소아에서의 치루 및 항문 주위 농양의 임상적 고찰

오수연,최금자,Oh, Soo-Youn,Choi, Kum-Ja 대한소아외과학회 2002 소아외과 Vol.8 No.2

To evaluate the clinical characteristics and results of treatment of fistula-in-ano and perianal abscess in childhood, we analyzed 95 cases of fistula-in-ano and/or perianal abscess seen in childhood, between January 1995 and June 2001 at the Department of General Surgery of Ewha Womans University Mokdong Hospital. Perianal abscess was in 25 patients, anal fistula in 62 and combined disease (perianal fistula and abscess) in 8. Male predominance was noted (95%). Median age was 8 months and 78% of cases were presented under the age of 1 year. Median duration of symptoms was 60 days. Twenty four abscesses (77%) and 18 lesions (72%) of combined disease (n=25) were located on both lateral sides of the anus, and fistulas located on both lateral sides were 33 (53%). Multiplicity of the lesion was noted in 25% of cases. Sixteen percent of abscess, 81% of fistula and 88% of combination group have had previous perianal abscesses. The perianal abscesses were treated with incision and currettage and fistulas were treated with fistulotomy or fistulectomy. There were no recurrent diseases and no complications after surgical treatment. Although the progresses of the perianal abscess and fistula in ano in childhood may be self-limitied, surgical management was safe and curable.

창자 가로절단-재문합 실험모델에서 창자신경계통의 형태계측학적 변화

오수연(Soo-Youn Oh),박웅채(Ung-Chae Park),김경래(Kyung-Rae Kim),왕준호(Jun-Ho Wang),이재동(Jae-Dong Lee),김순제(Soon-Je Kim),송우철(Wu-Chul Song),박승화(Seung-Hwa Park) 대한체질인류학회 2007 해부·생물인류학 (Anat Biol Anthropol) Vol.20 No.1

작은창자의 손상 후 시간경과에 따른 재생과정에서 근육층신경얼기와 제1형 카할사이질세포가 각각 어떻게 변화하는지를 살펴보고자 돌창자 가로절단-재문합 실험모델을 제작하여 형태계측학적 방법으로 비교분석 하였다. 형태계측학적 분석을 하기위해 Sprague Dawley계 성숙흰쥐의 돌창자를 가로절단한 후 재문합시킨 실험군과 가로절단을 하지 않고 개복 후 봉합수술만을 시행한 대조군에서 수술 후 3일, 7일, 15일, 30일군의 근육층신경얼기와 제1형 카할사이질세포의 변화를 영상분석기를 이용하여 계수하고 통계처리 하였다. 작은창자의 가로절단으로 인한 손상효과는 근육층신경얼기와 제1형 카할사이질세포에서 동시에 일어났으며 손상부위를 중심으로 앞쪽과 뒤쪽(구강쪽과 항문쪽) 양 방향으로 고르게 나타났다. 손상효과는 수술 후 3일군과 7일군에서 가장 심하게 나타나 근육층신경얼기의 경우 신경세포의 형태적 변성과 아울러 세포수가 약 40% 감소하였다. 제1형 카할사이질세포는 세포수가 20~37% 감소하였으며 대부분 세포의 세포질에는 많은 공포가 형성되어 있었다. 수술 후 15일 이후부터는 재생이 일어나기 시작하여 근육층신경얼기에서 신경세포의 감소정도는 20~25%로 줄어들었으며 세포의 염색정도나 형태가 정상으로 회복되는 양상을 보였다. 제1형 카할사이질세포 수의 감소정도도 13~20%로 줄어들었으며 세포질 내 공포가 형성된 세포의 수도 감소하였다. 수술 후 30일군에서 근육층신경얼기를 이루는 신경세포의 형태는 대조군과 유사하였으며 신경세포의 수는 수술 면을 기준으로 구강쪽과 항문쪽에서 각각 12.3%, 15.6% 씩 감소하여 (p<0.01) 정상으로의 완전한 회복은 이루어지지 않았다. 제1형 카할사이질세포 수는 구강쪽과 항문쪽에서 각각 7.5%, 4.2%씩 감소하였으나 유의한 차이는 없었으며(p>0.01) 세포 형태도 정상이었다. 이로서 작은창자의 가로절단으로 인한 손상효과는 근육층신경얼기에서 좀 더 심하게 나타나며 정상으로의 회복도 제1형 카할사이질세포에 비해 더디게 나타남을 알 수 있었다. This study was performed to investigate the morphometric changes of myenteric plexus and type 1 interstitial cells of Cajal (ICC-I) in regeneration process of small intestine transection. Sprague Dawley rats (200~250 g) were anesthetized with ether; then the full thickness of ileal wall were semitransected; and subsequent end-to-end anastomosis were performed by using 6-0 silk suture thread. Sham-operated rats, which only underwent the laparotomy, were used for control group. Experimental animals were sacrificed at 3 days, 7 days, 15 days, and 30 days after the operation. In each group myenteric plexus and ICC-Is were prepared by histochemical method (NADH-TR stain for myenteric plexus, ZIO stain for ICC-Is) and cell numbers were counted by image analyzer (Image plus pro-5.0, Media Cybermedics, USA). Degeneration of myenteric neurons and ICC-Is occurred simultaneously and it was similar in oral and anal to the site of transection. Degeneration effects were most prominent at 3 days and 7 days after intestinal transection. In myenteric plexus, many neurons had degenerated appearances and about 40% of them were lost. Most of ICC-Is had cytoplasmic vacuoles and 20~37% of the cells were lost. At 15 days after transection, there were no more degeneration in myenteric neurons (20~25% cell loss) and ICC-Is (20~13% cell loss). At 30 days after transection, numbers of myenteric neurons were not recovered as that of the control group. However numbers of ICC-Is were as similar as that of the control group. In conclusion, we confirmed that degeneration effects of intestinal transection are more severe in myenteric plexus than in ICC-Is, and recovery of cell loss occurs more slowly in myenteric plexus.

피부 관리실의 서비스품질이 소비자의 지각된 가치 및 구매 후 행동에 미치는 영향

신윤정 ( Youn Jeoung Shin ),오수연 ( Soo Yeon Oh ),전지현 ( Ji Hyun Jeon ) 한국미용학회 2012 한국미용학회지 Vol.18 No.2

With the economic growing, people has had the attention of health and appearance. Due to this trend, skin-care market was grown and service quality was the important variables to differentiate among skin-care shop. The purpose of this study was to examine service quality of skin-care shop and clarify the relation of perceived value and post-purchase behavior. For this study, a questionnaire survey was performed for randomly selected 280 customers using the skin-care shop lived in Pusan and Kyungnam. These surveys were analyzed as with SPSS-WIN 17.0 and Amos 5.0. The result was summarized as follows: 1. Service quality was classified 3 factorspeople, physical environment, policy. 2. Only the physical environment factor was affected the perceived value. 3. The perceived value was influenced the positive word-of-mouth and store loyalty. The findings of this study are expected to be utilized as fundamental data for developing and applying the service marketing strategy in skin-care shop.

조기위암의 치료 전략의 시기적 변화

염차경(Cha-Kyong Yom),오수연(Soo-Youn Oh),이주호(Joo-Ho Lee) 대한외과학회 2004 Annals of Surgical Treatment and Research(ASRT) Vol.66 No.6

위축 위염과 장형화생에서의 마이크로어레이를 이용한 유전자 발현

김경래 ( Kyong Rae Kim ),오수연 ( Soo Youn Oh ),박웅채 ( Ung Chae Park ),왕준호 ( Joon Ho Wang ),이재동 ( Jae Dong Lee ),권혁중 ( Hyuk Jung Kweon ),김상윤 ( Sang Yoon Kim ),박승화 ( Seung Hwa Park ),최동국 ( Dong Kug Choi ),김찬길 대한소화기학회 2007 대한소화기학회지 Vol.49 No.4

목적: 장형화생을 동반한 위축 위염은 최근까지 위암발생의 중요한 요인으로 여겨져 왔다. 그러나 아직 장형화생과 위축 위염에 발현하는 주요 유전자에 관해서 거의 알려진 것이 없다. 이번 연구는 기존의 유전자 탐색에 사용되었던 어떤 방법보다도 많은 장점을 가지고 있는 올리고뉴클레오티드 마이크로어레이를 이용하여 전반적인 유전자 변화와 함께 위암과의 관련성을 알아보고자 하였다. 대상 및 방법: 장형화생을 동반한 위축 위염환자의 위점막과 정상 점막에서 올리고뉴클레오티드 마이크로어레이 기술을 이용하여 대량의 유전자 정보를 얻었으며, 유전자들의 확인을 위해 SAM (Significance Analysis of Microarrays) package 방법을 사용하였다. Global normalization, intensity dependent normalization 그리고 box plot normalization를 사용하여 결과를 분석하였다. 결과: FABP, REG, OR6C1, MEP1, SLC6A1, SI, Mucin 1, RAB23 등 8개 유전자는 정상점막에 비해 10배이상 과발현되었고, LOC44119유전자 하나만이 10배 이상 저발현되었다. 알려진 위암의 발암과정에 관여된 유전자로는 FN1, SRMS, TP53, TP53IMP2, TP53I3, FGFR4, TGFB1, TGFA 등 모두 8개에서 공통적으로 2배 이상의 발현 증감을 보였다. 결론: 저자들은 위암의 전단계병변인 장형화생을 동반한 위축 위염에서 암화와 관련한 유전자를 확인할 수 있었으며, 이번 연구 결과는 위암 진단 및 치료와 같은 임상적용을 위한 분자생물학적인 특성을 이해하는 데에 도움이 될 것이다. Background/Aims: The atrophic gastritis with intestinal metaplasia of gastric mucosa has been considered to be the major factor of carcinogenesis in the stomach. However, the key molecules are still poorly understood. To elucidate the molecular genetic basis, we report the results of our initial microarray data to analyze the genome pattern in patients with atrophic gastritis and intestinal metaplasia of the stomach. Methods: We used oligonucleotide microarray technique to evaluate the gene expression profiles in atrophic gastritis with intestinal metaplasia, in comparison with those of normal mucosa. For the identification of differentially expressed genes, Significance Analysis of Microarrays (SAM) package method was used. The results were analyzed using global normalization, intensity dependent normalization, and box plot normalization. Results: Eight genes including FABP, REG, OR6C1, MEP1, SLC6A1, SI, Mucin 1, and RAB23 in mucosa of atrophic gastritis and intestinal metaplasia were up-regulated by more than 10 times as compared with normal gastric mucosa. Only one gene, LOC44119 was down-regulated by more than 10 times of the expression as compared with normal gastric mucosa. In respect to the expression of known genes related to gastric carcinogenesis, 8 genes including FN1, SRMS, TP53, TP53IMP2, TP53I3, FGFR4, TGFB1, and TGFA showed up- and down-regulations more than 2 folds in expression pattern. Conclusions: We could identify a total genome pattern in patient with atrophic gastritis and intestinal metaplasia using oligonucleotide microarray. We believe that the current results will serve as a fundamental bioinformative basis for clinical applications in diagnosis and treatment of gastric cancer and precancerous lesion in the future. (Korean J Gastroenterol 2007;49:209-224)

개의 동종 부분 간이식 후 허혈

정구용(Ku-Yong Chung),성순희(Soon Hee Sung),정규영(Gyu Young Jeong),오수연(Soo Youn Oh),김유선(Yu Seun Kim),조백환(Baik-Hwan Cho),최금자(Kum Ja Choi),최용만(Yong Man Choi) 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.63 No.5

문화소비 행위로서 텔레비전을 본다는 것에 관하여

김은미(Eun Mee Kim),이혜미(Hye Mi Lee),오수연(Soo Youn Oh) 한국방송학회 2012 한국방송학보 Vol.26 No.3

Dukes B 대장암에서 병리 검사한 림프절의 수가 예후에 미치는 영향

오수연,이석환,구혜수,김광호,박응범 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.3