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마우스 및 랫드에서 botulinum toxin type A의 단회 및 28일 반복투여 독성시험
전태원,김지영,현선희,김남희,이상규,김춘화,우희동,양기혁,정현호,정태천,Jeon, Tae-Won,Kim, Ji-Young,Hyun, Sun-Hee,Kim, Nam-Hee,Lee, Sang-Kyu,Kim, Chun-Hwa,Woo, Hee-Dong,Yang, Gi-Hyeok,Jung, Hyun-Ho,Jeong, Tae-Cheon 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.1
Single and 28-day repeated dose toxicity studies of botulimnn toxin type A were carried out in ICR mice and Sprague-Dawley rats, respectively. In the single dose toxicity study, botulinwn toxin was injected intraperitoneally to male and female mice at a single dose of 40, 59, 89 133 and 200 ng/10 ml saline/kg. All animals died from 59 ng/kg group. Some clinical signs, such as decrease in locomotor activity, dyspnea, prone position and ptosis, were observed in most of both sexes from 59 ng/kg group, but no signs were seen in all animals at 40 ng/kg group. The results showed that the median lethal dose of botulinum toxin might be in the range of 40-59 ng/kg in both sexes. In the repeated dose toxicity study, the test material was administered intradermally for 28 days at doses of 0 (vehicle-treated control), 1.25, 2.5, 5.0 and $10.0ng/head/50{\mu}{\ell}$ saline in male and female rats. No test material-related changes were noted in survivals, clinical signs, food and water consumptions and gross finding in any group. Botulinum toxin treatment significantly decreased the body weight gain rate in male of 5.0 ng/head group and over and in female of 10.0 ng/head group compared to vehicle-treated control. One or more relative organ weights (i.e., spleen, thymus, liver and kidney) were increased significantly from 5.0 ng/head group compared to vehicle-treated control in both sexes. Serum biochemistry revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase, total protein and albumin in male, and increases in AST and ALT and decreases in $K^+$ and $Cl^-$ in female without dose-pendent manners. In the histopathological study, physical stimulation by needle caused slight inflammations of dennis. In addition, botulinum toxin treatment induced denervation of nerve cell and disuse of muscle, resulting in atrophy of skeletal muscle in both sexes from 2.5 ng/head group. When the antibodies to toxin were determined in all animals, a significant increase in serum antibodies was observed from 5.0 ng/head group. The results showed that the NOAEL of botulinum toxin might be 1.25 ng/head for 28-day repeated dose toxicity in rats.
Chrysene이 BALB/c계 마우스의 면역기능에 미치는 영향
전태원,김춘화,이상규,김기환,전인혜,이동주,정혜민,정태천,Jeon, Tae-Won,Kim, Chun-Hua,Lee, Sang-Kyu,Kim, Ghee-Hwan,Jun, In-Hye,Lee, Dong-Ju,Jeong, He-Min,Jeong, Tae-Cheon 대한약학회 2006 약학회지 Vol.50 No.4
Effects of chrysene on immune functions were studied in female BALB/c mice. When mice were treated po with chrysene for 7 consecutive days, the antibody response was suppressed dose-dependently. Chrysene induced the enzyme activities of CYP LA and 2B time- and dose-dependently. In ex vivo lymphocyte proliferation, chrysene inhibited splenocyte proliferation by LPS and Con A. Moreover, the numbers of $CD4^+IL-2^+$ cells were reduced by chrysene. In conclusion, chrysene-induced immunotoxicity might be mediated, at least in part, via IL-2 production, and caused by mechanisms associated with metabolic activation.
유도전동시의 직접 벡터제어 시스템에서 기동기법에 관한연구
전태원(Tae-Won Chun),최명규(Meong-Kyu Choi) 전력전자학회 1999 전력전자학술대회 논문집 Vol.1999 No.7
본 논문은 유도전동기의 직접벡터제어 시스템에서 전동기가 기동 시 토크 충격없이 부드럽게 기동할 수 있는 기동기법을 제시한다 .직접 벡터제어에서 고정자 자속을 계산 시 사용되는 적분기 문제를 해결하기 위하여, 인버터주파수에 따라 시정수를 제어하는 프로그램어블 3-단계 저역필터를 적용한다. 이 3-단계 저역필터는 거의 완벽한 적분기능을 수행할 수 있으나, 이 저역필터는 고정자자속의 시간지연을 유발하므로 기동 시 전동기 토크의 충격을 발생된다는 문제점이 있다. 따라서, 기동시 고동자 자속의 시간지연을 보상하는 고정자 자속의 피이드포워드 기법을 제시하여, 전동기 기동 시토크 충격을 방지한다. 시뮬레이션을 통하여, 이 기동기법의 타당성을 확인한다.
약학박사 정 시련 교수 정년퇴임 기념호 : 연구논문(재록) ; 생명과학 : Rutaecarpine의 면역독성 연구
전태원 ( Tae Won Jeon ),김춘화 ( Chun Hua Jin ),이상규 ( Sang Kyu Lee ),전인혜 ( In Hye Jun ),김기환 ( Ghee Hwan Kim ),이동주 ( Dong Ju Lee ),정혜광 ( Hye Gwang Jeong ),이경복 ( Kyung Bok Lee ),장영동 ( Yurng Dong Jahng ),정태천 ( 영남대학교 약품개발연구소 2006 영남대학교 약품개발연구소 연구업적집 Vol.16 No.-
전태원(Tae-Won Chun),최명규(Meong-Kyu Choi) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
This paper describes the method to control the multimotor drive system with network The Lonworks network, which is a leading industnal control network, is applied to the yard crane pcsition control system driven by three motors. The host computer is able to control and monitor three motor drive systems in a yard crane through network. The performance of propcsed method 1S verified on experiments with the simulator of yard crane.