트리테이스프로텍트 ^®정(라미프릴 10mg)에 대한 라미프린 ^®정의 생물학적동등성

오수연,조종태,김형건,김윤균,Oh, Soo-Yeon,Cho, Jong-Tae,Kim, Hyung-Gun,Kim, Yoon-Gyoon 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.1

To evaluate the bioequivalence of two ramipril formulations, a standard 2-way randomized cross-over study was conducted in twenty-six healthy male Korean volunteers. A single oral dose of 10 mg of test formulation $Ramiprin^{(R)}$ (tablet) or reference formulation Tritace $Protect^{(R)}$ (tablet) was administered with one-week washout period. Plasma concentrations of ramipril were assayed over a period of 12 hr with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The values of area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$ were $77.45{\pm}44.78\;and\;78.96{\pm}45.64$ for test, and $70.30{\pm}42.27\;and\;71.99{\pm}43.55ng\;hr/mL$ for reference formulation, respectively. Similarly, maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $65.61{\pm}19.96ng/mL$ and $2.15{\pm}0.75hr$ for test, and $63.63{\pm}25.50ng/mL$ and $2.16{\pm}0.73hr$ for reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ for the test and the reference, were $0.51{\pm}0.22hr\;and\;0.52{\pm}0.18hr$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log-transformed values of $AUC_t\;and\;C_{max}$ were 1.03 to 1.19 and 0.98 to 1.17, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribed interchangeably.

제스트릴^®정(리시노프릴, 10 mg)에 대한 리시헥살^®정의 생물학적동등성

오수연,디펜드라 쿠마 아리얼,조종태,김형건,김윤균,Oh, Soo-Yeon,Aryal Dipendra Kumar,Cho, Jong-Tae,Kim, Hyung-Gun,Kim, Yoon-Gyoon 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.4

Lisinopril is one of the angiotensin-converting enzyme inhibitors, which have been used for treatment of hypertension and heart failure. The aim of this study was to evaluate the bioequivalence of two lisinopril tablet, $Lisihexal^{\circledR}$ and $Zestril^{\circledR}$ as a test and reference, respectively. The study was came out on 28 healthy male Korean volunteers in $2{\times}2$ crossover design. An analytical method with LC-MS-MS was developed for the quantification of lisinopril and enalapril(IS) using SPE method. The condition was selective, sensitive and precise in human plasma, that was enough for the pharmacokinetic study of lisinopril. The pharmacokinetic parameters such as $AUC_t,\;AUC_{inf},\;C_{max},\;T_{max}\;and\;t_{1/2}$ were calculated and ANOVA test was used for the statistical analysis of the parameters using log transformed $AUC_t,\;AUC_{inf}\;and\;C_{max}$. $t_{1/2}$ of test and reference drugs were calculated $11.4{\pm}5.1\;and\;16.1{\pm}9.9\;hr$, respectively. The 90% confidence intervals of $AUC_t,\;AUC_{inf}\;and\;C_{max}$ were log 0.9245$\sim$log 1.0603, log 0.9270$\sim$log 1.0601 and log 0.9548$\sim$log 1.1009, within the acceptable range of log 0.8 to log 1.25 by KFDA bioequivalence criteria. Two medications of lisinopril were evaluated bioequivalent and thus may be prescribed interchangeably.

유방암 여성 환자의 림프부종에 대한 림프배액맛사지의 효과

오수연,김현아,정광조,김정선,조종관,유화승,Oh, Soo-Yeon,Kim, Hyeon-Ah,Jung, Kwang-Jo,Kim, Jung-Sun,Cho, Chong-Kwan,Yoo, Hwa-Seung 대한암한의학회 2007 大韓癌韓醫學會誌 Vol.12 No.1

Objective: We have the purpose of evaluating the effects of lymphatic massage on lymphoedema in breast cancer patients. Method: The patient who has in condition of lymphoedema after the breast cancer therapy is taken massages with aroma oil for 5 days. We measured the upper arm circumference and edema index before and after the therapy. We also measure the edema index of normal arm to compare with the abnormal one. Results: We gave 4 patients the decongestive lymphatic therapy and now present the positive conclusion. 3cases of the 4 showed decrease of circumferences and edema index. It means that the edematous condition getting better during these therapy. Conclusion: Lymphatic massage with aroma therapy may have effectiveness on lymphoedema in breast cancer patients. but further advanced clinical trials are needed.

유한상태기계에 기반한 확장된 I-O 모델링 방법론

오수연,왕지남,김기형,김강석,Oh, Soo-Yeon,Wang, Gi-Nam,Kim, Ki-Hyung,Kim, Kangseok 한국시뮬레이션학회 2016 한국시뮬레이션학회 논문지 Vol.25 No.4

최근 자동 생산 시스템은 PLC (Programmable Logic Controller) 제어 프로그램을 일반적으로 사용하고 있다. 생산제품의 수명 주기가 길지 않기 때문에 공법과 라인 및 설비 변경이 자주 일어난다. 대부분, 기존 공정을 바탕으로 이루어지고 설비의 위치 및 제어정보를 수정한다. PLC 제어 프로그램 또한 기존 공정을 바탕으로 수정이 이루어진다. 새로운 제어 프로그램을 검증하기 위해서는 실제 생산 시스템을 구축하기 전에 가상의 공간에서 실제 공정과 같이 구성하여 순차적으로 공정이 진행되는 지 확인할 수 있는 방법이 필요하다. 본 연구는 순차제어(sequential control)와 병목현상 처리에 유용한 Timed-FSA를 기반으로 하는 논리적인 모델링 방법을 사용한다. 기존에 연구되었던 I-O 모델링과 I-O 모델링에서 요구되었던 하나의 설비에 다양한 상태의 정의를 통해 사용자의 시간과 공수를 절감하기 위한 기존 모델링에 페트리네트의 토큰(Petri Nets Coloured Token) 개념을 추가한 확장된 I-O 모델링 방법을 제안한다. 예제 설비를 통하여 사용자의 모델링 시간을 절감하는 실험과 사용자 평가를 통해 제안하는 확장된 I-O 모델링의 편의성을 검증한다. Recently manufacturing companies have used PLC control programs popularly for their automated production systems. Since the life cycle of production process is not so long, the change of the production lines occur frequently. Most of changes happen with modification of the position information and control process of the equipment. PLC control program is also modified based on the fundamental process. Therefore, to verify new PLC program by configuring virtual space according to real environment is needed. In this paper we show a logical modeling method, based on Timed-FSA useful for sequence control and dead-lock prevention. There is a problem wasting user's labor and time when defining a variety of states in a device. To overcome this problem, we propose an extended I-O model based on existing methods by adding a token concept of Petri Nets. Also we will show the usability of the extended I-O modeling through user study.

라이프스타일에 따른 소비자의 스킨케어 선호도에 관한 연구 -일반스킨케어와 메디컬스킨케어를 비교대상으로-

오수연 ( Soo Yeon Oh ),이영선 ( Young Sun Rhee ) 한국미용학회 2012 한국미용학회지 Vol.18 No.2

Modern people has grown attentive for appearance, which has been reflected in their life-style. This trend tends to polarize skin care market as market of general skin care and medical skin care. The goals of this study are to present marketing strategy for meeting needs of detailed market by doing an analysis of purchasing behavior between general skin care and medical skin care according to this customer`s changed life-style. In order to achieve the goals, a questionnaire survey was performed for randomly selected 500 customers using the skin care. These surveys were analyzed as with SPSS-WIN 19.0. and performed as frequency, factor, reliability, cluster, cross analysis and ANOVA. The customer`s 5 life-style factors, which are classified as health & economic-oriented life-style, leisure-oriented life-style, appearance & achievement-oriented life-style and convenience-oriented life-style, showed statistically significant difference. According to groups, it appeared to have a difference in preferred skin care style. Especially, appearance & achievement-oriented lifestyle was preferred from both general and medical skin care. Among the skin cares, face care in general skin care and laser therapy in medical skin care were occupied most of skin cares. In conclusion, the results of this study are to expect to be utilized as fundamental resource which plan differentiated marketing strategy for meeting of life-style of customers using skin care services.

피부관리실 종사자의 언어적, 비언어적 커뮤니케이션이 점포평가에 미치는 영향

오수연 ( Soo Yeon Oh ),한경희 ( Kyong Hee Han ),전지현 ( Ji Hyun Jun ) 한국미용학회 2011 한국미용학회지 Vol.17 No.5

This study examines the degree to which the service provider`s verbal and nonverbal communication has influence on the customer`s store evaluation. One of the important criteria of store evaluation is the truth through communication with service provider as well as service. For this study, the data were obtained from 275 male and female lived in Pusan, Kyungnam and Ulsan. The result is summarized as follows. First, verbal and nonverbal communication consists of three dimensions: verbal and paralanguage, physical appearance, kinesics. Second, verbal and paralanguage affects expert-based and benevolence-based trust but physical appearance and kinesics do not affect the trust. Third, expert-based trust and benevolence-based trust affect the store evaluation. The findings of this study are expected to be used as the basic data for developing and applying the program of skin-care workers` instruction.

외모관여수준에 따른 피부관리 구매동기와 상품평가속성 차이 연구

오수연 ( Soo Yeon Oh ),전지현 ( Ji Hyun Jeon ),이영선 ( Young Sun Rhee ) 한국미용학회 2013 한국미용학회지 Vol.19 No.5

With adding interest in the appearance, people have invested time and effort to make their appearance better. From recent advances in digital technology, people are interested in skin condition and care. Therefore, this study was to examine the appearance involvement and consumer purchasing behaviors(purchase motivation and attributes to evaluate) by involvement degrees. In order to achieve the goals, survey was performed for randomly selected 620 customers lived in Pusasn, Ulsan, Kyungnam, and Daejeon. These surveys were analyzed as with SPSS-WIN 19.0. and performed as frequency, factor, reliability, cluster, and ANOVA. The results were as follows. First, in measuring the level of involvement, respondents were divided to two groups according to means. Seconds, there were significant differences by the level of involvement in the purchase motivation. Thirds, there were significant differences by the level of involvement in the attributes to evaluate. In conclusion, the results of this study are to expect to be utilized as fundamental resource which plan differentiated marketing strategy for customers using skin care services.

트리테이스프로텍트(R)정(라미프릴 10mg)에 대한 라미프린(R)정의 생물학적동등성

오수연 ( Soo Yeon Oh ),조종태 ( Jong Tae Cho ),김형건 ( Hyung Gun Kim ),김윤균 ( Yoon Gyoon Kim ) 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.1

문화유산의 3차원 디지털 아카이브 열람 시스템에 관한 연구

오수연(Oh Soo-Yeon),여욱현(Yeo Wook-Hyun) 한국콘텐츠학회 2005 한국콘텐츠학회 종합학술대회 논문집 Vol.3 No.1

종래의 문화유산 디지털 아카이브는 사지이나 자료를 디지털화하여 보관되고 있는 것이 대부분이었으나, 최근에는 3차원 컴퓨터 그래픽을 이용한 3차원 디지털 아카이브의 구축이 확산되고 있다. 이러한 차원에서, 본 연구는 가상현실(Virtual Reality:VR)기술을 이용한 3차원 디지털 아카이브 열람 시스템의 개발에 관한 내용들로 구성되어 있다. 본 연구의 목적은, 이용자가 보존된 아카이브의 열람을 통하여 문화유산을 보다 쉽게 이해하고 지식을 습득할 수 있는 시스템의 개발이다. 시스템 개발에 활용된 기술은 DirectX기술의 가상현실이며, 각 콘텐츠의 이해를 돕기 위하여 두 가지 이상의 콘텐츠를 같은 화면에 제시하여 비교하면서 볼 수 있는 인터페이스를 개발하였다. 이러한 시스템은 터키공화국의 Gemiler섬에 있는 교회의 데이터를 이용하여 현재 남아있는 유적과 창건당시의 모습을 복원하여 비교하면서 콘텐츠에 대한 이해를 높이고 보다 많은 지식을 얻을 수 있도록 구축되었다. We will describe the function of interactive 3D digital archive prototype system that uses VR technology. This system allows the user or viewer to automatically control the viewpoint by selecting content based on the user's particular area of interest. However, it is not enough simply to look at the content. The user also needs to understand it. Therefore, we need systems that support the user's understanding of the content. An effective method to aid in understanding is comparison. In this paper, we are constructing a prototype system using the 3D digital archive of the ruins of a church on Gemiler Island in the Turkish Republic.

한국어교육을 위한 현대시의 문화 요소 분석

오수연(Soo Yeon Oh) 학습자중심교과교육학회 2023 학습자중심교과교육연구 Vol.23 No.20

목적 본 연구에서는 한국어교육에서 현대시를 문학적인 측면보다는 문화적인 관점에서 분석하고자 하며, 문화 요소를 기반으로 분석함으로써 한국어교육에서 현대시를 더 효과적으로 활용하는 방법을 제시하는 데 있다. 방법 이 연구를 위하여 학문목적 학습자의 분포가 가장 높은 서울 소재의 12개 대학교의 한국어교재 141권에 수록된 현대시 75편에서 중복된 시편을 제외한 55편을 분석 대상으로 삼았다. 한국어교재에 수록된 현대시를 분석하기 위해서는 국가 차원에서 마련된 ‘표준 교육과정’ 중 3단계 ‘「국제 통용 한국어 표준 교육과정 활용 점검 및 보완 연구」’의 문화 범주를 활용하여 시를 문화 요소로 분류하였다. 결과 「국제 통용 한국어 표준 교육과정 활용 점검 및 보완 연구」3단계의 문화 범주를 활용하여 55편의 현대시를 문화 분류 항목인 ‘의식주문화’, ‘생활문화’, ‘언어문화’, ‘정신문화’, ‘역사문화’, ‘예술문화’, ‘전통문화’, ‘제도문화’, ‘지리문화’, ‘정보문화’의 문화 요소로 분류하였다. 문화 요소로 분류한 문화 항목 빈도수로는 ‘언어문화’가 55회, ‘지리문화’가 37회, ‘정신문화’가 36회, ‘생활문화’가 18회, ‘의식주문화’가 17회 순으로 나타났다. 결론 한국어교재 141권에 수록된 현대시 55편을 ‘표준 교육과정’의 문화 요소로 분석한 결과 ‘언어문화’에 집중되어 있었고 그 다음으로는 ‘지리문화’, ‘정신문화’ 순으로 나타났다. 낮은 빈도의 ‘제도문화’, ‘전통문화’, ‘역사문화’, ‘예술문화’가 포함된 다양한 문화 요소로 분류할 수 있는 시편들이 추가되어야 할 것으로 보인다. Objectives This study aims to analyze modern poetry from a cultural perspective rather than a literary aspect in Korean language education, and to present a way to use modern poetry more effectively in Korean language edu-cation by analyzing cultural elements. Methods For this study, 55 modern poems, excluding overlapping psalms, were analyzed from 75 contemporary poems contained in 141 Korean textbooks at 12 universities in Seoul, which have the highest distribution of aca-demic learners. In order to analyze modern poetry contained in Korean textbooks, poetry was classified as a cul-tural element using the cultural category of the third stage of the “Standard Curriculum” prepared at the national level. Results Using the cultural category of the “Checking and Complementing the Use of the International Standard Korean Curriculum,” 55 modern poems were classified into cultural elements such as “Living Culture,” “Language Culture,” “History Culture,” “Art Culture,” “Traditional Culture,” “Instrumental Culture,” and “Information Culture.” The frequency of cultural items classified as cultural elements was 55 times for “language culture,” 37 times for “geographic culture,” 36 times for “spiritual culture,” 18 times for “living culture,” and 17 times for “receiving culture.” Conclusions As a result of analyzing 55 modern poems contained in 141 Korean textbooks as cultural elements of the “standard curriculum,” they were concentrated on “language culture,” followed by “geographical culture” and “mental culture.” Psalms that can be classified into various cultural elements including low frequency ‘institutional culture’, ‘traditional culture’, ‘historical culture’, and ‘art culture’ should be added.