일반연제 발표 : 부인과종양학 ; 항암제를 처리한 HeLa세포의 DNA합성 억제에 미치는 인삼추출물의 영향

최영배,윤지열,노흥태 대한산부인과학회 1990 대한산부인과학회 학술대회 Vol.66 No.-

Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea

최영배,유건희 대한암학회 2022 Cancer Research and Treatment Vol.54 No.2

Purpose Children with Down syndrome (DS) show a higher risk of acute leukemia than those without DS. In this study, we investigated the nationwide incidence of acute leukemia among children with DS and compared their epidemiologic characteristics with those of children with acute leukemia but without DS. Materials and Methods Using the National Health Insurance Service database, we selected patients with acute leukemia aged 0-19 years at diagnosis between 2007 and 2016. Results Among the 4,697 children with acute leukemia, 54 (1.1%) had DS. The median incidence rate of leukemia with DS by year was 1.3% (range, 0.2% to 2.0%). Sixteen patients with acute lymphoblastic leukemia (ALL; 29.6%) and 36 with acute myeloid leukemia (AML; 66.7%) had DS. The DS group showed younger age at diagnosis than the non-DS group, and diagnosis of AML was more frequent in the DS group than in the non-DS group (3 years vs. 9 years, p < 0.001; 66.7% vs. 32.4%, p < 0.001, respectively). The 5-year overall survival was comparable between the DS and non-DS groups (88.0% vs. 81.9%, p=0.375). Among all the Koreans born between 2007 and 2008, the incidences of acute leukemia, ALL, and AML were 49.25, 20.75, and 163.38 times higher, respectively, in the DS group than in the non-DS group. Conclusion Our findings support the fact that the incidence of acute leukemia is higher among patients with DS than among those without DS in Korea. However, the DS and non-DS groups in this study had a comparable overall survival rate. PurposeChildren with Down syndrome (DS) show a higher risk of acute leukemia than those without DS. In this study, we investigated the nationwide incidence of acute leukemia among children with DS and compared their epidemiologic characteristics with those of children with acute leukemia but without DS.Materials and MethodsUsing the National Health Insurance Service database, we selected patients with acute leukemia aged 0–19 years at diagnosis between 2007 and 2016.ResultsAmong the 4,697 children with acute leukemia, 54 (1.1%) had DS. The median incidence rate of leukemia with DS by year was 1.3% (range, 0.2%–2.0%). Sixteen patients with acute lymphoblastic leukemia (ALL; 29.6%) and 36 with acute myeloid leukemia (AML; 66.7%) had DS. The DS group showed younger age at diagnosis than the non-DS group, and diagnosis of AML was more frequent in the DS group than in the non-DS group (3 years vs. 9 years, p<0.001; 66.7% vs. 32.4%, P<0.001, respectively). The 5-year overall survival was comparable between the DS and non-DS groups (88.0% vs. 81.9%, p=0.375). Among all the Koreans born between 2007 and 2008, the incidences of acute leukemia, ALL, and AML were 49.25, 20.75, and 163.38 times higher, respectively, in the DS group than in the non-DS group.ConclusionOur findings support the fact that the incidence of acute leukemia is higher among patients with DS than among those without DS in Korea. However, the DS and non-DS groups in this study had a comparable overall survival rate.

Analysis of the changes in medium moisture content according to a crop irrigation strategy and the medium properties for precise moisture content control in rock wool

최영배,신종화 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3

The substrate moisture content aff ects crop absorption, microorganisms, oxygen concentration, water stress, and the ultimateevaporation amount. The moisture content in the rhizosphere can be controlled by the amount of water, the frequencyof water supply, the time of water supply, and the rate of water supply provided to the crops. The purpose of this studywas to investigate the physical properties of a rock wool medium and to investigate the water movement characteristics ofthe medium according to diff erent watering conditions. To measure the moisture content of the substrate and the drainageamount, load cells were used as weight sensors, and the total irrigation capacity was 99 and 198 mL/min, respectively. Themoisture content at each irrigation starting point was set from 30 to 80% of the substrate moisture content at each 5%. Therelationship of the starting point of drainage, the 30% drainage rate, the point of the fi rst saturation according to the twodiff erent irrigation rates, and the point of moisture content at the start of irrigation showed a sigmoidal relationship. Whenreviewing the irrigation to the fi rst saturation point, the substrate moisture content got higher as the moisture content at theirrigation start increased. Also, it was shown that the higher the irrigation rate, the higher the saturated moisture content seenin the substrate. The high irrigation rate is useful for the saturation of the substrate, but a large amount of water was neededto adjust the drainage rate. For this reason, we analyzed the irrigation rate under various cultivation conditions.

LSS(Laser Seam Stepper)를 이용한 초고강도강 차체부품(Panel Assembly Rocker) 기술 개발

최영배,김준수,이광원 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.11

현재 초고강도강(1.5GPa급) 제품의 롤 포밍 공정의 품질 저하 문제와 조립 공정 중 생산 효율이 낮은 용접 공정으로 인한 생산성 저하 문제가 발생되고 있다. 이러한 문제 해결을 위해서는 롤 포밍 공정의 단품 품질을 개선하여 불량률을 감소시킬 수 있는 품질 안정화 기술과 높은 생산 효율을 확보할 수 있는 용접 시스템 개발을 통한 생산 고도화 기술 개발이 필수적으로 요구되고 있다. 이를 해결하기 위해 품질 안정화 기술을 개발하여 불량률을 감소함과 동시에 시스템 최적화를 통해 생산 고도화 기술 개발을 진행하고자 한다. 본 발표에서는 산업통상자원부 양산성능평가 일환으로 추진 중인 “1.5GPa급 초고강도강 차체부품(Panel Assembly Rocker) 생산 고도화 기술 개발”의 연구내용이다. 본 과제에서 제작되는 Panel Assembly Rocker 부품의 주요 기능은 자동차 측면 충돌 시 충돌 에너지를 흡수하여 충격으로부터 운전자 및 탑승자를 보호하는 부품으로 정의된다. 본 과제에서 사용되는 레이저 심 스테퍼(이하 LSS용접 )용접은 점용접 대비 선 용접의 특성을 가짐으로써 비틀림 강성이 2~20% 강화되는 장비이다. LSS 용접은 비드형상을 변화하여 점 용점 부위에서 발생되는 응력 집중을 완화 시키며, 접합 플랜지 (Flange) 감소를 통한 차체 경량화를 구현할 수 있으므로 고 품질의 고강성 경량 차체 개발이 가능할 것으로 기대된다.

간질 중첩증과 뇌증이 합병된 마이코플라즈마 폐렴 1례

최영배,이동석,김두권,김애숙,조성민,이선주,서유경,최성민 대한 소아알레르기 호흡기학회 2007 Allergy Asthma & Respiratory Disease Vol.17 No.3

저자들은 이전 국내에 보고되지 않은 간질 중첩증과 뇌증이 합병된 마이코플라즈마 폐렴 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Mycoplasma pneumoniae is known to be a common respiratory pathogen in children and adolescents. It rarely causes neurologic complications, such as meningitis, encephalitis and cerebellar ataxia, in some patients as extrapulmonary manifestations. Neurologic symptoms, such as impairment of consciousness, seizure and paralysis, in the early stage. We report a case of lobar pneumoia caused by M. pneumoniae which was complicated with status epilepticus and encephalopathy.

Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma

최영배,배고은,이나희,김정선,이수현,유건희,성기웅,구홍호 대한의학회 2015 Journal of Korean medical science Vol.30 No.8

The records of 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed. All patients received nine cycles of induction chemotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT). Follow-up BM examination was performed every three cycles during induction chemotherapy and every three months for one year after the second HDCT/auto-SCT. BM tumor cells persisted in 48.4%, 37.7%, 23.3%, and 20.4% of patients after three, six, and nine cycles of induction chemotherapy and three months after the second HDCT/auto-SCT, respectively. There was no difference in progression-free survival (PFS) rate between patients with persistent BM tumor and those without during the induction treatment. However, after tandem HDCT/auto-SCT, the PFS rate was worse in patients with persistent BM tumor than in those without (probability of 5-yr PFS 14.7% ± 13.4% vs. 64.2% ± 8.3%, P = 0.009). Persistent BM tumor during induction treatment is not associated with a worse prognosis when intensive tandem HDCT/auto-SCT is given as consolidation treatment. However, persistent BM tumor after tandem HDCT/ auto-SCT is associated with a worse prognosis. Therefore, further treatment might be needed in patients with persistent BM tumor after tandem HDCT/auto-SCT.

인터넷 보안 프로토콜 IPSEC

최영배,황성운,이준석,윤기송,김명준,Choi, Y.B.,Hwang, S.O.,Lee, J.S.,Yoon, K.S.,Kim, M.J. 한국전자통신연구원 1999 전자통신동향분석 Vol.14 No.6

IPSEC (Internet Protocol Security) is a network layer security protocol that is designed to support secure TCP/IP environment over the Internet considering flexibility, scalability, and interoperability. IPSEC primarily supports security among hosts rather than users unlike the other security protocols. Recently, IPSEC is emphasized as one of the important security infrastructures in the NGI (Next Generation Internet). It also has suitable features to implement VPN (Virtual Private Network) efficiently and its application areas are expected to grow rapidly. In this paper, the basic concepts and related standard documents of IPSEC will be introduced.

개방된 통신 시장의 규제 완화와 NMF의 역할

최영배,박남훈,이계상,Choe, Yeong-Bae,Park, Nam-Hun,Lee, Gye-Sang 한국전자통신연구원 1996 전자통신동향분석 Vol.11 No.3

세계의 통신 시장이 개방되는 추세에 있고, 통신에 관한 규제가 완화됨에 따라 떠오르는 문제는 여러 가지 있겠으나 가장 큰 문제는 역시 표준화와 이에 따른 상호 운용성(interoperability)의 문제가 아닌가 생각한다. 본 고에서는 통신 분야의 서비스 관리에 있어서 세계적으로 주도적인 활동을 하고 있고, 그 중요성이 점차 부각되고 있는 NMF(Network Management Forum)의 역할에 대하여 소개하고자 하였다.

Network Management Forum(NMF) 의 최근 동향과 표준화

최영배,이춘희,박창순 한국통신학회 1997 정보와 통신 Vol.14 No.11

정보통신 서비스 관리 기술

최영배,이춘희,박창순 한국통신학회 1997 정보와 통신 Vol.14 No.12

정보통신 시장의 개방이 가속화 되고 사업자간의 경쟁이 치열해 짐에 따라, 이에 따른 서비스 관리의 필요성이 최근 중요한 문제로 대두되게 되었다. 지금까지는 정보통신 산업계에서 망 관리의 측면이 많이 강조되어 왔으나, 최근 고객의 요구가 다양해 짐에 따라 이를 보다 효율적으로 만족시켜 주기 위해 서비스 제공자 중심이 아닌 고객중심의 새로운 체제로 전환이 불가피하게 되었다. 본 고에서는 이러한 고객의 요구를 만족시켜 주는 데 핵심 기술이라고는 할 수 있는 정보통신 서비스 관리 기술에 대해 Network Management Forum (NMF)의 Service Management Business Process Model을 중심으로 알아보기로 한다.