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백서에서 Serine Protease 억제제가 난포성숙에 미치는 영향에 대한 연구
윤병구,이진용,Yoon, Byung-Koo,Lee, Jin-Yong 대한생식의학회 1993 Clinical and Experimental Reproductive Medicine Vol.20 No.1
Plasminogen activator (PA)-plasmin system in follicular fluid is involved in the process leading to follicular rupture at ovulation. It is well known that PA is closely associated with cellular differentiation and tissue remodeling on evidences from the study of normal and malignant tissues. This study was designed to ascertain a potential role of PA in the ovarian folliculogenesis. Immature Sprague-Dawley rats were injected with pregnant mare serum gonadotropin, followed by injection of serine protease inhibitor (SPI; mixture of 1 mol/L benzamidine and 1 mol/L amino-caproic acid) into the unilateral ovarian bursa. In the control study, mechanical effect of bursal injection and contralateral ovarian effect SPI were ruled out. Total antral follicular areas relative to total ovarian cross-sectional areas was siginificantly lower in SPI-injected ovary than in saline-injected ovary. SPI injection decreased the relative antral follicular area by 33 % respectively. Electron microscopic finding of granulosa cell in the atretic follicle showed the presence of pyknotic nucleus, blurring of neucleolemma, degeneration of mitochondria and dilation of endoplasmic reticulum. After induction of ovulation with hCG, the number of oocytes released was significantly decreased in SPI-injected oviduct than in saline-injected oviduct. From above results, author discussed that PA may play a role not only in ovulation but also in some processes of folliculogenesis.
폐경 후 여성에서 호르몬 대체요법이 체중 및 체지방 분포에 미치는 영향
윤병구(Byung Koo Yoon),한국선(Kuk Sun Han),안광화(Kwang Hwa Ahn),노정래(Cheong Rae Rho),신경자(Kyung Ja Shin),황종대(Jong Dae Hwang),최두석(Doo Seok Choi),이제호(Ja Ho Lee) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.2
N/A Background and Objective; Obesity, especially central fat distribution, is closely related to cardiovascular risk. Body weight and waist to hip ratio (WHR) tend to increase during the decade following menopause. Hormone Replacement Therapy (HRT) is reported to reduced the risk of cardiovascular disease by half. One of major concerns in women considering HRT is whether it might cause weight gain. Therefore this study was designed to investigate the effect of HRT on body weight and WHR in postmenopausal women. Subjects and Methods; 214 healthy postmenopausal women (estrogen only: 44, combined estrogen-progestin therapy: 170) underwent HRT for alleviation of acute menopausal symptom and prevention of osteoporosis and cardiovascular disease. Body weight and WHR were measured at baseline, 3, 6 and 12 month of HRT. Expected body weight and WHR were calculated from healthy 1,330 control with multiple regression analysis, and corrected value was defined to be measured valued divided by expected one. Results; Formula for expected value was as follows: expected weight =-0.076xAge+2.000xBMI+15.280, expected WHR =0.002xAge+0.011xBMl+0.420. Corrected weight did not change, but corrected WHR decreased significantly at 12 month with HRT. Conclusion; HRT dose not increase body weight and decrease WHR, which would contribute to cardioprotection in postmenopausal women.
윤병구 ( Byung Koo Yoon ),김도관 ( Doh Kwan Kim ),김종원 ( Jong Won Kim ),최두석 ( Doo Seok Choi ),배덕수 ( Duk Soo Bae ),나덕렬 ( Duk Lyul Na ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.1
배경 및 목적 : 치매는 낙상 가능성의 증가를 통하여 골절의 위험을 높힌다. 진행된 치매에서 관찰되는 골다공증은 영양실조에 의한 2차성 부갑상선항진증과 운동부족이 중요한 원인으로 알려져 있다. 본 연구의 목적은 알쯔하이머병 여성 환자에서 골다공증에 대한 유병률을 조사하는 것이다. 대상 및 방법 : 80명의 알쯔하이머병 환자를 대상으로 하였으며, 초기 치매는 임상치매척도가 1 이하이며, 운동 기능은 정상인 경우로 정의하였다. 과거력상 비외상성 골절의 유무를 조사하였고, osteocalcin과 deoxypyridinoline 등의 골대사지표와 함께 이중에너지 방사선흡수계측법을 이용하여 골밀도를 측정하였다. 결과 : 전체적으로 알쯔하이머병 여성에서 골다공증의 유병률은 58%이었다. 80명중 45명이 초기 치매에 해당하였다. 초기 치매환자에서 골다공증성 골절의 과거력이 38%, 골교체률이 증가한 경우가 72%이었으며 골다공증의 유병률은 62%이었다. 결론 : 여성에서 영양상태와 운동기능이 정상인 초기 알쯔하이머병은 골다공증과 매우 높은 연관성을 보이며, 이는 난포호르몬-알쯔하이머병 가설을 뒷받침하는 연구 결과이다. Background and objective : Dementia is one of the risk factors of fracture via increasing risk of falling down. Osteoporosis occurring in advanced dementia might be causally related to secondary hyperparathyroidism resulting from poor nutrition and physical activity. The purpose of this study is to examine the prevalence of osteoporosis (OP) in patients with Alzheimer`s disease (AD). Materials and methods : Past history of non-traumatic fracture, bone turnover markers such as osteocalcin and deoxypyridinoline and bone mineral density (BMD) using dual energy X-ray absorptiometry were assessed in 80 women with AD. Early AD was defined as clinicla dementia rating scale ≤ 1 and physical activity unimpaired. Results : In general, the prevalence of OP (T value on BMD ≤ -2.5) was 58% in women with AD. Forty-five out of 80 patients belonged to early AD. Thirty-eight percentage of early AD patients had history of fragility fracture, 72% increased bone turnover rate, and 62% osteoporosis. Conclusions : Early AD with normal nutritional status and physical activity might be highly associated with OP, which supports estrogen-AD hypothesis.
강병문 ( Byung Moon Kang ),김미란 ( Mee Ran Kim ),윤병구 ( Byung Koo Yoon ),이병석 ( Byung Seok Lee ),정혜원 ( Hye Won Chung ),최훈 ( Hoon Choi ),박형무 ( Hyoung Moo Park ),김정구 ( Jung Gu Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.2
연구목적: 한국 폐경 여성에서 운동이 골다공증이나 골감소증의 위험도에 미치는 영향에 대해서 조사하였다. 연구재료 및 방법: 폐경 여성 1,105명을 대상으로 이중 에너지 X선 흡수 계측기를 이용하여 요추와 대퇴골의 골밀도를 측정하였으며 대상 폐경여성들의 나이, 월경력, 신장, 체중 등을 조사하였다. 대상자에게 운동에 관하여 자가 기입식으로 설문지를 조사하였다. 결과: 하루에 걷는 거리가 1 km 이상인 군과 미만인 군으로 구분하여 비교한 결과 요추와 대퇴부의 골다공증 및 골감소증 위험도가 덜 걷는 군에서 30% 정도 증가하였다. 하루에 오르는 계단의 수가 20개 이상인 군과 미만인 군으로 나누어 비교한 결과 통계학적인 의의는 없었지만 요추와 대퇴부의 골다공증 및 골감소증 위험도가 계단수가 적은 군에서 증가하는 경향을 보였다. 일주일간에 운동시간이 2시간 이상인 군과 1시간 미만인 군으로 구분하여 비교한 결과 요추와 대퇴부의 골다공증 및 골감소증 위험도가 운동 시간이 적은 군에서 40∼50% 정도 증가하였다. 나머지 설문 문항중에서는 유의한 결과가 없었다. 결론: 운동은 골밀도에 긍정적인 영향을 주어 골소실 방지나 골량의 유지에 도움이 되는 것으로 보이며 그 효과는 운동강도나 크거나 운동시간이 길수록 더욱 높아지는 것으로 사료된다. Objectives: To determine relationship between exercise and bone mineral density of lumbar and femur sites in postmenopausal women. Methods: A cross-sectional study in 1105 Korean menopausal women, mean+SD age 55.8+7.0 years, all healthy and free of medications affecting bones, including estrogen. We explored physical activity and bone mineral density in postmenopausal women Bone mineral density (BMD) of lumbar and femur regions and body composition were measured by dual X-ray absorptiometry. Types, duration and other variable measures of exercise were assessed by questionnaire. Results: A group of postmenopausal women with more than 1 km daily walking showed 30% less risk of osteopenia or osteoporosis than women with less than 1km. A group of postmenopausal women with more than 20 step climbing showed tendency of less risk of osteopenia or osteoporosis than women with less than 20. A group of postmenopausal women doing exercise more than 2hours/week showed 40-50% less risk of osteopenia or osteoporosis than women doing exercise less than 1hour/week. Other variable measures of exercise did not show any statistical difference. Conclusion: The results support the notion that higher intensity and longer duration of exercise is more effective for bone sparing than lower intensity and shorter duration of exercise.