중금속 제거용 셀룰로오즈 잔테이트의 제조 및 응용

김형태,이태호,김상대,이경렬,윤진수,이기세 ( Hyung Tae Kim,Tae Ho Lee,Sang Dae Kim,Kyung Youl Lee,Jin Soo Yun,Ki Say Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

경항문 내시경 수술 도구에서의 최적 활동 반경 개선을 위한 컴퓨터 시뮬레이션 연구

김형태,김광기,남경원,김현호,손대경,Kim, Hyung-Tae,Kim, Kwang-Gi,Sohn, Dae-Kyung,Kim, Hyun-Ho,Nam, Kyoung-Won 대한의용생체공학회 2009 의공학회지 Vol.30 No.6

Conventional devices for transanal endoscopic microsurgery that are currently used clinically for intestine or rectal cancer patients have 40 mm external diameter of rectoscope tube - induces anal damage and long-term postoperative pain for small-sized patients. In this paper, we designed rectum and rectoscope models and calculated the changing trends of operation area of the surgical tools in accordance with the step-by-step variation of design parameters of the rectoscope tube - external diameter, axial length, and distal angle. Using the results of computer simulation, we suggested an optimal set of design parameters that minimizes external diameter of the rectoscope tube and at the same time, maintains similar operation area of the surgical tools compared with commercialized devices (${\geq}\;4274.7mm^2$). The results of the simulation showed that the optimal design parameters were 35 mm external diameter, 100 mm axial length, and $45^{\circ}$ distal angle of the rectoscope tube. This result can be applied to the development of endoscopic microsurgery device that can minimize side effects to the intestine or rectal cancer patients.

만성 육아종 질환에 동반된 급성 연쇄상 구균 감염 후 사구체 신염 1례

김형태,서정욱,김한성,이종국,Kim Hyung-Tae,Seo Jung-Wook,Kim Han-Seong,Lee Chong-Guk 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.2

Chronic granulomatous disease(CGD) is a rare inherited disorder of phagocytic cells which results in a susceptibility to infections by catalase-positive bacteria and fungi, as well as granuloma formation. And acute poststreptococcal glomerulonephritis(APSGN) is one of the most common glomerular lesions of gross hematuria in children. We experienced a case of APSGN accompanied with CGD presenting with a liver granuloma. 저자들은 만성 육아종 질환에 동반된 APSGN을 경험하였기에 문헌 고찰과 함께 보고한다.

가임신 흰쥐에 있어서 자궁척출 및 Prostaglandin F2α 투여가 혈청 Progesterone 의 농도 및 황체에 미치는 영향

김형태,정영채,김창근 ( Hyung Tae Kim,Yung Chai Chung,Chang Keun Kim ) 한국축산학회 1981 한국축산학회지 Vol.23 No.4

The purpose of this experiment was to investigate the effects of hysterectomy and administration of PGF₂α on serum progesterone level and corpus luteum in pesudopregnant rats. PGF₂α administration or hysterectomy was performed at day S of pseudopregnancy. Five rats from each group were randomly sacrificed at day 5,6,7,8,9 and 12 of pseudopregnancy for assay of serum progesterone level and microscopic observation of ovary. The results obtained were as follows; 1. In both normal and hysterectomized groups, PGF₂α administration caused significant reduction in serum progesterone level to 24.2% and 30.8% at day 6 and to 11.3% and 34.3% at day 9 of pseudopregnancy as compared with pretreatment level. The serum progesterone level of hysterectomized group untreated with PGF₂α remained elevated until day 12 of pseudopregnancy as compared to those of other three groups. 2. The ovarian weights of control group treated with PGF₂α were significantly reduced as compared to those of other three groups at day 9 of pseudopregnancy (p$lt;0.05). 3. The number of corpus luteum in groups treated with PGF₂α was slightly reduced, but there were no significant difference between PGF₂α and non-PGF₂α treated groups at day 6,7,8,9 of pseudopregnancy. 4. The number of lutein cell in corpus luteum of PGF₂α treated groups on day 9 of pseudopregnancy was significantly lower than those of PGF₂α untreated groups (p$lt;0.05).

트리메토프림과 ${\beta}$-시클로덱스트린 고분자 간의 포접복합체 형성에 의한 용출 및 안정성 향상

김형태,박경옥,서성훈,Kim, Hyung-Tae,Park, Kyung-Ock,Seo, Seong-Hoon 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2

To improve the solubility and dissolution rate of trimethoprim (TMP), which is slightly soluble drug, its inclusion complexes were prepared and studied in this experiment. Inclusion complexes of TMP with ${\beta}-cyclodextrin$ and ${\beta}-cyclodextrin$ polymer (CDPS) were prepared according to Fenyvesi method. These were compared with TMP and its physical mixture with CDPS. Water, diluted hydrochloric acid and phosphate buffer solution were used as dissolution media. And accelerated stability test was studied at $50,\;70\;and \;80^{\circ}C$. It was found that solubility and dissolution rate of inclusion complexes were increased in water. Especially, the solubility and dissolution rate of TMP was found to be markedly increased by inclusion complexation with CDPS. In stability test, ${\beta}-cyclodextrin$ inclusion complexes were more or less stable than TMP alone. This tendency was not led in CDPS. Consequently, CDPS was useful in increasing dissolution rate and stability of TMP.

심한 소장침범을 보인 Henoch-Schonlein Purpura의 치료 2례

김형태,문진수,장현오,조희승,이종국,김기홍,서정욱,김민경,Kim, Hyung Tae,Moon, Jin Soo,Jang, Hyun Oh,Jo, Heui Seung,Lee, Jong Guk,Kim, Ki Hong,Seo, Jung Wook,Kim, Min Kyung 대한소아소화기영양학회 2004 Pediatric gastroenterology, hepatology & nutrition Vol.7 No.1

보존적인 스테로이드 치료로 호전이 없는 심한 복부증상을 동반한 HSP 환자의 치료에는 아직까지 정설이 없으나, 저자들은 면역글로불린 정맥투여로 증상이 호전된 증례와 소장의 경장괴사를 동반하고 수술적 치료로 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a vasculitis of the small vessels in skin, joints, gastrointestinal (GI) tract and kidney. GI symptoms occur in up to 85% of patients and may lead to severe problems such as intussusception, obstruction, and perforation. GI symptoms may not be easily controlled, showing refractoriness to the conventional corticosteroid therapy. Although GI involvements of HSP are acute, and self-limited in most instances, they may cause fatal results in some unusual cases. In such conditions all the possible therapeutic modalities should be considered. We report two cases of severe small bowel involvement of HSP. One case presented with severe abdominal pain showing refractoriness to corticosteroid, but improved with IV immunoglobulin therapy. In the second case, HSP with transmural infarction in the small bowel could be cured with surgical intervention.

하악골의 발육중인 생쥐에서 기능력의 변화가 특이-유전자 발현에 미치는 영향

김형태,박주철,이창섭,박헌동,Kim, Hyung-Tae,Park, Joo-Cheol,Lee, Chang-Seop,Park, Heon-Dong 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.2

기능력은 뼈의 형성, 유지 및 개조 이외에도 치아이동, 교정치료, 기능성 악교정장치의 사용 등과 관련한 치주인대세포의 특성 변화 등에 중요한 영향을 미친다. 또한, 하악과두에서도 기능력의 변화에 따라서 다양한 특성의 변화가 나타난다. 본 연구에서는 ICR 생쥐를 8주 동안 soft-diet와 hard-diet의 식이 조절을 통해 기능력의 변화를 유도하여, 기능력의 변화와 관련한 특이 유전자를 검출하기 위하여 subtractive hybridization, northern 분석 및 mRNA in-situ hybidization 등의 실험을 시행하여 다음과 같은 결과를 얻었다. 1. Soft-diet군과 hard-diet군의 subtractive hybridization을 통하여 총 39개의 clone을 얻었고 이중에서 11개의 서로 다른 hard-diet군 특이 후보 유전자들을 분리하였다. 2. 11개의 후보 유전자들 중에서 homology 검색과 northern 분석을 통하여 기능력과 관련이 있을 것으로 생각되거나 hard-diet군에서 mRNA가 선택적으로 발현되는 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자를 선택하였다. 3. Soft-diet군과 hard-diet군의 형태학적 분석에서 soft-diet군은 hard-diet군에 비하여 골모세포의 활성과 골개조의 특성은 저하된 것으로 관찰되었으나, 하악과두의 연골성골화 과정은 오랜 시간동안 지속되는 것으로 나타났다. 4. FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자의 cRNA 탐침자를 이용한 in-situ hybridization에서 4개의 유전자의 mRNA들은 hard-diet군의 세포들에서는 강하게 발현되었으나 soft-diet군의 세포들에서는 그 발현이 미약하거나 나타나지 않았다. 이상의 결과를 종합하여 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자들은 대부분이 기능이 거의 알려져 있지 않는 것들로 기능력의 변화 과정에서 중요한 역할을 할 것으로 생각되나 앞으로 보완 연구를 통하여 각 각의 유전자들의 보다 정확한 기능을 이해하는 것이 필요 할 것으로 사료된다. Mechanical forces are known to have an effect on bone formation, maintenance and remodeling, and there is evidence that the development of the mandibular condyle in the rat or mouse is influenced by altered functional force. However, studies are lacking in molecular-biologic mechanism such as the identification of differentiation factor induced from functional force. Here a mouse model was used to investigate the functional stress-responsive gene or factors which is related to the altered force by comparing the expression genes of functional state and hypo-functional state of the mouse mandible. ICR mice were provisioned with either a soft, mushy diet (soft-diet group) or hard rat pellets (hard-diet group) beginning at weaning for the alteration of functional force and subsequently sacrificed at 89 days of age. Incisor of mice in group 1 were trimmed twice a week to reduce occlusal forces. After killing the animals, mandibular bone including condyle were collected for RNA extraction, subtractive hybridization, northern blot analysis and mRNA in-situ hybridization. The results as follows; 1. A total of 39 clones were sequenced, and 11 individual sequence types were subsequently identified by subtractive hybridization, as 28 clones were represented twice in the analyzed sets. 2. Consequently four candidate clones, FS-s (functional stress-specific)2, -5, -18, and -22 were identified and characterized by homolgy search and northern analysis. Four of these clones, FS-s2, -5, -18, and -22, were shown to be expressed differentially in the hard-diet group. 3. Histologic sections showed that osteoblastic activity along the bone trabeculae and active bone remodeling were significantly lower in soft than in hard diet animals. A soft diet seems to enable a longer period of endochondral ossification in the mandibular condyle. 4. Although the mRNAs of FS-s2, -5, -18, and -22 were expressed rarely by cells of the soft-diet group, highest expression was detected in the cells of the hard-diet group. Together with the above results, it is suggested that FS-s2, -5, -18, and -22 could act as an important factors controlling the tissue changes in response to functional stress. The exact functional significance of these findings remains to be established.

외래에서 시행되는 585 nm 펄스다이레이져 후두수술

김형태,Kim, Hyung-Tae 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.1

Introduction: 585 nm Pulsed dye laser (PDL) laryngeal surgery is based on the photodynamic characteristics of selective photothermolysis and photoangiolysis and recently considered to be the treatment for a variety of benign laryngeal disease. Objective: To review the indications and outcome of office-based 585nm PDL surgery and summarize new developments. Method: Retrospective study involving 402 patients was performed, The PDL surgery could be applied to various laryngeal diseases such as laryngeal papilloma, vocal fold dysplasia, laryngeal granuloma, vocal polyp, capillarectasia, scarred vocal fold and sulcus vocalis. Results : The physiologic properties of the vascular specificity of PDL provide many advantages and appear to be effective for laryngeal treatment. The PDL resulted in precise, selective coagulation of the microvasculature without damage to the surrounding tissue. Therefore PDL surgery is safe and effective for office-based treatment of benign laryngeal disease and for all patients regardless of their overall medical condition. Conclusion: PDL surgery provides potential benefits and advantage for treating common benign laryngeal disease.

고전문학 : 의원필담(醫員筆談)에 구현된 18세기 조일(朝日) 의료 풍속의 토포스(topos)적 특성

김형태 ( Hyung Tae Kim ) 배달말학회 2014 배달말 Vol.55 No.-

의원필담의 내용은 당시 병증(病症)과 치험례(治驗例), 물명(物名)이나 본초(本草) 관련 정체성 규명, 양국의 각종 풍속, 제도, 지리(地理) 등 다방면에걸쳐 정형화되어 있다. 그만큼 이는 당대 동아시아 풍속 및 문화지형도(文化地形圖) 구성상 그 가치가 크다. 통신사 의원필담 전반에 걸친 관심사를 종합하다 보면, 자연스럽게 18세기 조일 의료 풍속의 지형도가 그려지고, 그 안에 내포된 특성들이 돌출될 수 있으며, 이는 동아시아 풍속사의 구성 요소로 자리매김할 수 있다. 본 연구자는 우선 그 흔적을 ‘본초(本草)’와 ‘의료 분과의 특화(特化)’, ‘유행병(流行病)’이라는 세 부분에서 찾아보았고, 이를 통해 그 특성들을 확인해보는 데 본 논문의 목적이 있다. 본초를 중요하게 여기고 심도 있는 대화를 나누었던 이면에서 의서 중심의 의학적 지식보다는 실제 치료에 중점을 둔 그 당시 실용적 의료 풍속을 확인할 수 있다. 또한 의원필담의 주요 내용 중 하나는 치법과 관련된 내용인데, 그것은 실제 임상에 근거한 치법이라는 특성을 지닌다. 그리고 이는 조일 의원들 사이에 부인병과 소아병에 대한 특화된 관심의 확대로 표출된다. 아울러 의원필담을 남긴 일본 의원들의 주된 관심사 중 하나는 풍토병과 전염병 등 당시 일본에 유행하던 유행병들이었다. 광견병의 예에서 확인할 수 있듯이 전통 의학에 입각한 임상 처방을 중시하면서 치료에 힘쓰고자 했던 당시 조일 의료 풍속의 일반적 성향을 확인할 수 있다. In this paper, revealed in a written answer of the medical members(醫員筆談) to the Tong-sin mission(通信使) of Chosun and Japan both countries` interests and topics according to the doctor examined the orientation. The criteria is diagnostic point of view of the herbalism, interest in gynecopathy,pediatrics, epidemic. Previously books include medical theory based on medical books and scholarly interests are on the side. But this book is the 18th century, the two countries tend to experience medical prescription of based on actual medical practice shows that is important to us. In general, written answer of the medical members customs-related information contained in the disease, treatment, medicine, the name and identity of objects, each of them received medicines and medical books. The contents of this book is an important source of information containing comprehensive. In addition, customs at the time to look at two of the country`s medical is a very appropriate text. And ginseng(人蔘) records a very interesting and unique. Medicine meansand medical members(醫員) at the time of asking for the qualities and values can also look at. The medical members to the Tong-sin mission through a written answer of the 18th century Chosun and Japan doctors learn more about the identity and way of thinking can be. In addition, by recording the time and customs trends in East Asian medicine may be examined. Because of this, a written answer of the medical members to the Tong-sin mission has important cultural and historical value.

삼차신경통의 치료를 위한 삼차신경절 풍선압박술의 마취관리 -증례보고

김형태 ( Hyung Tae Kim ),안선경 ( Seon Kyeong An ),장인수 ( In Su Jang ),김형일 ( Hyoung Ihl Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.1

Trigeminal neuralgia is sudden, usually unilateral, severe brief stabbing recurrent pain in the distribution of one or more branches of the 5th cranial nerve. Treatments of trigeminal neuralgia include systemic trials of medications and surgical procedures such as microvascular decompression, stereotactic radiosurgery, percutaneous glycerol or alcohol rhizolysis, percutaneous radiofrequency rhizotomy, and percutaneous balloon compression (PBC). PBC of the trigeminal ganglion using a balloon catheter was introduced by Mullan and Lichtor in 1983. Since then, many papers have been published describing results of this technique. Typically, this procedure is performed under general anesthesia. However, little is known about the use of PBC for the treatment of trigeminal neuralgia in Korea. We report here our anesthetic management of percutaneous balloon compression of trigeminal ganglion for the treatment of the trigeminal neuralgia by total intravenous anesthesia. (Korean J Anesthesiol 2009; 57: 132~6)