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정상 한국 성인에서 혈청 암태아성항원의 경계치 및 이에 영향을 미치는 인자
김선욱,정준기,이동수,곽철은,정재민,김명기,이명철,고창순,이형기,유근영,안윤옥,김종순 ( Sun Wook Kim,June Key Chung,Dong Soo Lee,Cheol Eun Kwark,Jae Min Jeong,Myung Ki Kim,Myung Chul Lee,Chang Soon Koh,Hyung Kee Lee,Keun Young Yoo,Yoon Ok 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
Carcinoembryonic Antigen is one of most frequent.ly checked tumor markers in cancer management. We performed statistical analysis with serum CEA data of 2626 persons who received regular health examination and were thought to be free of active disease to determine the cutoff values of serum CEA level in normal Korean adults and to study the factors influencing serum (:EA levels in normal subjects. 1) The cutoff values of serum CEA in normal Korean adults in general were 9.28ng/ ml for men, 5.90 ng/ml for women. 2) Serum CEA level was influenced by age, present smoking history, sex, and abnormal findings in chest X ray. 3) Serum CEA level had no correlation with the history of amount of alcohol consumption or obesity. 4) Cutoff values of serum CEA in normal Korean adults were tabulated according to age, sex, and smoking histor y. Serum CEA level was influenced by age, sex, present smoking history and abnormal findings in chest X ray and cutoff values of serum CEA were tabulated according to age, sex, and smoking history.
뇌혈관질환에서 99mTc-HMPAO SPECT 를 이용한 국소뇌혈류의 정량적 분석
이선호,이명철,고창순,한대희,이명혜,노재규,명호진 대한핵의학회 1988 핵의학 분자영상 Vol.22 No.1
SPECT of regional cerebral blood flow was performed using Tc-99m-HMPAO in 28 patients with cerebrovascular disease and quantitative analysis was done. Cerebral asymmetry index and percent index of asymmetry of cerebellar hemisphere of patients with cerebral infarction or ischemia were 0.764±0.576 and -5.6±7.1% and those of intracranial hemorrhage was 0.416±0.251 and -2.5±4.1% respectively. According to PIA of cerebellar hemisphere, 12 patients showed crossed cerebellar diaschisis. Tc-99m-HMPAO SPECT seemed to be a useful tool for the evaluation of regional cerebral blood flow.
조보연,이홍규,김원배,고창순,박도준,정현경,전재석,김선욱 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.3
Background: It is important to recognize the independent prognostic factors of papillary carcinoma of thyroid in therapeutic and follow up planning. However, its good prognosis and its low prevalence make it difficult to analyze prognostic factors determining patients survival in a relatively short period of time. We retrospectively investigated the independent prognostic factors for determining disease recurrence after surgery which, in adults, are known to be closely related to the prognosis of cancer. Method: We retrospectively reviewed the clinical records of 456 patients(male 70, female 381, unknown 5, mean age of 43.9+-12.9 years) who had visited the thyroid clinic in Seoul National University Hospital and analyzed the data with statistical software program. Results: 1) At initial visit, chief complaint of the patients was abnormal neck mass in 90 percent. 2) In preoperative thyroid scan study, 82% showed cold area and 16% showed diffuse enlargement. 3) Of the 50 recurrent cases after surgery(11.5% of the total cases), 39 cases(78%) had recurred disease in neck area and 11 cases(22%) had recurrences at distant sites.(Lung 9 cases, Brain I case, Mediastinum 1case) 4) Statistically significant risk factors for recurrence after surgery were male sex, size of tumor (above 4.5cm in this study), extrathyroidal invasion of cancer, involvement of resection margin and no remnant ablation of thyroid tissue using radioiodine. Conclusion: Through retrospective study, we presented some clinical characteristics of papillary thyroid cancer in Korea and independent risk factors of cancer recurrences after surgery. (J Kor Soc Endocrinol 12:421-432, 1997)
미세침흡인 세포검사상 중간형 (Indeterminate) 의 갑상선결절에서 악성의 가능성이 높은 임상 지표들
이선화,조보연,김원배,고창순,김성연,박도준,김선욱,이홍규 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Background: The recommended management of patients who have cytologic diagnosis of indeterminate group by fine fine needle aspiration (FNA) in thyroid nodules is controversial. Our objective was to identify the incidence of malignancy through thyroidectomy in indeterminate group and clinical features associated with an increased risk of malignancy that might guide future practice. Methods: We retrospectively reviewed the medical records of 222 patients who had cytologic diagnosis of indeterminate group by FNA in thyroid nodules at Seoul National University Hospital from Jan. 1990 to Aug. 1998. Patients characteristics and clinical features were compared between benign and malignant nodules classified as pathologic findings through thyroidectomy. Results: The frequency of indeterminate group was 6% (222/3981) among patients underwent thyroid FNA. The frequency of malignant nodules was 47.4% (64/135) among 135 patients underwent thyroidectomy. Among clinical features, rapid increase in size (7.0% vs 20.3%, p=0.024), local symptoms such as dysphagia, hoarseness, pain (1.4% vs 15.6%, p=0.003), fixation (4.4% vs 35.7%, p$lt;0.001), hard consistency(15.7% vs 59.7%, p$lt;0.001) and irregular surface(6.3% vs 25.6%, p=0.001) were significantly more common in malignant nodules than in benign nodules. However, clinical features such as mean age of patients, male sex, presence of past history of benign thyroid disease, family history of benign thyroid disease, solitary nodule, presence of cervical lymph nodes, mean size of nodules and cold nodules by thyroid scan in malignant nodules were not significantly different from that in benign nodules. Among clinical features that were significantly more common in malignant nodules, fixation(p=0.042) and presence of local symptoms (p=0.043) were significantly independent risk factors predictive of malignancy. Conclusion: Its better to recommend thyroidectomy in patients with clinical features such as presence of local symptoms, fixed nodule and hard nodule in indeterminate group, in otherwise to decide treatment with repeated FNAs when clinical features such as patients symptoms and physical examinations of nodule change through regular follow-up.(J Kor Soc Endocrinol 14:505-513, 1999)