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이수미,임남주,김창원,강신원 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1
New active organic thin film optical wavegudie ion sensor is proposed. Poly-dimethylsiloxane(RTV3140) membrane based on indicator tetramethylmurexide (TMX) and co-polymer matric membrane based chromoionophore(ETH5294) were used as active waveguide itself. Utilizing thin film membrane, fast respense time and high sensitivity are obtained. And sensor could be measured a wide range of Ca^(++) concentrations ranging from 10^(-6) to 1M by measuring the absorbance change at the 488nm and 514nm wavelength of light. The dependence of attenuation of guided wave on the properties of transduction layer is discussed.
[CB-0004] Assembly of chromosome-level genome to accelerate octoploid strawberry breeding
Koeun Han(Koeun Han),Sun Yi Lee(Sun Yi Lee),Jinhee Kim(Jinhee Kim),Hye-Eun Lee(Hye-Eun Lee),Jinkwan Jo(Jinkwan Jo),Eun Su Lee(Eun Su Lee),Byoung-Cheorl Kang(Byoung-Cheorl Kang),Do-Sun Kim(Do-Sun Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Kang, Su Jin,Choi, Beom Rak,Kim, Seung Hee,Yi, Hae Yeon,Park, Hye Rim,Park, Soo Jin,Song, Chang Hyun,Park, Ji Ha,Lee, Young Joon,Kwang, Sae Society of Cosmetic Chemists 2015 Journal of cosmetic science Vol.66 No.3
<P>Synopsis Botanical antioxidants have attracted much attention as useful preventatives of skin damage. Pomegranate is consumed throughout the world for its beneficial health effects, including its antioxidant and anti-inflammatory activities. We investigated whether pomegranate concentrated solution (PCS) could serve as a potential functional cosmetic ingredient that exerts a skin-whitening effect and antiwrinkle activity. To investigate the moisturizing effect of PCS, hyaluronidase activity was examined in human keratinocytes (HaCaT). Elastase and procollagenase activities were assessed in normal human primary dermal fibroblast-neonatal (HDF-N) cells to determine their antiwrinkle effects. Metalloproteinase 1 (MMP-1) activity was also assessed following ultraviolet A (UVA) irradiation. Whitening effects were measured by a tyrosinase inhibition assay and melanin formation test in mouse melanocytes (Melan-a). In addition, histopathological analysis was performed to determine the number of microfolds formed on the epithelial surface, mean epithelial thickness, mean number of inflammatory cells infiltrating the dermis, and collagen fiber-occupied regions within the dermis. Hyaluronan synthesis was significantly increased by PCS in HaCaT cells, while procollagenase and elastase activities were decreased in HDF-N cells. A significant decrease in UVA-induced MMP-1 activity was also observed in PCS-treated HDF-N cells, compared with UVA-exposed cells. PCS effectively reduced melanin production and mushroom tyrosinase activity in Melan-a cells. Moreover, UVB-induced histopathological dermal sclerosis and inflammatory signs were significantly attenuated in PCS-administered mice compared with UVB-exposed mice. Conclusions: Our results suggest that PCS prevents signs of aging, including those related to photoaging. These effects are associated with enhanced hyaluronan synthesis, as well as suppressed elastase, collagenase, MMP-1, and tyrosinase activities and melanin production. UVB-induced photoaging, such as histopathological dermal sclerosis and inflammatory signs, were effectively reduced on the addition of PCS. These results also suggest that skin aging can be prevented and reduced by the antioxidant effects of PCS.</P>
쓰쓰가무시병 유행지역 일차진료 병원에 있어서의 임상진단의 정확성
이강수,정윤섭,유승근,전기환,배진기,홍관식,육동민,양상호,임정식 대한감염학회 1996 감염 Vol.28 No.2
목 적 : 쓰쓰가무시병 유행지역에 위치한 일차진료기관에서 임상소견을 근거로 이 병을 진단하였을 때 그 정확성을 검토하고자 하였다. 방 법 : 1994년 10월과 11월에 진해소재 의료기관에 내원한 쓰쓰가무시병이 의심된 환자의 임상진단의 정확도를 치료경과 및 IFA 시험 성적을 근거로 검토하였다. 결 과 : 쓰쓰가무시병으로 임상진단된 18명 환자중 발진은 모두에서, 농포는 1명에서, 가피는 15명에서, 림프절염은 13명에서 관찰되었다. 이 환자 중 17명에 대해서는 IFA 항체가 시험되어 15명에 있어서는 높은 항체가나 항체가의 상승을 보여 쓰쓰가무시병임이 확인되었다. 2명에 대해서는 각각 발병 제3일과 제4일에 시행된 1회의 항체시험이 음성이었으나 치료결과로 볼 때 쓰쓰가무시병으로 판단되었다. IFA 시험을 위해 polyvalent conjugate를 사용하여도 발병초기에는 양성결과를 얻을 수 없음을 보였다. 결 론 : 쓰쓰가무시병 유행지역에 있는 일차진료기관에서 임상소견을 근거로한 진단은 대부분 정확하였으며, 적절한 항균제로 치료되어 환자들이 회복된다는 결론을 얻었다. 또한primary lesion은 흑색 가피 상태로만 관찰되는 것이 아니고 발병초기에는 농포상태로도 관찰되며 발진은 모든 환자에서 관찰되었고 발병과 동시에 생긴다고 추측되었다. Background : Scrub typhus is endemic in many parts of Korea including Chinhae. Accurate and rapid diagnosis for effective treatment is usually based on clinical diagnosis without laboratory aids in endemic area. The aim of the study was to assess the accuracy of clinical diagnosis at primary-care clinics in an endemic area. Methods : During the period of October through November, 1994, 18 patients were clinically diagnosed as scrub typhus at primary-care clinics in Chinhae city. Clinical diagnosis was based on the presence of fever, rash, lymphadenitis and eschar (primary lesion). The accuracy of clinical diagnosis was assessed by the serological test and efficacy of treatment with tetracycline. Results : Among the 18 patients, rashes were noted in all patients, whereas lymphadenitis in 13 patients, eschars in 15 patients, and a pustule in one patient. Serologic studies showed high or rising IFA titer to Rickettsia tsutsugamushi in 15 patients. Clinical diagnosis of 3 patients without serologic evidences were considered accurate based on the clinical response to antimicrobial therapy. Two patients showed negative serology because of taking blood samples on the 3rd or 4th day of illness, respectively, and serologic test was not done in one patient. IFA test with ployvalent conjugate did not give faster positive results. Conclusion : Accurate and rapid clinical diagnosis of scrub typhus at primary-care clinics in endemic area is possible mainly based on clinical features, which makes early treatment with appropriate antimicrobial agents possible.