신경염증과 정신질환

송후림,이화영,심세훈,권영준,Song, Hoo Rim,Lee, Hwa-Young,Shim, Se-Hoon,Kwon, Young-Joon 대한생물정신의학회 2016 생물정신의학 Vol.23 No.1

Neuroinflammation is one of important allostatic loads contributory to the various psychiatric illness. It is mediated mainly by glial cells, which produce both proinflammatory and antiinflammatory cytokines, and the balance of them determines the inflammatory process in the central nervous system. S100 calcium-binding protein B, which is used as an inflammatory marker is also released by glial cells. In the molecular level, oxidative stress contributes to the neuroinflammation. Their disturbances have been revealed in the psychiatric illness and related with the dysregulation of the glutamatergic and monoaminergic systems. There is a possibility to use them as disease markers. The approach for inflammation using antiinflammatory drugs and antioxidants could be connected to the development of disease-modifying treatments. Also, a searching examination about specific subtypes who are vulnerable to inflammation in the patients is required to confirm their efficacy clearly.

소방공무원의 수면의 질에 대한 영향요인

오진욱,고미애,송후림,홍민하,김현수,김우정,Oh, Jinuk,Ko, Miae,Song, Hoo Rim,Hong, Min Ha,Kim, Hyun Soo,Kim, Woo Jung 한국정신신체의학회 2018 정신신체의학 Vol.26 No.1

연구목적 소방공무원은 업무의 특수성으로 인해 충격적인 사건에의 잦은 노출, 업무 시 높은 긴장감, 교대근무 등을 경험하게 되며, 불면을 호소하는 비율도 일반 인구에 비해 높은 편이다. 소방공무원의 수면의 질은 개인적인 삶의 만족도에 영향을 줄 뿐만 아니라, 국민의 안전을 위한 업무수행에도 영향을 미칠 수 있다. 소방공무원의 수면의 질 개선을 위해, 수면에 영향을 미치는 요소를 알아보고자 하였다. 방 법 서울 및 경기 지역 3개 소방서에 120부의 설문조사지를 인편으로 전달 후, 서면 동의를 받고 설문을 시행했으며, 93부의 설문지를 수거하였다. 소방공무원을 대상으로 알코올 사용, 흡연 여부, 교대근무, 사회경제적 상태, 정신과적 치료 과거력 등을 조사했으며 수면의 질, 우울감, 불안감, 충격적인 외상의 경험 및 직무 관련 스트레스에 대해 자가보고식 설문을 시행하였다. 수면의 질에 따라 소방공무원을 두 그룹으로 나누어서 조사된 각 변수들을 비교하고, 그 결과에 따라 로지스틱 회귀분석을 실시하였다. 결 과 수면의 질이 불량한 군에서 현재 알코올 사용, 우울감, 불안감 및 충격적인 사건의 경험이 유의하게 높게 나타났으며, 다변량분석을 통해 현재 알코올 사용이 수면에 유의한 영향을 주는 요소로 나타났다(Crude odds ratio=3.707, 95% confidence interval=1.288-10.672, p=0.015 ; Adjusted odds ratio=3.288, 95% confidence interval=1.011-10.694, p=0.048). 결 론 알코올 사용, 우울감, 불안감, 충격적인 사건의 경험이 수면의 질에 각각 영향을 미치는 것으로 나타났으며, 개별적 연관이 있는 요인들을 함께 고려했을 때 현재 알코올 사용 여부가 수면에 질에 유의한 영향을 주는 것으로 나타났다. 소방공무원의 수면의 질 개선을 위해서는, 알코올 사용에 대한 평가, 알코올 사용으로 인한 수면의 질 저하에 대한 교육, 알코올 사용을 줄이기 위한 구체적인 방안들을 마련하는 것이 필요할 것으로 보인다. Objectives : Firefighters frequently experience traumatic events, high-tension situations and shift work. Therefore, the prevalence of insomnia of firefighters is higher than one of general population. Not only does the quality of sleep affect the satisfaction of personal life, but it also influences their performance for the public's safety. We investigated which factors affect the quality of sleep of firefighters. Methods : After personally delivering 120 questionnaires to 3 fire stations, the survey was conducted when the consents were signed. It inquired about alcohol use, smoking, shift work, sleep quality, depression, anxiety, and experience of traumatic events. We then divided the firefighting officers in two groups according to the quality of sleep and compared the variables examined to conduct the logistic regression analyses according to the results. Results : The poor sleeper group reported a higher level of current alcohol consumption, depression, anxiety and experience of traumatic events. Logistic regression analyses showed that the current alcohol intake (Crude odds ratio=3.707, 95% confidence interval=1.288-10.672, p=0.015 ; Adjusted odds ratio=3.288, 95% confidence interval=1.011-10.694, p=0.048) has a significant effect on sleep quality. Conclusions : Current alcohol consumption, depression, anxiety and experience of traumatic events were respectively associated with sleep quality of firefighters. When all significant factors considered, the current alcohol use was the only statistically significant. To improve the quality of sleep for firefighters, it will be necessary to evaluate alcohol intake, educate the poor sleep quality caused by alcohol, and provide specific interventions to reduce consumption.

양극성 조증 입원 환자에서 과체중, 비만과 연관 인자 : 예비 연구

정영은,서호준,송후림,왕희령,전태연,박원명,Jung, Young-Eun,Seo, Ho-Jun,Song, Hoo-Rim,Wang, Hee-Ryung,Jun, Tae-Youn,Bahk, Won-Myong 대한불안의학회 2010 대한불안의학회지 Vol.6 No.2

Objective : Being overweight or obesity impairs quality of life and often causes treatment noncompliance in patients with bipolar disorder. This preliminary study evaluated the prevalence of overweight and obesity in inpatients with bipolar mania. Methods : Inpatients with bipolar mania, who were treated with adequate medications at least 4 weeks were included in a retrospective study. The body weight of each patient was measured and the body mass index (BMI) was calculated. Results : Of the 80 patients, 16.4% (N=13) were overweight, and 35.0% (N=28) were obese at discharge. Female patients had higher prevalence rates of overweight and obesity. Being overweight or obesity was associated with the number of previous episodes of depression and combination treatment with atypical antipsychotics and mood stabilizers. Conclusions : Being overweight or obesity is highly prevalent in patients with bipolar mania. Clinicians should pay more attention to weight gain and obesity when prescribing combination therapies. More research is required to identify the impact of specific risk factors for overweight and obesity in patients with bipolar mania.

한국판 저장행동평가척도의 표준화 연구

이혜민,장진구,송후림,이수영,홍민하,김세주,김찬형,Lee, Hye Min,Chang, Jhin Goo,Song, Hoo Rim,Lee, Soo Young,Hong, Minha,Kim, Se Joo,Kim, Chan-Hyung 대한불안의학회 2021 대한불안의학회지 Vol.17 No.2

Objective : The Hoarding Rating Scale-Self-Report (HRS-SR) is a five-item scale that simply assesses the hoarding symptoms. We evaluated the factor structure, reliability, and validity of the Korean version of the HRS-SR (HRS-SR-K). Methods : A total of 144 individuals completed the self-administered questionnaires including HRS-SR-K, Obsessive-Compulsive Inventory-Revised-Korean version (OCI-R-K), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Psychometric properties of the HRS-SR-K were analyzed. Results : The Cronbach's α value for internal consistency of the HRS-SR-K was excellent (Cronbach's α=0.84). The construct validity was analyzed on the basis of principal component analysis and one-factor structure of the original scale was maintained. The HRS-SR-K total score and each item scores were more strongly correlated with the hoarding subscale score in OCI-R-K (convergent validity, r=0.71, p<0.01) than the corresponding scores of nonspecific depression or anxiety measures (discriminant validity). Conclusion : The HRS-SR-K is a simple and reliable self-report scale for examining the severity of hoarding symptoms.

2020 이주 노동자 자살예방을 위한 정신건강실태조사

김숙진(Suk Jin Kim),송후림(Hoo Rim Song),김미선(Mi Sun Kim),이애란(Ae ran Lee),김유나(Yu Na Kim),김선영(Sun Young Kim),이서정(Seo Jung Lee) 대한사회정신의학회 2022 사회정신의학 Vol.27 No.1

목 적 : 본 연구는 이주 노동자 자살 예방사업 일환으로 이주 노동자들의 전반적 정신건강 실태와 자살에 대한 인식 및 경험에 대해 파악하여 시사점을 도출하고자 하였다. 방 법 : 2020년 6월 11일부터 7월 23일까지 국내에 거주하는 네팔, 중국, 미얀마 3개국 출신의 이주 노동자 총 102명을 대상으로 전반적 인구학적 정보 및 정신건강 실태 조사를 위해 우울감에 대한 자가 척도(The Center for Epidemiologic Studies Depression Scale [이하CES-D])를 수집하였다. 결 과 : 조사 참여자들은 스스로 느끼는 자신의 전반적 건강 상태가 보통 이상인 경우가 95명(93.1%), 주관적 행복감이 보통 수준 이상인 경우 90명(88.2%)이었다. 자가 보고형 우울 척도인 CES-D의 평균 점수는 13.9±10.4점으로 나타났다. CES-D 점수 분포는 15점 이하로 정상 범위가 68명(66.6%), 16-20점 사이로 경도 우울 상태가 13명(12.7%), 21-24점으로 중등도 우울 상태가 6명(5.8%), 25점 이상으로 고도 우울 상태가 15명(14.7%)이었다. 출신 3개국 간 CES-D 평균 점수는 통계학적으로 차이가 없었으나, 21점 이상 우울군은 네팔 출신 노동자들이 높게 나타났다. 결 론 : 본 연구에서는 다수의 이주 노동자들의 우울 점수가 정상 범위로 나타났으나, 우울 상태에 해당되는 경우에는 경도나 중등도 우울 상태인 비율보다 상대적으로 고도 우울 상태인 비율이 높게 나타났다. 이는 향후 이주민 노동자들 전반에 걸친 정신건강 서비스에 더하여 고도의 우울, 즉, 자살 고위험군을 발굴하고 이에 초점을 맞춘 서비스 개발이 필요함을 시사한다. Objectives : This study aimed to examine Korean migrant workers’ mental health status and perceptions and the experiences of suicide as part of suicide prevention program to derive its social implications. Methods : A sample of 102 migrant workers from Nepal, China, and Myanmar residing in Korea from June 11th to July 23rd, 2020 completed a self-administered depression scale (The Center for Epidemiologic Studies Depression Scale [CES-D]). Re-sponses were collected to investigate participants’ demographic data and mental health condition. Results : Of the survey participants, 95 (93.1%) had greater than average mental health status, and 90 (88.2%) participants' subjective feeling of their well-being was above average. The average score for CES-D was 13.9±10.4 points. The distribution of CES-D scores was in the normal range (≤15 points) in 68 (66.6%) participants, 13 (12.7%) participants had mild depressive status, 6 (5.8%) participants had moderate depressive status (21-24 points), and 15 (14.7%) participants had a high depressive status (≥25 points). There was no statistically significant difference in the average CES-D scores of migrant workers from the three countries of origin, but workers from Nepal showed higher scores in the high depressive status group, with scores of 21 or higher. Conclusion : In this study, most migrant workers demonstrated a normal mental health status. Regarding those in a depressive state, the proportion of those in a high depressive state was relatively higher than that of those in a mild or moderate depressive state. This result suggests that in addition to mental health services targeting migrant workers, it is necessary to discover groups at high risk of high-level depression and suicide to develop services focusing on them.

도시 쉼터 남성 노숙인의 우울, 아동기외상, 울분에 따른 중독 특성과의 관련성

정희연(Heeyeon Chung),조선진(Sun-Jin Jo),송후림(Hoo Rim Song),홍민하(Minha Hong),김우정(Woo jung Kim),김영종(Young-Jong Kim),김현수(Hyun-Soo Kim) 한국중독정신의학회 2017 중독정신의학 Vol.21 No.2

Objectives : This study investigated the effects of depression, child trauma, and embitterment on the characteristics on the addiction problems in homeless men. Methods : The subjects were 120 homeless men from a city shelter in Seoul. Questionnaires with socio-demographic and psychiatric content were administered. The instruments included the Patient Health Questionnaire-9, the Childhood Trauma Questionnaire, the Post-Traumatic Embitterment Disorder Self-rating Scale, the Alcohol Use Disorders Identification Test, the Fagerstrom Test for Nicotine Dependence, the Canadian Problem Gambling Index, and the Smartphone Addiction Scale-Short Form. We analyzed the demographic data, score of the above instruments, and frequencies of the addiction problems in homeless men. Results : Depressed subjects displayed significantly higher frequencies in problematic alcohol use, nicotine dependence, and problematic gambling. The child trauma group had significantly higher frequency in problematic alcohol use. The embitterment group exhibited significantly higher frequencies in problematic alcohol use, nicotine dependence, problematic gambling, and problematic smartphone use. Conclusion : The study findings suggest that homeless men with depression, child trauma, embitterment have higher frequencies in addiction problems compared to homeless men without those factors.

소년원생들의 우울증 예측에 기계학습을 적용한 예비연구

손동훈(Dong Hun Son),장진구(Jhin Goo Chang),송후림(Hoo Rim Song),이수영(Su Young Lee),이승훈(Seung Hoon Lee),방수영(Soo-Young Bhang),이미선(Mi-Sun Lee),김현수(Hyun-Soo Kim),홍민하(Minha Hong) 대한사회정신의학회 2021 사회정신의학 Vol.26 No.2

연구목적 : 청소년 범죄에서 정신건강의 문제와 범죄가 관련성이 높다는 것은 잘 알려져 있지만 국내에서는 아동청소년 범죄자들의 정신건강에 관한 연구가 거의 없다. 뿐만 아니라 아동청소년정신건강 영역에서 기계학습을 적용한 연구는 아직 초기단계이다. 본 예비연구에 서는 여자청소년 재소자들에서 정신건강 문제 중 우울증의 예측에 기계학습 알고리즘을 적용하여 적합한 지를 알아보고자 한다. 방 법 : 대상자는 청주소년원에 재소중인 87명의 여자청소년을 대상으로 하였다. 대상자들에게 설문지 패키지 (인구학적 정보, 범죄관련 정보, 자기보고척도 설문지(아동기부정적경험 설문지, 벡우울척도)를 배부하여 정보를 수집하였다. 기계학습 기법을 이용하여 수집된 재소자들의 기본 정보를 바탕으로 우울증을 예측할 수 있는 6개의 모델(Logistic regression, Random forest, Supportive vector machine, Decision tree, Nearest neighbor, Adaboost)을 생성하여 각 모델간의 예측 성능을 비교해 보았다. 결 과 : 대상자를 벡우울척도(절단점 13)로 군을 분류한 결과 정상군 18명(21%)과 우울증군 69명(79%)이었다. 6개 모델의 우울증 예측 정확도는 Logistic regression 81.8%, Random forest 81.8%, Supportive vector machine 68.18%, Decision tree 72.7%, Nearest neighbor 77.3%, Adaboost 63.6%였다. 그중에서 Random forest 모델의 AUC score는 0.75로 다른 모델들과 비교하여 가장 높았다. 결 론 : 본 연구는 재소청소년의 정신건강에 중점을 두어 현황을 파악하고,우울증의 예측에 기계학습 기법을 적용을 하여 높은 정확도를 확인하였다는 점에서 의의가 있다. 또한 취약계층의 정신건강 영역에 기계학습 기법을 적용하여 관리 및 감시에 적용 가능성에 대한 근거를 제공하였다. Objectives : It is well known that mental health problems and crime are highly related to youth crime, but there is little research on the mental health of young offenders in Korea. Furthermore, research on the application of machine learning in the mental health of children and adolescents is still novel. This preliminary study aims to investigate whether it is appropriate to apply machine learning algorithms to predict depression among female adolescent inmates. Methods : The subjects were 87 young females in Cheongju Juvenile Center. A questionnaire was distributed to the subjects to gather their demographic information and crime-related information, as well as their adverse childhood experiences and Beck depression inventory scores using self-reported scale questionnaires. Based on the collected information, six models (logistic regression, random forest, supportive vector machine, decision tree, nearest neighbor, Adaboost) that can predict depression were created to compare the predictive performance between models using machine learning techniques. Results : Results showed that 29 victims (25.7%) met the criteria of PTSD and 19 victims (16.8%) met the rigid criteria of PTSD. But, according to the subscales, 41 victims (36.3%) were diagnosed as PTSD. Victims with PTSD had more serious depression, anxiety, sleep disturbance, anger, social withdrawal and life stresses. Conclusion : This study identified the current mental health status of female inmates with high accuracy by applying machine learn-ing techniques to predict depression. The applicability of machine learning techniques to the management and surveillance of mental health in vulnerable groups was also highlighted.

전수면박탈이 정상인의 생리기능과 인지기능에 미치는 영향

정종현,송후림,신윤경,한진희,이성필,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Purpose of this study was to investigate physiological and neurocognitive effects of total sleep deprivation by using laboratory blood tests and the computerized neurocognitive function test in healthy subjects. Methods : Sixteen healthy volunteers participated in this study. Subjects were recommended to remain awake for 48 hour sunder continuous surveillance. Lab tests of cortisol, Prolactin, thyroid hormone, growth hormone, and immunoglobulin (IgG, IgA, IgM, IgD, IgE), CBC, BC and the Vienna test were performed before and after 48 hours of total sleep deprivation. Results : Concentration of T3 and T4 significantly increased after deprivation. In the reaction test, distribution reaction time significantly increased, and correct reaction significantly decreased. In the vigilance test, amount of correct reaction Signifi-cantly decreased, and the mean value of correct reaction time was significantly delayed. Level of fasting blood sugar, total protein, albumin, alkaline phosphatase and potassium significantly increased, respectively, except for the level of total bilirubin which was decreased. After total sleep deprivation, WBC counts significantly increased. Regarding immunoglobulin level, IgG,IgA and Ag M concentrations appeared to decrease, but the results were not statistically significant. Conclusion : The effect of total sleep deprivation on physiological function was significant in the level of thyroid hormone. Although statistically not significant, the results of growth hormone and the immune system showed a trend in relations to the effect oftotal sleep deprivation. Results of blood chemistry suggest that sleep dephvation may influence metabolism Of hepato-biliary system. Cognitive impairment was also seen in reactive and vigilant functions after total sleep deprivation.