황토몰탈로 마감한 대학기숙사 침실의 실내공기질 평가와 거주자의 심리적 효과

김범수(Kim Bum Soo),권혁중(Kweon Hyuk Jung),신동규(Shin Dong Kyu),장희순(Jang Hee Soon) 한국주거환경학회 2016 주거환경(한국주거환경학회논문집) Vol.14 No.3

This study attempted to investigate the characteristics of indoor air quality after using Hwangto mortar as the finishing materials for bedroom spaces of university dormitory and assess its psychological effects. For this, the concentration of the indoor air quality of the rooms finished with Hwangto mortar finishing materials was comparatively analyzed. The residents were divided into non-allergy group and allergy group, and changes in their emotions and depression and anxiety levels after staying in the dormitory bedroom for a certain period of time were analyzed. The analysis results found the followings: In terms of the indoor air quality of the room finished with Hwangto mortar, the measurements were below the required levels. Therefore, it appears that Hwangto mortar is an effective finishing material in improving indoor air quality. Compared the rooms finished with general water paints, no particular medical treatment effects for depression and anxiety were found in the Hwangto mortar finishing rooms after students stayed there for 2-3 months. In emotional assessment, in contrast, high scores were found. Therefore, it is likely that the rooms finished with Hwangto mortar would improve residents satisfaction and bring psychotherapy effects after a long stay.

의과대학생들의 성격성향과 관련된 환자중심적 태도

문석우(Seok Woo Moon),남범우(Beom Woo Nam),서정석(Jeong Seok Seo),류은정(Eun Jeong Ryu),권혁중(Hyuk Jung Kweon),손인기(In Ki Sohn),함 웅(Woong Hahm) 한국의학교육학회 2006 Korean journal of medical education Vol.18 No.1

Purpose: The patient-centered attitude is an effort to understand patients themselves as well as their disease. The doctor-oriented approach has been shifting to one where patients and participate in the deciding of medical service. We performed this study to investigate the patient-centeredness and influencing variables associated with personality traits. Methods: We recruited 94 medical students before their psychiatric clinical clerkship, and all subjects were assessed by a structured questionnaire including socio-demographic data, Minnesota Multiphasic Personality Inventory (MMPI), Meyers-Briggs type indicator (MBTI), the patientpractitioner Orientation Scale (PPOS), and the Authoritarian Personality scale (AP), The AP and PPOS questionnaires were repeated after the psychiatric clinical clerkship. Results: After the psychiatric clinical clerkship, the AP scores were significantly lower than before, and the PPOS significantly higher than before. The change in the AP scores were related to MBTI, correlated with MMPI subscales, however, inversely correlated with the changes in PPOS after the clinical clerkship. Conclusion: The authoritarian personality trait was related to, not only the personality trait including MBTI and MMPI subscales, but also to patient-centeredness in medical students.

위축 위염과 장형화생에서의 마이크로어레이를 이용한 유전자 발현

김경래 ( Kyong Rae Kim ),오수연 ( Soo Youn Oh ),박웅채 ( Ung Chae Park ),왕준호 ( Joon Ho Wang ),이재동 ( Jae Dong Lee ),권혁중 ( Hyuk Jung Kweon ),김상윤 ( Sang Yoon Kim ),박승화 ( Seung Hwa Park ),최동국 ( Dong Kug Choi ),김찬길 대한소화기학회 2007 대한소화기학회지 Vol.49 No.4

목적: 장형화생을 동반한 위축 위염은 최근까지 위암발생의 중요한 요인으로 여겨져 왔다. 그러나 아직 장형화생과 위축 위염에 발현하는 주요 유전자에 관해서 거의 알려진 것이 없다. 이번 연구는 기존의 유전자 탐색에 사용되었던 어떤 방법보다도 많은 장점을 가지고 있는 올리고뉴클레오티드 마이크로어레이를 이용하여 전반적인 유전자 변화와 함께 위암과의 관련성을 알아보고자 하였다. 대상 및 방법: 장형화생을 동반한 위축 위염환자의 위점막과 정상 점막에서 올리고뉴클레오티드 마이크로어레이 기술을 이용하여 대량의 유전자 정보를 얻었으며, 유전자들의 확인을 위해 SAM (Significance Analysis of Microarrays) package 방법을 사용하였다. Global normalization, intensity dependent normalization 그리고 box plot normalization를 사용하여 결과를 분석하였다. 결과: FABP, REG, OR6C1, MEP1, SLC6A1, SI, Mucin 1, RAB23 등 8개 유전자는 정상점막에 비해 10배이상 과발현되었고, LOC44119유전자 하나만이 10배 이상 저발현되었다. 알려진 위암의 발암과정에 관여된 유전자로는 FN1, SRMS, TP53, TP53IMP2, TP53I3, FGFR4, TGFB1, TGFA 등 모두 8개에서 공통적으로 2배 이상의 발현 증감을 보였다. 결론: 저자들은 위암의 전단계병변인 장형화생을 동반한 위축 위염에서 암화와 관련한 유전자를 확인할 수 있었으며, 이번 연구 결과는 위암 진단 및 치료와 같은 임상적용을 위한 분자생물학적인 특성을 이해하는 데에 도움이 될 것이다. Background/Aims: The atrophic gastritis with intestinal metaplasia of gastric mucosa has been considered to be the major factor of carcinogenesis in the stomach. However, the key molecules are still poorly understood. To elucidate the molecular genetic basis, we report the results of our initial microarray data to analyze the genome pattern in patients with atrophic gastritis and intestinal metaplasia of the stomach. Methods: We used oligonucleotide microarray technique to evaluate the gene expression profiles in atrophic gastritis with intestinal metaplasia, in comparison with those of normal mucosa. For the identification of differentially expressed genes, Significance Analysis of Microarrays (SAM) package method was used. The results were analyzed using global normalization, intensity dependent normalization, and box plot normalization. Results: Eight genes including FABP, REG, OR6C1, MEP1, SLC6A1, SI, Mucin 1, and RAB23 in mucosa of atrophic gastritis and intestinal metaplasia were up-regulated by more than 10 times as compared with normal gastric mucosa. Only one gene, LOC44119 was down-regulated by more than 10 times of the expression as compared with normal gastric mucosa. In respect to the expression of known genes related to gastric carcinogenesis, 8 genes including FN1, SRMS, TP53, TP53IMP2, TP53I3, FGFR4, TGFB1, and TGFA showed up- and down-regulations more than 2 folds in expression pattern. Conclusions: We could identify a total genome pattern in patient with atrophic gastritis and intestinal metaplasia using oligonucleotide microarray. We believe that the current results will serve as a fundamental bioinformative basis for clinical applications in diagnosis and treatment of gastric cancer and precancerous lesion in the future. (Korean J Gastroenterol 2007;49:209-224)

만성피로 환자들의 임상적 특성 분석 : 3차병원 입원 환자들을 중심으로 The Inpatients of a Tertiary General Hospital

권혁중 최신의학사 2000 最新醫學 Vol.43 No.5-6

3년간 한 대학병원의 말라리아 환자의 임상 분석

권혁중 최신의학사 2000 最新醫學 Vol.43 No.5-6

3차병원 가정의학과 입원환자의 내용 비교 분석

권혁중 최신의학사 2000 最新醫學 Vol.43 No.5-6

일차의료에서 우울증 진단과 치료

권혁중,조동영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Depressive disorder is prevalent illness. When depressive symptoms become qualitatively different, pervasive, or interfere with normal function, they are considered to be pathological. Major depressive disorder is defined as depressed mood or anhedonia lasting at least two weeks plus a set number of psychologic or physical symptoms. Dysthymia has fewer symptoms than major depression and is a chronic illness lasting at least two years. A condition known as depressive disorder not otherwise specified includes conditions that do not have enough symptoms (fewer than five) or are of insufficient duration to be considered major depressive disorder. Depression is second only to hypertension as the most common chronic condition encountered in general medical practice. A diagnosis of depressive disorder can be complicated by concomitant illnesses or medications that mimic the symptoms of depression. The keys to successful management of depression include thorough screening, patient engagement and education, early follow-up of adherence to the treatment plan and careful monitoring of response. By putting these strategies into practice, family physicians can provide excellent care for their depressed patients and, in many cases, help them achieve lasting remissions.

비만의 성공적인 관리

권혁중,조성일 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Obesity is a common health problem in worldwide, and effective management is challenging. Obesity is associated with an increased mortality rate and risk factors such as hypertension, hyperlipidemia and diabetes mellitus. Basic management of overweight and obese patients requires a comprehensive approach involving diet and nutrition, regular physical activity, and behavioral change, with an emphasis on long-term weight management rather than short-term extreme weight reduction. Modification of lifestyle behaviors that contribute to obesity (e.g., inappropriate diet and inactivity) is the cornerstone of management and the best management for long-term weight loss. Behavior modification involves using such techniques as self-monitoring, stimulus control, cognitive restructuring, stress management and social support to systematically alter obesity-related behaviors. Physicians and other health professionals have an important role in promoting preventive measures and encouraging positive lifestyle behaviors, as well as identifying and treating obesity-related comorbidities. Health professionals also have a role in counseling patients about safe and effective weight loss and weight maintenance programs.

대도시와 중소도시 여성의 골다공증에 대한 인식도

신욱태,권혁중,조동영 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

As average lifespan in human increased, women's concerns about health promotion after postmenopause are increased. Osteoporosis causes the serious health problem in postmenopausal women. We investigated comparison between Seoul and Chungju for women's recognition about osteoporosis to utilize patient's education data. Information, concerning whether the osteoporosis was well understood, were gather 405 patients, who visited an university hospital from January 1 to April 30, 2001. The mean age of 201 women in Seoul is 46.39 years old, and mean age of 204 in Chungju is 46.35 years old. Among 201 women in Seoul, 43(21.4%) women answered "well known" osteoporosis, and 32(15.9%) women answered "unknown" osteoporosis. Among 204 women in Chungju, 24(11.8%) women answered "well known" osteoporosis, and 32(15.9%) women answered "unknown" osteoporosis. There were significant association between recognition of osteoporosis and their education level, but not significant related with their economic level. Subjective and objective recognition for osteoporosis in Seoul was relatively higher than women in Chungju, but compliance about doctor in Chungju was relatively higher than women in Seoul. But we found that recognition level of postmenopausal osteoporosis is low in Seoul and Chungju. We concluded that knowledge for osteoporosis was relatively low, seoul was relatively higher than in Chungju. Therefore, correct patient education for prevention and treatment of osteoporosis would be needed.

혈소판감소증 : 임산부 및 신생아 중심으로

이창훈,권혁중,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

It is important to distinguish from physiologic incidental thrombocytopenia (IP) in pregnant women and pathologic thrombocytopenic conditions associated with pregnancy involving pre-eclampsia/eclampsia, HELLP syndrome/AFLP, TTP/HUS, DIC, and infectious diseases. And also, they should be differentiated from ITP, SLE, and drug-induced thrombocytopenia which are immunologic disorders. Although neonatal thrombocytopenia in most cases occurs from non-immune mediated dise-ases or pregnancy-induced thrombocytopenic conditions, but rarely, neonatal alloimmune thr-ombocytopenia (NAIT) which was caused by fetomaternal mismatch for human platelet all-oantigen (HPA) can occur.