therapeutic agent for cerebral disease. The effect of FV on the vascular system is not known. The purpose of this study was to investigated the effect of FV on the cerebral hemodynamics including the changes in blood pressure and regional cerebral blood flow(rCBF) of rats. 1. Blood pressure was not affected by FV in rats. 2. rCBF was increased by FV in a dose-dependent manner. 3. Pretreatment with L-NNA(Nω-nitro-L-argirinine) significantly decreased FV induced in blood pressure. 4. Pretreatment with propranolol, methylen blue, 1H〔1.2.4〕oxadizolo〔4,3-a〕quinoxalin-1-one(ODQ) or L-NNA signiicantly inhibited FV induced in rCBF. These results suggest that FV causes a diverse response of blood pressure and regional cerebral blood flow(rCBF)

數動 韓藥材가 血壓 및 局所腦血流量에 미치는 影響

金炯昌,黃勁澤,韓宗鉉 대한동의병리학회 2000 동의생리병리학회지 Vol.14 No.1

腦血管 疾患인 中風은 中樞神經系에 影響을 미치는 成人病중 다른 疾患에 비해서 致命的이며, 그 後遺症 또한 深刻한 社會的 問題를 惹起하는 重要한 問題이다. 現在 이러한 腦血管疾患은 歐美 先進 各國에서는 물론 우리나라에서도 發病 頻度나 이로 因한 後遺症 및 死亡率이 繼續 增加하고 있어 各種 癌으로 因한 死亡을 除外하고는 單一臟器의 疾患으로서는 단연 首位를 차지하고 있으나 이에 대한 뚜렷한 豫防 및 冶療法은 물론 根源的인 病因論 마저 제대로 確立되어 있지 못한 實情이다. 中風의 治療法으로는 鍼과 藥을 使用하였으며, 주로 理氣·順氣에 역점을 두었다. 中風의 治療 方法이 이러하기에 理氣之劑에 屬하는 藥物중 香附子와, 厚朴, 檳 및 白荳 를 選擇하여 效能를 살펴보았다. 그 結果 香附子, 厚朴, 檳랑 및 白荳寇는 局所腦血流量을 增加시켰으며 血壓은 濃度에 依存하여 低下하는 것을 알 수 있었으며, 앞으로 理氣之劑가 中風 病者의 豫防 및 治療에 있어 血壓의 低下 및 腦 保護를 할수 있는 것이라 思料되며, 또한 多樣한 活性을 나타내는 약물들에 대해서 實驗을 繼續 進行하여 機轉을 밝혀야 할 것으로 思料된다. Oriental medicine prescription has used for the treatment of various clinical symptoms associated with cerebral apoplexy. However, single herb drug does not used cerebral apoplexy and there mechanisms of action have not been defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation. The study was aimed to investigate the effect rhizoma cyperi(RC), cortex magnolia(CM), semen arecae(SA) and fructus amomi cardamomi(FAC) on the vascular systems including changes in blood pressure (BP), and regional cerebral blood foow (rCBF) and of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry. 1. Blood pressure was decreased by RC, CM and FAC in a dose-dependent manner. 2. Significantly Blood pressure was decreased by SA in a dose-dependent manner. 3. Significantly rCBF was increased by RC, CM, SA in and FGC in a dose-dependent manner. These results suggest that RC, CM, SA and FGC sauses a diverse response of blood pressure and regional cerebral blood flow(rCBF).

Tiafenacil의 미국 농작업자 위해성평가

김지현,황경택,박찬,송재영,김영권 한국농약과학회 2020 한국농약과학회 학술발표대회 논문집 Vol.2020 No.11

지하수 오염 예측 프로그램에 대한 결과 비교

강민경,송남숙,황경택,김영권 한국농약과학회 2022 한국농약과학회 학술발표대회 논문집 Vol.2022 No.11

Tiafenacil의 토양 생물 위해성 평가

이태구,송남숙,이명호,황경택,김영권 한국농약과학회 2023 한국농약과학회 학술발표대회 논문집 Vol.2023 No.11

청피(靑皮)가 뇌혈류와 복강내 Macrophage에 미치는 영향

김남순 ( Nam Soon Kim ),황경택 ( Kyung Taek Whang ),황일택 ( Il Taek Whang ),강덕수 ( Duk Soo Kang ),강학천 ( Hak Chun Kang ),한종현 ( Jong Hyun Han ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.2

Citri Reticulatae Viride Pericarpium is being used to regulate the flow of gi. However, the mechanism of its pharmacological actions is not well understood. The purpose of this research was to investigate effects of Citri Reticulatae Viride Pericarpium on peritoneal macrophages in mice and blood pressure, regional cerebral blood flow in rats. Nitric oxide production was tested using a Griess reagents, and a phagocytic activity of mouse peritoneal macrophage was tested using a luminometer. Blood pressure and regional cerebral blood flow was tested using a phygiograph, MacLab and Macintosh computer with data acquisition system. 1. Blood pressure was increased by Citri Reticulatae Viride Pericarpium in a dose-dependent manner. 2. rCBF was increased by Citri Reticulatae Viride Pericarpium in a dose-dependent manner. 3. Pretreatment with propranolol significantly inhibited Citri Reticulatae Viride Pericarpium induced increase in rCBF. 4. Citri Reticulatae Viride Pericarpium inhibited nitric oxide production from peritoneal macrophages in mice. 5. Citri Reticulatae Viride Pericarpium accelerated phagocytic activity of peritoneal macrophage in mice These results suggest that Citri Reticulatae Viride Pericarpium causes a diverse response of blood pressure, regional cerebral blood flow(rCBF), nitric oxide production and phagocytic activity. The increase in rCBF is also mediated by adrenergic βrecepter.