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홍민하,Duk Soo Moon,HyejungChang,Seung Yup Lee,Seong Woo Cho,Kyung-Sook Lee,Jin-Ah Park,Sang Min Lee,GeonHoBahn 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.2
ObjectiveaaWe aimed to investigate the current diagnostic incidence, and medical and psychiatric comorbidities of reactive attachment disorder (RAD) using the National Health Insurance Review and Assessment (HIRA) claims data. MethodsaaTo examine the diagnostic incidence, we selected patients who were under 10-year-old and who had at least one medical claim containing a 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for RAD (F94.1 and F94.2) and who had not been diagnosed in the previous 360 days, from 2010 to 2012. In this study, we used the term ‘reactive attachment disorder’ representing for both RAD per se and Disinhibited social engagement disorder. Comorbid disorders were categorized according to ICD-10. ResultsaaAmong 14,029,571, the total population under 10-year-old during 2010–2012, incident cases of RAD were 736. The mean diagnostic incidence of RAD was 5.25 per 100,000 annually. Language disorders (F80-84) were the most common psychiatric comorbidities in both boys and girls in age groups 0–3 years and 4–6 years, and attention deficit hyperactivity disorder was the most common in both sex aged 7–9 years. In non-psychiatric comorbidities, diseases of the respiratory system (J00–99) were the commonest in both sex in all age groups, and diseases of the digestive system (K00–99) were the next. ConclusionaaRAD was very rare in practice and would be disguised as other psychiatric disorders. Children with RAD might have more medical comorbidities than typically developed children.
홍민하,김봉석,황준원,방수영,최형윤,오인환,이연정,반건호 대한의학회 2016 Journal of Korean medical science Vol.31 No.4
We examined short- and long-term medication compliance among youth with attentiondeficit hyperactivity disorder (ADHD), using data from the National Health Insurance database in Korea. Of the 5,699,202 6-14-year-old youth in 2008, we chose those with at least 1 medical claim containing an ICD-10 code for diagnosis of ADHD (F90.0) and no prescription for ADHD within the previous 365 days. We tracked the data every 6 months between 2008 and 2011, to determine treatment compliance among newly diagnosed, medicated patients. Further, we checked every 1 month of the 6 months after treatment commencement. Treatment continuity for each patient was calculated by sequentially counting the continuous prescriptions. For measuring compliance, we applied the medication possession ratio (MPR) as 0.6, 0.7, and 0.8, and the gap method as 15- and 30-days’ intervals. There were 15,133 subjects; 11,934 (78.86%) were boys. Overall 6-month treatment compliance was 59.0%, 47.3%, 39.9%, 34.1%, 28.6%, and 23.1%. Monthly drop-out rates within the first 6 months were 20.6%, 6.5%, 4.7%, 3.7%, 3.0%, and 2.5%, respectively. When applying MPR more strictly or shorter gap days, treatment compliance lessened. This is the first nationwide report on 36-month treatment compliance of the whole population of 6-14-year-olds with ADHD. We found the beginning of the treatment, especially the first month, to be a critical period in pharmacotherapy. These results also suggest the importance of setting appropriate treatment adherence standards for patients with ADHD, considering the chronic course of ADHD.
프로모션 음료 패키지디자인의 뉴트로 트렌드에 따른 표현 분석
홍민하,남용현 한국일러스트레이션학회 2020 일러스트레이션 포럼 Vol.21 No.65
어느 시대에나 과거는 존재한다. 과거의 것을 추억 하며 동경하는 ‘레트로(Retro)’를 기반으로 대한민국 은 현재 ‘뉴트로(Newtro)’가 새로운 바람을 일으키고 있다. 이러한 트렌드에 맞춰 장수 음료 브랜드들이 뉴트로 프로모션 패키지디자인을 선보이는 사례가 눈 에 띄고 있다. 그래서 뉴트로 디자인의 무엇이 소비 자의 이목을 끌고 있는가와 그 특성을 분석하고자 한 다. 연구 방법으로는 문헌 조사를 통한 뉴트로 디자인 을 정의하고, 뉴트로 디자인의 현황을 조사하였다. 그 후 뉴트로를 활용한 패키지디자인의 사례를 수집하여 선정기준에 따라 선정하였으며, 시각적 특성을 살펴 보고자 패키지디자인의 6가지 요소를 설정하여 분석 하였다. 연구 결과, 색상의 간소화, 타이포그래피의 크기와 디자인의 변화, 일러스트를 통한 제품 특징 설명을 확인할 수 있었다. 레이아웃 또한 단순화되어 타이포 그래피나 캐릭터를 더 강조하고 있었다. 본 연구는 향후 뉴트로를 활용한 음료 패키지디자인의 시각적 요소 분석을 위한 자료로서 활용되기를 기대한다. The past exists in all ages. Based on "Retro," which recalls and yearns for the past, South Korea is currently creating a new wind called “Newrto”. In line with this trend, there is a case of introducing package design as a promotion for long-lived beverage brands. So Newtro design’s what attracts consumers' attention and analyze its characteristics. Newtro design was defined through literature research as research method, and the status of newtro design. Afterwards, cases of package design using Newtro were collected and selected according to the selection criteria, and six elements of package design were set up and analyzed to examine the visual characteristics. The results of the study showed the simplification of color, the size and design changes of typography, and the explanation of product characteristics through illustration. The layout was also simplified, putting more emphasis on typography or characters. This study is expected to be used as data for analyzing visual elements of beverage package design using newtro in the future.
홍민하,김미아,김태운,박상서,김명기,박영자,성윤희,신말순 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.S1
Purpose: Thrombotic stroke is a type of ischemic stroke characterized by motor dysfunction and memory impairments. In the present study, the effect of treadmill exercise on motor function and short-term memory was evaluated in relation with synaptic plasticity in the mice with photothrombotic stroke.Methods: Photothrombotic stroke was induced by cortical photothrombotic vascular occlusion. The mice in the treadmill exercise groups performed running on a motorized treadmill for 28 days. Motor function was determined using rota-rod test and foot fault test. Step-through avoidance task was conducted to evaluate short-term memory. Immunohistochemistry for 5-bromo-2′-deoxyuridine and doublecortin was conducted to detect new cell generation. Postsynaptic density protein 95, synaptophysin, brain-derived neurotrophic factor (BDNF), and tyrosine kinase B receptor (TrkB) were determined using western blot. The number of dendritic spines was determined using Golgi stain.Results: Treadmill exercise improved motor function and short-term memory in mice with the photothrombotic stroke. The infarct size was reduced and the number of dendritic spines and expression of postsynaptic density protein 95 and synaptophysin in the peri-infarct cortex and hippocampus were increased by treadmill exercise in photothrombotic stroke mice. Treadmill exercise enhanced neurogenesis through increasing the expression of the hippocampal BDNF and TrkB in photothrombotic stroke mice.Conclusions: Treadmill exercise improved motor function and short-term memory through increasing synaptic plasticity and neurogenesis in photothrombotic stroke mice. Treadmill exercise can be used as an effective treatment strategy to improve brain function related to stroke.
홍민하,이승엽,한주희,박진철,이연정,황보람,장혜정,조성우,방수영,김봉석,황준원,반건호 대한의학회 2017 Journal of Korean medical science Vol.32 No.10
Children with autism are often medicated to manage emotional and behavioral symptoms; yet, data on such pharmacotherapy is insufficient. In this study, we investigated the Korean National Health Insurance Claims Database (NHICD) information related to autism incidence and psychotropic medication use. From the 2010–2012 NHICD, we selected a total of 31,919,732 subjects under 19 years old. To examine the diagnostic incidence, we selected patients who had at least one medical claim containing an 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for pervasive developmental disorder, F84, not diagnosed in the previous 360 days. Psychotropics were categorized into seven classes. Then, we analyzed the data to determine the mean annual diagnostic incidence and psychotropic prescription trends. Diagnostic incidence was 17,606 for the 3 years, with a mean annual incidence per 10,000 population of 5.52. Among them, 5,348 patients were prescribed psychotropics. Atypical antipsychotics were the most commonly used, followed by antidepressants. An older age, male sex, and the availability of medical aid were associated with a higher rate of prescription than observed for a younger age, female sex, and the availability of health insurance. Psychotropic drugs were used for less than one-third of patients newly diagnosed with autism, and prescription differed by sex and age. Increased diagnostic incidence is associated with an increased prescription of psychotropic drugs. Therefore, medication-related safety data and policies for psychotropic drugs in autism should be prepared.
도서 정보·본문텍스트 통합 마이닝 기반 사용자 참여 형 시각화 및 추천 큐레이션 플랫폼 개발에 관한 연구
홍민하 ( Min-ha Hong ),최건희 ( Gun-hee Choi ),박경훈 ( Kyoung-hoon Park ),정광철 ( Kwang-chul Jung ),김승훈 ( Seung-hoon Kim ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
오늘날 인터넷의 발달과 전자 책(e-Book) 시장규모가 커짐에 따라 온라인을 통한 도서 정보 제공이 증가하고 있다. 하지만 현재 도서 정보나 도서 추천을 제공하는 온라인 사이트들은 기본 서지 정보만을 위주로 제공하고 있어 도서 본문을 활용한 정보 제공 및 추천 시스템의 필요성이 증가하고 있다. 따라서 본 논문에서는 도서 본문을 활용한 정보 제공 및 개인 맞춤형 추천을 위해 ‘도서 정보·본문텍스트 통합 마이닝 기반 사용자 참여형 시각화 및 추천 큐레이션 플랫폼’ 을 제안하고, 이를 구축하였다. 제안한 서비스 플랫폼은 독자에게 다양한 방법으로 도서 정보를 제공하며, 독자는 적은 시간으로 많은 정보를 얻을 수 있도록 하여 사용자의 도서 선택의 폭을 넓혀줄 것이다.