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백강잠(白?蠶)의 뇌혈류역학(腦血流力學)에 관한 연구(硏究)
황경택,한종현,강성용,Whang Kyung-Taig,Han Jong-Hyun,Kang Sung-Yong 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1
Oriental medicine prescription has been used for the treatment of various clinical symptoms associated with cerebral apoplexy. However, single herb drug does not used cerebral apoplexy and there mechanisms of action have not been defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation. The study was aimed to investigate the effect batryticatus bombycis(BB) on the vascular systems including changes in blood pressure (BP), and regional cerebral blood flow (rCBF) and of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry. 1. Blood pressure was not affected by BB in rats. 2. rCBF was increased by BB in a dose-dependent manner. 3. Pretreatment with methylene blue(1mg/kg), and propranolol(1mg/kg) did not inhibited BB induced increased in rCBF. 4. Pretreatment with propranolol(1mg/kg) was increased by BB in a dose-dependent manner in blood perssure. 5. Pretreatment with ODQ($10{\mu}g/kg$) and L-NNA(1mg/kg) were inhibited BB induced increased in rCBF. 6. Pretreatment with L-NNA(1mg/kg) was increased rCBF in a dose-dependent manner. These results suggest that BB causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased in rCBF is also mediated by nitric oxide synthease and guanylate cyclase.
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金炯昌,黃勁澤,韓宗鉉 대한동의병리학회 2000 동의생리병리학회지 Vol.14 No.1
腦血管 疾患인 中風은 中樞神經系에 影響을 미치는 成人病중 다른 疾患에 비해서 致命的이며, 그 後遺症 또한 深刻한 社會的 問題를 惹起하는 重要한 問題이다. 現在 이러한 腦血管疾患은 歐美 先進 各國에서는 물론 우리나라에서도 發病 頻度나 이로 因한 後遺症 및 死亡率이 繼續 增加하고 있어 各種 癌으로 因한 死亡을 除外하고는 單一臟器의 疾患으로서는 단연 首位를 차지하고 있으나 이에 대한 뚜렷한 豫防 및 冶療法은 물론 根源的인 病因論 마저 제대로 確立되어 있지 못한 實情이다. 中風의 治療法으로는 鍼과 藥을 使用하였으며, 주로 理氣·順氣에 역점을 두었다. 中風의 治療 方法이 이러하기에 理氣之劑에 屬하는 藥物중 香附子와, 厚朴, 檳 및 白荳 를 選擇하여 效能를 살펴보았다. 그 結果 香附子, 厚朴, 檳랑 및 白荳寇는 局所腦血流量을 增加시켰으며 血壓은 濃度에 依存하여 低下하는 것을 알 수 있었으며, 앞으로 理氣之劑가 中風 病者의 豫防 및 治療에 있어 血壓의 低下 및 腦 保護를 할수 있는 것이라 思料되며, 또한 多樣한 活性을 나타내는 약물들에 대해서 實驗을 繼續 進行하여 機轉을 밝혀야 할 것으로 思料된다. Oriental medicine prescription has used for the treatment of various clinical symptoms associated with cerebral apoplexy. However, single herb drug does not used cerebral apoplexy and there mechanisms of action have not been defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation. The study was aimed to investigate the effect rhizoma cyperi(RC), cortex magnolia(CM), semen arecae(SA) and fructus amomi cardamomi(FAC) on the vascular systems including changes in blood pressure (BP), and regional cerebral blood foow (rCBF) and of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry. 1. Blood pressure was decreased by RC, CM and FAC in a dose-dependent manner. 2. Significantly Blood pressure was decreased by SA in a dose-dependent manner. 3. Significantly rCBF was increased by RC, CM, SA in and FGC in a dose-dependent manner. These results suggest that RC, CM, SA and FGC sauses a diverse response of blood pressure and regional cerebral blood flow(rCBF).
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