Shared Protection of Lightpath with Guaranteed Switching Time over DWDM Networks

Chen Yen-Wen,Peng I-Hsuan The Korea Institute of Information and Commucation 2006 Journal of communications and networks Vol.8 No.2

Survivability is a very important requirement for the deployment of broadband networks because out of service links can affect volumes of traffic even if it is a very short time. And the data paths of broadband networks, which are critical for traffic engineering, are always necessary to be well protected. The procedure of protection or restoration for a path is initiated when failure is detected within the working path. In order to minimize the influence on transmission quality caused by the failure of links and to provide a definite time for the recovery from the failure, the protection switching time (PST) should be carefully considered in the path arrangement. Several researches have been devoted to construct the protection and restoration schemes of data paths over dense wavelength division multiplexing (DWDM) networks, however, there was rare research on the design of data paths with guaranteed protection switching time. In this paper, the PST-guaranteed scheme, which is based on the concept of short leap shared protection (SLSP), for the arrangement of data paths in DWDM networks is proposed. The proposed scheme provides an efficient procedure to determine a just-enough PST-guaranteed backup paths for a working path. In addition to selecting the PST-guaranteed path, the network cost is also considered in a heuristic manner. The experimental results demonstrate that the paths arranged by the proposed scheme can fully meet the desired PST and the required cost of the selected path is competitive with which of the shared path scheme.

Cav3.2 T-Type Ca2+ Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain.

Chen, Wen-Kwei,Liu, Ingrid Y,Chang, Ya-Ting,Chen, Yong-Cyuan,Chen, Chih-Cheng,Yen, Chen-Tung,Shin, Hee-Sup,Chen, Chien-Chang The Society 2010 The Journal of neuroscience Vol.30 No.31

<P>Treatments for chronic musculoskeletal pain, such as lower back pain, fibromyalgia, and myofascial pain syndrome, remain inadequate because of our poor understanding of the mechanisms that underlie these conditions. Although T-type Ca(2+) channels (T-channels) have been implicated in peripheral and central pain sensory pathways, their role in chronic musculoskeletal pain is still unclear. Here, we show that acid-induced chronic mechanical hyperalgesia develops in Ca(v)3.1-deficient and wild-type but not in Ca(v)3.2-deficient male and female mice. We also show that T-channels are required for the initiation, but not maintenance, of acid-induced chronic muscle pain. Blocking T-channels using ethosuximide prevented chronic mechanical hyperalgesia in wild-type mice when administered intraperitoneally or intracerebroventricularly, but not intramuscularly or intrathecally. Furthermore, we found an acid-induced, Ca(v)3.2 T-channel-dependent activation of ERK (extracellular signal-regulated kinase) in the anterior nucleus of paraventricular thalamus (PVA), and prevention of the ERK activation abolished the chronic mechanical hyperalgesia. Our findings suggest that Ca(v)3.2 T-channel-dependent activation of ERK in PVA is required for the development of acid-induced chronic mechanical hyperalgesia.</P>

DCT-based Image Compression with Efficient Enhancement Filter

Wen-Chien Yen,Yen-Yu Chen 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

This work adopts DCT and modifies the SPIHT algorithm to encode DCT coefficients. The algorithm represents the DCT coefficients to concentrate signal energy and proposes combination and dictator to eliminate the correlation in the same level subband for encoding the DCTbased images. The proposed algorithm also provides the enhancement function in low bit rate in order to improve the perceptual quality. This work contribution is that the coding complexity of the proposed algorithm for DCT coefficients is just close to JPEG but the performance is higher than JPEG2000. Experimental results indicate that the proposed technique improves the quality of the reconstructed image in terms of both PSNR and the perceptual results close to JPEG2000 at the same bit rate.

The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma

Yen-Hsiang Huang,Kuo-Hsuan Hsu,Jeng-Sen Tseng,Kun-Chieh Chen,Chia-Hung Hsu,Kang-Yi Su,Jeremy J. W. Chen,Huei-Wen Chen,Sung-Liang Yu,Tsung-Ying Yang,Gee-Chen Chang 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose The main objective of this study was to investigate the relationship among the clinical characteristics and the frequency of T790M mutation in advanced epidermal growth factor receptor (EGFR)mutant lung adenocarcinoma patients with acquired resistance after firstline EGFRtyrosine kinase inhibitor (TKI) treatment. Materials and Methods We enrolled EGFR-mutant stage IIIB-IV lung adenocarcinoma patients, who had progressed to prior EGFR-TKI therapy, and evaluated their rebiopsy EGFRmutation status. Results A total of 205 patients were enrolled for analysis. The overall T790M mutation rate of rebiopsy was 46.3%. The T790M mutation rates among patients with exon 19 deletion mutation, exon 21 L858R point mutation, and other mutations were 55.0%, 37.3%, and 27.3%, respectively. Baseline exon 19 deletion was associated with a significantly higher frequency of T790M mutation (adjusted odds ratio, 2.14; 95% confidence interval [CI], 1.20 to 3.83; p=0.010). In the exon 19 deletion subgroup, there was a greater prevalence of T790M mutation than other exon 19 deletion subtypes in patients with the Del E746-A750 mutation (61.6% vs. 40.6%; odds ratio, 2.35; 95% CI, 1.01 to 5.49; p=0.049). The progression- free survival (PFS) of first-line TKI treatment > 11 months was also associated with a higher T790M mutation rate (54.1% vs. 39.3%; adjusted odds ratio, 1.82; 95% CI, 1.02 to 3.25; p=0.044). Patients who underwent rebiopsy at metastatic sites had more chance to harbor T790M mutation (52.6% vs. 33.8%; adjusted odds ratio, 1.97; 95% CI, 1.06 to 3.67; p=0.032). Conclusion PFS of first-line EGFR-TKI, rebiopsy site, EGFR exon 19 deletion and its subtype Del E746- A750 mutation are associated with the frequency of T790M mutation.

Study of Data Placement Schemes for SNS Services in Cloud Environment

( Yen-wen Chen ),( Meng-hsien Lin ),( Min-yan Wu ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.8

Due to the high growth of SNS population, service scalability is one of the critical issues to be addressed. The cloud environment provides the flexible computing and storage resources for services deployment, which fits the characteristics of scalable SNS deployment. However, if the SNS related information is not properly placed, it will cause unbalance load and heavy transmission cost on the storage virtual machine (VM) and cloud data center (CDC) network. In this paper, we characterize the SNS into a graph model based on the users` associations and interest correlations. The node weight represents the degree of associations, which can be indexed by the number of friends or data sources, and the link weight denotes the correlation between users/data sources. Then, based on the SNS graph, the two-step algorithm is proposed in this paper to determine the placement of SNS related data among VMs. Two k-means based clustering schemes are proposed to allocate social data in proper VM and physical servers for pre-configured VM and dynamic VM environment, respectively. The experimental example was conducted and to illustrate and compare the performance of the proposed schemes.

Design of a De-ringing Filter for Wavelet-based Compressed Image

Yen-Yu Chen,Ying-Wen Chang,Wen-Chien Yen 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

JPEG2000 Standard is a new generation image compression technique, enabling encoding images at low bitrates with acceptable quality. Since JPEG2000 is based on wavelet transforms, the reconstructed image will contain perceivable ringing artifacts in medium and low bit-rate regimes of lossy compression. This work utilizes a quad-tree partitioning scheme for post-processing the reconstructed image in a spatially varying manner and presents a voting strategy to determine a set of morphological filters to be used for reducing the ringing artifacts. Simulation results demonstrate that the proposed technique enhances reconstructed image quality compared to unprocessed JPEG2000 output at an equivalent bit-rate accounting for the side-information overhead, in terms of both Peak Signal-to-Noise Ratio (PSNR) and Visible Ringing Measure (VRM).

A Research for Hakka Aged People Life Requirements - Taking Kaohsiung Mei-Nong County as an Example of This Study

Mei-Jung Chen,Wen-Wen Lin,Yen-Yen Chen 한국간호과학회 2005 한국간호과학회 학술대회 Vol.2005 No.10

2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation

Wei-Che Lin,Wen-Chieh Chen,Pei-Wen Wang,Yi-Chia Chan,Yen-Hsiang Chang,Harn-Shen Chen,Szu-Tah Chen,Wei-Chih Chen,Kai-Lun Cheng,Shun-Yu Chi,Pi-Ling Chiang,Chen-Kai Chou,Feng-Fu Chou,Shun-Chen Huang,Feng 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.3

Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies for specialists in interventional radiology, endocrinology, and endocrine surgery collaborated to develop the first consensus regarding thyroid RFA in Taiwan. The modified Delphi method was used to reach a consensus. Based on a comprehensive review of recent and valuable literature and expert opinions, the recommendations included indications, pre-procedural evaluations, procedural techniques, post-procedural monitoring, efficacy, and safety, providing a comprehensive review of the application of RFA. The consensus effectively consolidates advice regarding thyroid RFA in clinical practice for local experts.

Arm Exoskeleton Rehabilitation Robot with Assistive System for Patient after Stroke

Guan De Lee,Wei-Wen Wang,Kai-Wen Lee,Sheng-Yen Lin,Li-Chen Fu,Jin-Shin Lai,Wen-Shiang Chen,Jer-Junn Luh 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

Exercise dosage is proven to be an important factor in the physical treatment. Robot assistive approach can improve the rehabilitation quality and evaluate patient’s recovery quantitatively. This paper presents kinematic structure, assistive control system, and integrated F/T sensor for an upper limb rehabilitation robot. By using the human arm dynamic, there are three rehabilitation modes presented in this paper: active mode, assistive mode, and passive mode. In assistive mode, we have two strategies to implement it. One is to amplify interactive torque, and the other is to apply assist-as-needed concept. The goal of this mode is to assist patients to finish motion tasks. The rehabilitation robot under investigation has 7 degree of freedom (DOF) actuated by DC motors, which are programmed to drive the robot arm in the 3D space. To validate our control design, some realistic experiments are conducted and its satisfactory performance is demonstrated. This work is approved clinical testing by the Department of Health, Executive Yuan, R.O.C. So far, we are demonstrating the effect of our controller.

Treatment outcomes of patients with stage II pure endometrioid-type endometrial cancer: a Taiwanese Gynecologic Oncology Group (TGOG-2006) retrospective cohort study

Hung-Chun Fu,Jen-Ruei Chen,Min-Yu Chen,Keng-Fu Hsu,Wen-Fang Cheng,An Jen Chiang,Yu-Min Ke,Yu-Chieh Chen,Yin-Yi Chang,Chia-Yen Huang,Chieh-Yi Kang,Yuan-Yee Kan,Sheng-Mou Hsiao,Ming-Shyen Yen 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.5

Objective: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. Methods: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival. Results: Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI], 1.2–70.9) and grade 3 histology (HR=7.28; 95% CI, 1.45–36.6) were independent predictors of OS. Grade 3 histology was an independent predictor of RFS (HR=5.13; 95% CI, 1.38–19.1) and DSS (HR=5.97; 95% CI, 1.06–58.7). Patients receiving adjuvant RT had lower locoregional recurrence (p=0.046), but no impact on survival. Conclusion: Different treatment modalities yield similar survival outcomes. Patients receiving SH with RT had lower locoregional recurrent with acceptable morbidity. Age and tumor grading remained significant predictors for survival among patients with FIGO 2009 stage II EEC.