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박준은,Joseph Kang,유건희,성기웅,구홍회,임도훈,신형진,강형진,박경덕,신희영,김일한,조병규,임호준,서종진,박현진,박병규,안효섭 대한의학회 2010 Journal of Korean medical science Vol.25 No.8
The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with relapsed medulloblastoma were enrolled in the KSPNO-S-053 study from May 2005 to May 2007. All patients received approximately 4 cycles of salvage chemotherapy after relapse. Thirteen underwent HDCT/ASCT; CTE and CM regimen were employed for the first HDCT (HDCT1)and second HDCT (HDCT2), respectively, and 7 underwent HDCT2. One transplant related mortality (TRM) due to veno-occlusive disease (VOD) occurred during HDCT1but HDCT2 was tolerable with no further TRM. The 3-yr overall survival probability and event-free survival rates ±95% confidence intervals (CI) were 33.3±12.2% and 26.7%±11.4%, respectively. When analysis was confined to only patients who had a complete response (CR) or partial response (PR) prior to HDCT, the probability of 3-yr overall survival rates ±95% CI was 40.0±15.5%. No patients with stable disease (SD) or progressive disease (PD) survived. Survival rates from protocol KSPNO-S-053 are encouraging and show that tumor status prior to HDCT/ASCT is an important factor to consider for improving survival rates of patients with relapsed medulloblastoma.
박준은,노오규,이용희,최형수,한정우,한승민,류철주,이지원,유건희,구홍회,정선용,성기웅 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and evaluated its prognostic value in Korean children with FHWT. Materials and Methods We analyzed 101 FHWT patients who were diagnosed between 1996 and 2016 in Korean Society of Pediatric Hematology Oncology Group hospitals. Using paraffin-embedded kidney tissue samples sent from each center, we reviewed LOH at 1p and 16q in each patient and assessed the prognostic value of LOH status for clinical parameters affecting event-free survival (EFS). Results Of the 101 patients, 12 (11.9%) experienced recurrence; the 3-year EFS was 87.6%. LOH at 1p or 16q was detected in 19 patients (18.8%), with five having LOH at both 1q and 16q. The frequency of LOH at 1p was higher among younger patients (p=0.049), but there was no difference in LOH prevalence according to tumor stage. In the multivariate analysis, LOH at 16q was a significant negative prognostic factor affecting EFS (3-year EFS, 73.7% vs. 91.1%; hazard ratio, 3.95; p=0.037), whereas LOH at 1p was not (p=0.786). Conclusion LOH at 16q was a significant negative prognostic factor affecting outcome in Korean pediatric FHWT patients. Due to the small sample size of this study, large-scale multicenter trials are warranted to investigate the prognostic value of LOH at 1p and 16q in Korean children with FHWT.
박준은,이윤재,김기현,고한석,Park, Jun-Eun,Lee, Yoon-Jae,Kim, Ki-Hyeon,Ko, Han-Seok 한국전기전자학회 2009 전기전자학회논문지 Vol.13 No.2
본 논문에서는 핸즈프리 통신에서의 반향제거를 위한 음성 특징 기반의 동시통화 검출 기법을 제안한다. 동시통화 검출은 반향제거를 위한 적응 필터의 적응을 제어하는 역할을 하기 때문에 매우 중요한 분야이다. 이전까지의 연구에서는 동시통화 검출을 음성의 특징에 대한 고려 없이 단순히 신호처리 영역에서만 이루어졌다. 하지만 제안한 기법에서는 음성인식으로 사용되는 음성 특징을 핸즈프리 통신상에서의 근단 화자와 원단화자 사이의 차별성을 가지는 특징으로 사용하였다. 제안한 방식이 시간 축에서의 파형만을 이용하여 판단하는 동시통화검출기보다 우수한 성능을 나타내는 것을 실험을 통하여 입증하였다. In this paper, a speech feature based double-talk detector method is proposed for an acoustic echo cancellation in hands-free communication system. The double-talk detector is an important element, since it controls the update of the adaptive filter for an acoustic echo cancellation. In previous research, the double talk detector is considered in the signal processing stage without taking the speech characteristics into account. However, in the proposed method, speech features which are used for the speech recognition is used for the discriminative features between the far-end and near-end speech. We obtained a substantial improvement over the previous double-talk detector methods using the only signal in time domain.