小兒喘息에 대한 나의 處方

劉信愛 藥業新聞社 1985 (月刊) 醫藥情報 Vol.1985 No.4

경상북도 도민의 행복 정도에 따른 출산율 차이 분석

유신애,신재한,최성열,윤용규,김현기,박소영 인문사회 21 2022 인문사회 21 Vol.13 No.1

Analysis of the Difference in Childbirth According to theHappiness Level of Gyeongsangbuk-do ResidentsShinae Yu, Jaehan Shin, Sungyeol Choi, Yonggyu Yoon, Hyunki Kim, & Soyoung Park Abstract: The purpose of this study is to analyze the differences between the happiness level and the fertility-rate among Gyeongbuk-do residents, thereby conducting a basic research study necessary for the development of policies to encourage childbirth in the Gyeongbuk region, where population decline is severe. As for the research method, a survey was conducted targeting about 1,152 people through stratification sampling analysis of about 0.043% of the 2,644,757 residents of Gyeongbuk Province (as of 2020). The main contents of the study were differences in fertility and fertility-rate according to happiness indices such as life-satisfaction, marital-satisfaction, and happiness-florisi of Gyeongbuk-do residents. The higher the happiness index, the higher the fertility-rate, and the lower the happiness index, the lower the fertility-rate. Therefore, it is necessary to introduce policies or programs that can improve the happiness index of residents. In particular, a customized fertility policy that reflects the characteristics of Gyeongsangbuk-do, such as individual variables, environmental variables, and living area variables, is needed. Key Words: Happiness, Fertility-rate, Life-satisfaction, Marital-satisfaction, Happiness-florisi 경상북도 도민의 행복 정도에 따른 출산율 차이 분석유 신 애**ㆍ신 재 한***ㆍ최 성 열****ㆍ윤 용 규*****ㆍ김 현 기******ㆍ박 소 영******* 요약: 본 연구의 연구목적은 경북도민을 대상으로 행복 정도와 출산율에 대한 차이를 분석함으로써 인구감소 현상이 심각한 경북 지역의 출산장려 정책개발에 필요한 기초조사 연구이다. 연구방법은 경북도민 264만 4,757명(2020년 현재) 중에서 약 0.043%에 해당하는 인원을 유층 표집 분석을 통해서 약 1,152명을 대상으로 설문 조사를 실시하였다. 연구의 주요내용은 경북도민의 삶의 만족도, 결혼만족도, 행복플로리시 등 행복지수에 따라 출산율의 차이가 있었다. 행복지수가 높으면 출산율도 높고, 행복지수가 낮으면 출산율도 낮은 것으로 나타났다. 따라서 도민의 행복지수를 향상시킬 수 있는 정책이나 프로그램의 도입이 필요하며, 특히 개인 변인, 환경 변인, 거주지역 변인 등 경상북도의 특성을 반영한 맞춤형 출산장려 정책이 필요하다. 핵심어: 행복, 출산율, 삶의 만족도, 결혼만족도, 행복플로리시 □ 접수일: 2022년 1월 27일, 수정일: 2022년 2월 10일, 게재확정일: 2022년 2월 20일* 본 연구는 2021년 경상북도 정책과제 연구비의 지원을 받아 수행되었음. ** 주저자, 한국미래산업정책연구원 원장(First Author, CEO, Korea Future Industry Research, Email: lyusin3839@naver.com)*** 공동저자, 국제뇌교육종합대학원대학교 뇌교육학과 교수(Co-author 1, Professor, Brain Education Univ., Email: han3645@hanmail.net)**** 공동저자, 경북과학대학교 유아교육과 교수(Co-author 2, Professor, Kyongbuk Science College, Email: heart007@kbsc.ac.kr)***** 윤용규, 대경대학교 겸임교수(Co-author 3, Professor, Daekyeung Univ., Email: yokoyoon@naver.com)****** 대구가톨릭대학교 특임부총장(Co-author 4, Professor, Daegu Catholic Univ., Email: hyungi0506@cu.ac..kr)******* 교신저자, 보담브레인연구소 연구원(Corresponding Author, Researcher, Bodambrain Corp., Email: swamee@hanmail.net)

수종의 알레르기 관련 약물이 흰쥐의 복강내 비만세포에서 Hyaluronidase 및 히스타민 유리에 미치는 영향

유신애,김구자,하종식,Yoo, Shin-Ae,Kim, Ku-Ja,Hah, Jong-Sik 대한생리학회 1988 대한생리학회지 Vol.22 No.2

Type I allergic reaction and it's related clinical manifestations are known to occur by the effects of various chemical mediators. These chemical mediators are released from circulating basophils and tissue mast cells, which become 'sensitized' through the binding of antigens and antibodies of the IgE type to their cell surface receptors. Efforts to elucidate the mechanism of the release of these mediators, especially that of histamine, have been persued for years. The mechanism is not yet clarified at the present time. Recent reports of hyaluronidase, an enzyme known to be involved in the tissue inflammatory process, as possible participant in type I allergic reaction, initiated this study. Relationships between the hyaluronidase activity and histamine release from the sensitized rat peritoneal mast cells were investigated. Also anti-allergic agents, tranilast and disodium cromoglycate, along with known histamine releasers, morphine and compound 48/80, were used to observe the inhibitory and stimulatory effects of these substances on the hyaluronidase activity as well as histamine release from the rat mast cells. The results obtained are summarized as follows: 1) Hyaluronidase activity and histamine release from sensitiaed rat peritoneal mast cells started to increase on the 4th day of postsensitization. Hyaluronidase activity reached it's peak value on the 7th day of postsensitization and that of histamine release on the 14th day of postsensitization. 2) Hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, pre-treated with tranilast revealed significant decrease in comparison with those of non-treated cells. 3) Hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, pre-treated with tranilast, followed by morphine injection, revealed significant increase in comparison with those of tranilast treated cells. 4) In vitro study of hyaluronidase activity and histamine release from un-sensitized rat peritoneal mast cells, using morphine and compound 48/80 as activators, revealed significant increase compared to those of non-activator used cells. 5) In vitro study of hyaluronidase activity and histamine release from un-sensitized rat peritoneal mast cells, pre-treated with tranilast and disodium cromoglycate, using confound 48/80 and morphine as activators revealed significant decrease in comparison with those of tranilast and disodium cromoglycate treated cells. From above results, participation of enzyme hyaluronidase in the process of histamine release from sensitized rat pertioneal mast cells, could be suggested. It was also quite evident that the clinically used anti-allergic agents, tranilast and disodium cromoglycate, have significant inhibitory function on the hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, while morphine significantly increased the hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells.

고등학생의 부모애착과 주관적 안녕감의 관계에서 자아탄력성의 매개효과

유신애,박미화 한국발달지원학회 2016 발달지원연구 Vol.5 No.2

이 연구에서는 고등학생의 부?모애착, 자아탄력성, 주관적 안녕감과의 관계와 자아탄력성의 매개효과를 알아보고자하였다. 이를 위해 경기도 소재 고등학교 3개교에 재학 중인 남녀 학생을 대상으로 설문조사하 였으며, 342부의 설문지를 배부하여 325부를 회수하였으며, 불성실하게 응답한 설문지를 제외한 총 300부 를 통계 분석한 결과는 다음과 같다. 첫째, 고등학생의 부모애착과 자아탄력성은 정적 상관을 보였다. 부모 애착은 주관적 안녕감의 하위요인인 삶의 만족, 긍정적 정서와는 정적 상관을 보이고, 부정적 정서와는 부 적 상관을 보였다. 즉 부모에 대한 애착이 높을수록 자아탄력성이 높고 삶에 대한 만족과 긍정적 정서도 높으며 부정적 정서는 낮음을 확인할 수 있었다. 또한 자아탄력성은 주관적 안녕감의 하위요인인 삶의 만 족, 긍정적 정서와는 정적 상관을 보이고 부정적 정서와는 부적 상관을 보였다. 즉 자아탄력성이 높을수록 삶에 대한 만족과 긍정적 정서는 높으며 부정적 정서는 낮음을 확인할 수 있었다. 둘째, 자아탄력성은 부 애착과 주관적 안녕감의 하위요인에서 모두 부분 매개하였으며, 모 애착과 주관적 안녕감에서는 주관적 안 녕감의 하위요인인 삶의 만족, 부정적 정서의 관계에서는 부분 매개 역할을 하고, 긍정적 정서의 관계에서 는 완전 매개하는 것으로 나타났다. 따라서 부모애착과 자아탄력성은 고등학생의 주관적 안녕감에 영향을 미치는 중요한 요인이며, 자아탄력성은 고등학생에게 높은 수준의 주관적 안녕감을 갖게 하는데 중요한 변 인임을 확인할 수 있었다.

Performance Evaluation of MEDITAPE UC-11A Strip Test in Estimating the Urine Albumin-to-Creatinine Ratio and Urine Protein-to-Creatinine Ratio

유신애,송새암,전경란,이정녀 대한진단검사의학회 2020 Laboratory Medicine Online Vol.10 No.1

Background: Proteinuria, including albuminuria, is a primary or major clinical sign of kidney disease. The urine albumin-to-creatinine ratio (UACR) and urine protein-to-creatinine ratio (UPCR) are used to screen patients with chronic diseases, such as diabetes and hypertension, which increase the risk of chronic kidney disease. Here, we evaluated the performance of the MEDITAPE UC-11A strips (Sysmex, Japan), compared with that of the quantitative assay, in assessing UACR and UPCR. Methods: We obtained a total of 808 random urine specimens. UACR and UPCR, semiquantitatively analyzed using MEDITAPE UC-11A strips with a UC-3500 automated strip reader (Sysmex, Japan), were compared to UACR and UPCR measured by a quantitative assay. Results: The concordance rates of UACR and UPCR, analyzed using MEDITAPE UC-11A, and those analyzed using the quantitative assay, were 70.1% and 78.7%, respectively. Using UACR, analyzed via quantitative assay, as a reference to estimate albuminuria (UACR >30 mg/g), the concordance rate, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of UACR, analyzed using MEDITAPE UC11A, were 80.5, 97.5, 67.0, 70.3, and 97.1%, respectively. Using UPCR, analyzed via quantitative assay, as a reference to estimate proteinuria (UPCR >0.15 g/g), the concordance rate, sensitivity, specificity, PPV, and NPV of UPCR, analyzed using MEDITAPE UC-11A, were 86.7, 94.4, 81.5, 77.6, and 95.6%, respectively. Conclusions: UACR and UPCR, analyzed using MEDITAPE UC-11A, exhibited relatively high sensitivity and NPV, which is beneficial for laboratory screening for both albuminuria and proteinuria.

2015년 국내 HLA 교차시험 현황 설문조사

유신애,강은숙,박명희 대한진단검사의학회 2017 Laboratory Medicine Online Vol.7 No.3

Background: We carried out a questionnaire survey for laboratories performing human leukocyte antigen-crossmatch (HLA-XM) to provide a basis for laboratory standardization of HLA-XM tests in Korea. Methods: The questionnaires were distributed to 51 HLA laboratories participating in the HLA-XM part of the HLA proficiency survey program organized by the Korean Society for Laboratory Medicine and replies from 50 laboratories were analyzed. The questionnaires included following items: 1) HLA-XM methods performed and annual number of tests, 2) types of the specimen and lymphocyte separation methods, 3) test procedures and reagents for complement-dependent cytotoxicity crossmatch (CDC-XM) and flow cytometry crossmatch (FCXM). Results: The number of laboratories performing anti-human globulin (AHG) CDC-XM (47/49, 96%) and FCXM (30/50, 60%) was considerably increased compared to the 2005 survey (AHG CDC-XM, 35/43, 81%; FCXM, 7/44, 16%). As for the annual number of XM tests, more than 50% of the laboratories were low volume laboratories performing ≤50 tests, and only 10% of the laboratories were performing >500 tests. For cell isolation methods, negative selection was used by 43% (21/49) of laboratories performing CDC-XM. Number of cells reacted per 1 μL of serum varied among different laboratories in both CDC-XM (1,000–8,000) and FCXM tests (1,300-20,000). For the interpretation of FCXM, log fluorescence ratio (26/30, 87%) was more commonly used than channel shift values (5/30, 17%). Conclusions: Considerable variation is noted in both CDC-XM and FCXM methods performed by different laboratories. A continuous effort for laboratory standardization is needed to reduce inter-laboratory variation in the HLA-XM test results. 배경: HLA 교차시험(HLA crossmatch, HLA-XM) 표준화를 위한설문조사의 자료를 분석하여 HLA-XM을 시행하는 국내 기관의현황을 파악하고, 나아가 HLA-XM의 표준화를 이루기 위한 기초자료로 사용하고자 하였다. 방법: 2015년 8월을 기준으로 국내 HLA 검사 신빙도조사 중 HLAXM에참여하고 있는 51개의 의료기관을 대상으로 설문조사를 시행하여, 응답한 50개 기관을 대상으로 결과를 분석하였다. 설문항목은 1) 시행 중인 HLA-XM 종류와 연간 검사 건수, 2) HLA-XM 에 사용하는 검체의 종류와 림프구 분리방법, 3) 보체의존성 세포독성 교차시험(complement-dependent cytotoxicity crossmatch, CDC-XM) 및 유세포분석 교차시험(flow cytometry crossmatch, FCXM)의 검사방법 및 시약에 대해 조사하였다. 결과: Anti-human globulin (AHG) CDC-XM (47/49, 96%)과 FCXM (30/50, 60%)을 시행하고 있는 기관은 2005년 설문조사(AHG CDCXM, 35/43, 81%; FCXM, 7/44, 16%)에 비해 현저히 증가하였다. 연간 검사건수에서 50% 이상의 기관이 50건 이하를 실시하는 소규모 검사실에 속했고, 연간 500건을 넘는 검사를 실시하는 곳은10%에 불과했다. 세포 분리방법에 있어서는 CDC-XM을 실시하는기관의 43% (21/49)에서 negative selection 방법을 사용하고 있었다. 혈청 1 μL당 반응시키는 세포 수는 CDC-XM (1,000-8,000)과FCXM (1,300-20,000) 모두에서 넓은 범위의 분포를 보였다. FCXM 의 결과 판정에서 log 형광값 비율(log fluorescence ratio)을 사용하는 기관(26/30, 87%)이 channel shift 값을 사용하는 기관(5/30, 17%)에 비해 더 많았다. 결론: CDC-XM과 FCXM 모두에서 서로 다른 기관에서 사용하는검사방법이나 판정 기준에 상당한 차이가 있는 것이 확인되었다. 기관별 검사결과의 차이를 줄이기 위하여 HLA-XM의 표준화 작업을 지속적으로 시행하여야 할 것이다.

Analysis of Acute Myeloid Leukemia in Korean Patients with Sole Trisomy 6

유신애,권민정,이승태,우희연,박효순,김선희 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.5

Autosomal trisomy as a sole cytogenetic change has been de- scribed in several hematologic malignancy cases, but the num- ber of reports on the association between specific morphologies and individual structural cytogenetic abnormalities are few [1]. Trisomy 8 is the most common abnormality in myeloproliferative neoplasms (MPN), MDS, MDS/MPN and AML, and trisomy 4, 9, 11, 13, and 21 have been reported to be associated with my- eloid disorders [1, 2]. Here, we describe three patients with AML and show that trisomy 6 is the sole clonal cytogenetic bone marrow abnormality. The patients were adults without previous hematologic disorders, and were initially diagnosed with AML M1, M2, and M4, according to the French-American-British (FAB) classification. These patients received chemotherapy with or without allogenic peripheral blood stem cell transplantation (PBSCT), and showed variable clinical outcomes.

A Rare Case of Acute Leukemic Presentation of Blastic Plasmacytoid Dendritic Cell Neoplasm without Cutaneous Lesions

유신애,권민정,김경은,구동회,우희연,박효순 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.2

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a clinically aggressive phenotype arising from CD4/CD56-expressing plasmacytoid dendritic cell precursors [1]. BPDCN was categorized under “AML and re- lated precursor neoplasms” by the 2008 WHO classification, with most cases having been previously classified as blastic nat- ural killer (NK)-cell lymphoma/leukemia or agranular CD4+, CD56+ hematodermic neoplasm [2]. BPDCN cells generally ex- press CD4, CD56, CD123, and TCL-1 but are negative for other T-, B-, NK-cell, or myeloid markers [3]. Clinically, patients with this disease typically present with a high incidence of cutaneous involvement described as generalized, localized, or solitary mac- ules, plaques, and/or tumors, as the first manifestation, followed by involvement of bone marrow (BM), peripheral blood (PB), and lymph nodes (LNs). BM involvement usually occurs with leukemic progression of advanced or relapsed disease and is associated with a poor prognosis [4]. Diagnosis of leukemic BP- DCN without cutaneous manifestation is rare. Here, we report a 41-yr-old man who was diagnosed with BPDCN in the absence of skin manifestation.

Association of matrix metalloproteinase-7 with triiodothyronine levels in patients with ESRD on HD

유신애,이홍주 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1

임신 중 발생한 장막하 자궁근종의 꼬임 1예(초)

유신애,백윤지,주종길,김승철,이규섭 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-