간세포암에서 유래한 골전이의 방사선치료

금웅섭,성진실,이민정,박희철,한광협,전재윤,문영명,서창옥 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.3

목적: 간세포암의 골전이가 증가됨에 따라 이에 대한 치료의 중요성이 증가되고 있으며 본 연구는 간세포암에서 유래한 골전이 환자에서 방사선치료의 통증 조절 효과에 대하여 분석하였다. 대상과 방법: 1991년 1월부터 2000년 6월까지 간세포암에서 유래한 골전이로 방사선치료를 받은 55명의 환자 중 계획된 방사선치료를 마친 51명(77 골전이 병소) 을 대상으로 하였다. 대상환자 중 남자가 45명, 여자가 6명으로 남녀 비는 7.5 대 1 이었고 연령은 21세 에서 80세였고 중앙값은 55세였다. 방사선치료는 하루 1회 선량 2.5 Gy에서 4 Gy로 총선량 12.5 Gy에 서 50 Gy(중앙값 30 Gy)까지 시행되었다. 방사선치료에 대한 반응은 Wisconsin Brief Pain Questionnaire 검사로 분석하였으며 생존율 분석은 Kaplan-Meier법을 이용하였고 통계적 검증은 log rank test, Cox regression을 이용하였다. 결과: 원발 병소의 진단 당시 동시에 골전이가 있었던 경우가 20명 (39%), 원발 병소 진단 이후에 생긴 골전이는 31명 (61%)이었다. 골전이 진단시 골 이외의 전이 병소는 19명에서 관찰되었고 폐, 복강내 림프절, 부신 등이었다. 골전이 진단 당시 간내 병기는 IVA기가 37명 (73%)으로 대부분이었다. 골전이에 의한 증상은 통증이 주증상이었고(45명), 신경학적 이상을 동반한 경우가 13예, 촉지되는 종괴가 7예, 병적 골절이 5예 이었다. 단일 부위 골전이가 21명(41%), 다발성 골 전이가 30명(59%)이었으며 병소 수는 척추가 38예 로 가장 많았고 늑골 20예, 골반 19예 순 이었다. 골 전이 진단시로부터 생존율은 1년, 2년이 각각 15%, 4%였고 중앙생존기간은 5개월이었다. 예후 인자 단변량 분석에서 골전이 진단 당시 간내 병기 (p=0.014)와 골 이외 다른 부위 전이 유무(p=0.019)가 유의하였으나 다변량 분석에서는 독립적 예후 인자는 없었다. 총 51명 중 49명이 사망하였고 2명의 환자는 무병으로 추적 관찰되고 있다. 방사선치료 후 통증의 변화는 56 병소(73%)에서 호전되었으며, 14 병소(18%)에서는 변화가 없었고, 1 병소(1%) 는 치료 후에도 통증이 악화되었으며 6 병소(8%)는 평가할 수 없었다. 결론: 간세포암의 골전이 이후에 도 중앙생존기간은 약 5개월에 이르고 있다. 따라서 효과적인 증상완화 치료를 필요로 하며, 방사선 치료는 73%에서 통증의 호전을 보이는 유용한 치료로 생각된다 Background/Aim: Recent advances in both diagnosis and treatment have markedly improved the prognosis in patients with hepatocellular carcinoma (HCC). Bone metastasis has become a clinical problem in the treatment of HCC patients. The purpose of this study was to evaluate the palliative effect of radiotherapy for painful bone metastasis from HCC. Methods: From January 1991 to June 2000, 51 patients (77 sites) with painful bone metastasis from HCC were retrospectively analyzed. Ages ranged from 21 to 80 years (median 55 years). The male:female ratio was 7.5:1. Synchronous or metachronous bone metastasis was seen in 20 (39%) and 31 patients (61%), respectively. The most common symptom of bone metastasis was pain (45 patients, 88%). Twenty-one patients (41%) had a solitary bone metastasis while 30 (59%) had multiple ones. The sites of bone metastasis, in order of frequency, were the vertebra (38), rib (20), and pelvis (19). The total radiation dose ranged from 12.5 to 50 Gy (median 30 Gy). The Wisconsin Brief Pain Questionnaire was used to evaluate pain response. Results: The overall 1 and 2 year survival rates from the time of bone metastasis were 15% and 4%, respectively. The median survival time was 5 months. Intrahepatic stage(p=0.014), and metastasis to other organs(p=0.019) were significant prognostic factor for survival by univariate analysis. There was, however, no independent prognostic factor on multivariate analysis. Pain relief after radiotherapy was achieved for 56 sites (73%). Conclusion: The expected life span (median 5 months) in this group of patients suggests a strong necessity for effective treatment for symptomatic palliation. Radiation therapy was effective in pain palliation for bone metastasis from HCC, and this could improve patients' quality of life. (Korean J Hepatol 2002;8:304-311)

Art therapy using famous painting appreciation maintains fatigue levels during radiotherapy in cancer patients

금웅섭,최미연,이정심,박은정,김주혜,김선현,김용배 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.2

Purpose: The purpose of this study was to evaluate the efficacy of art therapy to control fatigue in cancer patients during course of radiotherapy and its impact on quality of life (QoL). Materials and Methods: Fifty cancer patients receiving radiotherapy received weekly art therapy sessions using famous painting appreciation. Fatigue and QoL were assessed using the Brief Fatigue Inventory (BFI) Scale and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) at baseline before starting radiotherapy, every week for 4 weeks during radiotherapy, and at the end of radiotherapy. Mean changes of scores over time were analyzed using a generalized linear mixed model. Results: Of the 50 patients, 34 (68%) participated in 4 sessions of art therapy. Generalized linear mixed models testing for the effect of time on mean score changes showed no significant changes in scores from baseline for the BFI and FACIT-F. The mean BFI score and FACIT-F total score changed from 3.1 to 2.7 and from 110.7 to 109.2, respectively. Art therapy based on the appreciation of famous paintings led to increases in self-esteem by increasing self-realization and forming social relationships. Conclusion: Fatigue and QoL in cancer patients with art therapy do not deteriorate during a period of radiotherapy. Despite the single-arm small number of participants and pilot design, this study provides a strong initial demonstration that art therapy of appreciation for famous painting is worthy of further study for fatigue and QoL improvement. Further, it can play an important role in routine practice in cancer patients during radiotherapy.

간세포암에서 유래한 골전이의 방사선치료

금웅섭,성진실,이민정,박희철,한광협,전재윤,문영명,서창옥 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.3

Background/Aim: Recent advances in both diagnosis and treatment have markedly improved the prognosis in patients with hepatocellular carcinoma (HCC). Bone metastasis has become a clinical problem in the treatment of HCC patients. The purpose of this study was to evaluate the palliative effect of radiotherapy for painful bone metastasis from HCC. Methods: From January 1991 to June 2000, 51 patients (77 sites) with painful bone metastasis from HCC were retrospectively analyzed. Ages ranged from 21 to 80 years (median 55 years). The male:female ratio was 7.5:1. Synchronous or metachronous bone metastasis was seen in 20 (39%) and 31 patients (61%), respectively. The most common symptom of bone metastasis was pain (45 patients, 88%). Twenty-one patients (41%) had a solitary bone metastasis while 30 (59%) had multiple ones. The sites of bone metastasis, in order of frequency, were the vertebra (38), rib (20), and pelvis (19). The total radiation dose ranged from 12.5 to 50 Gy (median 30 Gy). The Wisconsin Brief Pain Questionnaire was used to evaluate pain response. Results: The overall 1 and 2 year survival rates from the time of bone metastasis were 15% and 4%, respectively. The median survival time was 5 months. Intrahepatic stage(p=0.014), and metastasis to other organs(p=0.019) were significant prognostic factor for survival by univariate analysis. There was, however, no independent prognostic factor on multivariate analysis. Pain relief after radiotherapy was achieved for 56 sites (73%). Conclusion: The expected life span (median 5 months) in this group of patients suggests a strong necessity for effective treatment for symptomatic palliation. Radiation therapy was effective in pain palliation for bone metastasis from HCC, and this could improve patients' quality of life. (Korean J Hepatol 2002;8:304-311) 목적: 간세포암의 골전이가 증가됨에 따라 이에 대한 치료의 중요성이 증가되고 있으며 본 연구는 간세포암에서 유래한 골전이 환자에서 방사선치료의 통증 조절 효과에 대하여 분석하였다. 대상과 방법: 1991년 1월부터 2000년 6월까지 간세포암에서 유래한 골전이로 방사선치료를 받은 55명의 환자 중 계획된 방사선치료를 마친 51명(77 골전이 병소)을 대상으로 하였다. 대상환자 중 남자가 45명, 여자가 6명으로 남녀 비는 7.5 대 1 이었고 연령은 21세에서 80세였고 중앙값은 55세였다. 방사선치료는 하루 1회 선량 2.5 Gy에서 4 Gy로 총선량 12.5 Gy에서 50 Gy(중앙값 30 Gy)까지 시행되었다. 방사선치료에 대한 반응은 Wisconsin Brief Pain Questionnaire 검사로 분석하였으며 생존율 분석은 Kaplan- Meier법을 이용하였고 통계적 검증은 log rank test, Cox regression을 이용하였다. 결과: 원발 병소의 진단 당시 동시에 골전이가 있었던 경우가 20명(39%), 원발 병소 진단 이후에 생긴 골전이는 31명(61%)이었다. 골전이 진단시 골 이외의 전이 병소는 19명에서 관찰되었고 폐, 복강내 림프절, 부신 등이었다. 골전이 진단 당시 간내 병기는 IVA기가 37명(73%)으로 대부분이었다. 골전이에 의한 증상은 통증이 주증상이었고(45명), 신경학적 이상을 동반한 경우가 13예, 촉지되는 종괴가 7예, 병적 골절이 5예이었다. 단일 부위 골전이가 21명(41%), 다발성 골전이가 30명(59%)이었으며 병소 수는 척추가 38예로 가장 많았고 늑골 20예, 골반 19예 순 이었다. 골전이 진단시로부터 생존율은 1년, 2년이 각각 15%, 4%였고 중앙생존기간은 5개월이었다. 예후 인자 단변량 분석에서 골전이 진단 당시 간내 병기(p=0.014)와 골 이외 다른 부위 전이 유무(p=0.019)가 유의하였으나 다변량 분석에서는 독립적 예후 인자는 없었다. 총 51명 중 49명이 사망하였고 2명의 환자는 무병으로 추적 관찰되고 있다. 방사선치료 후 통증의 변화는 56 병소(73%)에서 호전되었으며, 14 병소(18%)에서는 변화가 없었고, 1 병소(1%)는 치료 후에도 통증이 악화되었으며 6 병소(8%)는 평가할 수 없었다. 결론: 간세포암의 골전이 이후에도 중앙생존기간은 약 5개월에 이르고 있다. 따라서 효과적인 증상완화 치료를 필요로 하며, 방사선 치료는 73%에서 통증의 호전을 보이는 유용한 치료로 생각된다색인단어: 방사선치료, 골전이, 신생물/간/간세포암

국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량

금웅섭(Woong Sub Koom),서창옥(Chang Ok Suh),김용배(Yong Bae Kim),심수정(Su Jung Shim),표홍렬(Hongryull Pyo),노재경(Jae Kyung Roh),정현철(Hyun Cheol Chung),김귀언(Gwi Eon Kim) 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.4

목적 : 두경부에 국한된 1기, 2기 대세포성(diffuse large cell) 비호치킨 림프종의 항암화학방사선 병용요법 시 방사선 조사영역 내의 재발을 예방하기 위한 적정 방사선 조사선량을 알아보고자 하였다. 대상 및 방법 : 1985년 5월부터 1998년 12월까지 국한성 두경부 대세포성 림프종으로 항암화학요법 후 방사선치료를 받은 53명을 대상으로 하였다. 나이는 13세부터 69세까지였으며 중앙값은 49세였다. 남녀 비는 1.65대 1이었고 1기, 2기 환자가 각각 27명, 26명이었다. 종양 크기별로 5cm 미만이 30명, 5cm 이상이 23명이었다. 원발부위는 경부림프절 22명, 편도 20명, 비인두 4명, 설기저부 3명, 부비동 2명, 후두 1명, 연구개 1명이었다. 항암화학요법은 1명을 제외하고 3회 이상 시행되었으며 방사선치료는 48명이 원발부위와 경부임파선을, 5명이 원발부위만 치료하였다. 생존율, 무병생존율, 조사영역 내 무재발생존율과 방사선 조사선량에 따른 방사선 조사영역 내에서의 재발빈도를 조사하였다. 결과 : 항암화학요법 후 44명(83%)이 완전관해 되었고 연이은 방사선치료 후 53명 모두 완전관해 되었다. 12명(23%)이 재발하였고 그중 2명은 방사선 조사영역 내 재발이었고 방사선 조사영역 바깥 재발은 11명으로 복강 및 ㄱ 반 내 림프절이 가장 많았다. 방사선 조사선량 별 조사영역 내 재발은 30~35 Gy에서 7명 중 1명, 35~40 Gy에서 16명중 1명이었고 40 Gy 이상에서는 재발이 없었다. 방사선 조사영역 내 재발은 30~35 Gy에서 7명 중 1명, 35~40 GY에서 16명중 1명이었고 40 Gy 이상에서는 재발이 없었다. 방사선 조사영역 내 재발에 유의한 예후인자는 없었으나 5cm 이상인 종양에서 재발하였고 5cm 미만인 종양은 30 Gy에서도 재발하지 않았다. 10년 방사선 조사영역내 무재발 생존율, 무병생존율, 전체생존율은 각각 96%, 76%, 75%였다. 결론 : 국한성 두경부 대세포성 림프종서 함암화학방사선 병용요법 시 종양의 크기가 5cm 미만은 경우에는 30 Gy의 방사선 조사선량으로도 국소제어를 할 수 있다. 따라서 방사선치료에 따르는 구강건조증을 최소화시킬 수 있을 것이다. 5cm 이상의 종양에서는 30 Gy 이상의 방사선 조사 선량이 필요하리라 생각된다. Purpose : To determine the optimal radiation dose in a localized non-Hodgkin's lymphoma of the head and neck in the treatment setting for combined chemoradiotherapy. Materials and Methods : Fifty-three patients with stage Ⅰ and Ⅱ diffuse large cell non-Hodgkin's lym-phoma of the head and neck, who were treated with combined chemoradiotherapy between 1985 and 1998 were retrospectively reviewed. The median age was 49 years, and the male-to-female ratio was ap-proximately 1.6. Twenty-seven patients had stage I disease and 26 had stage Ⅱ. Twenty-three patients had bulky tumors (≥5 cm) and 30 had non-bulky tumors (<5 cm). The primary tumors arose mainly from an extranodal organ (70%), most cases involving Waldeyer's ring (90%). All patients except one were initially treated with 3~6 cycles of chemotherapy, which was followed by radiotherapy. Radiation was de-livered either to the primary tumor area alone (9%) or to the primary tumor area plus the bilateral neck nodes (91%) with a minimum does of 30 Gy (range 30~60 Gy). The failure patterns according to the radiation field were analyzed, and the relationship between the dose and the in-field recurrence was evaluated. Results : The 10-year overall survival and the 10-year disease free survival rates were similar at 75% and 76%, respectively. A complete response (CR) after chemotherapy was achieved in 44 patients (83%). Subsequent radiotherapy showed a CR in all patients. Twelve patients (23%) had a relapse of the lym-phoma after the initial treatment. Two of these patients had a recurrence inside the radiation field. No clear dose response relationship was observed and no significant prognostic factors for the in-field recur-rence <5 cm in diameter, there were no in field recurrences after a radiation dose 30 Gy. The 2 in-field recurrences encoutered occurred in patients with a tumor ≥5 cm. conclusion : A dose of 30 Gy is sufficient for local control in patients with a non-bulky (<5 cm), lo-calized, diffuse large cell non-Hodgkin's lymphoma when combined with chemotherapy. An additional boost dose in the primary site is recommended for patients with bulky tumors (≥5 cm).

Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients: implications for adjuvant radiotherapy

장지석,금웅섭,김상운,김성훈,김용배,김영태,김귀언 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.2

Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5%) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4% of patients had a decline in CA-125 ≥90% between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0%) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1%. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55% of the overall patient population and their 5-year survival rate was 68%. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.

Efficacy of Postoperative Radiotherapy Using Modern Techniques in Patients with Retroperitoneal Soft Tissue Sarcoma

김현주,금웅섭,조재호,김효송,서창옥 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9

Purpose: Local recurrence is the most common cause of failure in retroperitoneal soft tissue sarcoma patients after surgical resection. Postoperative radiotherapy (PORT) is infrequently used due to its high complication risk. We investigated the efficacy ofPORT using modern techniques in patients with retroperitoneal soft tissue sarcoma. Materials and Methods: Eighty patients, who underwent surgical resection for non-metastatic primary retroperitoneal soft tissuesarcoma at the Yonsei Cancer Center between 1994 and 2015, were retrospectively reviewed. Thirty-eight (47.5%) patients receivedPORT: three-dimensional conformal radiotherapy in 29 and intensity-modulated radiotherapy in nine patients. Local failure-free survival (LFFS), overall survival (OS), and RT-related toxicities were investigated. Results: Median follow-up was 37.1 months (range, 5.8–207.9). Treatment failure occurred in 47 (58.8%) patients including localrecurrence in 33 (41.3%), distant metastasis in eight (10%), and both occurred in six (7.5%) patients. The 2-year and 5-year LFFSrates were 63.9% and 47.9%, respectively. The 2-year and 5-year OS rates were 87.5% and 71.1%. The 5-year LFFS rate was significantlyhigher in PORT group than in no-PORT group (74.2% vs. 24.3%, p<0.001). In multivariate analysis, PORT was the only independentprognostic factor for LFFS. However, there was no significant correlation between RT dose and LFFS. OS showed nosignificant difference between the two groups. Grade ≤2 acute toxicities were observed in 63% of patients, but no acute toxicity ≥grade 3 was observed. Conclusion: PORT using modern technique markedly reduced local recurrence in retroperitoneal sarcoma patients, with lowtoxicity. The optimal RT technique, in terms of RT dose and target volume, should be further investigated.

암 환자와 보호자의 미술치료에 대한 경험: Y 센터를 중심으로

노진아,금웅섭,김나영,최미연,박은정,김주혜,조연경 숭실대학교 부부가족상담연구소 2016 가족과 상담 Vol.6 No.1

Y 병원 암 지식 정보 센터는 C대학교 미술치료대학원과 함께 암 환자와 보호자를 대상으로 미술치료 프로그램을 진행하고 있다. 1년 동안의 미술치료 과정에서 암 환자와 보호자들로부터 획득한 설문지를 분 석하여 미술치료의 만족도를 알아보고자 하였다. 2014년 4월부터 2015년 5월까지 미술치료 프로그램을 이 용한 145명을 대상으로 하였다. 미술치료 프로그램은 매주 1회, 1시간 동안 시행되었고, 참여자의 선택에 따라 1회 이상의 미술치료가 진행되었다. 미술치료사 1인당 1명 혹은 2명의 대상자가 배정되었고, 미술치 료가 종료된 후에는 설문 조사를 시행하였다. 설문지 항목은 일반적인 환자 혹은 보호자의 정보와 미술치 료에 대한 만족도로 구성되어 있다. 또한 미술치료에 대한 개인적인 의견을 개방형으로 응답받았다. 미술 치료 내용에 대한 만족도에서 77%의 대상자가 매우 만족하는 것으로 나타났다. 또한 74%의 대상자가 미 술치료가 정서적 지지 측면에서 매우 큰 도움이 된다고 답변하였다. 진행 방식과 치료사의 태도 모두 매우 흡족한 결과를 얻었다. 107명의 대상자로부터 미술치료를 받고 나서 느낀 점에 대해서 개방형으로 답변을 받을 수 있었다. 40명(37%)에서 즐거움을, 26명(24%)에서 편안함을 표현하였다. 23명(21%)에서는 자신을 되 돌아보는 시간이었고 힐링이 되는 시간이었다고 답변하였다. 결론적으로 대부분의 참여 대상자들이 미술치 료에 대한 높은 만족도를 표현하였고, 미술치료를 통해 심리적 안녕을 가질 수 있음을 확인하였다.

포스터전시 : 간세포암종에서 방사선치료로 인한 간독성 예측인자로서 ICG-R15 검사의 임상적 유용성 (초)

윤홍인,금웅섭,이익재,김자경,한광협,성진실 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3(S)

포스터전시 : 국소 진행성 간암 환자에서 방사선치료 전후의 혈중 AFP와 PIVKA-2의 변화와 영상학적 종양 반응의 관계

김송이,금웅섭,성진실 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3(S)

Correlations of 3T DCE-MRI Quantitative Parameters with Microvessel Density in a Human-Colorectal-Cancer Xenograft Mouse Model

안성준,안찬식,금웅섭,송호택,서진석 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.6

Objective: To investigate the correlation between quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) parameters and microvascular density (MVD) in a human-colon-cancer xenograft mouse model using 3 Tesla MRI. Materials and Methods: A human-colon-cancer xenograft model was produced by subcutaneously inoculating 1 x 106 DLD-1 human-colon-cancer cells into the right hind limbs of 10 mice. The tumors were allowed to grow for two weeks and then assessed using MRI. DCE-MRI was performed by tail vein injection of 0.3 mmol/kg of gadolinium. A region of interest (ROI) was drawn at the midpoints along the z-axes of the tumors, and a Tofts model analysis was performed. The quantitative parameters (Ktrans, Kep and Ve) from the whole transverse ROI and the hotspot ROI of the tumor were calculated. Immunohistochemical microvessel staining was performed and analyzed according to Weidner’s criteria at the corresponding MRI sections. Additional Hematoxylin and Eosin staining was performed to evaluate tumor necrosis. The Mann-Whitney test and Spearman’s rho correlation analysis were performed to prove the existence of a correlation between the quantitative parameters, necrosis, and MVD. Results: Whole transverse ROI of the tumor showed no significant relationship between the MVD values and quantitative DCE-MRI parameters. In the hotspot ROI, there was a difference in MVD between low and high group of Ktrans and Kep that had marginally statistical significance (ps = 0.06 and 0.07, respectively). Also, Ktrans and Kep were found to have an inverse relationship with MVD (r = -0.61, p = 0.06 in Ktrans; r = -0.60, p = 0.07 in Kep). Conclusion: Quantitative analysis of T1-weighted DCE-MRI using hotspot ROI may provide a better histologic match than whole transverse section ROI. Within the hotspots, Ktrans and Kep tend to have a reverse correlation with MVD in this colon cancer mouse model. Objective: To investigate the correlation between quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) parameters and microvascular density (MVD) in a human-colon-cancer xenograft mouse model using 3 Tesla MRI. Materials and Methods: A human-colon-cancer xenograft model was produced by subcutaneously inoculating 1 x 106 DLD-1 human-colon-cancer cells into the right hind limbs of 10 mice. The tumors were allowed to grow for two weeks and then assessed using MRI. DCE-MRI was performed by tail vein injection of 0.3 mmol/kg of gadolinium. A region of interest (ROI) was drawn at the midpoints along the z-axes of the tumors, and a Tofts model analysis was performed. The quantitative parameters (Ktrans, Kep and Ve) from the whole transverse ROI and the hotspot ROI of the tumor were calculated. Immunohistochemical microvessel staining was performed and analyzed according to Weidner’s criteria at the corresponding MRI sections. Additional Hematoxylin and Eosin staining was performed to evaluate tumor necrosis. The Mann-Whitney test and Spearman’s rho correlation analysis were performed to prove the existence of a correlation between the quantitative parameters, necrosis, and MVD. Results: Whole transverse ROI of the tumor showed no significant relationship between the MVD values and quantitative DCE-MRI parameters. In the hotspot ROI, there was a difference in MVD between low and high group of Ktrans and Kep that had marginally statistical significance (ps = 0.06 and 0.07, respectively). Also, Ktrans and Kep were found to have an inverse relationship with MVD (r = -0.61, p = 0.06 in Ktrans; r = -0.60, p = 0.07 in Kep). Conclusion: Quantitative analysis of T1-weighted DCE-MRI using hotspot ROI may provide a better histologic match than whole transverse section ROI. Within the hotspots, Ktrans and Kep tend to have a reverse correlation with MVD in this colon cancer mouse model.