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도일,윤세찬,진영현,조영호 한국물리학회 2012 Current Applied Physics Vol.12 No.6
We present a rapid and low-temperature polymer fabrication method based on the direct patterning by UV light. Compared to the conventional polymer micromolding method for polydimethylsiloxane (PDMS) and cyclic olefin copolymers (COC), the present method has advantages of rapid fabrication in low-temperature environment. We used an AEO3000, UV-curable low-stress hyper-branched polymer (HBP), as a polymer material. The AEO3000 layer was selectively exposed to UV light by a photomask at room temperature for 3 min. Using the present method, we designed the rigid substrate for the microelectrofluidic bench. The measured electrical and fluidic interconnection characteristics in the bench were 0.75 ± 0.44 Ω and 8.3 kPa (at the flow rate of 100 ml/min), respectively. Both electric and fluidic characteristics were equivalent or lower than the sum of individual devices. We also successfully verified the bio-sample analysis through the interconnected devices on the microelectrofluidic bench using yeast cell samples. The proposed method offers fast and bio-compatible process applicable to biomedical micro total analysis systems.
황화물계 전고체 전지의 효율, 에너지밀도를 높이기 위한 전극설계 및 소재기술
김도일,김창우,손윤국,오필건,마지영,윤정식 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
본 연구의 목표는 고효율, 고에너지밀도 황화물계 전고체 전지의 전극 설계를 초점으로 두고 있다. 황화물계 전고체 전지는 최근 LIB의 안전성 문제가 대두 되면서 국내외 여러 기업이나 연구소에서 많은 연구가 진행되고 있다. 본 연구는 고에너지 밀도 전고체 전지를 구현하기 위해 그동안의 문제점으로 지적되어 왔던 고체 전해질의 낮은 이온전도도와 높은 계면 저항 문제를 개선함으로 고에너지 밀도, 고효율 양극 전극을 개발하고자 한다. 본 연구는 전극내 활물질 비율을 증가시키고 전해질-양극 계면 저항을 줄이기 위해, 전극에 고압을 가하는 방법을 택했다. 이와 함께, 전고체 전지에 주로 사용되는 이차입자형 물질은 고압을 가하면 형태가 파괴되기 때문에 일차입자형 NCM811 소재를 적용하였다. 실험 결과, 188mAh/g의 높은 가역용량이 측정되었고 쿨롱 효율도 80%에 육박했다.
이미영 ( Mi Young Lee ),윤도일 ( Do Il Yoon ) 대한무용학회 2012 대한무용학회논문집 Vol.70 No.6
The purpose of this study was to set up a standard for the amount of physical activity related to body composition for preschool children. Eight-hundred children at age six in Gyeonggi-do and Seoul are observed, equally balanced with regards to sex and weight. The result showed statistical significance that male subjects walk more than female subjects and normal weight group walks more than overweight group (P<.05). Consequently, this comprehensively established standard (male=11.977; female=11.584) is reasonable for the prevention of children obesity of 6-year-olds in Korea.
박성훈,오길찬,김기성,송규태,유광하,심연수,이영주,이명구,윤장욱,김현수,김이형,이원준,김도일,차형건,이재명,서중산,정기석 대한의학회 2015 Journal of Korean medical science Vol.30 No.10
The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. probable pneumonia, n = 75), and 1.8% (n = 8) were positive for atypical pathogens (Bordetella pertussis, n = 3; B. parapertussis, n = 0; Mycoplasma pneumoniae, n = 1; Chlamydophila pneumoniae, n = 3; Legionella pneumophila, n = 1). Among clinical symptoms and signs, only post-tussive vomiting was more frequent in patients with atypical pathogens than those without (P = 0.024). In all, 72.2% of the enrolled patients received antibiotic treatment at their first visits, and β-lactams (29.4%) and quinolones (20.5%) were the most commonly prescribed agents. In conclusion, our study demonstrates that the incidence of atypical pathogens is low in patients with acute bronchitis, and the rate of antibiotic prescriptions is high.
안성귀,남석진,안세현,정용식,박형규,이수정,강성수,한원식,박경화,박용래,이지현,윤현조,김준현,유영범,송정윤,고병균,곽금희,정민성,김성용,조서현,김도일,장명철,문병인,김이수,김세중,박민호,김태현,조지형,임철완,배영태,공경엽,배영경,이아원,정준 한국유방암학회 2021 Journal of breast cancer Vol.24 No.2
Purpose: In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, we report the clinical outcome in postmenopausal women with HR-positive breast cancer treated with adjuvant letrozole according to estrogen receptor (ER) expression levels. Methods: In this multi-institutional, open-label, observational study, postmenopausal patients with HR-positive breast cancer received adjuvant letrozole (2.5 mg/daily) for 5 years unless they experienced disease progression or unacceptable toxicity or withdrew their consent. The patients were stratified into the following 3 groups according to ER expression levels using a modified Allred score (AS): low, intermediate, and high (AS 3–4, 5–6, and 7–8, respectively). ER expression was centrally reviewed. The primary objective was the 5-year disease-free survival (DFS) rate. Results: Between April 25, 2010, and February 5, 2014, 440 patients were enrolled. With a median follow-up of 62.0 months, the 5-year DFS rate in all patients was 94.2% (95% confidence interval [CI], 91.8–96.6). The 5-year DFS and recurrence-free survival (RFS) rates did not differ according to ER expression; the 5-year DFS rates were 94.3% and 94.1%in the low-to-intermediate and high expression groups, respectively (p = 0.6), and the corresponding 5-year RFS rates were 95.7% and 95.4%, respectively (p = 0.7). Furthermore, 25 patients discontinued letrozole because of drug toxicity. Conclusion: Treatment with adjuvant letrozole showed very favorable treatment outcomes and good tolerability among Korean postmenopausal women with ER-positive breast cancer, independent of ER expression.