Monocrotaline을 투여한 백서 폐의 초기 혈관병변에 관한 주사전자현미경적 관찰

박인애,함의근,Park, In-Ae,Ham, Eui-Keun 한국현미경학회 1991 Applied microscopy Vol.21 No.1

An experimental study was performed to observe the early effects of monocrotaline on pulmonary vascular system by means of light microscopy and scanning electron microscopy, attempting to expore the mechanism behind the process of pulmonary hypertension. Experimental animal(Sprague-Dawley male rats ; 150-200g B. W.) were intra-peritoneal administered with 100mg/kg B. W. monocrotaline. Authors observed light microscopically various gradational increase of wall thickness in pulmonary muscular and non-muscular arteries in duration from 2 weeks to 5 weeks after monocrotaline administration and the changes were more sever in the latter than the former. The scanning electron microscopy shows severe and diffuse endothelical cell swelling, microvilli and microbleb formation since 1 hour after monocrotaline administration and during the course, after 5 hours the severity of endothelial cell damage was prominent with presence of fibrin, webs, platelet thrombi and white cell adherence. It was concluded that the monocrotaline primarily induced severe and diffuse endothelial cell damage of pulmonary arteries and laterly added the participation of platelets, which attributed to the pathogenesis of monocrotaline induced pulmonary vascular lesions in relation to pulmonary hypertension.

자궁경부암의 세포병리학적 진단

박인애 주식회사 녹십자 1999 녹십자의보 Vol.27 No.4

사랑의 손길

박인애 수필미학 2020 수필미학 Vol.30 No.-

폐암의 세포병리학적 진단에 관한 검토

박인애,함의근,Park, In-Ae,Ham, Eui-Keun 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.1

In order to evaluate the role of cytopathologic diagnosis of sputum, bronchial washing and bronchial blushing in the diagnosis of lung cancer, we performed this study. The patients included in this study had undergone sputum, bronchial washing and brushing cytology over the 20-month period of 1985 through 1987. The total number of specimens was 5,495 of 2,242 patients, including 4,830 sputa and 665 bronchial washing and brushings. The average number of sputa and bronchial washings and brushings per case was 2.4 and 1.2 respectively. Among them, about 10% were unsatisfactory specimen, and three-fourths were negative specimens. In sputum cytology, the diagnosis of "atypical cells" was given to 3%, "suspicious for malignancy" was given to 1 %, and "malignancy" was given to 13%. In bronchial washing and brushing cytology, the diagnosis of "atypical cells", "suspicious for malignancy" and malignancy" was given to 6%, 3%, and 20% respectively The cases diagnosed as "atypical cells" in cytology were actually malignancy in 95% and 84.8% of sputum and bronchial washing and brushings respectively, and the "suspicious for malignancy" were actually malignancy in 100% in both methods. The detection rates of malignancy were 504% and 55.2% in sputum and bronchial washing and blushing respectively, and the specificity was 100% in both methods. The accuracy of cell typing was 92% in sputum and 89.7% in bronchial washing and blushing.

비설거지 외 1편

박인애 천년의시작 2019 (계간)시작 Vol.18 No.4

The Heavy Metal Removal with MnOx Carbon Nano Composite Electrode in Capacitive Deionization

박인애,유선경,김한주,박수길 한국공업화학회 2012 한국공업화학회 연구논문 초록집 Vol.2012 No.-

Cycliability Improvement of Electrode Using ACF in Capacitive Deionization System

박인애,유선경,김한주,박수길 한국공업화학회 2012 한국공업화학회 연구논문 초록집 Vol.2012 No.1

Cytopathologic Diagnosis of Bile Obtained by Percutaneous Biliary Drainage

박인애,함의근,Park, In-Ae,Ham, Eui-Keun The Korean Society for Cytopathology 1992 대한세포병리학회지 Vol.3 No.1

췌-담도 및 배터 팽대부 주위의 암은 조기진단이 어려워 처음 발견시 질병이 상당히 진행되어 있어, 근치술은 물론 생검진단도 수행하기가 어려운 경우가 흔히 있다. 과거 이런 환자들의 진단 방법의 하나로 십이지장에서 담즙을 얻어 세포병리 검사가 시도 되었었으나, 이 경우 얻어진 담즙에 위액 및 췌액이 섞여 있어 변성을 쉽게 초래하고, 염증세포들이 많이 섞여 있을 뿐만 아니라 주위의 염증으로 비정형 세포변화를 초래하여 진단이 어려운 경우가 흔히 있었다. 최근 이런 환자들에 있어 수반되는 증상인 폐색성 황달의 완화와 방사선학적 진단을 위해 경피 경간 담도 조영술 및 담즙배출술이 시행되고 있는데, 이때 비교적 세포형태가 잘 유지된 담즙을 반복 채취하여 세포 병리검사가 시행된다. 저자들은 이 방법으로 얻어진 담즙의 세포 병리학적 진단 성적을 검토하여 다음과 같은 결과를 얻었다. 총 검체는 148명 환자의 275 검체로 이들의 세포 병리학적 진단은 선암 30예 (20.3%) 편평상피 세포암 1예 (0.75%), 전이성 소 세포암 1예 (0.7%), 선조성 비후 8예 (5.4%) 비정형 6예 (4.1 %), 간 흡충증 17예 (11.5), 양성 질환 57예 (38.5%)였고 28명 (18.9%)에서는 부적합 검체가 의뢰 되었었다. 그중 105명에서 의무기록의 확인이 가능하였는데 이들의 임상진단은 99명에서는 악성 질환 이었고 6명에서는 총 담관 결석과 협착과 같은 양성 질환 이었다. 담즙 세포 병리검사에서의 이들 악성 진단율은 23.2%이었다. 이들 악성 질환을 담도 유래의 종양과(1군)부근 림프절의 전이성암, 췌장암, 배터 팽대부 주위암 등의 외인성으로 담도를 압박하는 종양(2군)으로 나누어 보면 악성 진단율은 각각 37%와 11.6%로 현저한 차이가 있었다. 이들중 조직학적 진단이 가능 하였던 9예의 경우 세포 병리 진단율은 각각 50%(1군)와 20%(2군)로 역시 현저한 차이가 있었다 임상진단이 양성 질환 이었던 예들은 전예에서 세포 병리학적으로 양성으로 진단되어 담즙 세포 병리검사의 임상진단과의 일치율은 27.6%, 특이도는 100%이었다. 이상으로 이 담즙세포 검사의 악성 진단율은 그리높지 않으나, 경피 경간 담즙 배출술로 환자의 증상을 완화 시키면서 부수적으로 진단도 얻을 수 있는 유용한 방법이라 하겠고, 그중 담도유래의 종양군에서 외인성으로 담도를 압박하게 되는 종양군에 비해 현저히 높은 진단율을 보였다. From the one hundred forty eight patients with evidence of biliary tract obstruction, 275 bile samples were obtained from percutaneously placed biliary drainage catheters. Of the 148 patients, ova of Clonorchis sinensis were demonstrated in 17 patients (11.5%), with the epithelial cells. Among them, one case also demonstrated coexisting adenocarcinoma. In 105 patients, the medical records were available for review and the clinical diagnoses were malignancy in 99 patients and benign lesion in 6 patients. Of the 99 patients in which clinico-radiologic diagnosis were malignant, cytologic results were positive in 23.2%. Dividing the patients Into two groups, the ones with tumor of bile duct origin (group I) and the others with tumors producing extrinsic compression of bile duct, such as periampullary carcinoma, pancreas head carcinoma or metastatic carcinoma in lymph nodes from tumors of adjacent organs (group II), the cytologic results were positive in 37% and 11.6%, respectively. In patients with histologic confirmation, the positive correlation was found in 50% and 20% in group I and group II, respectively, with remarkable difference between two groups. There were no false positives in cytologic diangosis. The overall concordance rate of cytologic diagnosis with diagnosis of clinical investigation in both benign and malignant lesions was 27.6% and the diagnostic specificity was 100%.

유화제와 액정 형성에 관한 연구

박인애,안인숙 대한피부미용학회 2007 대한피부미용학회지 Vol.5 No.2

Emulsion that contains a multilayer structure has a similar structure with the multilayer structure existing in the stratum corneum. Emulsion is highly effective for caring a sensitive skin and atopic dermatitis, which a dry skin caused by the damaged stratum corneum of a skin and a reduction of the content of ceramide in a living body, are known as the causes for. However, it is difficult to make an end product of emulsion have the structure stably because stability becomes different, depending on the ratio among ceramide, fatty acid (intercellularlipid), and cholesterol, on the mixture ratio of oily components, on the mixture ratio of emulsifiers, and the mixture ratio of polyhydric alcohol. In this study, a multilayer structure was made by differentiating emulsifiers only without any changes in the kinds and the ratio of other components. By doing this, an emulsifier, which makes it easy to create lamellar liquid crystal, was developed, through which a more stable multilayer structure could be made. Used emulsifiers are C14-22Alcohol & C12-20Alkyl Glucoside, Lechthin & C12-16Alcohol & Palmitic Acid, Hydrgenated Lecithin & C12-16Alcohol & Palmitic Acid, Myristyl alcohol & Hydrogenated Lecithin & Palmitic acid & Cetearyl Alcohol & Lecithin & Glyceryl Stearate, Batyl Alcohol & Stearic acid & Lecithin, Sorbitan Stearate & Sucrose Cocoate, Stearath 21, Stearath 2, Cetearyl Glucoside & Cetearyl Alcohol and Cetearyl Olivate & Sorbitan Olivate. As another experiment, this paper selected myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin, and glyceryl stearate, which have the best optical aeolotropy, out of the emulsifier made in the first experiment. And then, it made ceramide-3 of the same type as found in the human bodies by purifying yeast. Using the components selected from the emulsifier and the ceramide-3, it made another emulsifier and observed its aeolotropy through an optical microscope. The emulsifier containing ceramide was found to have a greater number of clearer maltese cross of a fixed size than the ceramide-free emulsifier. Thispaper kept the emulsifier containing ceramide, myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin and glyceryl stearate in a cycling incubator at -20℃〫~45℃(cooling and heating or freezing and thawing conditions are available) for 6 weeks and had a stability test. No difference in the optical aeolotropy was found before and after that. In order to measure the effect of moisturizing the skins and Transepidermal Water Loss(TEWL), this paper applied Liquid A (containing ceramide, myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin, glyceryl stearate), Liquid B of a gel type (the control group of Liquid A), and Liquid C of a traditional O/W type, about 2mg/cm² each, on the right and the left. And then, it made non-treatment control measurement on the outside of the applied part. It let the subject apply them twice a day, in the morning and in the evening. The measurement was made on the 3rd, the 7th, and the 14th day of the experiment. As a result, the emulsifier of the multilayer structure containing ceramide showed the best skin-moisturizing effect and evaporation-suppressing effect.of this study is to examine.

해바라기

박인애 수필미학 2022 수필미학 Vol.37 No.-