Relationship between Incidence of Endometritis and Metabolic Status during Peri- and Postpartum Periods in Dairy Cows

정재관,최인수,강현구,정영훈,허태영,김일화,Jeong, Jae-Kwan,Choi, In-Soo,Kang, Hyun-Gu,Jung, Young-Hun,Hur, Tai-Young,Kim, Ill-Hwa The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2

본 연구는 임상형 혹은 준임상형 자궁내막염에 이환된 젖소와 자궁내막염이 발생되지 않은 젖소 사이에 분만 전 후 기간 동안 혈액 대사물질의 농도를 비교하였다. 분만 전 4주, 분만 후, 분만 1, 2, 4, 6주 후 혈액을 채취하였으며, 혈청 분리 후 calcium, magnesium, non-esterified fatty acids (NEFAs), total cholesterol, albumin, urea nitrogen, ${\beta}$-hydroxybutyrate (BHBA), aspartate aminotransferase (AST), ${\gamma}$-glutamyltransferase, glucose 및 phosphorus 농도를 측정하였다. 분만 후 4주에, 임상형 혹은 준임상형 자궁내막염 발생 유무에 따라 대조군(n = 104), 임상형 자궁내막염군(n = 66) 및 준임상형 자궁내막염군(n = 37)으로 구분하였다. Calcium과 magnesium 농도는 실험 전 기간에 걸쳐 임상형 자궁내막염군이 대조군과 준임상형 자궁내막염군에 비해 낮았으나(p < 0.05 to 0.0001), NEFAs 농도는 실험전 기간에 걸쳐 임상형 자궁내막염군이 대조군에 비해 높았다(p < 0.01). Total cholesterol 농도는 분만 전 및 분만 후 기간 중 임상형 자궁내막염군이 대조군과 준임상형 자궁내막염군에 비해 낮았다(p < 0.05 to 0.001). Albumin 농도는 분만 후 기간 동안 임상형 자궁내막염군이 대조군과 준임상형 자궁내막염군에 비해 낮았다(p < 0.05 to 0.001). Urea nitrogen 농도는 분만 후 4주 및 6주에 임상형 자궁내막염군이 대조군과 준임상형 자궁내막염군에 비해 낮았다(p < 0.01). 분만 후 1주에, BHBA 농도는 임상형 자궁내막염군이 대조군에 비해 높았으나(p < 0.01), AST 농도는 임상형 자궁내막염군과 준임상형 자궁내막염군이 대조군에 비해 높았다(p < 0.05). 결론적으로, 분만 후 혈청 calcium, magnesium, total cholesterol, albumin 및 urea nitrogen 농도의 감소와 NEFAs, BHBA 및 AST 농도의 증가가 임상형 자궁내막염의 발생과 관련되었으며, 이것은 전환기 중의 균형 잡힌 영양의 중요성을 제시한다. This study compared blood metabolites during peri- and postpartum periods among cows with clinical or subclinical endometritis and cows without endometritis. Blood samples from 207 Holstein dairy cows were collected at 4 weeks prepartum, just after calving, and at 1, 2, 4, and 6 weeks postpartum to measure serum concentrations of calcium, magnesium, non-esterified fatty acids (NEFAs), total cholesterol, albumin, urea nitrogen, ${\beta}$-hydroxybutyrate (BHBA), aspartate aminotransferase (AST), ${\gamma}$-glutamyltransferase, glucose, and phosphorus. Clinical endometritis was diagnosed by the observation of vaginal discharge (> 50% pus) and subclinical endometritis was diagnosed by the evaluation of uterine cytology (> 18% neutrophils) at 4 weeks postpartum. Cows were divided into three groups based on the presence or absence of clinical or subclinical endometritis: the control group (n = 104), the clinical endometritis group (n = 66), and the subclinical endometritis group (n = 37). Calcium and magnesium concentrations were lower in the clinical endometritis group than in the control and subclinical endometritis groups throughout the study period (p < 0.05 to 0.0001), whereas the NEFAs concentration was higher in the clinical endometritis group than in the control group throughout the study period (p < 0.01). The total cholesterol concentration was lower in the clinical endometritis group than in the control and subclinical endometritis groups throughout the pre- and postpartum periods (p < 0.05 to 0.001). The albumin concentration was lower in the clinical endometritis group than in the control and subclinical endometritis groups during the postpartum period (p < 0.05 to 0.001). The urea nitrogen concentration was lower in the clinical endometritis group than in the control and subclinical endometritis groups at 4 and 6 weeks postpartum (p < 0.01). At 1 week postpartum, the BHBA concentration was higher in the clinical endometritis group than in the control group (p < 0.05), whereas the AST concentration was higher in the clinical endometritis and subclinical endometritis groups than in the control group (p < 0.05). In conclusion, lower serum concentrations of calcium, magnesium, total cholesterol, albumin, and urea nitrogen, but higher concentrations of NEFAs, BHBA, and AST during the postpartum period were associated with the incidence of clinical endometritis, indicating the importance of balanced nutrition during the transition period.

A New Radiation-Shielding Device for Restraining Veterinary Patients

Songyi Kim,Minju Lee,Miju Oh,Yooyoung Lee,Jiyoung Ban,Jiwoon Park,Sojin Kim,Uhjin Kim,Jaepung Han,Dongwoo Chang The Korean Society of Veterinary Clinics 2023 한국임상수의학회지 Vol.40 No.6

In veterinary medicine, most radiographic images are obtained by restraining patients, inevitably exposing the restrainer to secondary scattered radiation. Radiation exposure can result in stochastic reactions such as cancer and genetic effects, as well as deterministic reactions such as skin burns, cataracts, and bone marrow suppression. Radiation-shielding equipment, including aprons, thyroid shields, eyewear, and gloves, can reduce radiation exposure. However, the risk of radiation exposure to the upper arms, face, and back remains, and lead aprons and thyroid shields are heavy, restricting movement. We designed a new radiation-shielding system and compared its shielding ability with those of conventional radiation-shielding systems. We hypothesized that the new shielding system would have a wider radiation-shielding range and similar shielding ability. The radiation exposure dose differed significantly between the conventional and new shielding systems in the forehead, chin, and bilateral upper arm areas (p < 0.001). When both systems were used together, the radiation-shielding ability was better than when only one system was used at all anatomical locations (p < 0.01). This study suggests that the new radiation-shielding system is essential and convenient for veterinary radiation workers because it is a step closer to radiation safety in veterinary radiography.

Learning Curve of a Low-Volume Veterinary Surgeon for Laparoscopic Salpingectomy in Asiatic Black Bear (Ursus thibetanus)

Dongwook Heo,Seong-Min Kim,Dae-Yoen Hwang,Ill-Hwa Kim,Hyun-Gu Kang The Korean Society of Veterinary Clinics 2023 한국임상수의학회지 Vol.40 No.6

The aim of this study was to analyze the learning curve of a low-volume veterinary surgeon for laparoscopic salpingectomy of Asiatic black bear. A total of 66 Asiatic black bears (Ursus thibetanus) were presented for sterilization using laparoscopic salpingectomy. These 66 bears were divided into three groups of 22 bears according to the order of surgery (A, B, and C groups, 22 bears per group). One veterinarian performed laparoscopic salpingectomy. There was no significant difference in age, body weight, or crown-rump length between groups. The hazard of completion for salpingectomy by 5 minutes was higher (p < 0.0001) in B and C groups than A group, whereas the hazard was not significant different between B and C groups. The factor that affected the hazard of completing salpingectomy by 5 minutes was heart rate, not age or weight. Operation time was 12.61 ± 8.04 minutes for group A, 5.35 ± 4.38 minutes for group B, and 2.80 ± 1.16 minutes for group C. The operation time for salpingectomy shortened over time. However, significant difference in operation time was present only between groups A and C (p = 0.001). The operation time for laparoscopic salpingectomy decreased rapidly for the first 7 bears (p < 0.05). It then decreased gradually until the 66th case. Operation time of laparoscopic salpingectomy was significantly decreased and stabilized after 33 cases (p < 0.05). As a result, the number of bears required for a low-volume veterinary surgeon to be proficient in laparoscopic salpingectomy is 33 or more.

Quality Evaluation of Ultrasonographic Equipment Using an ATS-539 Multipurpose Phantom in Veterinary Medicine

Cho, Young-kwon,Lee, Youngjin,Lee, Kichang The Korean Society of Veterinary Clinics 2022 한국임상수의학회지 Vol.39 No.3

The purpose of this study is to examine the status of quality control using multipurpose phantom of ultrasound equipment used in hospital of veterinary college in South Korea by using ATS-539 multipurpose phantom so as to examine quantitative and objective new image evaluation method. Specialists discussed and analyzed multipurpose phantom images acquired by using convex transducer of 10 ultrasound imaging devices, currently used in 9 veterinary colleges, at 4.0-6.0 MHz. Total 8 items that can be measured with ATS-539 multipurpose phantom including dead zone, vertical and horizontal measurement, axial/lateral resolution, sensitivity, focal zone, functional resolution and gray scale/dynamic range were evaluated. For qualitative evaluation, valid decisions were made based on dead zone, axial/lateral resolution, and gray scale/dynamic range which are resolution index, and coefficient of variation (COV) and blind referenceless image spatial quality evaluator (BRISQUE) were found to increase objectivity. As a result of experiment, all the targeted ultrasonic devices were found appropriate from qualitative evaluation items of dead zone, axial/lateral resolution, and gray scale/dynamic range. In other evaluation items, they were found to be appropriate from focal zone and vertical measurement of quantitative evaluation while inappropriate from horizontal measurement, sensitivity, and functional resolution. COV value was 0.12 ± 0.04, and BRISQUE value was 47.77 ± 2.77, both analysis results show that the noise level of all ultrasonic devices was located within tolerance range. Upon image examination using ATS-539 multipurpose phantom, they were 100% appropriate with inspection standards of dead zone, axial/lateral resolution, and gray scale/dynamic range, and besides, focal zone and functional resolution can be used as evaluation items. In the field of veterinary medicine, 8 standard items using ATS-539 multipurpose phantom and image evaluation items using COV and BRISQUE can be used as standards for quality control of ultrasonography machine.

Metabolism and Pharmacokinetics of Albendazole in Korean Native Cattle

Yun, Hyo-in,Park, Byung-Kwon,Park, Kyoung-hwan,Lim, Jong-hwan,Hwang, Youn-hwan The Korean Society of Veterinary Clinics 2001 한국임상수의학회지 Vol.18 No.3

한우에서 albendazole을 경구투여하였을 때의 albendazole의 생체내 대사 및 약물동태학적 특성을 밝히고자 하였다. 거의 모든 가축종에서 albendazole은 투여 후 신속하게 대사산물로 전환되기 때문에 albendazole 대사산물에 대한 분석법 확립이 albendazole의 생체내 거동을 파악하기 위하여 매우 긴요하다. 본 연구에서는 albendazole 및 그 대사산물인 albendazole sulfoxide(ABZSO)와 albendazole sulfone(ABZS $O_2$)을 LC/MS을 이용하여 높은 분석능을 획득할 수 있었다. Albendazole을 한우에 5 mg/kg을 경구토여하였을 때 모약인 albendazole은 첫 두 채혈시점인 0.5 h 1h에서만 측정되었을 뿐 그 이후에는 측정되지 않았다. 한편, ABZSO와 ABZS $O_2$은 첫 채혈 시점인 0.5h부터 측정되어 투여 후 각각 48h 및 72h까지 측정이 가능하였다. 두 대사산물의 초기 생성속도는 비슷하였다. 혈중최고농도 도달시간 ($T^{max}$)은 ABZSO가 12.00 h로서 ABZS $O_2$의 22.50$\pm$3.00h보다 빨랐으며 (p<0.005), ABZSO의 최고농도 ( $C_{max}$)는 0.96$\pm$0.15 $\mu\textrm{g}$/ml이었고 ABZS $O_2$의 그것을 1.05$\pm$0.05 $\mu\textrm{g}$/ml를 나타내었다. 소실반감기 ($t^$\frac{1}{2}$, ke/$)는 ABZSO는 4.14$\pm$0.30 h로 ABZS $O_2$의 6.95$\pm$0.36 h보다 빨랐으며 (p<0.005), MRT (mean residence time)는 각각 13.11$\pm$0.05 h와 21.60$\pm$1.99h로서 ABZS $O_2$가 생체내에 더욱 오래 머물렀다 (p<0.005). ABZSO는 AU $C_{0}$$\longrightarrow$$\infty$/는 ABZS $O_2$의 그것보다 작았다. 이러한 사실로 미루어보아 ABZ을 한우에 구충목적으로 투여할 때 구충활성을 가진 것으로 알려져 있는 ABZSO의 생체내 거동을 고려하여 용법용량을 설정하여야 할 것으로 사료된다. Metabolism and phamacokinetics of albendazole have been studied in Korean native cattle after oral administration of 5 mg/kg of albendazole. As ABZ is known to be rapidly biotransformed to many metabolites in most animal species, it is very imperative to establish the analytical conditions for its metabolites. LC/MS methods for ABZSO and ABZS $O_2$met every requirement enough to study the metabolism of pharmacokinetics of albendazole in Korean native cattle. The parent drug (ABZ) was only measured at first two time points of 0.5 h and 1h, whereas two metabolites were consistently formed between 0.5 h to 48-72 h post-treatment. Formation kinetics for ABZSO and ABZS $O_2$were similar. Time to peak concentration (Tmax) of ABZ-SO appeared at 12h post-treatment of ABZ, faster than that of ABZS $O_2$at 24h. Cmax of ABZS $O_2$(1.05$\pm$0.05 ug/ml) was 1.09 times higher than that of ABZSO (0.96$\pm$0.15). Elimination half-life of ABZS $O_2$(4.2 h) was much shorter than ABZS $O_2$(7.0h) (p<0.005). ABZSO was detected until 48h post-administration but ABZS $O_2$was measurable even at 72h post-dosing. AU $C_{0longrightarrow{\infty}}$ of ABZSO was smaller than that of ABZS $O_2$. Regimen of ABZ is advised to take into consideration is metabolite profiles, especially that of ABZSO, an active metabolite.

Ultrasonography of the Kidney and Urinary Bladder in Male Korean Native Goat

김명철,전무형,Kim Myung-Cheol,Jun Moo-Hyung The Korean Society of Veterinary Clinics 1993 한국임상수의학회지 Vol.10 No.2

한국재래산양에서의 신장 및 방광의 기초적인 초음파검사법 관찰을 하기 위하여 본 연구를 수행하였다. 초음파검사법에 의하여 7두의 웅성 한국재래산양을 대상으로 하여 신장 및 방광의 위치, 크기 및 구조를 관찰하였다. 모든 검사는 진정후의 횡와자세상태의 산양에서 수행하였다. 좌신은 4.2~5.9cm의 길이, 2.5~3.6cm의 폭 및 2.4-3.2cm의 깊이를 나타내었다. 좌심의 수질 및 신동의 직경은 각각 0.7~1.3cm 및 0.7~1.4cm의 범위내에 있었다. 신추체의 원주는 1.3~1.9cm의 범위내에 있었다. 우심에서는 유사한 초음파측정치를 나타내었다. 산양에서 방광의 직경은 2.1~5.4cm의 범위내에 있었다. 본 연구에서 기술된 초음파검사법 소견은 한국재래산양에서의 신장 및 방광의 형태학적 변화에 대한 참고자료로서 활용될 수 있을 것으로 사료된다. The purpose of this study was to make fundamental ultrasonographic observations of kidney and urinary bladder in Korean native goat. The position, dimensions, and structure of the kidneys and bladders In 7 male Korean native goats were determinded by use of ultrasonography. A 3.5%.MHz linear transducer was used. All examinations were performed on goats in lateral recumbency under sedation. The left kidney was 4.2 to 5.9 cm long, 2.5 to 3.6 cm wide, and 2.4 to 3.2 cm deep. Diameter of the parenchyma and renal sinus of the left kidney ranged between 0.7 and 1.3 cm and 0.7 and 1.4 cm, respectively. Circumferences of the medullary Pyramids varied between 1.3 and 1.9 cm. Similar ultrasonic measurements were obtained for the right kidney. The diameter of the urinary bladder varied between 2.1 and 5.4 cm in the goats. It was concluded that the ultrasonographic findings described in this study can be used as references for diagnosis of morphologic changes in the kidney and urinary bladder of Korean native goat.

Clinical Characteristics of Trauma-Related Chronic Osteomyelitis in 3 Wild Raccoon Dogs (Nyctereutes procyonoides)

Ha, Minjong,Ahmed, Sohail,Lee, Do Na,Han, Janghee,Yoon, Junghee,Yeon, Seong-Chan The Korean Society of Veterinary Clinics 2022 한국임상수의학회지 Vol.39 No.3

Osteomyelitis typically occurs because of the direct inoculation of bacteria or fungi after penetrating trauma or surgical contamination or, by extension, from soft tissue infection. Osteomyelitis is rarely reported in wildlife animals, though severe chronic osteomyelitis cases do exist in wildlife owing to the scarcity of medical support in the wild environment. This report describes three cases of chronic osteomyelitis in wild raccoon dogs related to trauma. The typical symptoms of three reported cases were ataxia, stiffness, muscle atrophy, and lethargy. All three cases were relevant to traumatic or severe external injury, and skin infestation caused by ectoparasites was apparent on an ocular inspection. In the radiographic examination, diffuse sites of osteolytic lesions and remarkable periosteal responses were demonstrated around the injured limb in all three cases. Apparent neutrophilia with a left shift, lymphocytosis, and monocytosis in hematological examinations generally indicated chronic infection as shown in case 1 and 3. Treatment was attempted with broad-spectrum antibiotics and non-steroidal anti-inflammatory drugs, such as amoxicillin/clavulanic acid, enrofloxacin, clindamycin, and meloxicam. These treatment options helped improve the overall prognosis of chronic osteomyelitis, but the outcomes did not meet the treatment goal entirely. Osteomyelitis can be extremely challenging to treat, particularly in wild animals, because of their distinctive traits, such as masking phenomenon and uncontrolled exposure to ectoparasites. Earlier diagnosis with a radiographic examination, hematological examinations, and careful patient monitoring, followed by prolonged antibiotic therapy and restricted exercise, are the key factors leading to a better prognosis.

Clinical Hemodialysis Cases with Estimation of the Adequacy in Four Dogs

이창민,임채영,김승곤,강민희,박희명,Lee, Chang-Min,Lim, Chae-Young,Kim, Seung-Gon,Kang, Min-Hee,Park, Hee-Myung The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2

급성 또는 급성 악화 신장 손상으로 혈액투석을 위해 4마리의 개가 내원하였다. 모든 증례에는 난치성의 구토, 식욕 부진, 설사, 침울 등을 포함하는 요독증 증후군을 가지고 있었다. 기존의 일반적인 치료를 받았으나, 치료적 반응은 없었으며 심한 임상증상은 남아있었다. 4마리의 증례에서 간헐적 혈액투석(IHD)이 실시 되었다. 본 논문은 혈액투석을 실시한 4마리의 환자의 임상증상과 생화학적 특징을 Kt/V로 나타나는 투석 적절성에 대하여 기술하였다. 본 논문은 개에서의 혈액투석 치료의 표준화의 설정에 도움이 되기 위하여 실제 증례에서 투석 적절성을 평가하였다. Four cases of acute or acute-on-chronic kidney injury were referred for hemodialysis therapy. All cases had a history of uremic syndrome including refractory vomiting, anorexia, diarrhea and depression. They already had been treated with conventional therapies but the intractable clinical signs were remained without response of medications. Intermittent hemodialysis (IHD) sessions were executed in four cases. This study describes the clinical signs and biochemical features of four hemodialysis patients with dialysis adequacy indexed by Kt/V. This report introduced the estimation of hemodialysis adequacy method with clinical cases for establishment of standardization of hemodialysis therapy assess in dogs.

Veterinary Clinicostatistical Observation on the Productive Performance in A Breeding Sow Herd in Japan

다케오 사카이,수폴 루엔요스르에찰,이원창,Sakai Takeo,Luenyosluechaul Supol,Lee Won-Chang The Korean Society of Veterinary Clinics 1993 한국임상수의학회지 Vol.10 No.2

저자들은 일본국내의 종빈돈장에 대한 능력을 관찰코저 시도하여 1990년 1월부터 12월까지사이에 신내천현의 현대식 종빈돈장 일부를 연구대상으로 하여 조사하고, 그 결과를 수의임상통계학적으로 분석, 다음과 같이 적요 한다. 전산화시설에 의한 분석에서, 월평균 종빈돈의 출산은 355이었고, 종빈돈의 종부능력은 월평균 28회이었으며, 이유는 20.8일, 시장출하 비육은 18.8 그리고 연간 평균출산은 2.25이었다. 한편 출산후 포유중 사망률은 평균 17.8%이고, 수의임상적 증상을 나타낸 이환율은 0.2% (200 per 100,000)이었다. Veterinary clinicostatistical observation on the productive performance in a breeding sow herd in Japan during the period from January to December in 1990, in a modernized breeding sow herd in kanagawa prefecture, consist monthly, varied from 347 to 363 sows on production(average 355) and boar on service of between 26~29(average 28) shows computerized analysing figures of moderate high production results per year of 20.8 weaning pigs per sow or 18.8 fatteners at market weight per sow when continue their rearing within farm. Sows perform average 2.25 litters per sow that year. On other hand, morbidity rate of piglets with clinical signs and symptoms was 0.2%(morbidity rate : 200 per 100,000 population In piglets) on average in year and that of mortality rate in suckling from birth was 17.8%, respectively Finally, these information may be used or reference in further study of the field of veterinary clinicostatistics and medicine.

Epidemiological Investigation of Diseases in Korean Native Suckling Calves

권오덕,최경성,이승옥,정환,이주묵,Kwon, Oh-Deog,Choi, Kyoung-Seong,Lee, Seung-Ok,Jang, Hwan,Lee, Joo-Mook The Korean Society of Veterinary Clinics 2000 한국임상수의학회지 Vol.17 No.1

This study was carried out to investigate the epidemiological prevalence of diseases from birth to weaning in 268 Koeran native calves which was delivered from three stock farm in Chonbuk area. We examined body weight gain, incidence rate of diseases and mortality rate in relation to age, season, environmental temperature and rearing management conditions for one year. The results of this experiment were as follows: Birth weight and body weight gain of Korean native calves born of primiparae were lower than those of multiparae. Body weight gain of diseased calves was lower than normal calves. Of 268 delivered calves, 242 calves(90.3%) were affected with gastronistestinal and/or respiratory diseases. The prevalence of the diseases were gastronitestinal disease(54.1%), gastronitestinal and respiratory disease(21.6%), and respiratory disease(14.5%). Of 242 diseased calves, 33 calves(13.6%) were occurred gastronitestinal disease and respiratory disease at different time respectively. Of 268 delivered calves, 126 calves were died(47%). The prevalence of the death were gastronitestinal disease(31.4%), gastronitestinal and respiratory disease(14.5%), and respiratory disease(1.1%). 81% of the diseases and 76.2% of the death were occurred in winter and a change of season(December to May). 59.1% of the diseases and 52.4% of the death were occurred at atmospheric temperatures below 1$0^{\circ}C$. 91.7% of the diseased calves and 96.8% of the dead calves were born of primiparae. 77.2% of the gastronitestinal disease were occurred within 2 weeks old, and the incidence was decreased with increasing age. Whereas the incidence of respiratory disease was incidence with ageing, and 69.2% of the respiratory disease were occurred between 2 weeks and 5 weeks old. And 62% of the gastronitestinal and respiratory disease wre occurred between 1 week and 3 weeks old. 65.1% of the dead calves were died within 2 weeks old. The morbidity and population mortality rate in each farm stock were 56.5%-104.9%, and 14.5%-64.2%, respectively.