통앞뇌증과 동반된 얼굴 이상형태증

김민정 ( Min Jeong Kim ),박인양 ( In Yang Park ),김연희 ( Yon Hee Kim ),최미나 ( Mi Na Choi ),김명신 ( Myung Shin Kim ),이영 ( Young Lee ),신종철 ( Jong Chul Shin ),김사진 ( Sa Jin Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.4

목적: 본 연구의 목적은 통앞뇌증과 연관된 얼굴 이상형태증을 정의하고 분류하고자 하는데 있다. 방법: 1995년부터 2007년까지 가톨릭대학교 산부인과에서 통앞뇌증으로 진단된 태아 및 신생아를 대상으로 초음파 소견과 임상적, 병리학적 자료를 후향적으로 조사하였다. 결과: 통합뇌증으로 진단받은 경우는 총 12예로, 진단시 평균 임신 주수는 28주 (14~41주)였고, 8예가 조기자연분만, 2예가 계류유산, 1예가 정상 만삭 자연분만을 하였으며, 정상 만삭 제왕절개 1예였다. 관련된 태아기형의 빈도는 9예 (75%)로 단안증, 주둥이, 입술갈림증, 누두두증, 무탁융합귀증과 같은 얼굴 이상형태증이었으며, 비정상적 염색체핵형은 6예 중 3예 (50%)였다. 결론: 산전 초음파검사에서 가운데 뇌 이상이 발견되었을 때, 자세하게 얼굴 이상형태증을 산전에 초음파 등을 이용하여 확인하는 것이 주요한 구조적 이상과 예후가 좋지 않은 통앞뇌증을 좀 더 정확하게 진단하는데 도움이 될 것이다. Objective: The purpose of this study is to determine and classify holoprosencephlay with the associated facial abnormalities. Methods: This was a retrospective study in which were reviewed the sonographic findings in correlation with the clinical and pathologic data of fetuses or neonates identified with holoprosencephaly at the Department of Obstetrics and Gynecology of the Catholic University in the period 1995-2007. Results: Twelve cases with a Holoprosencephaly were found. Mean gestational age at diagnosis and delivery was 28 weeks of pregnancy (range from 14 to 41 weeks). Modes of delivery were 8 cases of preterm spontaneous delivery, 2 cases of missed abortion, 1 case of normal fullterm spontaneous delivery, and 1 case of full term cesarean delivery. Associated facial anomalies were present in 9/12 cases (75%) which involved with cyclopia, proboscis, cleft lip and palate, ethomocephaly and otocephaly. Among those anomalies, abnormal karyotypes were 3/6 cases (50%). Conclusions: When a midline brain anomaly is detected by antenatal sonography, accurate sonographic analysis of midline facial defect may allow more definitive diagnosis of holoprosencephaly, and the outcome of affected fetuses often have other major structural abnormalities and nearly always fatal.

손발톱 주위의 난치성 사마귀에 대한 색소 레이저와 병변 내 Bleomycin 주사 병합요법과 병변 내 Bleomycin 주사 단독요법의 비교연구

엄효숙 ( Hyo Sook Aum ),김연희 ( Yon Hee Kim ),김두한 ( Du Han Kim ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.1

VoIP 서비스를 위한 SIP - H323 Translator 설계

곽지영(Ji-Young Kwak),이경희(Kyung Hee Lee),설동명(Dong Myung Sul),김연희(Yon Hee Kim) 한국정보과학회 2002 한국정보과학회 학술발표논문집 Vol.29 No.2Ⅲ

인터넷 이용자 수의 급격한 증가와 인터넷 서비스 보급의 대중화에 따라 인터넷에서 최고의 미래가치를 갖는 기술로 VoIP(Voice over IP) 기술이 부각되고 있다. 현재 가장 활발하게 연구되고 있는 VoIP 기술로는 H.323과 SIP(Session Initiation Protocol)가 있다. SIP는 사용자 간에 멀티미디어 세션을 생성, 수정, 해제하는 응용 계층의 시그널링 프로토콜로서, H.323에 비해 단순한 구조를 가지고 있고 새로운 부가 서비스를 추가하기가 쉽다는 장점이 있어서 앞으로 많은 사용이 예상된다. 비록 SIP가 차세대 네트워크 및 서비스에 이용될 전망이지만, H.323 기반의 기존 서비스를 무시할 수 없으므로 H.323 기반의 서비스를 사용자에게 투명하게 제공하면서 SIP 기반 구조로의 변환 모색이 필요하다. 따라서, 본 논문에서는 SIP와 H.323간의 연동 서비스를 제공하는 SIP-H.323 Translator의 설계에 대해 기술하고자 한다.

이 달의 영상 : 내시경 점막하 박리절제술로 제거한 용종성 낭종성 위염

박혜정 ( Hye Jung Park ),조인래 ( In Rae Cho ),김연희 ( Yon Hee Kim ),이상길 ( Sang Kil Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2

유전자 재조합 B 형 간염 바이러스 표면 항원 , CJC-50100 의 일반약리작용

정성학(Seong Hak Jeong),최재묵(Jae Mook Choi),이남중(Nam Jung Lee),전형수(Hyung Soo Jeon),김연희(Yon Hee Kim),김재승(Jae Seung Kim),하석훈(Suk Hoon Ha),김영훈(Young Hoon Kim),이나경(Na Gyung Lee),김제학(Je Hak Kim),박완제(Wan Je Park 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.1

N/A CJC-50100 is a recombinant hepatitis B virus surface antigen (HBsAg) expressed in yeast. The general pharmacological properties of CJC-50100 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses were 0.33∼33.3 ㎍/㎏ i.m. for mice and rats and 3.3∼9.9 ㎍/㎏ i.v. for dogs. The concentrations of 0.002∼0.02 ㎍/mlwere used for the assay with guinea pig ileum. Intramuscular administration of CJC-50100 at the doses did not alter general behavior and the responses for central nervous system, smooth muscle, gastrointestinal system, cardiovascular and respiratory system, and water and electrolytes excretion. In summary, CJC-50100 had no pharmacological effect in these studies even up to the 100-fold of the expected clinical dose, 20 ㎍/man/60 kg.

色素性 蕁麻疹의 2例

金燕姬,咸姃希,金秀男,姜炯齋 최신의학사 1972 最新醫學 Vol.15 No.10

Urticaria Pigmentosa, also known as Xanthelasmoidea, is a manifestation of mastocytosis due to local and systemic accumulation of mast cells in the skin, reticuloendothelial system, other organs, characterized by usually persistant pigmented cutaneous lesions of various size, shape, from light brown to purplish color that tend to urticate upon mechanical, chemical irritation. As a rule this disease appear in a new born infant and children, rarely in adult. We report two cases of urticaria pigmentosa who showed clinically and histologically typical lesions on the entire body. In these cases, laboratory findings were W. N. L. First case was a 50 yrs old man, since 30 yrs ago skin lesion has been showed. Second case was a newborn infant, and then from at birth, skin eruption was presented, but from 1 month after at birth, the skin lesion began to fade out. 3 months after at birth, skin lesion has discolorated and disappeared but facial flushing was showed. In these cases, antihistamine and antiserotonine with cyproheptadine-hydrochloride was recommened, and follow up. Literature was briefly reviewed for the discussion of clinical and microscopic findings of this disease.

낙엽형 천포진의 1 예

김연희,국홍일,함정희 대한피부과학회 1973 大韓皮膚科學會誌 Vol.11 No.2

The authors observed a case of typical pemphigus foliaceus who was 26 year old male. The pemphigus foliaceus is a rare chronic vesicobullous skin disease which is a type of pemphigus, which has been reported rarely in Korea. This patient has been compained of formication of the face, trunk and upper arms since 7 monthes ago. The skin lesion revealed pea sized, flaccid bullar formation and dark bownish colored hyperpigmented macular eruptions with scattering distribution on the face, trunk, back and upper arms. This patient has experienced localized and generalized exfoliation during 7 rnonthes after onset, but he has not affected in general health condition. Biopsies were performed from the skin of the back, left wrist, and histopathologically the skin showed typical pemphigus foliaceus. So, diagnosis was confirmed by clinical appearance, histopathological finding and others. This patient was markedly imporved by prednisolone without immunesuppressant drugs, and antibiotics and antihistaminics etc.

소아에서 발생한 색소성 방추세포 모반 1예

김종윤,엄효숙,김연희,김두한 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4

Pigmeted spindle cell nevus (PSCN) is often interpreted as a Spitz nevus or misdiagnosed as a malignant melanoma. Some authors consider PSCN as a pigmented variant of Spitz nevus, but many dermatologists classify it as a separate disease. We report a case of pigmented spindle cell nevus which occurred in a 4-year-old boy. The lesion was a well-demarcated, 3×3㎜ sized, black macule on the dorswn part of the 4th finger, left hand. The histopathologic findings of the excisional biopsy specimen revealed the proliferation of uniform, spindle shaped, pigmented melanocytes at the dermoepidermal junction and sharply defined lateral margins. The pathologic features were consistent with PSCN. (Korean J Dermatol 2004;42(4):482~484)

모장 (毛掌) , 족척에 발생하는 농포증 (膿泡症) 의 병리조직소견 및 NBT 검사에 대한 관찰

김명실,김연희,김원석,박효숙 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.1

For many years there has been a great dea,l of disagreement about the classification and histology of recalcitrant pustular eruptions of the palms and soles and the rela.tion of this condition to psoriasis. It is the purpose of this investigation to describe histological changes in fresh pustules from patients witb pustular eruptions of the palms and soles and compare these changes between patients with clinically preceding or co-existing psoriasis (4cases) and without clinically preceding or co-existing psoriasis (7cases). Nine biopsies of pustules were exarnined and the results were compared between two groups. Histopathological findings were otherwise uniform and typical intradermal well-delineated pustules. No significant differences were found bet.ween th two groups. In view of the uniforrn histology, the unknown etiology, and uncertain clinicaI classification, the authors prefer the clearly descreptive term pustulosis palrnaris et plantaris(PPP). Recently the phagocytic ability of neutrophilic leukocytes was reported to be impaired in patients suffering from pustular eruptions of the palms and soles. In our study this ability was performed with the aid of the NBT. dye reduction test before and after administration of Descresept (aristolochic acid). The aim of the present study was to observe the effect of Descresept on NBT test in relation to the clinical acitivity of PPP. The results were as follows: 1. In 6 of 11 patients, clinical improvement was accompanied with increasing NBT' scores. 2. In 2 of 11 patients, clinical aggravation was noted in spite of Descresept adrninistration. In these 2 cases, increase in dosage of Descresept made clinical improvement again with increasing NBT scores. 3. In 3 of the 11 patients, there was noted clinical improvement, but NBT scores were slightly decreased.

DNCB 감작도포법에 의한 우췌의 치료시험

김명실,김연희,김원석 대한피부과학회 1975 대한피부과학회지 Vol.13 No.4

Warts are benign turnors caused by oncogenic human papovavirus which has been clearly identified on electronmicroscopy, although repeated atternpts at culture have not been successful. Various therapeutic modalities have been tried for the treatment of warts, however thete is no saisfactory method and the clinical course as well as the prognosis is always variable. Recently several authors have reported successful therapeutic results in the treatment of warts by DNCB sensitization method based on the findings that warts are often regressing spontaneously and that the spontaneous regression seems to depend on host's ability to mount an immune response against the wert virus. The present study was undertaken to evaluate the DNCB sensitization method for possible routine use in the treatment of warts. Fifteen cases including five verruca vulgaris and ten verruca plana juvenilis patients were sensitized with 1000ug of DNCB in acetone solution on either side of their inner forearms. Seven or ten days after sensitization, several warts, which were unintentionally selected, were challenged with 0.05 to 0.1ml of weaker DNCB solution(50ug-25ug/0.1ml)at weekly interval. Four patients with verruca vulgaris and three patients with verruca plana juvenilis did not return after 1 to 4 times of challenge, however six out of these 7 patients showed a slight decrease in size and number of the warts. One patient with verruca plana juvenilis developed marked irritative and delayed cutaneous hypersensitivity reaction to the 3 times of challenge, so that this patient was excluded from further study. The remaining 7 patients consisted of I verruca vulgaris and 6 verruca plana juvenilis patients showed complete disappearance of all warts including those which were never challenged, after 1 to 13 times of DNCB challenge application. The authors reviewed the possible therapeutic mechanism of DNCB sensitization in the wart patients, the possible advantage and disadvantage of this method and concluded that this method can be cautiously used in seleted patients with warts whose response to the conventional treatment methods are poor.