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김윤경,이제현,송계용,박성규,김정숙,Kim, Yun-Kyung,Lee, Je-Hyun,Song, Kye-Yong,Park, Seong-Kyu,Kim, Chung-Sook 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.1
Objective : This study was carried out to evaluate the liver toxicities of Wild Aconiti Tuber decoction. Methods : The amounts of aconitine in the methanol extract of Wild Aconiti Tuber was measured by HPLC. Safeties was studied by LD50 in mice. Liver toxicities were evaluated histologically and by CBC, blood chemistry after 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat. Results : 1. The amounts of aconitine in the methanol extract of Wild Aconiti Tuber is $1.697{\pm}0.052mg/g$. But aconitine was not detected in the water decoction of Wild Aconiti Tuber. 2. To evaluate LD50 and safeties of Wild Aconiti Tuber decoction, ICR mice were given high dose of 2, 5, 10g/kg for single time and were observed for 2 weeks. There were no dead animal and abnormal clinical sign and no abnormalities at the autopsy. So, LD50 was admitted to higher than 10g/kg. 3. After 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat, there was no significant change in the CBC and blood chemistry. 4. In the liver tissues of clinical dosage, mitotic figures, apoptosis and individual cell death were observed, but clear liver toxicities like fatty liver or necrosis were not observed. the liver tissues of high dose in mice, hydropic changes were getting severe as dose grows. Conclusions : According to the results, though aconitine was not detected in the Wild Aconiti Tuber decoction, 0.4g/kg/day 2 weeks p. o (clinical dosage) group showed weak changes in the liver tissues and high dose group showed liver toxicities like hydropic changes.
지황 (地黃) 재식밀도가 (栽植密度) 생육 및 수량에 미치는 영향
최인식(In Sik Choi),송인규(In Kyu Song),김준호(Jun Ho Kim),조진태(Jin Tae Cho),홍유기(Yu Ki Hong),박성규(Song Kyu Park),박종귀(Jong Kooi Park) 한국약용작물학회 1993 한국약용작물학회지 Vol.1 No.1
This experiment was carried out to investigate the effect of planting density on the growth and yield of Rehmannia glutinosa. A local variety was planted on the 100㎝ row, with different planting density of 20, 30 and 40 plants per ㎡. Nitrogen, phosporus and potassium fertilizers were applied as 12, 12, and 16 ㎏/10a, respectively with compost of 1,000㎏/10a. Plant height became shorter with increase in the planting density from 20 to 40 plants /㎡. But emergence date, leaf length and width were not significantly changed with planting density. As the planting density was increased, tuber diameter got slender and tuber number was decreased, but tuber length was not affected. The tuber yield was 793㎏/10a at the planting density of 20 plants/㎡and it increased 40% at 30 plants/㎡and 45% at 40 plants/㎡. Regarding on the farmer`s income, optimum planting density was estimated 30 plants/㎡.
위선암 환자에서 혈장 Vascular Endothelial Growth Factor ( VEGF ) 의 임상적 가치
홍대식(Dae Sik Hong),이규택(Kyu Taek Lee),백승호(Seung Ho Baick),박성규(Sung Kyu Park),원종호(Jong Ho Won),박희숙(Hee Sook Park),이문수(Moon Soo Lee),송옥평(Ok Pyung Song),김창진(Chang Jin Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.3
N/A Objective : Angiogenesis is an essential step in growth and metastasis of solid tumors. Vascular endothelial growth factor(VEGF) is one of the most important mediators of angiogenesis. VEGF selectively stimulates endothelial cell proliferation and induces angiogenesis. Also VEGF was expressed by several human solid tumors and serum VEGF levels have previously been shown to be raised in patients with breast cancer, gastrointestinal cancer, renal cancer and melanoma. To evaluate the clinical value of plasma VEGF of patients with stomach cancer we studied correlations between plasma VEGF, tumor stage, tumor resection and microvessel invasion by tumor. Methods : VEGF level was measured by ELISA methods in plasmas from 88 patients and after surgical tumor resection from 48 patients with gastric carcinoma. Microvessel staining was done by immunohistochemical staining using anti-CD34 monoclonal antibody on paraffin embedded tissues. Results : The plasma VEGF levels were significantly higher in the stomach cancer patients than in normal controls(p<0.0001). In stomach cancer patients, plasma VEGF level was significantly increased according to stage progression(p<0.05). Moreover early cancer, T1, showed a significantly elevation of plasma VEGF level than that of controls. The level of plasma VEGF fell after surgical resection(n=48) of stomach cancer(p<0.05). Also the plasma VEGF levels were significantly higher in microvessel invasion by tumor(n=25) than in those without invasion(n=19)(p<0.05). Conclusion : In conclusion, plasma VEGF may be useful for predicting disease status and prognosis of patients with stomach cancer.
G-CSF로 투여받은 정상공혈자로부터 원심분리기와 적혈구침강촉진제를 이용한 효과적인 백혈구수집의 임상경험
박성규,한치화,김동욱,이종욱,김상돌,송차숙,최정현,민우성,신완식,김춘추,김원일,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1
In recent days, the granulocyte transfusion is re-emerging because several investigators reported the effectiveness of large granulocytes (mord than 2×10^(10)per day) to control life-threatening infections for severe neutropenic patients. Application of continuous cell separators as well as erythrocyte sedimentation enhancing agents (hydroxyethylstarch, HES) made it possible to collect enough therapeutic number of granulocytes from a single donor. To increase the efficiency of granulocyte collection we gave G-CSF to normal donors at least 12 hours before harvest. Also, 10% pentastarch solution (low molecular weight-HES) which has minimal side effects compared with 6% hetastarch (high molecular weight-HES) was used to enhance erythrocyte sedimentation during centrifugation. We measured the vitro effect of HESs on the erythrocyte sedimentation rate (ESR) of peripheral whole blood depending their concentrations; the ESR (mm/hr) of 10% PS was significantly higher than that of 6% PS or HS(39.19±11.52 vs 11.62±7.26 or 15.23±6.86, p< 0.01) and that of PBS (5.17±2.85, p< 0.01). We compared the efficiency of granulocyte collection between G-CSF treated (n=9) and untreated (n=30) donors: the total number of granulocytes in the latter cases ranged 0.2 to 1.7×10^(10) (median 2.9×10^(10)) (p<0.01). Of interest, the peripheral WBC counts of donors when the counts were over 10,000/mm³ on the day of collection, correlated with the yield of granulocytes in the final products (r=0.75). Except one donors who had peripheral WBC count more than 10,000/mm³ without G-CSF, all cases showing peripheral WBC count over 10,000/mm³ had received G-CSF before collection. Furthermore, the WBC kinetics in G-CSF trealed donors showed that the peripheral WBC counts rose over 10,000/mm³ quickly (within 12 hours) and sustained during the period of injection. Among three neutropenic patients who had been received large dose grannlocgtes daily due to definitive critical infection, two patients (one in induction for ALL, and the other in early recovery phase of allogeneic BMT for severe aplastic anernia) recovered completely. However one who firstly diagnosed as SAA showed only temporary responses during granulocyte transfusion. Therefore, we suggest that (1) collection of large dose of granulocytes using a continuous cell separator with 10% PS is possible from a donor when pretreated by G-CSF, (2) such therapeutic granulocyte transfusion is effective to control life-threatening infections of severe neutropenic patients whose granulocyte counts are expected to recover within several days.
有機色素分子와 陰이온 界面活性劑 사이의 相互作用에 關한 吸收分光學的 硏究
송기동,김일두,박성규,김준태,김성현 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1
The metachromatic behavior of methylene blue (MB) ia aqueous solution and in the presense of sodium dodecyl sulfate (SDS) have been studied by the absorption spectroscopic method. The results are as follows. The association force of the MB molecules in aqueous solution seems to be complex of three factors, i.e., London's dispersion force, the hydrophobic interaction and the interaction between permanent dipoles it has been measured of critical micelle concentration (CMC) in aqueous solution of SDS and that of MB-SDS to be 8.0mM and 7.9mM respectively. This indifference between CMC values of the pure SDS and MB-SDS system would mean the formation of dye-rich induced micelles(drim). The spectral changes of MB-SDS system with the addition of the inorganic salts have been observed. The addition of the salt into the solution causes the redistribution of MB molecules in the complex(D_n^+ S_m^-). It would be resulted from the decrease of the stacking effect between the bound MB molecules. The spectral changes observed in the MB-SDS system with the increase of the S/D values are analyzed and the behavior of the meta band is explainsd in terms of the stacking theory and micelle formation theory