고온/고차압 제어밸브의 트림 형상에 따른 유동특성 고찰

류제혁(Jea-Hyuk Ryu),천화동(Haw-Dong Cheon),채철주(Cheol-Ju Chai),지현(Hyun Jee) 한국유체기계학회 2023 한국유체기계학회 학술대회 논문집 Vol.2023 No.7

An Effective Way for Northeast Asia to Defuse the Adverse Impact of US-China Trade War : Focus on South Korean-China-Japan FTA

류천정,문철주 한국산업경제학회 2019 산업경제연구 Vol.32 No.6

As the world's two largest economies, there is no doubt that the trade war between China and the United States will cause a negative impact on the world economy. Concerning the economic gross amount, Northeast Asia Region (Hereinafter referred to as “NEAR”) is one of the top three economic circles in the world, how can NEAR defuse the adverse impact of this trade war on the regional economy? The successful experience of the Europe Union (EU) and the North American Free Trade Agree- ment(NAFTA) shows that Free Trade Area (FTA) might be a good choice to promote regional economic integration and defuse the adverse impact of this trade war. If the FTA among South Korean, China and Japan could be established, it might be of great practical significance to maintaining the prosperity and stability of the regional and even the world economy. In fact, as the largest economies in this region, South Korea, China and Japan have already had frequent commercial intercourse and strong economic complementarity. And Asia, especially NEAR countries was expected to be the most dynamic developments area all over the world in the 21st century. Which reflects as the new economic development direction in South Korea ,the rapid economic growth of China and the economic recovery in Japan. The regional economic integration in NEAR will push all countries in this region to get more stable economic growth, which also contribute a lot to raise the regional status in the international economy. This paper focus on the establishment of South Korea-China-Japan FTA (Hereinafter referred to as “KCJ’s FTA”) among , take the exploratory development method, try to proof that FTA among this three countries is an effect way to promote regional economic integration and defuse the adverse impact of this trade war.

우리나라 지방 공공기관의 생성과 운영에 대한 이해: A시 산업진흥원 사례를 중심으로

이철주,류숙원 한국조직학회 2023 한국조직학회보 Vol.19 No.4

본 연구는 지방자치단체 소속의 지방공기업이 체계적으로 관리된 것과는 달리 지방출자・출연기관의 수가 급격히 증가하는 이유에 대해 의문을 가지고 원인을 분석해보고자 한데서 시작하였다. 최근에 설립된 A시 산업진흥원을 대상으로 이해관계자들의 인터뷰 조사결과를 통해서 지방자치단체 출자출연기관의 생성과정을 검토하고, 이러한 과정이 어떠한 원인들로 나타나고 있는가를 유추하여 그 의미를 해석한 후, 생성된 조직들이 정책과 행정현실에서 살아남기 위하여 어떻게 운영되고 있는지를분석하였다. 분석결과에 대한 본 연구의 시사점은 첫째, 중앙정부의 사업 확장 및 예산출처의 다변화로 인해 이에 대응하는 지방자치단체 입장에서는 사업과 예산을 관리하는 기관 신설이 유리한 상황으로 인지되어 지방자치단체의 기관 신설을 자극할가능성이 있다는 점이다. 특히 기관의 신설과 운영과정에서 나타나는 단체장-지방의원-관료의 여러 가지 행태 등에 대한 다양한 역동성에 주목할 필요가 있다. 둘째, 지방 공공기관의 무한증식 가능성과 생성된 조직의 변형과 경로 등을 확인하면서 중앙정부의 일과 지방자치단체의 일을 어떤 목적으로 누가 하고 있는지를 살펴보는 작업및 그 책임성에 대하여 추적할 필요가 있을 것으로 보인다. 셋째, 지방자치단체 출자・출연기관들이 새롭게 생성되는 원인과 과정, 생성된 이후 출자・출연기관들이 운영되는 구체적인 모습을 살펴봄으로써 현재 지방자치단체 출자・출연기관의 생성과운영의 양상이 앞으로의 양상에도 지속될지에 대한 다양한 논의가 필요하다.

Misfolding-assisted Selection of Stable Protein VariantsUsing Phage Displays

신종식,이철주,유명희,류승현 한국생화학분자생물학회 2006 BMB Reports Vol.39 No.1

An Effective Way for Northeast Asia to Defuse the Adverse Impact of US-China Trade War : Focus on South Korean-China-Japan FTA

Liu, Quanding(류천정),Mun, Cheolju(문철주) 한국산업경제학회 2019 산업경제연구 Vol.32 No.6

세계 양대 경제대국으로서 중국과 미국의 무역전쟁은 세계경제에 악영향을 미치고 있다. 세계경제총액과 관련하여 동북아 지역경제동합(NEAR)은 세계 3대 경제 공동체 중 하나이다. 따라서 NEAR는 어떻게 미·중간의 무역 전쟁이 지역경제에 미치는 부정적인 영향을 완화시킬 수 있을까? 유럽통합(EU)과 북미자유무역협정(NAFTA)의 성공적인 경험은 지역경제동합을 촉진하고 이는 무역정쟁의 부작용을 해소하는 좋은 방법이 될 수 있다. 한·중·일등 삼자간의 FTA가 협정체결이 될 수 있다면, 그것은 지역경제성장뿐만 아니라 세계경제의 번영과 안정을 유지하는데 큰 실직적인 의미가 있을 것이다. 실제로 동북아지역의 최대경제국으로서 한·중·일 3국은 이미 빈번한 무역교역과 상호경제의 의존성과 상호보완성을 갖고 있다. 특히 미래 NEAR 국가들은 21세기에 전 세계에서 가장 발전지역이 될 것으로 기대되었다. 이것은 한국의 새로운 경재발전방향, 중국의 빠른 경제성장과 일본의 경제회복을 반영한다. NEAR의 지역 경제통합은 이 지역의 모든 나라들로 하여금 보다 안정적인 경제 성장을 이루도록 할 것이며, 이것은 또한 국제경제 지역적 위상을 높이는데 많은 기여를 할 것이다. 따라서 본 연구는 탐색적 연구로 한·중·일 상호 FTA 협정체결을 통한 지역경제통합이 미·중 무역정쟁의 부작용을 완화하기 위한 효과적인 방안들을 밝힐 것이다. As the world"s two largest economies, there is no doubt that the trade war between China and the United States will cause a negative impact on the world economy. Concerning the economic gross amount, Northeast Asia Region (Hereinafter referred to as “NEAR”) is one of the top three economic circles in the world, how can NEAR defuse the adverse impact of this trade war on the regional economy? The successful experience of the Europe Union (EU) and the North American Free Trade Agree- ment(NAFTA) shows that Free Trade Area (FTA) might be a good choice to promote regional economic integration and defuse the adverse impact of this trade war. If the FTA among South Korean, China and Japan could be established, it might be of great practical significance to maintaining the prosperity and stability of the regional and even the world economy. In fact, as the largest economies in this region, South Korea, China and Japan have already had frequent commercial intercourse and strong economic complementarity. And Asia, especially NEAR countries was expected to be the most dynamic developments area all over the world in the 21st century. Which reflects as the new economic development direction in South Korea ,the rapid economic growth of China and the economic recovery in Japan. The regional economic integration in NEAR will push all countries in this region to get more stable economic growth, which also contribute a lot to raise the regional status in the international economy. This paper focus on the establishment of South Korea-China-Japan FTA (Hereinafter referred to as “KCJ’s FTA”) among , take the exploratory development method, try to proof that FTA among this three countries is an effect way to promote regional economic integration and defuse the adverse impact of this trade war.

Linear Type 구동기 YOKE의 구조해석을 통한 내진 환경 건전성 검토

천화동(Haw-Dong Cheon),류제혁(Jea-Hyuk Ryu),채철주(Cheol-Ju Chai),지현(Hyun Jee) 한국유체기계학회 2023 한국유체기계학회 학술대회 논문집 Vol.2023 No.7

Loss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factor in Korean Pediatric Patients with Favorable Histology Wilms Tumor: A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)

박준은,노오규,이용희,최형수,한정우,한승민,류철주,이지원,유건희,구홍회,정선용,성기웅 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and evaluated its prognostic value in Korean children with FHWT. Materials and Methods We analyzed 101 FHWT patients who were diagnosed between 1996 and 2016 in Korean Society of Pediatric Hematology Oncology Group hospitals. Using paraffin-embedded kidney tissue samples sent from each center, we reviewed LOH at 1p and 16q in each patient and assessed the prognostic value of LOH status for clinical parameters affecting event-free survival (EFS). Results Of the 101 patients, 12 (11.9%) experienced recurrence; the 3-year EFS was 87.6%. LOH at 1p or 16q was detected in 19 patients (18.8%), with five having LOH at both 1q and 16q. The frequency of LOH at 1p was higher among younger patients (p=0.049), but there was no difference in LOH prevalence according to tumor stage. In the multivariate analysis, LOH at 16q was a significant negative prognostic factor affecting EFS (3-year EFS, 73.7% vs. 91.1%; hazard ratio, 3.95; p=0.037), whereas LOH at 1p was not (p=0.786). Conclusion LOH at 16q was a significant negative prognostic factor affecting outcome in Korean pediatric FHWT patients. Due to the small sample size of this study, large-scale multicenter trials are warranted to investigate the prognostic value of LOH at 1p and 16q in Korean children with FHWT.

Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group

박경미,유건희,김성구,이재욱,정낙균,주희영,구홍회,류철주,한승민,한정우,최정윤,홍경택,강형진,신희영,임호준,고경남,김혜리,국훈,백희주,김보람,양의진,임재영,박은실,최은진,박상규,이재민,심예지,김지윤,박지경,공섬김,최영배,조빈,임영탁 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1

Purpose Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. Materials and Methods Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Results Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020). Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment. Purpose Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.Materials and Methods Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.Results Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020).Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.

Children’s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) System for Pediatric Patients with Hepatoblastoma: A Retrospective, Hospital-Based Cohort Study in South Korea

김평화,신현주,윤희망,최영훈,남궁정만,김대연,고경남,이미정,윤혜성,류철주,한정우,한승민,조영아 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1

Purpose In 2017, the Children’s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma. Materials and Methods This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis. Results We included 129 patients (mean age, 2.6±3.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age ≥ 8 (vs. age ≤ 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS. Conclusion The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS. Purpose In 2017, the Children’s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma.Materials and Methods This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis.Results We included 129 patients (mean age, 2.6±3.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age ≥ 8 (vs. age ≤ 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS.Conclusion The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS.

Effectiveness and Safety of Clofarabine Monotherapy or Combination Treatment in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia: A Pragmatic, Non-interventional Study in Korea

최정윤,홍채리,홍경택,강형진,김성구,이재욱,장필상,정낙균,조빈,김혜리,고경남,임호준,서종진,한승민,한정우,류철주,양유진,임영탁,유건희,구홍회,국훈,전인상,조하나,신희영 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4

Purpose Effectiveness and safety of clofarabine (one of the treatment mainstays in pediatric patients with relapsed/refractory acute lymphoblastic leukemia [ALL]) was assessed in Korean pediatric patients with ALL to facilitate conditional coverage with evidence development. Materials and Methods In this multicenter, prospective, observational study, patients receiving clofarabine as mono/combination therapy were followed up every 4-6 weeks for 6 months or until hematopoietic stem cell transplantation (HSCT). Response rates, survival outcomes, and adverse events were assessed. Results Sixty patients (2-26 years old; 65% B-cell ALL, received prior ≥ 2 regimen, 68.3% refractory to previous regimen) were enrolled and treated with at least one dose of clofarabine; of whom 26 (43.3%) completed 6 months of follow-up after the last dose of clofarabine. Fifty-eight patients (96.7%) received clofarabine combination therapy. Overall remission rate (complete remission [CR] or CR without platelet recovery [CRp]) was 45.0% (27/60; 95% confidence interval [CI], 32.4 to 57.6) and the overall response rate (CR, CRp, or partial remission [PR]) was 46.7% (28/60; 95% CI, 34.0 to 59.3), with 11 (18.3%), 16 (26.7%), and one (1.7%) patients achieving CR, CRp, and PR, respectively. The median time to remission was 5.1 weeks (95% CI, 4.7 to 6.1). Median duration of remission was 16.6 weeks (range, 2.0 to 167.6 weeks). Sixteen patients (26.7%) proceeded to HSCT. There were 24 deaths; 14 due to treatment-emergent adverse events. Conclusion Remission with clofarabine was observed in approximately half of the study patients who had overall expected safety profile; however, there was no favorable long-term survival outcome in this study.