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자궁목질 바른표본에서 비정형 편평세포의 p16에 대한 면역세포화학염색
김활웅,이종실,이정희,고경혁,Kim, Hwal-Woong,Lee, Jong-Sil,Lee, Jeong-Hee,Ko, Gyung-Hyuck 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.1
It was reported that the main cause of intraepithelial neoplasm and squamous cell carcinoma of the uterine cervix is human papilloma virus infection, and that the expression of p16 is increased in cells infected by human papilloma virus. We performed an immunocytochemical staining for protein p16 in 17 cases of cervocovaginal smears initially diagnosed as atypical squamous cells of undetermined significance, to know whether the staining could help the differentiation of neoplastic cells from reactive atypical cells. Of 17 smears, 6 were diagnosed finally as high grade intraepithelial neoplasm or invasive squamous cell carcinoma by follow-up biopsy and smear, and 5 of the 6 were positive for p16. Three were diagnosed as koilocytosis, and one of them was weakly positive for p16. Eight were diagnosed as reactive atypical cells, and all of them were negative for p16. We thought that immunocytochemical staining of p16 in cervocovaginal smears could help the differentiation of neoplastic cells from reactive atypical cells.
타액선의 다형성 선종에서 발견한 암종의 세침흡인 세포학적 소견 -5 예 보고-
최현주,김활웅,함의근,박인애,Choi, Hyun-Joo,Kim, Hwal-Woong,Ham, Eui-Keun,Park, In-Ae 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2
Carcinoma ex pleomorphic adenoma(CXPA) is a rare malignant tumor of the salivary gland, fine needle aspiration cytology(FNAC) of which are rarely reported. We retrospectively reviewed FNAC of five cases of histologically proven CXPA of the salivary glands diagnosed in Seoul National University Hospital to evaluate their cytologic characteristics. Histologically, the carcinoma components were low-grade in three cases and high-grade in two cases. The cytologic diagnosis were malignancy in two cases(40%), suspicious for malignancy in one(20%), and benign(pleomorphic adenoma) in two(40%). All of the high-grade carcinomas were correctly diagnosed by FNAC, however, 2 cases of low-grade carcinomas were diagnosed as benign by FNAC. The low sensitivity in cytologic diagnosis is due to interpretative difficulties in low-grade tumors. The characteristic cytologic features of CXPA were high cellularity, necrotic, bloody, and inflammatory background, marked nuclear overlapping, coarsely granular chromatin, prominent macronucleoli, and atypical mitosis in epithelial component in addition to the typical biphasic pattern of pleomorphic adenoma consisting of epithelial cells admired with spindle-shaped cells and chondromyxoid stroma. Even though low-grade tumors show mild pleomorphism, the cytologic findings of necrotic background, moderate to high cellularity, and nuclear overlapping could lead to an accurate cytodiagnosis of CXPA.
윤만수 ( Man Soo Yoon ),장성규 ( Sung Kyu Jang ),이동형 ( Dong Hyung Lee ),김기형 ( Ki Hyung Kim ),나용진 ( Yong Jin Na ),김활웅 ( Hwal Woong Kim ),김지연 ( Jee Yeon Kim ),최경운 ( Kyung Un Choi ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.7
목적: 상피성 난소종양을 대상으로 조직배열법을 이용한 면역조직화학염색을 실시하여 여러 임상병리학적 인자에 따른 MTA1발현의 상관관계를 알아보고자 하였다. 연구 방법: 양성 종양 53예, 경계성 종양 27예, 악성 종양 68예를 대상으로 면역조직화학염색을 시행하여 MTA1의 발현을 판정하였고, 악성 종양의 여러 임상병리학적 인자에 따른 MTA1의 발현의 차이를 분석하였다. 결과: 종양의 악성도 등급별 MTA1 염색의 성적은 악성도가 높을 수록 MTA1의 고발현 예가 많고 양성 종양에서는 저발현 예가 많아 유의한 차이를 보였고, 종양의 병기가 높을 수록 MTA1의 발현이 증가하였으며, 특히 원격전이를 보이는 4기의 경우 모두가 고발현군이었다. 그 외 환자의 나이, 조직학적 분류, 종양의 크기에 따른 MTA1 발현 정도에는 유의한 차이는 없었다. 결론: 이러한 결과들을 토대로 난소종양에서 MTA1은 종양의 침습과 공격성을 결정하는 주요한 인자일 것으로 추측할 수 있었으며 난소암의 치료나 예후에 중요한 정보를 제공할 수 있을 것으로 사료된다. Objective: MTA1 has been identified as a metastasis-promiting gene, and its gene expression is correlated with invasion and metastasis in several cancers. We examined MTA1 expression levels in epithelial ovarian neoplasm. Methods: Expression of MTA1 was evaluated by immunohistochemistry and tissue array in 53 benign tumors, 27 borderline tumors and 68 malignant tumors. The data was analyzed in reference to various clinicopathological parameters. Results: Increased expression of MTA1 was significantly correlated with histologic grade and FIGO stage. There was no relationship between MTA1 expression and age, histologic type, tumor size. Conclusion: These results suggest that MTA1 is closely related to invasiveness and progression in epithelial ovarian neoplasm. The MTA1 could thus potentially provide information on the mechanism of cancer invasion and metastasis.
위암 침윤 염증세포의 thymidine phosphorylase (TP): TP의 예후와 종양 신혈관생성과의 관계
장정순 ( J Soon Jang ),이종석 ( Jong Seok Lee ),고경혁 ( Gyung Hyuck Ko ),하우송 ( Woo Song Ha ),이원섭 ( Won Sup Lee ),김동훈 ( Dong Hoon Kim ),강기문 ( Ki Mun Kang ),김활웅 ( Hwal Woong Kim ) 대한내과학회 2005 대한내과학회지 Vol.68 No.5
배경 : Thymidine phosphorylase (TP)는 thymidine 에서 thymine으로 변화하는데 관여하는 효소로 종양의 신 혈관 형성에도 관여한다. 최근 TP의 발현이 종양세포 외에 종양 침윤염증세포에서도 발현됨이 보고되고 이 역시 종양의 신혈관 형성에 관여 하고 예후에도 영향을 보이는 것이 보고됨에 따라 본 연구자들은 종양 세포와 종양 침윤 염증 세포에서의 TP 발현을 각각 분리하여 평가하고 이것을 바탕으로 신혈관 생성과 종양의 예후 Background : Thymidine phosphorylase (TP) is an enzyme catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. TP plays a role in angiogenesis. Evidences suggest that infiltrating inflammatory cells adjacent cancer
자궁경관에 동시에 병발한 선암과 신경내분비형 소세포암 1예
신정규,김활웅,최원준,이순애,이종학,백원영 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3
최근 자궁경부의 소세포암은 조직학적으로 편평세포형 소세포암과 신경내분비형 소세포암으로 구별하고 있으며 이중 자궁경부의 원발성 신경내분비형 소세포암은 폐의 소세포암과 형태학적으로 동일하며 진행 및 전이가 매우 빨라서 예후가 극히 불량한 것으로 알려져 있다. 자궁경부의 신경내분비형 소세포암의 증례 보고는 매우 드물며 더욱이 자궁경관 선암과 병발한 예는 국내외적으로도 몇 예에 불과하다. 이에 저자들은 최근 자궁경관에 신경내분비형 소세포암과 선암이 함께 병발하면서 이미 임파선 전이가 되어있는 예를 경험하여 문헌 고찰과 함께 보고하는 바이다. Concurrent occurrence of neoplasms, adenocarcinoma and small cell carcinoma, have been rarely reported to occur in several areas of the body, including gastrointestinal tract, breast, prostate, lung, skin, and kidney. Also concurrent occurrence of adenocarcinoma and small cell carcinoma in the uterine endocervix is extremely rare. We report a case of concurrent occurrence of primary neruoendocrine type small cell carcinoma and infiltrating adenocarcinoma in the uterine endocervix with multiple pelvic lymph node metastases.
자궁 경부 인유두종 바이러스 감염에 대한 세포검사와 DNA 검사의 비교 연구
최경운,김활웅,김지연,이창훈,설미영 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20
Purpose: A newly introduced HPV detection technique in cervical intraepithelial lesion, the HPV DNA Chip test, contains 24 HPV probes and has the advantage of being able to detect 24 HPV types simultaneously. The authors performed HPV genotyping test in cervical specimens from September 2005 to March 2006, and compared their cytologic and histologic diagnoses. Subject and Methods: The HPV DNA Chip test was performed in samples of 263 patients. Among these, 49 patients underwent cervical smear cytology and biopsy. Results: In 160 cases (60.8%) of 263 cases, the HPV DNA was detected. HPV-16 (37.5%), HPV-58 (16.3%), HPV-33 (12.5%), and HPV-18 (10.0%) were frequently detected, including single and multiple infections. The multiple HPV infection was found in 31 cases (11.8%). The sensitivity (91.7%) of the HPV genotyping test using the DNA chip method for detecting HSIL or worse was superior compared with the sensitivity (79.2%) of cytologic diagnosis. Conclusions: Our results indicate that HPV DNA chip test can overcome the low sensitivity of cytologic test and improve the sensitivity of the screening test for cervical intraepithelial lesion.