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Research on Value Creativity of Taiwan`s Small and Medium-sized Enterprises
( Shiaw Wen Tien ),( Yi Chan Chung ),( Chih Hung Tsai ),( Chia Hsiang Hsieh ),( Hung Hsi Chen ) 한국품질경영학회 2007 The Asian Journal on Quality Vol.8 No.1
This research probes into the execution of small and medium-sized enterprises` value creativities by a difference analysis with different classifications, different capital, different turnover, different employees, and different established years. This study develop a questionnaire about value creativity with five dimensions and thirty-five items according to “Valuation” by McKinsey and Company, Inc. and Copeland et al., such as: “Aspiration and target,” “Portfolio management,” “Organization design,” “Process management,” and “Business and individual performance management.” The results are as follows: (1) Most small and medium-sized enterprises (SMEs) have executed value creativities; (2) There is a difference in the execution of value creativities between the livelihood industry and the chemical industry; the execution of value creativities by livelihood industry is better than the chemical industry; (3) For value creativities of the execution of different capital and turnover for SMEs, bigger entities are better than smaller ones; (4) For the value creativities of the execution of different numbers of staff in SMEs, those with more staff are better than those with fewer staff; (5) For the value creativities of the execution of different established years for SMEs, those established longer are better than those established shorter.
Research on the Structure and Application of Fuzzy Environmental Impact Assessment Model
Tien, Shiaw-Wen,Hsneh, Chia-Hsiang,Chung, Yi-Chan,Tsai, Chih-Hung,Yu, Yih-Huei The Korean Society for Quality Management 2004 The Asian Journal on Quality Vol.5 No.2
Any business activities may have impact on environment to a certain extent. Enterprises must find appropriate approaches to measure the impact on these environmental aspects, which can be used as the basis to direct enterprises' efforts to improve the environmental impact. The method used to evaluate significant factors in life cycle assessment standards is the one most commonly used by enterprises in general to measure environmental impact. By this method, the decisive factors of each environmental aspect are given scores according to the preset scoring standard of the organization. The scores are added up for each aspect and ranked to assess major environmental aspects. The drawback of this assessment method, that is, it ignores the degree to which each of these factors affects the environment, results in poor credibility. Therefore, this study attempts to solve some qualitative problems by applying to fuzzy theory, in particular, by identifying appropriate fuzzy numbers through fuzzy sets and membership function. Moreover, the study seeks to obtain a crisp value in the process of defuzzifization in order to make up for the shortfall of the original method in dealing with relative weight of decisive factors and thus increase its applicability and credibility. The department of light production of an electronics company is used as an example in this study to measure environmental aspects by employing both the traditional significant factor method and the fuzzy environmental impact assessment model proposed in this study. Based on verification and comparison of results, the model proposed in this study is more feasible as it reduces partiality in decision-making by taking the relative weights of decisive factors into consideration.
Research on Value Creativity of Taiwan's Small and Medium-sized Enterprises
Tien, Shiaw-Wen,Chung, Yi-Chan,Tsai, Chih-Hung,Hsieh, Chia-Hsiang,Chen, Hung-Hsi The Korean Society for Quality Management 2007 The Asian Journal on Quality Vol.8 No.1
This research probes into the execution of small and medium-sized enterprises' value creativities by a difference analysis with different classifications, different capital, different turnover, different employees, and different established years. This study develop a questionnaire about value creativity with five dimensions and thirty-five items according to "Valuation" by McKinsey and Company, Inc. and Copeland et al., such as: "Aspiration and target," "Portfolio management," "Organization design," "Process management," and "Business and individual performance management." The results are as follows: (1) Most small and medium-sized enterprises (SMEs) have executed value creativities; (2) There is a difference in the execution of value creativities between the livelihood industry and the chemical industry; the execution of value creativities by livelihood industry is better than the chemical industry; (3) For value creativities of the execution of different capital and turnover for SMEs, bigger entities are better than smaller ones; (4) For the value creativities of the execution of different numbers of staff in SMEs, those with more staff are better than those with fewer staff; (5) For the value creativities of the execution of different established years for SMEs, those established longer are better than those established shorter.
Deubiquitination and Stabilization of PD-L1 by CSN5
Lim, Seung-Oe,Li, Chia-Wei,Xia, Weiya,Cha, Jong-Ho,Chan, Li-Chuan,Wu, Yun,Chang, Shih-Shin,Lin, Wan-Chi,Hsu, Jung-Mao,Hsu, Yi-Hsin,Kim, Taewan,Chang, Wei-Chao,Hsu, Jennifer L.,Yamaguchi, Hirohito,Ding Elsevier 2016 Cancer cell Vol.30 No.6
<P><B>Summary</B></P> <P>Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation </LI> <LI> Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization </LI> <LI> CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination </LI> <LI> Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Wei-Che Lin,Wen-Chieh Chen,Pei-Wen Wang,Yi-Chia Chan,Yen-Hsiang Chang,Harn-Shen Chen,Szu-Tah Chen,Wei-Chih Chen,Kai-Lun Cheng,Shun-Yu Chi,Pi-Ling Chiang,Chen-Kai Chou,Feng-Fu Chou,Shun-Chen Huang,Feng 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.3
Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies for specialists in interventional radiology, endocrinology, and endocrine surgery collaborated to develop the first consensus regarding thyroid RFA in Taiwan. The modified Delphi method was used to reach a consensus. Based on a comprehensive review of recent and valuable literature and expert opinions, the recommendations included indications, pre-procedural evaluations, procedural techniques, post-procedural monitoring, efficacy, and safety, providing a comprehensive review of the application of RFA. The consensus effectively consolidates advice regarding thyroid RFA in clinical practice for local experts.