히알루론산 나트륨과 카복시메틸셀룰로스 점안제의 임상적 효과성 비교: 체계적 문헌고찰

박지정,강민주,신상진 한국보건의료기술평가학회 2020 보건의료기술평가 Vol.8 No.1

Objectives: Through a systematic review, we aimed to compare the effectiveness of sodium hyal- uronate (SH) eye-drops and carboxymethylcellulose (CMC) in patients with dry eye syndrome. Methods: A comprehensive search was performed in three foreign databases (MEDLINE, Embase, and CENTRAL) and five Korean databases up to March 2019 for a systematic review. We included studies that reported tear break-up time (TBUT) or Schirmer’s test results from clinical studies that compared SH eye-drops and CMC. A meta-analysis using random-effects model was conducted to consider the heterogeneity among the studies. Results: Nine studies (10 comparisons) across 754 subjects were selected. Among those, eight studies used randomized control trials (RCTs). The re- sults of a meta-analysis on TBUT showed no statistically significant difference between SH eye- drops and CMC [mean difference (MD) -0.47; 95% confidence interval (CI) -1.11, 0.18], and on Schirmer’s test (MD 0.39; 95% CI -0.71, 1.49). No significant differences between the two groups were found on corneal staining score [standardized mean difference (SMD) -0.10; 95% CI -0.31, 0.12], conjunctival staining score (SMD -0.12; 95% CI -0.34, 0.11), and symptom score (SMD -0.00; 95% CI -0.18, 0.17). Conclusion: Compared with SH and CMC eye-drops, result of this meta- analysis provides evidence that both medicines were found to have no significant differences in all major results that measure the effectiveness of clinical treatment in dry eye syndrome.

한국에서 경동맥 협착증 관련 건강상태별 삶의 질 조사

박지정,오성희,유지혜,이자연,신상진 한국보건의료기술평가학회 2016 보건의료기술평가 Vol.4 No.1

Objectives: This study was carried out to investigate the impact of carotid artery stenosis on qualify of life in Korea. Methods: A health scenario for each health states after undergoing carotid endar- terectomy or carotid artery stent was developed, and Time Trade Off and EQ-5D-3L tools were used on 400 general population to examine health-related quality of life. In addition, the 5th Korea Na- tional Health and Nutrition Examination Survey (2012) and Stoke Registry of Seoul National Uni- versity Bundang Hospital were utilized to find out quality of life of stroke and myocardial infarction, which are major complications of carotid artery stenosis. Results: As a result of survey, utility weight for health states without major complications after undergoing carotid endarterectomy or carotid artery stent to treat carotid artery stenosis was 0.79 (±0.10), and utility weight was further decreased to 0.61 (±0.13) for health states after undergoing reoperation due to restenosis. These weight were similar to major complications, which showed utility of 0.77 (±0.05) for myocardial infarction and 0.79 (±0.06) for minor stroke. They were higher than weight of 0.41 (±0.48) for major stroke. Con- clusion: The results of this study showed that quality of life of carotid artery stenosis is similar to myocardial infarction and minor stroke. The meaning of this study is in that it produced Korean utility weight of each health states related to carotid artery stenosis which are regarded as critical data re- quired for cost-utility analysis in the future.

Comparative Effectiveness of Telepsychotherapy for Depressive Disorder: A Systematic Review and Meta-Analysis

박지정,김세희,박동아 한국보건의료기술평가학회 2019 보건의료기술평가 Vol.7 No.1

Objectives: The objective of this study is to evaluate the clinical effectiveness of telepsychotherapy compared to care as usual(CAU) for depressive disorder. Methods: We searched MEDLINE, Embase, CENTRAL, PsycINFO and 5 domestic electronic databases from its inception to March 2016. Randomized controlled trials for reporting clinical outcomes of synchronous and interactive telepsychotherapy were included. Results: A total 8 studies (9 articles) with 2393 patients were included. In comparison with telepsychotherapy and CAU, depressive symptom score was significantly lower in the telepsychotherapy (standard mean difference, -0.28; 95% confidence interval, -0.46 to -0.09; I2=69%). Especially, improvement of depressive symptom was significantly higher for telepsychotherapy in studies where telepsychotherapy was performed more than twice a month, and the follow up period was between 4−11 months. Conclusion: Telepsychotherapy may be effective than care as usual in depressive symptom improvement in patients with depressive disorder. However most of the studies were performed before 2010 with telephone based intervention, so additional studies are needed to confirm the clinical effectiveness of telepsychotherapy.

전자지도 이용 변량시비가 쌀 수량 및 품질에 미치는 영향

지정현,이재홍,김희동,최병열,박중수,박경열,정인규 한국작물학회 2009 한국작물학회지 Vol.54 No.2

지구온난화 등에 따른 세계적 환경변화에 대응하고 정부의 친환경 농업육성 정책에 부응하는 정밀농업기술 중 GPS를 이용한 이앙과 동시 변량시비가 벼 생육 및 품질에 미치는 영향을 구명한 결과는 다음과 같다. 1. 시험전 후 토양 질소검정량에 대한 공간변이 정도를 나타내는 Nugget값은 관행 대비 변량시비 후 낮아졌고, 공간구조 강도를 나타내는 Q값은 두 처리 모두 없어 공간의 존성이 존재하지 않았다. 2. 분얼기부터 성숙기까지 초장, 경수, 수수 등의 생육량은 관행 대비 변량시비에서 증가되었고 생육 요인별 변이계수가 낮아 상대적으로 균일한 경향을 보였다. 3. 완전미 수량은 관행 450 kg 대비 변량시비에서 492 kg으로 유의성 있게 증가 되었고 변이계수는 현저히 낮아졌다. 4. 아밀로스, 단백질 함량, 백도 등 품질은 처리간 큰 차이가 없었으나 변이계수는 변량시비에서 낮아졌다. 5. 비료살포작업에 대한 투입노동력은 관행 11.8시간/ha 대비 변량시비에서 61%(7.2시간)가 절감 되었다. This study was conducted to investigate the effect of site-specific variable fertilization following digital fertility map generated from soil analysis on rice growth and yield. The site-specific application of fertilizer was implemented by using rice transplanter equipped with side dressing applicator and global positioning system (GPS). Coefficient of variation (C.V.) of soil nitrogen content was reduced after the experiment, and spatial variation of semivariogram was reduced. Rice growth from tillering to ripening stage, plant height, tiller and panicle number increased at site-specific variable fertilization treatment, and coefficient variation (C.V.) of each growth characteristics was lower than those of conventional fertilization treatment. As a result, fertility in the rice field was more uniform become of site-specific fertilizer application. Head rice yield of site-specific application plot increased by 9% (i.e., to from 450 kg/10a to 492 kg/10a of the control plot) and its CV was significantly reduced to 3.5 compared to 7.8 of the control plot. In addition, there was no significant difference in amylose, protein contents and whiteness of milled rice, but its CV was reduced.

IoT 주요 기술 현황 분석

김지정 ( Ji-jeong Kim ),박석천 ( Seok-cheon Park ),윤석환 ( Seok-hwan Yoon ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1

전 세계 IoT 시장은 폭발적으로 성장하여 2017년 7조 3000억 달러에 이를 것으로 전망하고 있으며 세계 각국 정부는 IoT 분야를 미래 핵심 성장 동력으로 전망하고, IoT 핵심기술 및 디바이스 개발에 많은 투자를 하고 있다. 따라서 본 논문에서는 최근 IoT 분야 주요기술 현황을 분석하고 그 발전 동향을 제시한다.

복막에 발생한 고분화 유두상 중피종

지정현,정회인,박재준 대한소화기학회 2023 대한소화기학회지 Vol.81 No.2

A Study on the polyimide surface modification for the improvement of adhesion between metal and polyimide by wet process

박성실,이수,이지정,장도연,이규환 한국고분자학회 2004 한국고분자학회 학술대회 연구논문 초록집 Vol.2004 No.04

Carotid Stenting Versus Endarterectomy in Symptomatic Patients with ≥50% Stenosis: Cost-Effective Options in Patients Aged <70 and ≥70 Years

오성희,박지정,이자연,전평,조용필,김태선,김병문,박현선,신상진 한국보건의료기술평가학회 2019 보건의료기술평가 Vol.7 No.2

The Carotid Revascularization Endarterectomy versus Stenting Trial showed that the relative efficacy of carotid artery stenting (CAS) and carotid endarterectomy (CEA) differs according to patient age. We assessed the cost-effectiveness of CAS vs. CEA in patients aged <70 years and ≥70 years with symptomatic stenosis ≥50%. Methods: Cost-effectiveness analysis was conducted using a Markov model over a lifetime from the Korean healthcare system perspective. Clinical effectiveness was estimated based on a multi-center retrospective cohort study. Costs were calculated using resource use and national health insurance claims data. Health utility weight was assessed using survey data. Results: In the base-case analysis, quality-adjusted life-years (QALYs) for CAS and CEA were 6.49 and 6.71, respectively. The incremental cost of CAS was $1536 compared with CEA. CEA was dominated option in patients with symptomatic stenosis ≥50%. However, in patients aged <70 years, CAS cost $411 less while increasing QALYs by 0.27; in patients aged ≥70 years, CAS cost $3392 more and decreased QALYs by 0.64. Probabilistic sensitivity analyses indicated that CAS would be a cost-effective option in 90.3% of patients aged <70 years and in 7.6% of patients aged ≥70 years. Conclusion: Patient age should be considered when deciding on treatment option for symptomatic stenosis. We believe that CEA would be a cost-effective option in patients aged ≥70 years, whereas CAS could be preferred in patients aged <70 years.

전신마취시 가온·가습한 가스 환기가 수술중, 후 환자 체온에 미치는 효과

김명희,박지정,이미영,김광미,정민정,박선혜,유혜숙,길예한,박광옥,황규삼 병원간호사회 2000 임상간호연구 Vol.6 No.1

The purpose of this study was to review the effects of heated and humidified gas inhaled on patients' body temperature during and after surgery with general anesthesia, and thereby, find new nursing interventions to help maintain patients' body temperature during and after surgery. For this purpose, the test group was subject to the heated and humidified gas for 12 weeks, while the control group was subject to the ordinary gas neither heated nor humidified for another 12 weeks. During these 24 weeks, each group member's core temperature was checked every 10 minutes during an hour-long surgery, and every 30 minutes during his or her recovery. In short, this study was designed as a time-series study with two heterogeneous groups. The collected data were processed using the PC-SAS for Mann-Whitney U test to verify subjects' homogeneity, and for two-way repeated measure ANOVA to check subjects' core temperatures. The results of this study can be summarized as follows ; 1) The experimental group showed a slower fall of core temperature during surgery than the control group. 2) The experimental group showed a better effect of core temperature during surgery than the control group. 3) The experimental group showed a better effect of core temperature during post-surgery in recovery room than the control group. All in all, it was confirmed by this study that the heated and humidified gas would serve to keep patient's body temperature from falling much during surgery and maintain his or her body temperature after surgery. Based on the above findings, the following suggestions were put forwards ; 1) It is necessary to study how much the heated and humidified gas inhaled would help to check the temperature falling of a patient undergoing a long-hour surgery. 2) This study should be properly followed up.

전신마취시 가온i/가습한 가스 환기가 수술중, 후 환자 체온에 미치는 효과

김명희,박지정,이미영,김광미,정민정 병원간호사회 2000 임상간호연구 Vol.6 No.1