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허지수 ( Ji Su Huh ),서석교 ( Seok Kyo Seo ),김미란 ( Mee Ran Kim ),정혜원 ( Hye Won Chung ),윤병구 ( Byung Koo Yoon ),이병석 ( Byung Seok Lee ),강병문 ( Byung Moon Kang ),최훈 ( Hoon Choi ),박형무 ( Hyung Moo Park ),김정구 ( Jun 대한폐경학회 2011 대한폐경학회지 Vol.17 No.3
연구목적: 조기 난소 부전은 40세 이전에 무월경, 고성선 자극 호르몬증이 동반되는 질환이다. 본 연구에서는 조기난소 부전의 임상적인 양상을 고찰하기 위하여 일차성 무월경과 이차성 무월경으로 나누어 임상 양상을 비교해 보고자하였다. 연구재료 및 방법: 8개 대학병원에서 시행한 후향성 다기관 연구로 262명의 조기 난소 부전 환자를 68명의 일차성 무월경과 194명의 이차성 무월경으로 나누어 내분비학적 소견과 혈청 검사 소견, 임신율과 배란 유도제에 따른 임신율, 내분비학적 소견에 따른 임신율, 골밀도를 비교하였다. 결과: Estradiol 2치는 일차성 무월경에서 유의하게 이차성 무월경보다 낮았으며 진단 전 임신율은 이차성 무월경에서 43.3%로 일차성 무월경의 0% 보다 의미 있게 높았다. 치료후의 임신율은 일차성 무월경에서 5.9%, 이차성 무월경에서 1.5%였다. 호르몬 치료후의 임신율은 일차성 무월경에서 8.3%, 이차성 무월경에서 2.8%였으며 임신이 성공한 9 케이스에서 7 케이스는 estrogen-progestin (EP), 1 케이스는 clomiphene citrate (CC), 1 케이스는 EP/human menopausal gonodotropin (EP/hMG)로 치료받았다. 또한 9 케이스의 임신 성공 중 6 케이스에서 난자 공여로 성공하였으며 다른 내분비학적 소견에 따라 임신율의 차이는 없었다. 골밀도는 일차성 무월경에서 현저히 낮게 나타났다. 결론: 조기 난소 부전은 젊은 여성의 신체적, 정신적으로 영향을 미치는 중요한 질환으로 효과적인 치료를 위하여 빠른 진단과 증상을 완화시키기 위한 호르몬 보충 요법과 골다공증과 같은 장기간 영향을 미치는 질환에 대비한 적절한 약물 요법이 필요하며 난자 공여와 같은 생식 보조술도 고려하여야 한다. Objectives: Premature ovarian failure (POF) is a syndrome defined as the cessation of ovarian function before the age of 40 years that is characterized by amenorrhoea associated with elevated gonadotropin levels. The aim of this study was to compare clinical manifestation of primary amenorrhea and secondary amenorrhea group. Methods: This study was designed as a retrospective multicenter study of 262 women with premature ovarian failure. Sixty eight women with primary amenorrhea and 194 women with secondary amenorrhea were evaluated and hormonal level, lipid profile, bone mineral density, and pregnancy rates were compared. Results: The estradiol level was markedly lower in primary amenorrhea than secondary amenorrhea. The pregnancy rate of 43.3% before the diagnosis in secondary amenorrhea was markedly higher than the rate of 0% in primary amenorrhea. The pregnancy rates after treatment was 5.9% in primary amenorrhea, but 1.0% after diagnosis and 2.8% after treatment in secondary amenorrhea. The pregnancy rate after hormonal treatment was 3.7% in total, 8.3% in primary amenorrhea, and 2.8% in secondary amenorrhea. In nine cases of pregnancy, seven cases were after estrogen-progestin (EP), one case was after clomiphene citrate and one case was after EP/human menopausal gonodotropin (hMG). And In nine cases of pregnancy, six cases resulted from oocyte donation. The prevalence of osteopenia/osteoporosis was markedly higher in primary amenorrhea than in secondary amenorrhea. Conclusion: Premature ovarian failure has negative influences on the physical and psychological health of young patients. Effective management should include earlier diagnosis and intensive medical intervention to relieve symptoms of estrogen deficiency and to treat long-term disease such as osteoporosis and in assisted pregnancy by oocyte donation. (J Korean Soc Menopause 2011;17:160-165)
스마트팜을 통한 청년 공유주거의 지역 커뮤니티 확장 가능성
허지수(Hur, Jisu),임은택(Lim, Eunteak),송주형(Song, Juhyeong),변나향(Byun, Nahyang),손동화(Shon, Donghwa) 한국주거학회 2023 한국주거학회 학술대회논문집 Vol.35 No.2
Recently, shared housing has emerged in which young people can form a community through space and activity sharing, but most of them are focusing on sharing physical space, so there is a limit to the formation of a sustainable community. Smart farms can create a variety of activities, so they can expect the connection between shared housing and local communities. Therefore, this study proposes the possibility of expanding the local community of shared housing for young people through smart farms. In the study, the possibility of expanding the local community of shared housing for young people through smart farms was presented from the perspective of space, activities, and participants. The research method is to present shared housing for young people with smart farms from the perspective of the local community. Through smart farms’ activities and social functions, the possibility of expanding space, activities, and participants from young people’ shared housing to local communities was suggested. It presented the meaning of the expansion of the local community through smart farms in the community. This study intend to contribute to revitalizing exchanges in the local community by expanding the local community through smart farms.
A New Antimicrobial Substance Produced by Staphylococcus pasteuri Isolated from Vegetables
홍지수,Lin-Hu Quan,허성기,정규석,한상욱,문은표,노은정 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Staphylococcus aureus is important food-bornepathogen in agricultural products consumed in a fresh state. The antimicrobial activities of staphylococci isolated fromvegetables in Korea against S. aureus were investigated. Coagulase-negative staphylococci (CNS) isolates (12) withantimicrobial activities against S. aureus were identified asS. xylosus, pasteuri, and epidermidis. CNS isolates exhibitedantimicrobial activities against Gram-positive bacteria. Inactivation of S. pasteuri antimicrobial activity by proteasessuggested that the substances evaluated were antimicrobialpeptides or bacteriocins. None of the S. pasteuri isolatespossessed homologous DNA fragments known to bebacteriocin genes, except for nukacin. The nukM gene thatencodes a post-translational modification enzyme in thenukacin gene cluster was not detected in S. pasteuriisolates. S. pasteuri probably produces one or more newantimicrobial substances.