구안와사(말초성 안면신경마비) 입원환자 100례에 대한 임상적 고찰

김민정,김종한,박수연,최정화,정민영,송진수,이유진,이지은,양미성,Kim, Min-Jeong,Kim, Jong-Han,Park, Soo-Yeon,Choi, Jeong-Hwa,Jung, Min-Young,Song, Jin-Su,Lee, Eu-Jin,Lee, Ji-Eun,Yang, Mi-Sung 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.2

Objectives : The purpose of this study is to make a survey on the oriental medical care and to enlarge the domain of oriental medical treatment concerning facial paralysis. Methods : From May 2008 to April 2009, a clinical study was done on 100 inpatients who were diagnosed and treated as facial nerve paralysis at Mok-dong Oriental Medicine Hospital, Dong-shin University Results : The result were as the following 1. The distribution of sex: male 35%, female 65%. The distribution of age was disclosed that fifty was the most in 22 cases(22%). 2. The distribution of the region of facial palsy: Lt 58%(male 23%, female 35%) Rt 41%(male 11%, female 30%) 3. In distribution of contributing frequence in month, June was the most in number(12%) and in season, spring, summer, winter were the same percentage(26%). 4. In distribution of cause, stress(34%), excessive labor(25%), unknown(22%) were investigated higher than other conditions. 5. The distribution of past history: hypertension 14%, diabetes mellitus 4%, both(hypertension, diabetes mellitus) 6% 6. The distribution of period before admission: within a week 80%, 1$\sim$2 week 8%, 3$\sim$4 week 6% in order. 7. The distribution of attended symptoms: mastoid pain 43 cases, dryness of eye 26 cases, tearing 22 cases, headache 12 cases, dizziness 9 cases in order. 8. Other offices patients visited before coming to this clinic: oriental clinic or hospital 35%, local clinic or hospital 29%, none 26%, both(oriental clinic & local clinic) 10%. 9. The distribution of House-Brackmann grade on admission: Gr III 38%, Gr IV 26%, Gr II 22%, Gr V 14% in order. 10. The distribution of House-Brackmann grade on discharge: Gr II 34%, Gr I 32%, Gr III 22%, Gr V 7%, Gr IV 5% in order.

Characterization Analysis of Functional Gochujang including Grain Syrup with Tomato Puree

Min Jeong Seo(서민정),Byoung Won Kang(강병원),Jeong Uck Park(박정욱),Min Jeong Kim(김민정),Hye Hyeon Lee(이혜현),Zae Suk Kim(김재숙),Mi Bok Yoo(유미복),Hyun Suk Kim(김현숙),Su Mi Kim(김수미),Yong Kee Jeong(정영기) 한국생명과학회 2012 생명과학회지 Vol.22 No.11

전통발효식품인 고추장의 기능성을 부가하고 맛과 기호성을 개선하기 위하여 토마토 퓨레조청을 첨가한 고추장을 최적발효조건을 설정하기 위해 소금의 농도를 달리하여 GCJ 14, 16, 18, 20의 조건으로 제조한 후 발효하여 고추장의 이화학적 성분의 변화로 발효의 최적조건을 설정하였으며, 기능성 성분인 라이코펜의 함량을 분석하였다. 그 결과 토마토 퓨레 조청 함유 고추장의 pH의 변화는 발효기간동안 감소하였으며, 당도는 감소하였다 증가를 반복하였으며, 수분과 염도, 색도는 유의적인 변화를 나타내지 않았다. 미생물의 변화는 발효가 진행됨에 따라 총균수와 유산균수는 증대되었으며, 총균수 대비 유산균의 생성비율은 GCJ 18와 GCJ 20조건에서 높은 비율을 확인하였다. 토마토 기능성 성분인 라이코펜의 함량의 변화는 발효과정 동안 유의적 변화를 나타내지 않았다. 그리고 제조된 고추장의 조단백질, 조지방, 조회분, 탄수화물의 일반성분함량의 변화와 맛, 기호성 등의 관능검사에서 GCJ 20에서 가장 발효에 적합한 조건으로 판단된다. 따라서 토마토 퓨레조청 함유 고추장으로 현대인의 기호에 맞으면서 기능성이 부과된 고추장의 개발의 가능하다고 사료된다. To add functional specialty in a traditional fermentation product, Gochujang, and improve the taste and preference, an optimum fermentation condition of Gochujang supplemented with tomato puree was established in the conditions of GCJ 14, -16, -18, and -20. Varying the salinity concentration and the manufactured fermentation products, Gochujang was analyzed by the chemical nature, change in bacterial characteristics and contents of a functional chemical, lycopene, and sensory taste. As a result, the pH change of Gochujang containing tomato puree with grain syrup was diminished during the fermentation process. Its sugar contents were repeated by the increase and decrease. In addition, the water contents, salinity, and chromaticity of the Gochujang showed no significant change. Regarding the change in bacterial characteristics, total bacterial number and lactic acid bacteria number increased, with the rate of increase depending on the fermentation process. The ratio of lactic acid bacteria number against total bacterial number was confirmed to be significantly high at the conditions of GCJ 18 and -20. No significant change in the contents of lycopene was observed during the fermentation process. Notably, the change in crude proteins, crude fat, crude ash, and carbohydrates in addition to a sensory examination including taste and preference of the manufactured Gochujang suggest that the optimal fermentation product is produced in the condition of GCJ 20. Therefore, functional Gochujang satisfying a modern preference can be produced by using tomato puree with grain syrup.

식품 3D 프린팅 기술과 3D 프린팅 식품 소재

김민정(Min-Jeong Kim),김미경(Mi-Kyung Kim),유영선(Young-Sun You) 한국청정기술학회 2020 청정기술 Vol.26 No.2

최근 3년간 세계 식품 3D프린팅 시장은 연 평균 31.5%의 높은 성장률과 약94억 6000만 달러에 이르는 산업규모를 보이고 있다. 식품 3D 프린팅 기술은 기존 식품을 자유롭게 디자인함으로써 개인의 취향과 목적에 따라 식품을 제작할 수 있어 다양한 범위로 활용이 가능하다는 장점을 지니고 있다. 세계 여러 국가에서는 식품 3D프린터를 제작하여 식품 3D 프린팅의 장점들을 활용한 음식과 같은 시제품들을 내놓고 있으며 전투식량, 우주식량, 음식점, 유동식, 노인식, 환자식, 유아식 등의 여러 분야에서까지 활용하고자 시도 중에 있다. 성장가능성이 높고 산업 규모가 지속적으로 확대될 전망인 3D 프린팅 시장은 블루오션이 될 가능성이 다분한 반면 우리나라는 식품 3D 프린팅 기술뿐만 아니라 전반적인 3D프린팅 활용률이나 산업 규모 자체가 작다. 이는 선진국에 비해 미흡한 제도화와 표준화된 국산소재 개발이 지연 등의 문제가 존재하기 때문으로 따라서 본고에서는 식품 3D프린팅의 필요성에 대해 알리고 우리나라의 식품 3D 프린팅 시장 활성화라는 부가 효과를 얻고자 식품 3D프린팅 기술과 식품소재에 관해 기술하고자 한다. Over the last 3 years, the global food 3D printing market has grown at an average annual rate of 31.5% and has shown an industry size that reached about U$ 9.46 billion. Food 3D printing technology has the advantage of being utilizable in diverse ranges because it enables free design of existing foods so that foods can be produced according to individuals’ tastes and purposes. Many countries around the world are producing food 3D printers to release trial products such as foods employing the advantages of food 3D printing. They are also attempting to apply food 3D printing in various fields such as combat rations, space rations, restaurants, liquid foods, foods for the elderly, diets for patients, and baby foods. Whereas the 3D printing market, which has a high growth potential and is expected to continue to expand in size, is highly likely to become a blue ocean, not only is food 3D printing technology small in South Korea, but also the overall ratio of 3D printing utilization and the scale of the relevant industry are small. This is attributable to the fact that South Korea has problems such as insufficient institutionalization compared to developed countries and delays in the development of standardized domestic materials. Therefore, this paper is intended to inform the necessity of food 3D printing and describe food 3D printing technology and food 3D materials in order to obtain the additional effect of vitalizing the South Korean food 3D printing market.

여성과학인의 성장기 환경과 여성과학인으로서의 특성

김민정(Kim Min Jeong),김정미(Kim Jeong Mi),김정주(Kim Jung Ju),이여경(Lee Yeo Kyong),장정애(Jang Jeong Ae) 한국열린유아교육학회 2008 열린유아교육연구 Vol.13 No.2

본 연구는 5명의 여성과학인을 대상으로 그들의 성장기 환경에 대한 의미를 살펴보고, 여성과학인으로서의 공통적인 특성에 대해 살펴봄으로써 부모와 유아교사로 하여금 유아기 과학적 경험과 태도의 중요성을 깨닫고 가정과 교실현장에서 활용할 수 있는 기초자료를 제공하는데 그 목적을 두고 수행되었다. 면담을 통해 수집된 자료의 분석결과 첫째 연구대상은 유아기부터 가정과 기관에서 과학과 관련한 놀이를 개방적이고 자율적으로 경험하고 있었으며, 가족구성원과 교사의 끊임없는 격려와 긍정적인 지지를 받고 있었다. 둘째 연구대상은 주면 환경에 대하여 호기심을 갖고 관찰하고 실험하고 예측하는 과학의 과정을 실천하고 있었으며 호기심. 인내와 끈기의 과학적 태도를 보였다. 또한 섬세함과 꼼꼼함을 여성성의 장점으로 인식하여 문제 상황에 대처하는 한편 과학인과 여성의 역할에 대한 균형을 유지하기 위해 노력하는 것으로 나타났다. This study show the characteristics of female scientist drawn from a survey of their childhood education in order to provide the groundwork to educate teacher and parents. The data for this study was collected from in-depth interviews of five female scientists. The results are as follows. First, subjects experienced the play related to science in toleratant and self-controlled family atmosphere and support from family members and teachers. Second, subjects were interested in their environments and implemented the process of science in their life, which indicats that they had scientific attitudes. In addition, to subjects have recognized the effects of gender and scientifically applied it to their life. on the other hands, subjects have tried to balance our their roles as a scientists with their roles as women.

통앞뇌증과 동반된 얼굴 이상형태증

김민정 ( Min Jeong Kim ),박인양 ( In Yang Park ),김연희 ( Yon Hee Kim ),최미나 ( Mi Na Choi ),김명신 ( Myung Shin Kim ),이영 ( Young Lee ),신종철 ( Jong Chul Shin ),김사진 ( Sa Jin Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.4

목적: 본 연구의 목적은 통앞뇌증과 연관된 얼굴 이상형태증을 정의하고 분류하고자 하는데 있다. 방법: 1995년부터 2007년까지 가톨릭대학교 산부인과에서 통앞뇌증으로 진단된 태아 및 신생아를 대상으로 초음파 소견과 임상적, 병리학적 자료를 후향적으로 조사하였다. 결과: 통합뇌증으로 진단받은 경우는 총 12예로, 진단시 평균 임신 주수는 28주 (14~41주)였고, 8예가 조기자연분만, 2예가 계류유산, 1예가 정상 만삭 자연분만을 하였으며, 정상 만삭 제왕절개 1예였다. 관련된 태아기형의 빈도는 9예 (75%)로 단안증, 주둥이, 입술갈림증, 누두두증, 무탁융합귀증과 같은 얼굴 이상형태증이었으며, 비정상적 염색체핵형은 6예 중 3예 (50%)였다. 결론: 산전 초음파검사에서 가운데 뇌 이상이 발견되었을 때, 자세하게 얼굴 이상형태증을 산전에 초음파 등을 이용하여 확인하는 것이 주요한 구조적 이상과 예후가 좋지 않은 통앞뇌증을 좀 더 정확하게 진단하는데 도움이 될 것이다. Objective: The purpose of this study is to determine and classify holoprosencephlay with the associated facial abnormalities. Methods: This was a retrospective study in which were reviewed the sonographic findings in correlation with the clinical and pathologic data of fetuses or neonates identified with holoprosencephaly at the Department of Obstetrics and Gynecology of the Catholic University in the period 1995-2007. Results: Twelve cases with a Holoprosencephaly were found. Mean gestational age at diagnosis and delivery was 28 weeks of pregnancy (range from 14 to 41 weeks). Modes of delivery were 8 cases of preterm spontaneous delivery, 2 cases of missed abortion, 1 case of normal fullterm spontaneous delivery, and 1 case of full term cesarean delivery. Associated facial anomalies were present in 9/12 cases (75%) which involved with cyclopia, proboscis, cleft lip and palate, ethomocephaly and otocephaly. Among those anomalies, abnormal karyotypes were 3/6 cases (50%). Conclusions: When a midline brain anomaly is detected by antenatal sonography, accurate sonographic analysis of midline facial defect may allow more definitive diagnosis of holoprosencephaly, and the outcome of affected fetuses often have other major structural abnormalities and nearly always fatal.

EGCG, genistein, resveratrol 처리에 의한 ATF3와 NAG-1 유전자 발현변화의 p53 의존성 분석

김민정(Min-Jeong Kim),김현지(Hyun-Ji Kim),서유미(Yu-Mi Seo),이은주(Eun-Joo Lee),김종식(Jong-Sik Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.5

EGCG는 녹차의 카테킨 중의 하나로서 항산화, 항염증 그리고 항암 활성 등 다양한 생리활성을 가지고 있는 물질로 알려져 있다. 본 연구에서는 EGCG를 처리한 HCT116 세포와 p53-null HCT116 세포에서 oligo DNA microarray 실험을 통하여 유전자 발현 변화를 분석하였다. Microarray 실험에서 EGCG를 처리한 HCT116 세포주에서 증가된 유전자 4개(ATF3, CDKN1A, DDIT3, NAG-1)를 선별하여, p53-null HCT116에서의 데이터와 비교하였다. NAG-1을 제외한 3개의 유전자는 p53의 상태와 관계없이 발현이 증가하였고, p53-null HCT116 세포주에서는 EGCG에 의해 NAG-1의 발현이 증가되지 않았다. EGCG의 처리에 의해 ATF3와 NAG-1의 유전자와 단백질의 발현을 확인한 경우 동일한 결과를 보여주었다. 또한, 파이토케미칼 genistein과 resveratrol을 처리한 후 ATF3와 NAG-1의 발현을 연구한 결과 genistein은 p53의 상태와 관계없이 ATF3 발현에 영향을 주지 못하는 반면, NAG-1 단백질은 p53 존재 하에서만 발현이 증가되었다. 이에 반해 resveratrol은 p53의 상태와는 관계없이 ATF3와 NAG-1 단백질의 발현을 증가시켰다. 따라서, 항암 활성을 가진 3 종류의 파이토케미칼이 각각 다른 기전으로 항암 유전자를 발현시키는 것으로 생각된다. 종합적으로 본 연구결과는 파이토케미칼 EGCG, genistein, resveratrol에 의해 매개되는 항암 활성의 기전을 이해하는데 도움을 줄 것으로 생각된다. Epigallocatechin-3-gallate (EGCG), one of catechins of green tea, has been known to possess anti-oxidation, anti-inflammation, and anti-cancer effects. The present study analyzed global gene expression changes in EGCG-treated HCT116 cells and p53-null HCT116 cells by oligo DNA microarray analysis. Among the differentially expressed genes in EGCG-treated HCT116 cells, four were selected that are known as tumor suppressor genes (activating transcription factor 3 [ATF3], cyclin dependent kinase inhibitor 1A [CDKN1A], DNA damage-inducible transcript 3 [DDIT3] and non-steroidal anti-inflammatory drug activated gene [NAG-1]) and their expression was compared to the expression of genes in p53-null HCT116 cells. We found that the expression of these genes was not dependent on their p53 status except for NAG-1, which was only up-regulated in HCT116. The results of RT-PCR and Western blot analysis showed that ATF3 up-regulation by EGCG was not affected by the presence of p53, whereas NAG-1 expression was not induced in p53-null HCT116 cells. We also detected ATF3 and NAG-1 expression changes through genistein and resveratrol treatment. Interestingly, genistein could not up-regulate ATF3 regardless of p53 status, but genistein could induce NAG-1 only in HCT116 cells. Resveratrol could significantly induce NAG-1 as well as ATF3 independent of p53 presence. These results indicate that EGCG, genistein and resveratrol may have different anti-cancer effects. Overall, the results of this study may help to increase our understandings of molecular mechanisms on anti-cancer activities mediated by EGCG, genistein and resveratrol in human colorectal cancer cells.

영유아교사의 과학 교과교육학지식, 과학적 태도와 과학교수 적극성에 대한 연구

김민정(Kim Min Jeong),민미희(Min Mi hee),김지현(Kim Ji hyun) 한국유아교육·보육복지학회 2017 유아교육·보육복지연구 Vol.21 No.1

이 연구는 영유아교사의 과학활동 관련 지식, 태도, 행동의 차원으로 과학 교과교육학지식, 과학적 태도, 과학교수 적극성을 선택하고, 이 변인들이 교사의 담당학급(영아반, 유아반), 경력, 학력에 따라 차이를 보이는지를 알아보았다. 어린이집 교사 208명을 대상으로 질문지 조사를 실시하였으며, 수집된 자료는 삼원다변량분석과 삼원변량분석을 통해 분석하였다. 연구결과 영유아교사의 과학 교과교육학지식은 교사의 경력과 학력에 따라 차이를 보였고, 과학적 태도에서는 교사의 학력에 따른 차이가 나타나면서 동시에 유아교사에서 경력에 따른 차이가 나타났다. 영유아교사의 과학교수 적극성에는 학력에 따른 차이가 있었다. 이 연구결과는 영유아교사의 담당학급, 경력, 학력에 따른 교사교육 프로그램의 내용을 제시했다는 점에서 의의가 있다. This study is aimed to identify whether there are any meaningful differences in infants and young children’s teachers’ pedagogical content knowledge of science teaching, scientific attitudes, science teaching intentions according to teachers’ class (infants vs. young children), career, and education level. To this end, we conducted questionnaire surveys on 208 educare teachers, and analyzed collected date through 3-way MANOVA and 3-way ANOVA. The results showed that the educare teachers’ pedagogical content knowledge of science teaching was different according to their career and education level. In their scientific attitudes, there was gap depending on their education level, and for only young children’s teachers, there was difference according to their career. In addition, the educare teachers’ science teaching intentions were varied depending on their education level. These results have implications in suggesting the content of teacher education program with necessary assistance for class, different career, and education level.

2006~2007년 국내 종오리 농장에서의 HPAI 증례 보고

김민정 ( Min Jeong Kim ),조성준 ( Seong Joon Joh ),김민철 ( Min Chul Kim ),이윤정 ( Youn Jeong Lee ),정옥미 ( Ok Mi Jeong ),우계형 ( Gye Hyeong Woo ),권준헌 ( Jun Hun Kwon ),모인필 ( In Pil Mo ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.2

Korea had experienced second epidemic highly pathogenic avian influenza (HPAI), and there were the seven affected farms, including two breeder duck farms, from 22nd November 2006 to 6th March 2007. Here, we reported the clinico-pathological characteristics of domestic breeder ducks farms naturally infected with HPAI virus (H5N1). Clinically, the most ducks showed various signs from depression, decreased egg production and feed consumption to even, death. The most commonly gross changes were hepatomegaly, splenomegaly, petechial and ecchymotic hemorrhage on the liver surface, a white stripe on the cardiac muscle, and severely hemorrhagic and deformed eggs. The most significant histopathological changes were necrosis of various cells such as neuron, lymphocytes, cardiac myocytes, hepatocytes, blood vessels and pancreatic acinar epithelium. The viral antigen was mainly detected in the endothelium of blood vessels of various organs and tissues, peripheral nerves and neuronal cells. Based on the above results, we identified that HPAI H5N1 induced systemic infection in the adult breeder ducks.

자궁각절제술 후 발생한 임신 35주의 자궁파열

김민정 ( Min Jeong Kim ),이미라 ( Mi Ra Lee ),전혜지 ( Hye Ji Jeon ),최슬아 ( Sl A Choi ),조은규 ( Eun Kyu Cho ),김윤숙 ( Yun Sook Kim ),배동한 ( Dong Han Bae ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3

Uterine rupture in pregnancy is a rare condition, but an obstetric emergency. It threatens the life of both the mother and the newborn. Hemorrhage from the wound surface is the principal complication. Therefore, mortality rates strongly depend on the time elapsed between onset and diagnosis of the uterine rupture, and on the possibility of immediate surgical intervention. Prompt diagnosis of the uterine rupture is of prime importance. The major risk factor for uterine rupture is previous cesarean delivery. Other risk factors identified as contributing to uterine rupture are malpresentations, second stage dystocia, labor induction, use of epidural for pain control, preterm delivery and delivery after the 42nd week of gestation. We experienced a woman with a history of corneal resection 1 year ago, who suffered uterine rupture at 35 weeks` gestation during preterm labor.

줄기밀도에 따른 겨울철 파프리카 생육 및 건물분배 차이

김효중(Hyojoong Kim),조윤섭(Yoon-seob Jo),김희곤(Hee-Gon Kim),정종모(Jong-mo Jeong),임경호(Gyung-ho Lim),김성준(Seong-jun Kim),김민정(Min-jung Kim),이재신(Jae-sin Lee),장미향(Mi-hyang),손동모(Dong-mo Son),이야성(Ya-seong Lee),이정현(Jeo 한국원예학회 2017 한국원예학회 학술발표요지 Vol.2017 No.10