무액면 주식에서의 발행가액과 자본구성

장지석 한국상사법학회 2000 商事法硏究 Vol.19 No.1

주식의 가치에 관한 법적 고찰

장지석 연세법학회 2000 연세법학 Vol.7 No.1

Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients: implications for adjuvant radiotherapy

장지석,금웅섭,김상운,김성훈,김용배,김영태,김귀언 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.2

Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5%) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4% of patients had a decline in CA-125 ≥90% between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0%) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1%. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55% of the overall patient population and their 5-year survival rate was 68%. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.

Bladder filling variations during concurrent chemotherapy and pelvic radiotherapy in rectal cancer patients: early experience of bladder volume assessment using ultrasound scanner

장지석,윤홍인,차혜정,정윤선,조예나,금기창,금웅섭 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.1

Purpose: To describe the early experience of analyzing variations and time trends in bladder volume of the rectal cancer patients who received bladder ultrasound scan. Materials and Methods: We identified 20 consecutive rectal cancer patients who received whole pelvic radiotherapy (RT) and bladder ultrasound scan between February and April 2012. Before simulation and during the entire course of treatment, patients were scanned with portable automated ultrasonic bladder scanner, 5 times consecutively, and the median value was reported. Then a radiation oncologist contoured the bladder inner wall shown on simulation computed tomography (CT) and calculated its volume. Results: Before simulation, the median bladder volume measured using simulation CT and bladder ultrasound scan was 427 mL (range, 74 to 1,172 mL) and 417 mL (range, 147 to 1,245 mL), respectively. There was strong linear correlation (R = 0.93, p < 0.001) between the two results. During the course of treatment, there were wide variations in the bladder volume and every time, measurements were below the baseline with statistical significance (12/16). At 6 weeks after RT, the median volume was reduced by 59.3% to 175 mL. Compared to the baseline, bladder volume was reduced by 38% or 161 mL on average every week for 6 weeks. Conclusion: To our knowledge, this study is the first to prove that there are bladder volume variations and a reduction in bladder volume in rectal cancer patients. Moreover, our results will serve as the basis for implementation of bladder training to patients receiving RT with full bladder.

Intensity Modulated Radiotherapy and Volumetric Modulated Arc Therapy in the Treatment of Breast Cancer: An Updated Review

장지석,장지현,김나리,김용배,신경환,김규보 한국유방암학회 2022 Journal of breast cancer Vol.25 No.5

Radiation therapy (RT) plays a critical role in breast cancer treatment. In the modern technological era, innovations and progress in breast RT and delivery techniques have greatly improved the clinical outcomes. Intensity-modulated RT (IMRT) is a modern RT technology that permits the modulation of RT beams, ensuring a more uniform dose distribution through the target tissue and better avoidance of underlying critical structures. Recently, several studies have been published on breast IMRT. However, the interpretation of these results can be challenging because of the wide diversity of patients and treatment. The purpose of this study was to review these studies, focusing on the impact of IMRT on reducing toxicity and increasing convenience, as well as addressing concerns regarding breast IMRT.

Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer

장지석,김나리,김지예,도성임,조연아,김현수,김용배 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.6

Objective: Kallikrein 5 (KLK5), which is frequently observed in normal cervico-vaginalfluid, is known to be related to prognosis in several solid tumors. We investigated theprognostic significance of KLK5 in uterine cervical cancer using tumor tissue microarray andimmunohistochemistry staining. Methods: We analyzed samples of 165 patients with uterine cervical cancer who receiveddefinitive radiation therapy between 2004 and 2012. We divided patients into two groupsstratified by their KLK5 activity by immunohistochemistry staining: negative/weak (0–1+)(n=120 patients) and moderate/strong (2–3+) group (n=45 patients). Patient and tumorcharacteristics, patterns of failure, and survival outcomes were compared. Univariable andmultivariable analyses were performed to identify prognostic factors. Results: Patients with KLK5 2–3+ were younger (median: 52 vs. 60 years) and had frequentparaaortic lymph node involvement (40.0% vs. 18.3%) than those with KLK5 0–1+. With amedian follow-up of 60.8 (interquartile range, 47.5–77.9) months, patients with KLK5 2–3+had inferior 5-year locoregional recurrence-free survival and distant metastasis-free survivalof 61.7% (vs. 77.5% in KLK5 0–1+ group) and 59.4% (vs. 72.8% in the KLK5 0–1+ group),respectively (all p<0.05). KLK5 2–3+ expression retained its significance after adjusting forother well-known prognostic factors of tumor size and stage in multivariable analysis. Conclusions: KLK5 overexpression is associated with the aggressiveness of cervical cancerand may underlie the diminished response to conventional treatments. Therefore, KLK5could be a reliable prognostic factor in cervical cancer.

Patterns of Care for Radiotherapy in the Neoadjuvant and Adjuvant Treatment of Gastric Cancer: A Twelve-Year Nationwide Cohort Study in Korea

장지석,최영,신재용,김경환,금기창,김효송,금웅섭,박은철 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1

Purpose Although Korea has the highest incidence of gastric cancer worldwide and D2-lymphadenectomies are routinely performed, radiotherapy (RT) practice patterns have not been well studied. Therefore, we examined RT usage trends for neoadjuvant/adjuvant patients and identified factors associated with RT. We also examined survival benefits and net medical cost advantages of adding RT. Materials and Methods Patients diagnosed with gastric cancer who underwent gastrectomy from 2002-2013 were identified using National Health Insurance Service-National Sample Cohort. Results Annually, 30.9 cases per 100,000 population in crude rate underwent gastrectomy in 230 hospitals and 49.8% received neoadjuvant/adjuvant therapy in 182 hospitals. For neoadjuvant/ adjuvant patients, postoperative chemo-RT was administered in 4% of cases in 26 hospitals. No significant trends regarding treatment type were observed over time. Having undergone RT was inversely associated with being ! 60 years old and having a low income. Having undergone RT was positively related to having a Charlson comorbidity index ! 4, hospital location and hospital volume (! 2,000 beds). Significant portions of patients treated with RT in this nation (52%) were concentrated in one large-volume hospital. Use of RT linked to increased cost of primary treatment, yet not to reduced overall medical expense. RT did not influence both on overall and disease-specific survivals after adjusting for potential confounders (p > 0.05). Conclusion RT was uncommonly utilized as adjuvant or neoadjuvant treatment by physicians in Korea. Despite intrinsic drawback in this data, we did not find either survival benefit or net medical cost advantage by adding RT in adjuvant treatment.

18F-FDG/PET May Help to Identify a Subgroup of Patients with T1-T2 Breast Cancer and 1-3 Positive Lymph Nodes Who Are at a High Risk of Recurrence after Mastectomy

장지석,이정심,김현정,김경환,윤미진,김승일,금기창,서창옥,김용배 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose The purpose of this study is to assess the utility of positron emission tomography (PET) for predicting recurrence among patients with T1-T2/N1 breast cancer who were treated with mastectomy. Materials and Methods Of 712 consecutive patients with T1-T2/N1 breast cancer treated during 2003-2012, 109 had undergone preoperative 18F-fluorodeoxyglucose/PET and were included. Metabolic (maximum standardized uptake value [SUVmax]), volumetric (metabolic tumor volume [MTV]), and combined (total lesion glycolysis [TLG]) indices were measured. The resulting values were analyzed and compared with clinical outcome. Results At the median follow-up of 46.7 months, the 3-year relapse-free survival (RFS) rate was 95.2%. SUVmax (area under curve, 0.824) was more useful than MTV or TLG as a means of identifying patients at high risk for any recurrence. In multivariate analysis, SUVmax remained an independent risk factor for RFS (p=0.006). Using the method of Contal and O’Quigley, a SUVmax threshold of 5.36 showed the best predictive performance. The PET-based highrisk group (! 5.36 in either breast or nodes) had more T1c-T2, high-grade, hormone-receptor negative, and invasive ductal carcinoma tumors than the low-risk group (< 5.36 in both breast and nodes). The prognosis was much worse when high SUVmax (! 5.36) was detected in nodes (p < 0.001). In the no-radiotherapy cohort, the PET-based high-risk group had increased risk of locoregional recurrence when compared to the low-risk group (p=0.037). Conclusion High SUVmax on preoperative PET showed association with elevated risk of locoregional recurrence and any recurrence. Pre-treatment PET may improve assessments of recurrence risk and clarify indications for post-mastectomy radiotherapy in this subset of patients.

패션 스타일 트렌드 분석의 정량화를 위한 의사 결정 시스템 개발에 관한 연구

장지석(Jiseok Jang),전영승(Youngseung Jeon),한경식(Kyungsik Han) 한국통신학회 2020 한국통신학회 학술대회논문집 Vol.2020 No.8

Team Competence and Warmth’s Influence on Perceived Value and Media Consumption Intentions : As Moderated by Interdependent Self-Construal

Chang, Jisuk(장지석),Lim, Choong Hoon(임충훈),Jang, Woo-Seok(장우석),Oh, Inae(오인애) 한국체육과학회 2021 한국체육과학회지 Vol.30 No.2

The purpose of the current study was to investigate how a sport team’s competence and warmth as perceived by a non-fan of the team, influence their media consumption intentions. Furthermore, the current study proposes that this relationship is mediated by the perceived value of the team’s games, as moderated by interdependent self-construal. In pursuit of the purpose, the current study recruited 212 NBA fans residing in the United States. Hypotheses testing was conducted utilizing Partial Least Squares Structural Equation Modeling using SmartPLS 3.3.3 software. The results revealed a full mediation effect where the perceived competence of a team influenced media consumption intentions through perceived value of the team’s games. Meanwhile, perceived value partially mediated the relationship between perceived team warmth and media consumption intentions, where both the direct and indirect paths remained significant. Furthermore, interdependent self-construal moderated the relationship between perceived warmth and perceived value. Finally, interdependent self-construal did not have a moderating effect on the relationship between perceived team competence and media consumption intentions. The findings of the current study add to the literature on factors that influence the consumption of media content related to other teams in a sport league. Furthermore, the current study is the first to apply the Stereotype Content Model dimensions to a sport consumption context and provides insight as to the role of interdependent self-construal.