심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

흰쥐 경동맥 풍선손상 모델에서 리포좀 전달체를 이용한 에스트로겐의 국소전달 효과

윤영섭,장양수,정광회,박요석,김형관,강웅철,권진욱,정보영,조상호,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

R.C.造에서 超音波速度에 미치는 鐵1筋의 影響 : 길이방향鐵筋을 중심으로 On the longitudinal Steel bar

윤석천,정수영,연길환 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.2

Ultrasonic testing of a reinforced concrete member by means of the ultrasonic testing apparatus is affected by the steel bar embedded in concrete. A test location avoid the zone of steel effect when selecting test location in reinforced concrete member. But if it is impossible, it is necessary to make a correction to the measured value to provide an estimate of the velocity of the pulse in the plain concrete. The purpose of this study is to analyze the effect of steel bar on ultrasonic pulse velocity and the evaluate optimum correction formular by means of comparison between pulse velocity in concrete and effective pulse velocity according to steel bar diameters. Concrete mixes having water cement ratio of 0.4 and 0.6 by weight and slump values of 18㎝ in fresh concrete were used to make 20×30×60㎝ cubes for pulse velocity in concrete and effective pulse velocity. The diameters of the plain bars were 6, 9, 12, 19, 25, 32, 38 and 50㎜.

유치원교사 역할에 대한 공ㆍ사립유치원교사의 인식비교

윤기영,송석희,박복희 서원대학교 교육대학원 2000 교육논총 Vol.4 No.-

The purpose of this study is that public kindergarten teachers and private kindergarten teachers perceive the kindergarten teachers' role and related degree of role importance, and as looking into what is difference recognition of kindergarten teachers and private kindergarten teachers . To achieve the study purpose, investigator choose the study method by the questionnaire. It consisted of 47 items reflecting the 6 areas of roles. To perform this study, In order to conduct this study we gave several test's to 135 public kindergarten teachers and 137 private kindergarten teachers in chunk-buk province by either in person or by mail, By using the SPSS/PC+ program it resulted to the T-test, the oneway ANOVA and the Tukey after inspection. The result of this study is as follows. 1. We discovered that public kindergarten teachers had a conscious recognition of the importance of their roles and had pride in what they wear Therefore the support for extension of specialization will lead into positive effiency for their roles performance as teachers. 2. Both public kindergarten teachers and private kindergarten teachers have a high recognition in the importance of kindergarten' roles which led into the sympathetic response to each other that they be closely connected with each other. 3. According to the related transformation cause. between the public kindergarten teachers and private kindergarten teachers group. kindergarten teachers role recognition has a little difference of related teacher's age and educational career.

首都圈 衛星都市의 住民福祉向上을 위한 市議會와 行政機關의 役割에 관한 硏究 : Centering Around Koyang-Shi Kyung Ki-Do Area. (京畿道 高揚市를 中心으로)

윤석달,박오화,함영훈,황정룡,허희영 한국항공대학교 1993 論文集 Vol.31 No.-

地方化時代의 到來로 高揚市는 많은 變化가 豫想되고 있다. 1980年부터 繼續的으로 論議되던 地方自治의 問題가 지금은 現實化되어 1991年 4月에는 基礎地方自治의 議會를 構成하고 6月에는 廣域自治團體의 議會를 構成하였고 머지않은 將來 에 地方自治團體의 長을 選出할 豫定이다. 앞으로 많은 施行錯誤가 있을 수 있겠으나 地方自治時代에 돌입한 것은 누구 도 否認 할 수 없는 사실이다. 1997年경의 住民構成은 1990年代初期의 高揚市에 居住하고 있던 原住民과 一山을 포함한 新高揚 開發地域에 90萬의 新 入住者로 구성될 것이며, 이러한 高揚市 住民構成의 變化는 地方自治에 커다란 衝擊要因으로 작용될 것이다. 新.原住民의 要求를 調和하는 問題는 여러 形態로 나타날 수 있으나 住民福祉라는 側面이 매우 강하게 대두될 것이다. 高揚市의 福祉活動은 生活保護者들을 위한 특수한 경우를 제외하고는 거의 전무한 상태이다. 地方自治制度가 어느정도 安定的인 국면으로 접어들면, 地域的 次元에서 市民 모두를 위한 福祉活動이 深度있게 展開되어야 할 것이다. 市行政機 關과 市議會는 兒童福祉, 婦女福祉, 老人福祉및 醫療福祉에 대한 現況울 把握하고 이에 대한 해결의 優先順位를 결정하 여 다가오는 人口의 增加에 따른 福祉需要를 충족시켜 나가야 할 것이다. 福祉需要에 대한 優先順位를 硏究者들이 제시하여 보면 託兒施設과 더불어 綜合病院施設을 擴充하여 市民들에게 奉仕 하는 태세를 體系化하여야 할 것이며 그밖에는 施設을 擴充하는 方式보다는 年齡과 性別 및 職業 등의 基準에 맞게 "프 로그램"을 積極的으로 開發하는 努力이 경주되어야 할 것이다. 그러으로써 量的인 意味에서 뿐만이 아니라 質的인 意味 에서 福祉活動을 展開할 수 있는 基盤을 造成할 수 있을 것이다. It is expected that Koyang City have lots of changes according to the emergence of Decentralization era. Nowdays local self-government has been realized since its disscussion in 1980. On april, 1991, the assembly of basic self-government was established, and the assembly of extensive self-government constructed on june, 1991. The chairman of local-government assembly is supposed to be elected in the new future. None can deny the beginning of local-government era inspite of potential trial and errors. Population structure in 1997 is expected to be composed of the existing civilians of Koyang City in early 1990's and about 0.90millions of new comers in new cities including llsan area, and he change of the city population will significant impacts on the self-government scheme of Koyang City. The problem to coordinate desires of existing civilians and that of new comers might be embodied in many kinds of aspects, but welfare-raising will be strengthed first of all. Existing welfare programme of Koyang City dosen't show any signigicant activities except the case of Green Card programme. It is desirable that whole-sideed welfare programme be perfomed by local levels in the stage of staionary self-government systems. Administrative institutions and assembly of city should survey and research the present situations of children welfare, female welfare, the old age welfare, and medical welfare, and decide their priorities to meet increasing desires coming from rapid increase of city-population. We, researchers, propose several outstanding problems by priority as follows; to expand medical institutions and public nursery schools accompanies by strenthening the attitude of government employees for public service, to develop various programmes in order to activate many exiting institutions more efficiently rather than to build new institutions needed, in consideration of ages, sex and occupations of their users. If these propositions accomplished the welfare programme will have cornerstone to enrich its activities as well as activities as well as enlarge it bounderies.

Benign Partial Epilepsy with Occipital Paroxysm 1례

윤석중,이영혁,김교순 건국대학교 의과학연구소 1994 건국의과학학술지 Vol.4 No.-

Benign epilepsy of childhood with occipital paroxysm is characterized by seizures which include visual symptoms followed by motor manifestations. The EEG is also characterized by repetitive occipital discharges of spikes, sharp waves or spike-wave complexes appearing only after eye closure. No occipital lesions have been found, the children are neurologically normal. Recently we experienced a case of benign epilepsy of childhood with occipital paroxysm which showed favorable response to anticonvulsant treatment. A brief review of related literatures is included in this report

Ethanol을 전처치한 흰쥐의 간 및 혈청 Xanthine Oxidase 활성에 미치는 Bromobenzene의 영향

윤종국,임영숙 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.1

To evaluate the effect of ethanol pretreatment on the liver and serum xanthine oxidase(XO) actively, the bromobenzene(400㎎/㎏ body wt., i.p.) was orally given 3 times daily to the Sprague-Dawley male rats pretreated with 5% ethanol throughout 2 months. Bromobenzene treated rats pretreated with ethanol showed the more decreased activity of serum and liver XO. and lower value of V_(max) than those of only bromobenzene treated rats. By the bromobenzene treatment, ethanol pretreated rats showed the more decreased levels of serum alanine aminotransferase activity and liver weight/body weight(%), and decreased degree of liver damage on histopathological observation than the control group.

Thermomicrobium roseum 유래 Alcohol Dehydrogenase의 정제 및 특성

윤석영,홍민표,김은호,공광훈 중앙대학교 기초과학연구소 2000 基礎科學硏究所 論文集 Vol.14 No.-

Alcohol dehydrogenase from Thermomicrobium roseum was purified to electrophoretic homogeneity approximately 77-fold with a 38% activity yield by adenosine 5'-monophosphate and Mono Q column chromatography. The molecular weight of the enzyme was determined to be approximately 43,000 by SDS-polyacrylamide gel electrophoresis and 88,000 by gel chromatography, indicating a homodimeric structure. The Km and Vmax values of the enzyme for ethanol were 24.2 mM and 12.8 ㎛ol/min/mg, respectively. Pyrazole notably inhibited the enzymatic activity. Ca2+ ion activated the enzyme activity, but Cu2+ inhibited. The activity of the enzyme was optimal at pH 10.0 and 60℃.