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랫드에서 Sodium Hyaluronic Acid Solution과 가교처리한 Hyaluronic Acid Gel 혼합액의 복강내 유착 형성 방지 효과
송문용,강규일,황원구,최완규,김현희,허호진,장환수,박현정,장광호,권영삼 한국임상수의학회 2011 한국임상수의학회지 Vol.28 No.1
This study was performed to evaluate the efficacy of 0.8% sodium hyaluronic acid solution and crosslinked hyaluronic acid mixture for the prevention of postoperative intraperitoneal adhesion in rats. Forty-five animals were divided into three groups ; 0.9% saline treated control group, 1% sodium carboxymethyl cellulose treated group (SCMC),and 0.8% sodium hyaluronic acid solution and crosslinked hyaluronic acid mixture treated group (SHCH). Adhesions were induced by suturing both the ileal serosa and peritoneum abrased until petechial bleeding occurred. Fourteen days later, adhesions were evaluated clinically and histopathologically. The mean tensile strength was significantly decreased in the SCMC and SHCH groups compared to the control group (p < 0.05), and the SHCH group had the lowest tensile strength. The distance of adhesion site was highest in the control group and significantly decreased in the SHCH group comparing control group (p < 0.05). The inflammatory cell infiltration, collagen hyperplasia and neovascularization of the SCMC and SHCH groups were significantly lower than the control group (p < 0.05). Therefore,it was concluded that the SHCH may be useful to prevent postoperative intraperitoneal adhesion in rats.
김영흥,송문용 한국임상수의학회 1998 한국임상수의학회지 Vol.15 No.1
The purposes of the present study were to evaluate the effect of estrone on the prevention of implantation and pregnancy and the concentrations of estradiol and progesterone or sodium and potassium in the plasma or uterine fluid of pregnant rats injected a single dose of 0, 0.1, 0.4 or 1.0 mg on days 5, 9, or 13 of pregnancy. The body weight gains of pregnant rats were significantly decreased in administering estrone on day 5 of pregnancyi no effect obtained on days 9 or 13. Numbers of viable fetuses were significantly decreased and pre- and post-implantation loss increased by administering estrone 0.1, 0.4 or 1.0 mg and numbers of implantation sites significantly increased by administering estrone 0.1 mg but significantly decreased or not occurred by 0.4 or 1.0 mg on day 5 of pregnancy, respectively, but no effect obtained on days 9 or 13. Plasma estradiol concentrations of pregnant rats were significantly increased on 1, 2 or 18 days after treatment with estrone (1.4 or 1.0 mg and 3 days after 0.4 mg on day 5 of pregnancy, respectively. But plasma progesterone concentrations had no effect on the treatment with estrone. Plasma sodium contents were significantly increased on 1 day after treatment with estrone 0.1 or 1.0 mg and 3 days after 0.1 mg on day 5 of pregnancy, respectively, except potassium content were no detectable change. Sodium contents in uterine fluid were significantly increased on 1 day after treatment with estrone 1.0 mg and 3 days after 0.1, 0.4 or 1.0 mg on day 5 of pregnancy, respectively. And potassium contents were significantly increased on 1 or 2 days after treatments with estrone 0.1 mg but significantly decreased on 3 days after 0.4 or 1.0 mg on day 5 of pregnancy, respectively. It is suggested that the prevention of implantation and failure of pregnancy could be induced by treatment with estrone 0.4 mg on day 5 of pregnancy and might be interrelated with changes of plasma estradiol concentration and sodium and potassium contents in uterine fluid.
유민숙,송문용,김민하,김동수 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.9
Lithium polymer batteries are an improvement from the existing lithium ion batteries in terms of the risks of electrolyte leakage and explosion. Demand for lithium polymer batteries is rapidly increasing because of their advantages such as stability, light, and higher degree of freedom of shape. Accordingly, the demand for aluminum pouches, which are the exterior material of lithium polymer batteries, is increasing and research and development of aluminum pouches are actively being conducted. In the case of aluminum pouches, the forming area and depth that can accommodate the battery cell are increased according to the capacity of the battery, and stable formability is essential for aluminum pouches. In this study, manufacturing processes were changed to examine ways to improve formability. First, by changing the process order so that the surface treatment coatings on both sides of the aluminum foil were carried out simultaneously, the number of times when there was contact of the nylon film with the work roll was reduced. As a result, formability was improved because damage to the surface of the nylon film was reduced and the slipperiness was maintained. In addition, with regard to the drying temperature of the adhesive that constitutes the innermost layer, as the drying temperature increased (120 °C), solvent volatility increased, leading to stronger adhesion between the interfaces and resulting in improved formability.
Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
윤성호,박지희,박정규,김만섭,김달원,송문용,황원구,구세광,장광호,권영삼 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.5
The objective of this study was to compare the biocompatibility for local irritation and bioavailability of GentacolTM and CollatampTM, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both GentacolTM and CollatampTM loaded regions. No detectable gentamicin was observed in the plasma of GentacolTM and CollatampTM loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of CollatampTM and GentacolTM. These results suggest GentacolTM may show favorable local bioavailability and induce only slight local irritations as comparable as CollatampTM without systemic exposures in the condition of this experiment.
Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
윤성호,박지희,박정규,김만섭,김달원,송문용,강규일,황원구,구세광,장광호,권영삼,Yun, Sung-Ho,Park, Jihee,Park, Jeongkyu,Kim, Manseop,Kim, Dalwon,Song, Moon-Yong,Kang, Gyoo-Il,Hwang, Won-Koo,Ku, Sae-Kwang,Jang, Kwang-Ho,Kwon, Young-Sam The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
The objective of this study was to compare the biocompatibility for local irritation and bioavailability of $Gentacol^{TM}$ and $Collatamp^{TM}$, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded regions. No detectable gentamicin was observed in the plasma of $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of $Collatamp^{TM}$ and $Gentacol^{TM}$. These results suggest $Gentacol^{TM}$ may show favorable local bioavailability and induce only slight local irritations as comparable as $Collatamp^{TM}$ without systemic exposures in the condition of this experiment. 본 연구의 목적은 겐타마이신 함유 스폰지인 겐타콜과 콜라템프를 랫드 근육내 이식 후 생체적합성을 비교하는 것이다. SD 랫드 66 마리를 네 그룹으로 나누었다; (1) 대퇴사두근에 무처치한 군 (대조군, 6 마리), (2) 대퇴사두근에 겐타마이신 액을 주사한 군 (겐타마이신 군, 6 마리), (3) 대퇴사두근에 콜라템프를 이식한 군 (콜라템프 군, 27마리), (4) 대퇴사두근에 겐타콜을 이식한 군 (겐타콜 군, 27 마리). 겐타콜과 콜라템프 이식 한근육 내 겐타마이신 농도는 시간이 지남에 따라 점차 감소하였다. 혈액 내에 겐타마이신 농도는 측정되지 않았다. 조직학적으로 겐타마이신액을 주사 후 근육 내에 다형핵백혈구, 림프구, 대식세포를 포함하는 염증세포가 중등도에서 심하게 침윤되었고, 경도에서 중등도의 근육내 부종이 관찰되었다. 그러나, 이러한 국소 자극의 조직학적 변화는 콜라템프와 겐타콜 군에서는 현저히 감소하였다. 이상의 결과, 겐타콜은 콜라템프와 비교하였을 때에 전신적인 영향을 미치지 않으며 국소자극의 정도가 유사하였고, 생체이용성이 유사하여 좋은 생체적합성을 가지는 것으로 생각된다.