Effectiveness and feasibility of concurrent chemoradiotherapy using simultaneous integrated boostintensity modulated radiotherapy with and without induction chemotherapy for locally advanced pancreatic cancer

오은상,김태현,우상명,이우진,이주희,윤상희,한성식,박상재,김대용 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.3

Purpose: To evaluate the effectiveness and feasibility of chemoradiotherapy (CRT) using simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in locally advanced pancreatic cancer (LAPC) patients. Materials and Methods: Between January 2011 and May 2015, 47 LAPC patients received CRT using SIB-IMRT. Prior to SIBIMRT, 37 patients (78.7%) received induction chemotherapy (IC-CRT group) and remaining 10 patients (21.3%) did not received induction chemotherapy (CRT group). During SIB-IMRT, all patients received concomitant chemotherapy, with gemcitabine (n = 37) and capecitabine (n = 10). Results: At the time of analysis, 45 patients had died and 2 patients remained alive and the median follow-up time was 14.2 months (range, 3.3 to 51.4 months). For all patients, the median times of local progression-free survival (LPFS), progression-free survival (PFS), and overall survival (OS) were 18.1, 10.3, and 14.2 months, respectively. The median time of LPFS between IC-CRT and CRT groups was similar (18.1 months vs. 18.3 months, p = 0.711). IC-CRT group had a higher trend in PFS (10.9 months vs. 4.1 months, p = 0.054) and had significantly higher OS (15.4 months vs. 9.5 months, p = 0.007) than CRT group. In multivariate analysis, the use of induction chemotherapy and tumor response were significant factors associated with OS (p < 0.05, each). During SIBIMRT, toxicity of grade ≥3 was observed in 7 patients (14.9%) in all patients. Conclusions: CRT using SIB-IMRT is feasible and promising in LAPC patients.

팔선주와 알코올의 계속적인 투여가 흰쥐 위점막에 미치는 행태학적 영향

오은상,한두석 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.2

This study was carried out to compare with the effect of chronic 10% Palsun liquor with 10% ethyl alcohol drinking upon the gastric mucosa of Rats. Sprague-Dawley rats (200~250 gm) were fed 10% Palsun liquor and 10% alcohol instead of water and were maintained on regular feed. They drank about 20 cc of 10% Palsun liquor and 10% alcohol a day. The experimental groups sacrificed after 1, 2, 4 and 8 weeks. The gastric mucosa from the gastric body in vicinity of fundus and the pylorus were fixed in neutral formalin, dehydrated in graded ethanol, embedded in paraffin. Tissues were sectioned and stained with hematoxylin and eosin, and alcian blue pH 2.5. The results were as follows: 1. In all the 10% ethyl alcohol treated group, mucosal epithelium of the gastric mucosa was destroyed a little in some focal areas, but not severely. Some parietal cells covered the damaged areas. The thickness of gastric mucosa was decreased from 12.5±1.79μm of control to 6.5±0.5μm. 2. Mucosal haemorrhage was obserbed in some areas, and the thickness of gastric mucosa was decreased 7.3±0.96μm at 1 weeks after 10% palsun liquor ingestion. However, mucosal epithelium was not destroyed, as was seen in 10% alcohol group and already was recovered to that of normal at 4 weeks. 3. Alcian blue pH 2.5 positive mucosal epithelium was decreased from 1 week in all the experimental groups, but increased again at 4 weeks in 10% Palsun liquor drinking groups. 4. The surface mucous cells of the gastric pit in the body near by the pylorus were decreased in number and the mucous neck cells of the gastric gland also were decreased in number with time in all the 10% alcohol drinking groups. 5. In 8th weeks of experimental group treated with 10% ethyl alcohol, the thickness of gastric mucosa was decreased in some focal areas. However, Palsun liquor treated group was normal. The results suggest that 10% palsun liquor was less destroyed gastric mucosa than 10% ethyl alcohol.

안전한 멀티캐스트 서비스 제공을 위한 효율적인 그룹 관리 기법

은상아(Sang-A Eun),조태남(Tae-Nam Cho),채기준(Kijoon Chae),이상호(Sang-Ho Lee),박원주(Won-Joo Park),나재훈(Jae-Hoon Na) 한국통신학회 2002 한국통신학회 학술대회 및 강연회 Vol.2002 No.4

구강 및 편도궤양을 동반한 크론씨병 1예

은상용,이상훈,박성준,김환재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.5

급속 응고된 Fe-Mn-Si계 합금 리본의 γ→ε 마르텐사이트변태 특성에 미치는 냉각속도 및 어닐링 온도의 영향

은상원,조무현,장우양 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.2

Effects of colling rate and heat treatment on the microstructure and grain size have been investigated in Fe-Mn-Si based SMA Ribbons, and the correlationship between those intrinsic factors and martensitic transformation charactehstics has been discussed. When Fe-Mn-Si based SMA ribbons were fabricated by RSP, grain size of the ribbon was refined up to 4 ㎛ and the uniformity of grains were improved by increasing wheel speed i.e cooling rate. The volume fraction of thermal ε martensite was increased by increasing colling rate. Refined grains of the melt-spin ribbon were partially grown by annealing above 300℃×3min. By increasing annealing temperature, the volume fraction of thermal e martensite was increased and that of α' martensite were also highly increased in the resultant ribbons. Ms temperature of annealed ribbon was higher than that of as-spun ribbon and transformation temperature hysteresis(A_(f-)M_(s)) was decreased by increasing annealing temperature.

스퍼터링법으로 TiN 및 ZrN 피막 코팅된 STD 61의 표면특성

은상원(Sang-Won Eun),최한철(Han-Cheol Choe) 한국표면공학회 2010 한국표면공학회지 Vol.43 No.6

STD 61 steel has been widely used for tools, metallic mold and die for press working because of its favorable mechanical properties such as high toughness, and creep strength as well as excellent oxidation resistance. The STD 61 tool steel coated with TiN and ZrN by sputtering results in improvement of wear and corrosion resistance. In this study, surface characteristics of TiN and ZrN film coated STD 61 by sputtering were studied by using FE-SEM, EDS, XRD, and XRR and nanoindentation tests. From the results of surface characteristics of coated specimen, the ZrN coated surface showed finer granular than that of TiN coated surface. The coated layer structures of ZrN and TiN were grown to (111) and (200) preferred orientation. From the results of XRR test for surface roughness, density and growth rate of coating film, surface roughness and growth rate of ZrN coated film revealed lower values those of TiN coated film, whereas density of ZrN coated film showed higher values than that of TiN coated film. From the nanohardness and elastic modulus test, nanohardness value and elastic modulus of ZrN coated film became higher than those of TiN coated film.

Composite Right/Left-Handed Transmission Lines 결합기를 이용하여 선형성과 효율을 향상한 outphasing E급 전력 증폭기

은상기(Sang-Ki Eun),조춘식(Choon Sik Cho),이재욱(Jae W. Lee),김재흥(Jaeheung Kim) 한국전자파학회 2008 한국전자파학회논문지 Vol.19 No.12

Composite right/left-handed transmission lines(CRLH-TL) 결합기를 이용한 outphasing E급 전력 증폭기를 2.4 ㎓ 대역에서 동작하도록 설계하였다. CRLH 전송 선로가 포함된 전력 결합기는 2차와 3차 고조파를 억제하여 선형성을 향상시켰다. 또한, 기존의 outphasing 전력 증폭기가 갖고 있던 출력 손실 문제를 해결하여 PAE 측면에서도 이점을 얻었다. 본 연구에서는 14 ㏈m의 전력이 인가되었을 때 31.8 ㏈m의 최대 출력 전압을 측정하였으며, 이 때 PAE는 약 50 %로 확인되었다. 선형성 향상을 확인하기 위한 IMD3 측정에서는 일반적인 기존의 λ/4 전송 선로를 사용하는 outphasing 전력증폭기를 사용하였을 때보다 약 5 ㏈ 정도의 향상을 확인할 수 있었다. outphasing class-E power amplifier using composite right/left-handed transmission lines(CRLH-TL) is proposed at 2.4 ㎓. The power combiner including CRLH-TL is designed to suppress the second and third harmonics to increase linearity and the output problem of the conventional outphasing amplifier is also solved by the proposed outphasing amplifier. So the PAE is improved. The measured maximum output power at the fundamental frequency shows 31.8 ㏈m, whereas the PAE shows 50 % with 14 ㏈m input power excited. The IMD3 is improved by 5 ㏈ compared to that of conventional outphasing amplifier.

복합재료의 미시 역학적 특성에 대한 이론적 해석

은상원,이재현 조선대학교 생산기술연구소 2005 生産技術硏究 Vol.27 No.2

By applying Eshelby's theory on the 'transformation' and 'inhomogeneity' problems of an ellipsoidal inclusion, a microscopic stress-strain is formulated for a composite material consisting of a matrix and a large number of aligned ellipsoidal inclusions. Some of the composites of practical interest, such as unidirectionally fiber-reinforced, particle dispersion strengthened and layered composites can be treated by changing the axial ratios of the ellipsoidal inclusion. The microscopic stress-strain relation obtained is applicable to elastic and elasto-plastic deformation of the composite in uniform loading.

전산화단층사진을 이용한 치성각화낭과 법랑모세포종의 감별진단

은상아,김기덕,박창서,Eun Sang-A,Kim Kee-Deog,Park Chang-Seo 대한영상치의학회 2002 Imaging Science in Dentistry Vol.32 No.2

Purpose: The objective of this study is to find the differentiating characteristics of ameloblastomas and odontogenic keratocysts of the jaw by analyzing computed tomography (CT) images of the lesions, clarify radiological characteristics associated with jaw lesions, and to make a diagnsis based on these findings. Materials and Methods : Test subjects were chosen among the patients who were diagnosed as having an odontogenic keratocyst or ameloblastoma at the Yonsei University Dental Hospital from January 1996 to December 2000 and had CT scans taken preoperatively. The subject pool was comprised of 51 cases of odontogenic keratocyst and 37 cases of ameloblastoma. The following measures were used for image analysis of the lesion: the anatomic location, CT pattern, mesiodistal width, buccolingual width, the ratios between mesiodistal width and buccolingual width, height, CT number, homogeneity of radiodensity, the appearance of a sclerotic rim, continuity of adjacent cortical bone, and displacement and resorption of adjacent teeth. Results: Comparing the CT patten, mesiodistal width, buccolingual width, height, CT number, homogeneity, appearance of sclerotic rim, continuity of adjacent cortical bone, there were statistically significant differences between ameloblastoma and odontogenic keratocyst test subjects (p<0.05). Comparing the ratios between mesiodistal width and buccolingual width, displacement and resorption of adjacent teeth, there were no statistically significant differences (p>0.05). Conclusion: We compared odontogenic keratocysts and ameloblastomas in CT scans. They occurred most frequently in the posterior to the ramus of the mandible. The findings of patterns of the CT images showed that size and border of lesions were more aggressive in ameloblastomas than in odontogenic keratocysts. The internal contents represented an increased attenuation area (IAA) in odontopenic keratocyst. Odontogenic keratocysts were shown to have higher CT numbers than ameloblastomas.

안전한 멀티캐스트 서비스 제공을 위한 효율적인 그룹 관리 메커니즘 및 구조

은상아,조태남,채기준,이상호,박원주,나재훈,Eun, Sang-A,Jo, Tae-Nam,Chae, Gi-Jun,Lee, Sang-Ho,Park, Won-Ju,Na, Jae-Hun 한국정보처리학회 2002 정보처리학회논문지 C : 정보통신,정보보안 Vol.9 No.3

멀티캐스트 서비스들이 점차 다양해지고, 서비스 사용자의 폭도 넓어지고 있다. 이에 비례하여 공격자들의 주목을 받게되고 정보의 누출 가능성도 높아진다. 따라서 멀티캐스트 서비스 활용과 동시에 그에 대한 보안 연구도 함께 이루어져야 한다. 본 논문에서는 멤버의 동적인 가입 탈퇴가 발생하는 그룹에서 효율적인 그룹 관리를 적용하여 안전한 멀티캐스트 서비스를 제공할 수 있는 구조를 제안한다. 제안한 구조는 한 명의 송신자와 다수의 수신자로 구성된 멀티캐스트 통신 상황에서, 보안 측면을 고려하여 많은 이용자들에게 안전한 멀티캐스트 서비스를 제공할 수 있다. 시뮬레이션을 통하여 기존의 구조와 성능을 비교·분석한 결과, 제안하는 구조는 멤버 관리가 효율적이고, 전송 지연을 줄이면서 보다 안전하게 데이터를 전송할 수 있다는 것을 알 수 있었다. Multicast services are gradually diversified and used widely. Proportionately, they become the center of attackers' attention and there are growing possibilities of an intelligence leak. Therefore, research related to secure multicast should be required to provide multicast service efficiently. This paper presents the architecture for secure multicast which provides efficient group management mechanism in group consists using member's dynamic join and leave. This architecture can provide secure multicast services to many users with regard to security aspects in one-to-many communication. The simulation results show that the proposed architecture achieves an efficient group management and a secure data transmission with low latency compared with the other existing secure multicast architecture.