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도일,임현균,안봉영,지영준,이종실,오재훈,Doh, Il,Lim, Hyun Kyoon,Ahn, Bongyoung,Chee, Youngjoon,Lee, Jongshill,OH, Jae Hoon 대한의용생체공학회 2017 의공학회지 Vol.38 No.3
Blood pressure is one of the important vital signs for monitoring the medical condition of a patient. Automated NIBP(non-invasive blood pressure) monitoring devices calculate systolic and diastolic blood pressures from the oscillation in cuff pressure caused by a pulsation of an artery. To validate the NIBP devices, we developed a simulator to supply the oscillometric waveforms obtained from human subjects. The simulator provided pressure pulses to device-under-test and device readings were compared to the auscultatory references. Fully automated simulation system including OCR(optical character recognition) were developed and used for NIBP monitoring devices. The validation results using the simulator agreed well with previous clinical validation. More validation studies using the standardized oscillometric waveforms would be required for the replacement of clinical trials to validate a new automated NIBP monitoring device.
집속초음파 자극기의 성능평가를 위한 팬텀 내부온도 측정
도일,조주형,김성목,백경민,김용태,박승민 대한의용생체공학회 2022 의공학회지 Vol.43 No.3
This research is to measure real-time temperature distribution inside a tissue-mimicking phantom for the safety and effectiveness evaluations of focused ultrasound (FUS) device capable of linear scanning stimulation. Since the focusing area of the FUS stimulation device is smaller than diameter of conventional thermal probe and keeps moving, it is impossible to monitor temperature distribution inside the phantom. By using the phantom with a thin film temperature sensor array inserted, real-time temperature change caused by the FUS device was measured. The translation of the measured temperature peak was also tracked successfully. The present phantom had been exper- imentally proven to be applicable to validate the performance and safety of the therapeutic ultrasound devices.
도일,윤세찬,진영현,조영호 한국물리학회 2012 Current Applied Physics Vol.12 No.6
We present a rapid and low-temperature polymer fabrication method based on the direct patterning by UV light. Compared to the conventional polymer micromolding method for polydimethylsiloxane (PDMS) and cyclic olefin copolymers (COC), the present method has advantages of rapid fabrication in low-temperature environment. We used an AEO3000, UV-curable low-stress hyper-branched polymer (HBP), as a polymer material. The AEO3000 layer was selectively exposed to UV light by a photomask at room temperature for 3 min. Using the present method, we designed the rigid substrate for the microelectrofluidic bench. The measured electrical and fluidic interconnection characteristics in the bench were 0.75 ± 0.44 Ω and 8.3 kPa (at the flow rate of 100 ml/min), respectively. Both electric and fluidic characteristics were equivalent or lower than the sum of individual devices. We also successfully verified the bio-sample analysis through the interconnected devices on the microelectrofluidic bench using yeast cell samples. The proposed method offers fast and bio-compatible process applicable to biomedical micro total analysis systems.
도일,Yoonji Kim,조영호 한국물리학회 2013 Current Applied Physics Vol.13 No.5
We present a high-efficient particle trapping chip, where a wide and uniform slit is formed by a deformable membrane barrier with air bubble plugs. The previous particle trapping methods based on membrane barriers resulted in low trapping efficiency due to the non-uniform slit gap between the membrane and the substrate, especially at the side walls of rectangular channel. In the present method,the air bubble plugs remained in the extended microchannel during sample filling process, block the particle passage at the both side ends of the membrane, thus all particles flow through the uniform slit gap. Therefore, high-efficient particle trapping without particle loss can be achieved. The present particle trapping chip was composed of three layers: pneumatic (top), membrane and channel (bottom) layers. The membrane was deformed by the pneumatic pressure applied from the top layer. In the experimental study using 10.3 mm-diameter polystyrene beads, the membrane barrier with the air bubble plugs successfully trapped the injected beads with the trapping efficiency of 100% at the flow rate of 10 ml/min,while the barrier without the air bubble plugs showed low efficiency of 20%. At the increased flow rate of 20 ml/min, beads were still trapped with trapping efficiency over 98% in the present device. By using a mixture of 5.7 and 10.3 mm-diameter beads, we also verified the present method was capable to trap and release the beads selectively according to their size with the release efficiency of 95.1%. The present simple and effective particle trapping device is applicable for the high-efficient bioparticle isolation and recovery in the micro total analysis system.
Accuracy assessment of a PION TCI pump based on international standards
도일,이석환,이용헌,전보경,최병문,노규정 대한마취통증의학회 2019 Anesthesia and pain medicine Vol.14 No.4
Background: Inaccuracies associated with target-controlled infusion (TCI) delivery systems are attributable to both software and hardware issues, as well as pharmacokinetic variability. However, little is known about the inaccuracy of the syringe pump operating in TCI mode. This study aimed to evaluate the accuracy of the TCI pump based on international standards. Methods: A test apparatus for accuracy evaluation of a syringe pump (PION TCI®, Bionet Co. Ltd.) was designed to apply the gravimetric method. Pump accuracy was evaluated in terms of deviation defined by the following equation: infusion rate deviation (%) = (Ratemea − Rateest) / Rateest × 100, where Ratemea is the infusion rate (ml/h) as measured by the gravimetric system, and Rateest is the infusion rate (ml/h) as estimated by the pump. An infusion rate representing TCI mode was determined from previous clinical trial data which evaluated the predictive performance of the pharmacokinetic model. The PION TCI pump used in that clinical trial was used to evaluate accuracy of the syringe pump. The distribution of infusion rates obtained from the clinical trial was calculated, and the median value of the distribution was determined as the representative value. Results: The representative infusion rate representing TCI mode was 31 ml/h, at which the infusion rate deviation was 4.5 ± 1.6%. Conclusions: The inaccuracy of the syringe pump contributing to TCI system inaccuracy is insignificant.